NO984508L - Tiazolinsyre-derivater - Google Patents

Tiazolinsyre-derivater

Info

Publication number
NO984508L
NO984508L NO984508A NO984508A NO984508L NO 984508 L NO984508 L NO 984508L NO 984508 A NO984508 A NO 984508A NO 984508 A NO984508 A NO 984508A NO 984508 L NO984508 L NO 984508L
Authority
NO
Norway
Prior art keywords
thiazoline derivatives
thiazoline
derivatives
chelators
useful
Prior art date
Application number
NO984508A
Other languages
English (en)
Other versions
NO984508D0 (no
NO315608B1 (no
Inventor
Raymond J Bergeron Jr
Original Assignee
Univ Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida filed Critical Univ Florida
Publication of NO984508D0 publication Critical patent/NO984508D0/no
Publication of NO984508L publication Critical patent/NO984508L/no
Publication of NO315608B1 publication Critical patent/NO315608B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/04Chelating agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/10Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO19984508A 1996-03-29 1998-09-28 Tiazolinsyre-derivater, anvendelse av dem og farmasöytiske preparater inneholdende dem NO315608B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/624,289 US5840739A (en) 1992-11-16 1996-03-29 Thiazoline acid derivatives
PCT/US1997/004666 WO1997036885A1 (en) 1996-03-29 1997-03-31 Thiazoline acid derivatives

Publications (3)

Publication Number Publication Date
NO984508D0 NO984508D0 (no) 1998-09-28
NO984508L true NO984508L (no) 1998-11-23
NO315608B1 NO315608B1 (no) 2003-09-29

Family

ID=24501405

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19984508A NO315608B1 (no) 1996-03-29 1998-09-28 Tiazolinsyre-derivater, anvendelse av dem og farmasöytiske preparater inneholdende dem

Country Status (13)

Country Link
US (1) US5840739A (no)
EP (3) EP2096112A3 (no)
JP (2) JP3800559B2 (no)
KR (1) KR20000005100A (no)
AT (1) ATE449088T1 (no)
AU (1) AU715889B2 (no)
BR (1) BR9708460A (no)
CA (1) CA2250243C (no)
DE (1) DE69739670D1 (no)
NO (1) NO315608B1 (no)
NZ (2) NZ332049A (no)
PL (1) PL329172A1 (no)
WO (1) WO1997036885A1 (no)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7045531B1 (en) 1997-03-11 2006-05-16 The General Hospital Corporation Composition comprising a metal chelator and a method of treating amyloidosis by administering the metal chelator
CA2319255C (en) 1998-02-04 2010-01-26 University Of Florida Research Foundation, Inc. Pharmaceuticals comprising n,n'-bis(2- hydroxybenzyl) ethylenediamine-n, n'-diacetic acid for iron chelating therapy
US6323218B1 (en) 1998-03-11 2001-11-27 The General Hospital Corporation Agents for use in the treatment of Alzheimer's disease
US6638711B1 (en) 1999-04-29 2003-10-28 The General Hospital Corporation Methods for identifying an agent that inhibits oxygen-dependent hydrogen peroxide formation activity but does not inhibit superoxide-dependent hydrogen peroxide formation
US6083966A (en) * 1998-08-31 2000-07-04 University Of Florida Thiazoline acid derivatives
US6159983A (en) * 1998-09-18 2000-12-12 University Of Florida Method and composition for treatment of inflammatory bowel disease
NZ526880A (en) * 1998-09-21 2005-05-27 Univ Florida Antimalarial agents
EP1488791A3 (en) * 1998-09-21 2005-04-06 University Of Florida Research Foundation, Inc. Antimalarial agents
AU2456201A (en) 1999-12-21 2001-07-03 University Of Florida Research Foundation, Inc. N,n'-bis(2-hydroxybenzyl)ethylenediamine-n,n'-diacetic acid in iron chelating therapy
US6689788B1 (en) * 2000-08-25 2004-02-10 University Of Florida Method and composition for treatment of inflammatory bowel disease
US6875883B2 (en) * 2002-05-15 2005-04-05 Genzyme Corporation Synthesis of benzonitriles from substituted benzaldehyde
US20040044220A1 (en) * 2002-08-22 2004-03-04 University Of Florida Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin
US20040132789A1 (en) * 2002-08-22 2004-07-08 University Of Florida Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin
CA2497560A1 (en) 2002-09-20 2004-04-01 Promega Corporation Luminescence-based methods and probes for measuring cytochrome p450 activity
AU2003270473A1 (en) * 2003-09-09 2005-04-27 University Of Florida Desferrithiocin derivatives and their use as iron chelators
BRPI0610644B8 (pt) * 2005-04-04 2021-05-25 Univ Florida composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável.
EP2778234B1 (en) 2005-05-31 2017-09-27 Promega Corporation Luminogenic and fluorogenic compounds and methods to detect molecules or conditions
NZ579994A (en) 2007-03-15 2011-09-30 Univ Florida Desferrithiocin polyether analogues useful in the treatment of pathological conditions responsive to chelation or sequestration of trivalent metal
JP5597200B2 (ja) 2008-08-18 2014-10-01 プロメガ コーポレイション ルミネッセンスを生じる化合物およびチトクロムp4503a酵素を検出するための方法
CN102648189A (zh) * 2009-07-27 2012-08-22 费罗金生物科学股份有限公司 作为金属螯合剂的脱氮杂去铁硫辛聚醚类似物的前药
AU2012352025B2 (en) 2011-12-16 2018-01-18 University Of Florida Research Foundation, Inc. Uses of 4'-desferrithiocin analogs
EP3071201A4 (en) 2013-11-22 2017-04-26 University of Florida Research Foundation, Inc. Desferrithiocin analogs and uses thereof
JP6703484B2 (ja) 2014-01-29 2020-06-03 プロメガ コーポレイションPromega Corporation 細胞による取り込み測定のための、標識用試薬としての、キノンでマスクされたプローブ
KR20170140306A (ko) * 2015-04-27 2017-12-20 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 대사적으로 프로그램화된 금속 킬레이트화제 및 그의 용도
SG11202011534YA (en) 2018-05-29 2020-12-30 Cersci Therapeutics Inc Compounds for pain treatment, compositions comprising same, and methods of using same
CN113874360A (zh) 2019-05-10 2021-12-31 瑟赛治疗公司 噻唑啉抗痛觉过敏剂的制造方法和多晶型物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1137529A (en) * 1967-05-04 1968-12-27 Wyeth John & Brother Ltd Thiazole compositions
GB1262292A (en) * 1968-04-09 1972-02-02 Wyeth John & Brother Ltd Novel thiazoline derivatives, the preparation thereof and compositions containing the same
DE3002989A1 (de) * 1980-01-29 1981-07-30 Hoechst Ag, 6000 Frankfurt Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels
EP0045281B1 (de) * 1980-07-28 1985-05-08 Ciba-Geigy Ag Thiazolinderivate und Verfahren zu ihrer Herstellung
US5393777A (en) * 1990-11-15 1995-02-28 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon Health Sciences University Deferration using anguibactin siderophore
WO1994011367A1 (en) * 1992-11-16 1994-05-26 University Of Florida Research Foundation Inc. 2-(pyrid-2'-yl)-2-thiazoline-4(s)-carboxylic acid derivatives

Also Published As

Publication number Publication date
BR9708460A (pt) 2000-01-04
DE69739670D1 (de) 2009-12-31
EP1380577B1 (en) 2009-11-18
CA2250243C (en) 2002-10-08
JP2000505086A (ja) 2000-04-25
JP3800559B2 (ja) 2006-07-26
AU715889B2 (en) 2000-02-10
US5840739A (en) 1998-11-24
EP0900209A4 (en) 2001-09-19
EP0900209A1 (en) 1999-03-10
PL329172A1 (en) 1999-03-15
NZ332049A (en) 2001-04-27
EP2096112A3 (en) 2009-09-09
NZ509967A (en) 2005-06-24
NO984508D0 (no) 1998-09-28
EP1380577A1 (en) 2004-01-14
NO315608B1 (no) 2003-09-29
ATE449088T1 (de) 2009-12-15
EP2096112A2 (en) 2009-09-02
JP2006152004A (ja) 2006-06-15
KR20000005100A (ko) 2000-01-25
AU2541097A (en) 1997-10-22
CA2250243A1 (en) 1997-10-09
WO1997036885A1 (en) 1997-10-09

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Legal Events

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