ATE449088T1 - Thiazolinsäure-derivate - Google Patents
Thiazolinsäure-derivateInfo
- Publication number
- ATE449088T1 ATE449088T1 AT03021526T AT03021526T ATE449088T1 AT E449088 T1 ATE449088 T1 AT E449088T1 AT 03021526 T AT03021526 T AT 03021526T AT 03021526 T AT03021526 T AT 03021526T AT E449088 T1 ATE449088 T1 AT E449088T1
- Authority
- AT
- Austria
- Prior art keywords
- acid derivatives
- thiazolic
- thiazolic acid
- derivatives
- thiazoline
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 150000002739 metals Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/04—Chelating agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/624,289 US5840739A (en) | 1992-11-16 | 1996-03-29 | Thiazoline acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE449088T1 true ATE449088T1 (de) | 2009-12-15 |
Family
ID=24501405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03021526T ATE449088T1 (de) | 1996-03-29 | 1997-03-31 | Thiazolinsäure-derivate |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5840739A (de) |
| EP (3) | EP0900209A4 (de) |
| JP (2) | JP3800559B2 (de) |
| KR (1) | KR20000005100A (de) |
| AT (1) | ATE449088T1 (de) |
| AU (1) | AU715889B2 (de) |
| BR (1) | BR9708460A (de) |
| CA (1) | CA2250243C (de) |
| DE (1) | DE69739670D1 (de) |
| NO (1) | NO315608B1 (de) |
| NZ (2) | NZ509967A (de) |
| PL (1) | PL329172A1 (de) |
| WO (1) | WO1997036885A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7045531B1 (en) | 1997-03-11 | 2006-05-16 | The General Hospital Corporation | Composition comprising a metal chelator and a method of treating amyloidosis by administering the metal chelator |
| DE69922787T2 (de) * | 1998-02-04 | 2005-12-15 | University of Florida Research Foundation, Inc., Gainesville | N,n'-bis(2-hydroxybenzyl)ethylendiamin-n,n'-diessigsäure und natriumsalze davon zur eisenchelatierungstherapie |
| US6323218B1 (en) | 1998-03-11 | 2001-11-27 | The General Hospital Corporation | Agents for use in the treatment of Alzheimer's disease |
| US6638711B1 (en) | 1999-04-29 | 2003-10-28 | The General Hospital Corporation | Methods for identifying an agent that inhibits oxygen-dependent hydrogen peroxide formation activity but does not inhibit superoxide-dependent hydrogen peroxide formation |
| US6083966A (en) * | 1998-08-31 | 2000-07-04 | University Of Florida | Thiazoline acid derivatives |
| US6159983A (en) * | 1998-09-18 | 2000-12-12 | University Of Florida | Method and composition for treatment of inflammatory bowel disease |
| CN1585639A (zh) * | 1998-09-21 | 2005-02-23 | 佛罗里达大学研究基金会 | 抗疟疾制剂 |
| EP1488791A3 (de) * | 1998-09-21 | 2005-04-06 | University Of Florida Research Foundation, Inc. | Mittel gegen malaria |
| CA2394524A1 (en) | 1999-12-21 | 2001-06-28 | Raymond J. Bergeron | N,n'-bis(2-hydroxybenzyl)ethylenediamine-n,n'-diacetic acid in iron chelating therapy |
| US6689788B1 (en) * | 2000-08-25 | 2004-02-10 | University Of Florida | Method and composition for treatment of inflammatory bowel disease |
| US7038073B2 (en) * | 2002-05-15 | 2006-05-02 | Genzyme Corporation | Synthesis of 2-alkyl amino acids |
| US20040044220A1 (en) * | 2002-08-22 | 2004-03-04 | University Of Florida | Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin |
| US20040132789A1 (en) * | 2002-08-22 | 2004-07-08 | University Of Florida | Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin |
| EP1546162B1 (de) | 2002-09-20 | 2011-06-22 | Promega Corporation | Auf lumineszenz basierende verfahren und sonden zur messung der cytochrom-p450-aktivität |
| WO2005034949A1 (en) * | 2003-09-09 | 2005-04-21 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
| TR201910900T4 (tr) | 2005-04-04 | 2019-08-21 | Univ Florida | Desferritiyokin polieter analogları. |
| EP2272972A1 (de) | 2005-05-31 | 2011-01-12 | Promega Corporation | Luminogene und fluorogene Verbindungen und Verfahren für den Nachweis von Molekülen oder Leiden |
| WO2008115433A1 (en) * | 2007-03-15 | 2008-09-25 | University Of Florida | Desferrithiocin polyether analogues |
| US8288559B2 (en) | 2008-08-18 | 2012-10-16 | Promega Corporation | Luminogenic compounds and methods to detect cytochrome P450 3A enzymes |
| EP2459544A4 (de) * | 2009-07-27 | 2012-12-05 | Ferrokin Biosciences Inc | Prodrugs aus desazadesferrothiocin-polyether-analogen als metallchelierungsmittel |
| EP3620161A1 (de) | 2011-12-16 | 2020-03-11 | University of Florida Research Foundation, Inc. | Verwendung von 4'-desferrithiocin-analoga |
| AU2014352780A1 (en) | 2013-11-22 | 2016-06-09 | University Of Florida Research Foundation, Inc. | Desferrithiocin analogs and uses thereof |
| US9790537B2 (en) | 2014-01-29 | 2017-10-17 | Promega Corporation | Quinone-masked probes as labeling reagents for cell uptake measurements |
| KR20170140306A (ko) * | 2015-04-27 | 2017-12-20 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 대사적으로 프로그램화된 금속 킬레이트화제 및 그의 용도 |
| AU2019279761A1 (en) | 2018-05-29 | 2020-12-10 | Cersci Therapeutics, Inc. | Compounds for pain treatment, compositions comprising same, and methods of using same |
| EP3966200A1 (de) | 2019-05-10 | 2022-03-16 | Cersci Therapeutics, Inc. | Herstellungsverfahren und polymorphe eines thiazolin-antihyperalgetischen mittels |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1137529A (en) * | 1967-05-04 | 1968-12-27 | Wyeth John & Brother Ltd | Thiazole compositions |
| CY800A (en) * | 1968-04-09 | 1976-12-01 | Wyeth John & Brother Ltd | Novel thiazoline derivatives, the preparation thereof and compositions containing the same |
| DE3002989A1 (de) * | 1980-01-29 | 1981-07-30 | Hoechst Ag, 6000 Frankfurt | Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels |
| DE3170401D1 (en) * | 1980-07-28 | 1985-06-13 | Ciba Geigy Ag | Triazoline derivatives and processes for their preparation |
| US5393777A (en) * | 1990-11-15 | 1995-02-28 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon Health Sciences University | Deferration using anguibactin siderophore |
| WO1994011367A1 (en) * | 1992-11-16 | 1994-05-26 | University Of Florida Research Foundation Inc. | 2-(pyrid-2'-yl)-2-thiazoline-4(s)-carboxylic acid derivatives |
-
1996
- 1996-03-29 US US08/624,289 patent/US5840739A/en not_active Expired - Fee Related
-
1997
- 1997-03-31 AU AU25410/97A patent/AU715889B2/en not_active Ceased
- 1997-03-31 BR BR9708460-3A patent/BR9708460A/pt not_active Application Discontinuation
- 1997-03-31 NZ NZ509967A patent/NZ509967A/en unknown
- 1997-03-31 NZ NZ332049A patent/NZ332049A/en unknown
- 1997-03-31 CA CA002250243A patent/CA2250243C/en not_active Expired - Fee Related
- 1997-03-31 EP EP97916924A patent/EP0900209A4/de not_active Withdrawn
- 1997-03-31 WO PCT/US1997/004666 patent/WO1997036885A1/en not_active Ceased
- 1997-03-31 JP JP53533897A patent/JP3800559B2/ja not_active Expired - Fee Related
- 1997-03-31 DE DE69739670T patent/DE69739670D1/de not_active Expired - Fee Related
- 1997-03-31 EP EP03021526A patent/EP1380577B1/de not_active Expired - Lifetime
- 1997-03-31 KR KR1019980707738A patent/KR20000005100A/ko not_active Ceased
- 1997-03-31 PL PL97329172A patent/PL329172A1/xx unknown
- 1997-03-31 EP EP09160649A patent/EP2096112A3/de not_active Withdrawn
- 1997-03-31 AT AT03021526T patent/ATE449088T1/de not_active IP Right Cessation
-
1998
- 1998-09-28 NO NO19984508A patent/NO315608B1/no not_active IP Right Cessation
-
2006
- 2006-03-13 JP JP2006067600A patent/JP2006152004A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2541097A (en) | 1997-10-22 |
| JP2006152004A (ja) | 2006-06-15 |
| NZ332049A (en) | 2001-04-27 |
| WO1997036885A1 (en) | 1997-10-09 |
| AU715889B2 (en) | 2000-02-10 |
| EP0900209A1 (de) | 1999-03-10 |
| BR9708460A (pt) | 2000-01-04 |
| NZ509967A (en) | 2005-06-24 |
| NO315608B1 (no) | 2003-09-29 |
| EP2096112A3 (de) | 2009-09-09 |
| NO984508D0 (no) | 1998-09-28 |
| JP2000505086A (ja) | 2000-04-25 |
| NO984508L (no) | 1998-11-23 |
| CA2250243C (en) | 2002-10-08 |
| EP0900209A4 (de) | 2001-09-19 |
| KR20000005100A (ko) | 2000-01-25 |
| US5840739A (en) | 1998-11-24 |
| EP1380577A1 (de) | 2004-01-14 |
| CA2250243A1 (en) | 1997-10-09 |
| EP1380577B1 (de) | 2009-11-18 |
| JP3800559B2 (ja) | 2006-07-26 |
| DE69739670D1 (de) | 2009-12-31 |
| PL329172A1 (en) | 1999-03-15 |
| EP2096112A2 (de) | 2009-09-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |