NO981252L - Transdermalt matrikssystem - Google Patents
Transdermalt matrikssystemInfo
- Publication number
- NO981252L NO981252L NO981252A NO981252A NO981252L NO 981252 L NO981252 L NO 981252L NO 981252 A NO981252 A NO 981252A NO 981252 A NO981252 A NO 981252A NO 981252 L NO981252 L NO 981252L
- Authority
- NO
- Norway
- Prior art keywords
- weight
- parts
- matrix system
- group
- transdermal matrix
- Prior art date
Links
- 239000011159 matrix material Substances 0.000 title abstract 5
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 abstract 2
- 239000005556 hormone Substances 0.000 abstract 2
- 229940088597 hormone Drugs 0.000 abstract 2
- BGRXBNZMPMGLQI-UHFFFAOYSA-N 2-octyldodecyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCC(CCCCCCCC)CCCCCCCCCC BGRXBNZMPMGLQI-UHFFFAOYSA-N 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 230000001076 estrogenic effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
- Absorbent Articles And Supports Therefor (AREA)
- Telephonic Communication Services (AREA)
- Soy Sauces And Products Related Thereto (AREA)
Abstract
Et nytt transdermalt matrikssystem for perkutan avlevering av et hormon inkludert en bærer og en adhesivmatriks. Matriksen omfatter (a) 39 til 61 vektdeler av en etylen/vinylacetatkopolymer, (b) 12 til 17 vektdeler 2-oktyldodecylmyristat, (c) 5 til 17 vektdeler dietylftalat, (d) l O til 16 vektdeler av en forbindelse valgt blant N-alkyl-2-pyrrolidoner der alkyl- gruppen er en C4.I5-gruppe, og (e) l til 12 vektdeler av minst et hormon valgt fra gruppen estrogeniske og progestiniske komponenter. Det beskrives en fremgangsmåte for fremstilling av dette transdermale matrikssystem samt den terapeutiske anvendelse av systemet.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9511326A FR2739032B1 (fr) | 1995-09-27 | 1995-09-27 | Systeme matriciel transdermique d'administration d'un oestrogene et/ou d'un progestatif a base d'eva, procede de preparation et utilisation en therapeutique |
PCT/FR1996/001494 WO1997011687A1 (fr) | 1995-09-27 | 1996-09-25 | Systeme matriciel transdermique |
Publications (2)
Publication Number | Publication Date |
---|---|
NO981252D0 NO981252D0 (no) | 1998-03-19 |
NO981252L true NO981252L (no) | 1998-03-19 |
Family
ID=9482961
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO981252A NO981252L (no) | 1995-09-27 | 1998-03-19 | Transdermalt matrikssystem |
Country Status (25)
Country | Link |
---|---|
US (1) | US6013276A (no) |
EP (1) | EP0852492B1 (no) |
JP (1) | JPH11514988A (no) |
KR (1) | KR19990063732A (no) |
CN (1) | CN1083259C (no) |
AT (1) | ATE209031T1 (no) |
AU (1) | AU702542B2 (no) |
BG (1) | BG102322A (no) |
BR (1) | BR9610665A (no) |
CA (1) | CA2233162A1 (no) |
CZ (1) | CZ95398A3 (no) |
DE (1) | DE69617252T2 (no) |
DK (1) | DK0852492T3 (no) |
EE (1) | EE9800082A (no) |
ES (1) | ES2170266T3 (no) |
FR (1) | FR2739032B1 (no) |
HU (1) | HUP9900375A3 (no) |
IL (1) | IL123594A0 (no) |
NO (1) | NO981252L (no) |
NZ (1) | NZ319181A (no) |
PL (1) | PL325644A1 (no) |
PT (1) | PT852492E (no) |
SK (1) | SK282613B6 (no) |
TR (1) | TR199800563T1 (no) |
WO (1) | WO1997011687A1 (no) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10211832A1 (de) * | 2002-03-16 | 2003-10-02 | Lohmann Therapie Syst Lts | Hormonhaltiges transdermales therapeutisches System mit einem Wirkstoffreservoir auf der Basis von Vinylacetat-Vinylpyrrolidon-Copolymer mit verbesserter Kohäsion |
US7833545B2 (en) | 2003-04-29 | 2010-11-16 | The General Hospital Corporation | Methods and devices for the sustained release of multiple drugs |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
ES2885523T3 (es) | 2011-11-23 | 2021-12-14 | Therapeuticsmd Inc | Formulaciones y terapias de reposición hormonal de combinación naturales |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
RU2016143081A (ru) | 2014-05-22 | 2018-06-26 | Терапьютиксмд, Инк. | Натуральные комбинированные гормонозаместительные составы и терапии |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3049628C2 (de) * | 1980-12-31 | 1982-10-21 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Überwachung des Entstehens und Fortschreitens von Rissen in Maschinenteilen und Bauteilen sowie eine Vorrichtung zur Durchführung des Verfahrens |
JPS58189115A (ja) * | 1982-04-30 | 1983-11-04 | Kowa Co | 外用剤 |
US4816258A (en) * | 1987-02-26 | 1989-03-28 | Alza Corporation | Transdermal contraceptive formulations |
FR2612785A1 (fr) * | 1987-03-25 | 1988-09-30 | Lhd Lab Hygiene Dietetique | Dispositif auto-adhesif d'administration d'un principe actif par voie percutanee |
JPH03275619A (ja) * | 1990-03-23 | 1991-12-06 | Nitsusui Seiyaku Kk | 外用剤組成物 |
US5286490A (en) * | 1990-05-04 | 1994-02-15 | Colgate-Palmolive Company | Transdermal fluoride medication |
US5122382A (en) * | 1990-10-29 | 1992-06-16 | Alza Corporation | Transdermal contraceptive formulations, methods and devices |
US5453279A (en) * | 1992-04-21 | 1995-09-26 | Tbs Laboratories, Inc. | Enhancing transdermal absorption compositions; transdermal dosage form; and process |
FR2717688B1 (fr) * | 1994-03-28 | 1996-07-05 | Lhd Lab Hygiene Dietetique | Système matriciel transdermique d'administration d'un oestrogène et/ou un progestatif à base d'EVA. |
-
1995
- 1995-09-27 FR FR9511326A patent/FR2739032B1/fr not_active Expired - Fee Related
-
1996
- 1996-09-25 AU AU71349/96A patent/AU702542B2/en not_active Ceased
- 1996-09-25 ES ES96932647T patent/ES2170266T3/es not_active Expired - Lifetime
- 1996-09-25 NZ NZ319181A patent/NZ319181A/xx unknown
- 1996-09-25 BR BR9610665A patent/BR9610665A/pt not_active Application Discontinuation
- 1996-09-25 EE EE9800082A patent/EE9800082A/xx unknown
- 1996-09-25 CA CA002233162A patent/CA2233162A1/en not_active Abandoned
- 1996-09-25 JP JP9513181A patent/JPH11514988A/ja active Pending
- 1996-09-25 HU HU9900375A patent/HUP9900375A3/hu unknown
- 1996-09-25 PL PL96325644A patent/PL325644A1/xx unknown
- 1996-09-25 DE DE69617252T patent/DE69617252T2/de not_active Expired - Fee Related
- 1996-09-25 PT PT96932647T patent/PT852492E/pt unknown
- 1996-09-25 KR KR1019980702199A patent/KR19990063732A/ko not_active Application Discontinuation
- 1996-09-25 IL IL12359496A patent/IL123594A0/xx not_active IP Right Cessation
- 1996-09-25 TR TR1998/00563T patent/TR199800563T1/xx unknown
- 1996-09-25 CN CN96197187A patent/CN1083259C/zh not_active Expired - Fee Related
- 1996-09-25 EP EP96932647A patent/EP0852492B1/fr not_active Expired - Lifetime
- 1996-09-25 US US09/043,760 patent/US6013276A/en not_active Expired - Fee Related
- 1996-09-25 DK DK96932647T patent/DK0852492T3/da active
- 1996-09-25 SK SK406-98A patent/SK282613B6/sk unknown
- 1996-09-25 WO PCT/FR1996/001494 patent/WO1997011687A1/fr not_active Application Discontinuation
- 1996-09-25 AT AT96932647T patent/ATE209031T1/de not_active IP Right Cessation
- 1996-09-25 CZ CZ98953A patent/CZ95398A3/cs unknown
-
1998
- 1998-03-12 BG BG102322A patent/BG102322A/xx unknown
- 1998-03-19 NO NO981252A patent/NO981252L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1083259C (zh) | 2002-04-24 |
DE69617252T2 (de) | 2002-07-25 |
CZ95398A3 (cs) | 1998-07-15 |
NZ319181A (en) | 1998-10-28 |
EP0852492B1 (fr) | 2001-11-21 |
KR19990063732A (ko) | 1999-07-26 |
HUP9900375A3 (en) | 1999-11-29 |
HUP9900375A2 (hu) | 1999-06-28 |
PL325644A1 (en) | 1998-08-03 |
WO1997011687A1 (fr) | 1997-04-03 |
ES2170266T3 (es) | 2002-08-01 |
BG102322A (en) | 1998-10-30 |
PT852492E (pt) | 2002-05-31 |
FR2739032A1 (fr) | 1997-03-28 |
MX9802327A (es) | 1998-08-30 |
ATE209031T1 (de) | 2001-12-15 |
NO981252D0 (no) | 1998-03-19 |
SK282613B6 (sk) | 2002-10-08 |
TR199800563T1 (xx) | 1998-06-22 |
AU702542B2 (en) | 1999-02-25 |
CA2233162A1 (en) | 1997-04-03 |
BR9610665A (pt) | 1999-07-13 |
US6013276A (en) | 2000-01-11 |
AU7134996A (en) | 1997-04-17 |
DE69617252D1 (de) | 2002-01-03 |
EP0852492A1 (fr) | 1998-07-15 |
FR2739032B1 (fr) | 1997-11-21 |
IL123594A0 (en) | 1998-10-30 |
CN1197390A (zh) | 1998-10-28 |
JPH11514988A (ja) | 1999-12-21 |
SK40698A3 (en) | 1998-09-09 |
DK0852492T3 (da) | 2002-05-13 |
EE9800082A (et) | 1998-10-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |