NO974890L - Radicicolderivater - Google Patents

Radicicolderivater

Info

Publication number
NO974890L
NO974890L NO974890A NO974890A NO974890L NO 974890 L NO974890 L NO 974890L NO 974890 A NO974890 A NO 974890A NO 974890 A NO974890 A NO 974890A NO 974890 L NO974890 L NO 974890L
Authority
NO
Norway
Prior art keywords
hydrogen
alkenoyl
alkanoyl
same
derivatives
Prior art date
Application number
NO974890A
Other languages
English (en)
Other versions
NO974890D0 (no
Inventor
Tsutomu Agatsuma
Yutaka Saitoh
Yoshinori Yamashita
Tamio Mizukami
Shiro Akinaga
Kasushige Gomi
Kazuhito Akasaka
Isami Takahashi
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Publication of NO974890D0 publication Critical patent/NO974890D0/no
Publication of NO974890L publication Critical patent/NO974890L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Flanged Joints, Insulating Joints, And Other Joints (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Radicicolderivater representert ved generell formel (I) eller farmakologisk akseptable salter derav: (I) hvori R1 og R2 kan være like eller forskjellige og hver repre- senterer hydrogen, alkanoyl, alkenoyl eller tert-butyldi- metylsilyl, og (1) når X representerer halogen, da represen- terer Y et oksygenatom eller R4-O-N (idet R4 er hydrogen eller (u)substituert lavere alkyl) og R3 representerer hydrogen, alkanoyl, alkenoyl etc., mens (2) når X er kombinert med R3 til å representere en enkeltbinding, representerer Y R4B-O-N (idet R4B er det samme som R4) . Derivatene har en tyrosin- kinase-inhiberende aktivitet og har således ulike farmako- logiske aktiviteter slik som antitumor-, antibakterielle og immunundertrykkende effekter.
NO974890A 1995-04-26 1997-10-23 Radicicolderivater NO974890L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10262695 1995-04-26
PCT/JP1996/001158 WO1996033989A1 (fr) 1995-04-26 1996-04-26 Derives de radicicol

Publications (2)

Publication Number Publication Date
NO974890D0 NO974890D0 (no) 1997-10-23
NO974890L true NO974890L (no) 1997-12-29

Family

ID=14332458

Family Applications (1)

Application Number Title Priority Date Filing Date
NO974890A NO974890L (no) 1995-04-26 1997-10-23 Radicicolderivater

Country Status (13)

Country Link
US (1) US5977165A (no)
EP (1) EP0823429B1 (no)
JP (1) JP3938936B2 (no)
KR (1) KR19990008051A (no)
AT (1) ATE194610T1 (no)
AU (1) AU700840B2 (no)
CA (1) CA2218981C (no)
DE (1) DE69609325T2 (no)
ES (1) ES2149468T3 (no)
HU (1) HUP9901344A3 (no)
NO (1) NO974890L (no)
NZ (1) NZ311790A (no)
WO (1) WO1996033989A1 (no)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2216130T3 (es) 1996-10-25 2004-10-16 Kyowa Hakko Kogyo Co., Ltd. Derivados de radicicol.
AU740668B2 (en) * 1997-07-25 2001-11-08 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Macrocyclic lactones, compositions, and methods of use
AU3534499A (en) * 1998-04-24 1999-11-16 Kyowa Hakko Kogyo Co. Ltd. Radicicol derivatives
GB9822450D0 (en) * 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
EP1140069A1 (en) 1998-12-24 2001-10-10 Novation Pharmaceuticals Inc. COMPOUNDS WHICH AFFECT mRNA STABILITY AND USES THEREFOR
GB9914486D0 (en) 1999-06-21 1999-08-18 Smithkline Beecham Plc Medicaments
GB9917406D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB9917408D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
MXPA03000708A (es) 2000-07-26 2003-06-04 Smithkline Beecham Plc Aminopiperidin quinolinas y sus analogos azaisostericos con actividad antibacteriana.
WO2002016369A2 (en) * 2000-08-25 2002-02-28 Sloan-Kettering Institute For Cancer Research Novel macrocycles and uses thereof
GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
AU2002310065B2 (en) * 2001-05-23 2007-07-05 Sloan Kettering Institute For Cancer Research Method of treatment for cancers associated with elevated HER 2 levels
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
US20040192638A1 (en) * 2001-07-02 2004-09-30 Oaks John A. Method and composition for prolonging the residence time of drugs in the gut
EP1470131A2 (en) 2002-01-29 2004-10-27 Glaxo Group Limited Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them
US7312212B2 (en) 2002-01-29 2007-12-25 Glaxo Group Limited Aminopiperidine derivatives
JP4575294B2 (ja) 2003-06-27 2010-11-04 協和発酵キリン株式会社 Ｈｓｐ９０ファミリー蛋白質阻害剤
WO2005018674A1 (ja) * 2003-08-22 2005-03-03 Kyowa Hakko Kogyo Co., Ltd. イムノグロブリン遺伝子の転座を伴う疾患の治療薬
WO2005061481A1 (en) * 2003-12-19 2005-07-07 Sloan-Kettering Institute For Cancer Research Novel ma crocycles and uses thereof
ES2651019T3 (es) 2006-08-11 2018-01-23 Universite De Strasbourg Compuestos macrocíclicos útiles como inhibidores de cinasas y de HSP90
US20110190237A1 (en) * 2008-01-15 2011-08-04 Nexgenix Pharmaceuticals Macrocyclic Prodrug Compounds Useful as Therapeutics
RU2534527C2 (ru) * 2008-01-15 2014-11-27 Юниверсите Де Страсбур Синтез лактонов резорциловой кислоты, используемых в качестве терапевтических агентов
CN102015673B (zh) * 2008-02-21 2014-10-29 昂科协同公司 用作治疗剂的大环前药化合物
WO2016196256A2 (en) 2015-06-04 2016-12-08 University Of North Carolina At Greensboro Non-aromatic difluoro analogues of resorcylic acid lactones

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4228079A (en) * 1978-10-30 1980-10-14 W. R. Grace & Co. Dialkoxy monorden derivatives
IE911915A1 (en) * 1990-06-06 1991-12-18 Sankyo Co Radicicol derivatives, their preparation and their¹anti-tumor activity
GB9225396D0 (en) * 1992-12-04 1993-01-27 Sandoz Ltd Improvements in or relating to organic compounds

Also Published As

Publication number Publication date
DE69609325D1 (de) 2000-08-17
EP0823429A1 (en) 1998-02-11
CA2218981C (en) 2007-01-16
US5977165A (en) 1999-11-02
EP0823429B1 (en) 2000-07-12
ATE194610T1 (de) 2000-07-15
HUP9901344A3 (en) 2001-05-28
EP0823429A4 (en) 1998-07-08
AU700840B2 (en) 1999-01-14
KR19990008051A (ko) 1999-01-25
JP3938936B2 (ja) 2007-06-27
WO1996033989A1 (fr) 1996-10-31
DE69609325T2 (de) 2000-11-23
ES2149468T3 (es) 2000-11-01
HUP9901344A2 (hu) 2001-04-28
NZ311790A (en) 1999-04-29
AU6292796A (en) 1996-11-18
NO974890D0 (no) 1997-10-23
CA2218981A1 (en) 1996-10-31

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application