NO974750L - Peptid antagonister av cellulær mitogenese og motogenese og deres terapautiske anvendelse - Google Patents
Peptid antagonister av cellulær mitogenese og motogenese og deres terapautiske anvendelseInfo
- Publication number
- NO974750L NO974750L NO974750A NO974750A NO974750L NO 974750 L NO974750 L NO 974750L NO 974750 A NO974750 A NO 974750A NO 974750 A NO974750 A NO 974750A NO 974750 L NO974750 L NO 974750L
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- treatment
- motogenesis
- metastasis
- transfer process
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Foreliggende oppfinnelse angår peptider og peptidomimetiske forbindelser og farmasøytiske sammensetninger som inneholder disse som nyttige farmakologiske midler i kontroll eller behandling av proliferative sykdommer slik som kanser, mot tumorvekst og/eller tumora! metastase, og psoriasis og i kontroll eller behandling av inflammatorisk, allergisk, autoimmun, viral og kardiovaskulære sykdommer. Disse nye forbindelsene har den unike egenskapen at de hemmer gjenkjenning av flere fosfotyrosininneholdende motiver i alle cellulære reseptorer og sytosole transdusere i et vidt spektrum av SH2- domener inneholdt i sytosolltransduserne og andre effektorproteiner som befinner seg langs forskjellige veier på signaloverføringsprosessen og med en særlig høy affinitet for SH2-domene av adaptortransduser Grb2, et nøkkelelement langs veien til mitogenese og motogenese, den sistnevnte aktivitet fører til invasivhet og metastase. Oppfinnelsen angår også fremgangsmåter for fremstilling av forbindelsene og metoder for behandling som benytter forbindelsene.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9603227.1A GB9603227D0 (en) | 1996-02-15 | 1996-02-15 | Peptide antagonists of cellular mitogenesis and motogenesis and their therapeutic use |
PCT/EP1997/000595 WO1997030079A1 (en) | 1996-02-15 | 1997-02-10 | Peptide antagonists of cellular mitogenesis and motogenesis and their therapeutic use |
Publications (2)
Publication Number | Publication Date |
---|---|
NO974750D0 NO974750D0 (no) | 1997-10-14 |
NO974750L true NO974750L (no) | 1997-12-10 |
Family
ID=10788833
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO974750A NO974750L (no) | 1996-02-15 | 1997-10-14 | Peptid antagonister av cellulær mitogenese og motogenese og deres terapautiske anvendelse |
Country Status (21)
Country | Link |
---|---|
US (1) | US6245742B1 (no) |
EP (1) | EP0821696B1 (no) |
JP (1) | JPH11504658A (no) |
KR (1) | KR19990007783A (no) |
CN (1) | CN1185785A (no) |
AR (1) | AR005808A1 (no) |
AT (1) | ATE266041T1 (no) |
AU (1) | AU1768297A (no) |
BR (1) | BR9702084A (no) |
CA (1) | CA2218378A1 (no) |
DE (1) | DE69728938D1 (no) |
EA (1) | EA199700318A1 (no) |
GB (1) | GB9603227D0 (no) |
HU (1) | HUP9900661A3 (no) |
IL (1) | IL121853A0 (no) |
MX (1) | MX9707771A (no) |
NO (1) | NO974750L (no) |
NZ (1) | NZ328895A (no) |
PL (1) | PL322779A1 (no) |
WO (1) | WO1997030079A1 (no) |
ZA (1) | ZA971171B (no) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020055463A1 (en) * | 1998-12-24 | 2002-05-09 | Christiane Garbay | Pseudopeptide compounds having an inhibiting activity with respect to paths activated by proteins with active tyrosine kinase activity and pharmaceutical compositions containing same |
FR2787793B1 (fr) * | 1998-12-24 | 2001-03-23 | Inst Nat Sante Rech Med | Composes pseudopeptidiques dotes d'une activite inhibitrice a l'egard des voies activees par les proteines a activite tyrosine kinase et les compositions pharmaceutiques les contenant |
FR2793796A1 (fr) * | 1999-04-14 | 2000-11-24 | Hoechst Marion Roussel Inc | Nouveaux derives d'imidazoles, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant |
FR2796381A1 (fr) * | 1999-07-12 | 2001-01-19 | Hoechst Marion Roussel Inc | Derives bicycliques de thioazepine ou de caprolactame, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant |
US20040191926A1 (en) * | 2001-09-26 | 2004-09-30 | Zhong-Yin Zhang | Ptp1b inhibitors and ligands |
US7736911B2 (en) * | 2004-04-15 | 2010-06-15 | Albert Einstein College Of Medicine Of Yeshiva University | Activity-based probes for protein tyrosine phosphatases |
EP2140267B1 (en) | 2007-02-26 | 2017-11-15 | StemCell Technologies Inc. | Method of reducing curvature in a meniscus of liquid medium |
US8703072B2 (en) | 2008-09-12 | 2014-04-22 | Oliver Egeler | Cell culture vessels for meniscus reduction with aqueous solutions |
CN103387602B (zh) * | 2012-05-09 | 2018-07-06 | 中国科学院上海药物研究所 | 一种新型开链四肽类似物及其制备方法和用途 |
EP2943409B1 (en) | 2013-01-10 | 2020-12-23 | Stemcell Technologies Inc. | Meniscus reducing member |
US10537891B2 (en) | 2013-01-10 | 2020-01-21 | Stemcell Technologies Inc. | Meniscus reducing member |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5801149A (en) * | 1991-06-19 | 1998-09-01 | Joslin D-Abetes Center, Inc. | Inhibition of signal transduction molecules |
US5739278A (en) * | 1993-05-10 | 1998-04-14 | University Of Washington | Compositions for protein tyrosine phosphatases |
WO1995001376A1 (en) | 1993-06-30 | 1995-01-12 | Pharmacia S.P.A. | Peptide inhibitors of mitogenesis and motogenesis |
AU4972096A (en) * | 1995-02-01 | 1996-08-21 | Affymax Technologies N.V. | Peptides and compounds that bind to sh2 domains |
GB9516842D0 (en) * | 1995-08-17 | 1995-10-18 | Ciba Geigy Ag | Various acylated oligopeptides |
GB9517060D0 (en) * | 1995-08-17 | 1995-10-25 | Ciba Geigy Ag | Acylated oligopeptide derivatives |
-
1996
- 1996-02-15 GB GBGB9603227.1A patent/GB9603227D0/en active Pending
-
1997
- 1997-02-10 DE DE69728938T patent/DE69728938D1/de not_active Expired - Lifetime
- 1997-02-10 AT AT97903250T patent/ATE266041T1/de not_active IP Right Cessation
- 1997-02-10 IL IL12185397A patent/IL121853A0/xx unknown
- 1997-02-10 MX MX9707771A patent/MX9707771A/es unknown
- 1997-02-10 CN CN97190189A patent/CN1185785A/zh active Pending
- 1997-02-10 WO PCT/EP1997/000595 patent/WO1997030079A1/en active IP Right Grant
- 1997-02-10 EA EA199700318A patent/EA199700318A1/ru unknown
- 1997-02-10 PL PL97322779A patent/PL322779A1/xx unknown
- 1997-02-10 KR KR1019970707306A patent/KR19990007783A/ko not_active Application Discontinuation
- 1997-02-10 BR BR9702084A patent/BR9702084A/pt unknown
- 1997-02-10 AU AU17682/97A patent/AU1768297A/en not_active Abandoned
- 1997-02-10 CA CA002218378A patent/CA2218378A1/en not_active Abandoned
- 1997-02-10 EP EP97903250A patent/EP0821696B1/en not_active Expired - Lifetime
- 1997-02-10 US US08/930,616 patent/US6245742B1/en not_active Expired - Fee Related
- 1997-02-10 NZ NZ328895A patent/NZ328895A/xx unknown
- 1997-02-10 JP JP9528961A patent/JPH11504658A/ja not_active Withdrawn
- 1997-02-10 HU HU9900661A patent/HUP9900661A3/hu unknown
- 1997-02-12 ZA ZA9701171A patent/ZA971171B/xx unknown
- 1997-02-13 AR ARP970100572A patent/AR005808A1/es not_active Application Discontinuation
- 1997-10-14 NO NO974750A patent/NO974750L/no unknown
Also Published As
Publication number | Publication date |
---|---|
NZ328895A (en) | 1999-03-29 |
CA2218378A1 (en) | 1997-08-21 |
HUP9900661A2 (hu) | 1999-08-30 |
PL322779A1 (en) | 1998-02-16 |
IL121853A0 (en) | 1998-02-22 |
KR19990007783A (ko) | 1999-01-25 |
MX9707771A (es) | 1997-12-31 |
BR9702084A (pt) | 1999-07-20 |
EA199700318A1 (ru) | 1998-04-30 |
ZA971171B (en) | 1997-09-03 |
WO1997030079A1 (en) | 1997-08-21 |
AR005808A1 (es) | 1999-07-14 |
GB9603227D0 (en) | 1996-04-17 |
ATE266041T1 (de) | 2004-05-15 |
US6245742B1 (en) | 2001-06-12 |
CN1185785A (zh) | 1998-06-24 |
JPH11504658A (ja) | 1999-04-27 |
DE69728938D1 (de) | 2004-06-09 |
NO974750D0 (no) | 1997-10-14 |
EP0821696B1 (en) | 2004-05-06 |
HUP9900661A3 (en) | 2000-03-28 |
AU1768297A (en) | 1997-09-02 |
EP0821696A1 (en) | 1998-02-04 |
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