NO990947L - Anvendelse av inhibitorer for PKC til fremstilling av et medikament for behandling av sentralnervesystemsykdommer forbundet med HIV-infeksjon - Google Patents

Anvendelse av inhibitorer for PKC til fremstilling av et medikament for behandling av sentralnervesystemsykdommer forbundet med HIV-infeksjon

Info

Publication number
NO990947L
NO990947L NO990947A NO990947A NO990947L NO 990947 L NO990947 L NO 990947L NO 990947 A NO990947 A NO 990947A NO 990947 A NO990947 A NO 990947A NO 990947 L NO990947 L NO 990947L
Authority
NO
Norway
Prior art keywords
nervous system
central nervous
hiv infection
pkc
medication
Prior art date
Application number
NO990947A
Other languages
English (en)
Other versions
NO990947D0 (no
Inventor
Michael R Jirousek
Douglas K Ways
Lawrence E Stramm
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1997/015583 external-priority patent/WO1998008510A1/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO990947D0 publication Critical patent/NO990947D0/no
Publication of NO990947L publication Critical patent/NO990947L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Fremgangsmåte for behandling av sentralnervesystemsykdom forbundet med HIV-infeksjon er beskrevet, særlig ved anvendelse av den isozymselektive PKC- inhibitor (S)-3,4-[N,Nl-l,l'-((211- etoksy)-3' ' '(O)-4 ' ' '-(N,N-dimetyl- amino)-butan)-bis-(3,3'-indolyl)]-l(H)- pyrrol-2,5-dionhydrokloridsalt.
NO990947A 1996-08-30 1999-02-26 Anvendelse av inhibitorer for PKC til fremstilling av et medikament for behandling av sentralnervesystemsykdommer forbundet med HIV-infeksjon NO990947L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2486996P 1996-08-30 1996-08-30
US91736297A 1997-08-26 1997-08-26
PCT/US1997/015583 WO1998008510A1 (en) 1996-08-30 1997-08-28 Use of inhibitors of pkc for the manufacture of a medicament for the treatment of central nervous system diseases associated with hiv infection

Publications (2)

Publication Number Publication Date
NO990947D0 NO990947D0 (no) 1999-02-26
NO990947L true NO990947L (no) 1999-04-28

Family

ID=26698961

Family Applications (1)

Application Number Title Priority Date Filing Date
NO990947A NO990947L (no) 1996-08-30 1999-02-26 Anvendelse av inhibitorer for PKC til fremstilling av et medikament for behandling av sentralnervesystemsykdommer forbundet med HIV-infeksjon

Country Status (11)

Country Link
EP (1) EP0834313A1 (no)
JP (1) JP2002514178A (no)
KR (1) KR20000035863A (no)
CN (1) CN1231607A (no)
BR (1) BR9711375A (no)
CA (1) CA2263499A1 (no)
EA (1) EA199900244A1 (no)
IL (1) IL128494A0 (no)
NO (1) NO990947L (no)
PL (1) PL331761A1 (no)
TR (1) TR199900774T2 (no)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506231A (en) * 1989-03-31 1996-04-09 The Children's Medical Center Corporation Treatment of aids dementia, myelopathy and blindness
JPH08511785A (ja) * 1993-06-17 1996-12-10 チバ−ガイギー アクチェンゲゼルシャフト プロテインキナーゼｃ阻害剤として有用なインドロカルバゾール
UA44690C2 (uk) * 1993-12-07 2002-03-15 Елі Ліллі Енд Компані Макроциклічна сполука іміду біс-індол-малеїнової кислоти, спосіб її одержання та фармацевтична композиція, макроциклічні сполуки іміду біс-індол-малеїнової кислоти та біс-індол-малеїнового ангідриду, спосіб одержання (варіанти)

Also Published As

Publication number Publication date
CA2263499A1 (en) 1998-03-05
BR9711375A (pt) 1999-08-17
PL331761A1 (en) 1999-08-02
TR199900774T2 (xx) 1999-07-21
KR20000035863A (ko) 2000-06-26
EA199900244A1 (ru) 1999-10-28
CN1231607A (zh) 1999-10-13
EP0834313A1 (en) 1998-04-08
NO990947D0 (no) 1999-02-26
IL128494A0 (en) 2000-01-31
JP2002514178A (ja) 2002-05-14

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application