NO974125L - N-benzylazoliumderivater - Google Patents

N-benzylazoliumderivater

Info

Publication number
NO974125L
NO974125L NO974125A NO974125A NO974125L NO 974125 L NO974125 L NO 974125L NO 974125 A NO974125 A NO 974125A NO 974125 A NO974125 A NO 974125A NO 974125 L NO974125 L NO 974125L
Authority
NO
Norway
Prior art keywords
general formula
group
hydrogen
formula
independently
Prior art date
Application number
NO974125A
Other languages
English (en)
Other versions
NO974125D0 (no
Inventor
Ichihara Shigeyasu
Sawada Daisuke
Murasaki Chikako
Shimma Nobou
Ohga Noriko
Shirai Michio
Ohwasa Jun
Umeda Isao
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO974125D0 publication Critical patent/NO974125D0/no
Publication of NO974125L publication Critical patent/NO974125L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

N-Benzylazoliumderivater med den generelle formel (I) R2 hvor Q er resten av en azolforbindelse med formel II N---Q (II) som har antifungal aktivitet; Z betyr nitrogen eller metin; R1 og R2 hver uavhengig betyr et hydrogenatom eller en gruppe -OY [hvor Y betyr en gruppe som er lett hydroly- serbar under fysiologiske betingelser]; R3 og R4 hver uavhengig betyr et hydrogen- eller halo- genatom, lavere alkyl, lavere alkoksy, lavere alkyltio, (lavere alkylkarbonyl)tiometyl, karboksy eller metoksy- karbonyl; og X' betyr et farmasøytisk akseptabelt anion; samt salter, hydrater eller solvater av forbindelsene med den generelle formel (I) har antifungale egen- skaper.
NO974125A 1996-09-09 1997-09-08 N-benzylazoliumderivater NO974125L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96114390 1996-09-09
EP97114246 1997-08-18

Publications (2)

Publication Number Publication Date
NO974125D0 NO974125D0 (no) 1997-09-08
NO974125L true NO974125L (no) 1998-03-10

Family

ID=26142161

Family Applications (1)

Application Number Title Priority Date Filing Date
NO974125A NO974125L (no) 1996-09-09 1997-09-08 N-benzylazoliumderivater

Country Status (12)

Country Link
US (2) US5900486A (no)
JP (1) JP2965532B2 (no)
KR (1) KR100252433B1 (no)
CN (1) CN1182739A (no)
AU (1) AU3685097A (no)
CA (1) CA2214669A1 (no)
CZ (1) CZ282897A3 (no)
HU (1) HUP9701479A3 (no)
IL (1) IL121691A0 (no)
MA (1) MA26440A1 (no)
NO (1) NO974125L (no)
NZ (1) NZ328607A (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999045008A1 (en) 1998-03-06 1999-09-10 F. Hoffmann-La Roche Ag 3-[4-(4-cyanophenyl)thiazol-2-y)]-1-(1h-1,2,4-triazol-1-yl)-butan-2-ol derivatives having antifungal activity
WO2000030655A1 (en) * 1998-11-20 2000-06-02 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6319933B1 (en) 2000-04-17 2001-11-20 Basilea Pharmaceutica Ag Azole derivatives
WO2003051113A1 (en) * 2001-12-14 2003-06-26 The University Of Wyoming Methods and compositions for controlled release of drugs
TW200606129A (en) * 2004-07-26 2006-02-16 Chugai Pharmaceutical Co Ltd Novel cyclohexane derivative, its prodrug, its salt and diabetic therapeutic agent containing the same
CN101391985B (zh) * 2007-09-18 2013-09-11 西南大学 具抗微生物活性的三唑鎓类化合物及制备方法和医药用途
EA032840B8 (ru) * 2011-06-22 2020-06-18 Вайоми Терапеутикс Лимитед Пролекарства на основе конъюгатов противогрибковых агентов и их применение
CN104974143A (zh) * 2015-05-12 2015-10-14 深圳致君制药有限公司 一种季铵盐类化合物、其制备方法以及用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH468788A (de) * 1966-04-29 1969-02-28 Basf Ag Mischung zur Bekämpfung von Algen und Pilzen
US4017631A (en) * 1974-11-19 1977-04-12 Janssen Pharmaceutica N.V. Imidazolium salts
DE2531031C3 (de) * 1975-07-11 1978-03-16 Schuelke & Mayr Gmbh, 2000 Norderstedt 1 -Benzyl-3-alkyI-imidazoliumsalze
DE2643563A1 (de) * 1976-09-28 1978-03-30 Bayer Ag Alpha-(4-biphenylyl)-benzyl-azolium- salze, verfahren zu ihrer herstellung sowie ihre verwendung zur bekaempfung von mikroorganismen
DE2714290A1 (de) * 1977-03-31 1978-10-05 Bayer Ag Fungizide mittel
US4267179A (en) * 1978-06-23 1981-05-12 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4402957A (en) * 1979-04-04 1983-09-06 Janssen Pharmaceutica N.V. Heterocyclic derivatives of [4-(piperazin-1-ylphenyloxymethyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazoles and 1H-1,2,4-triazoles
FR2486079A1 (fr) * 1980-07-07 1982-01-08 Rhone Poulenc Agrochimie Sels quaternaires d'alcoyl-1-imidazolium de l'acide phosphoreux ou ses monoesters, procedes pour les preparer et compositions fongicides les contenant
US4490530A (en) * 1981-01-14 1984-12-25 Janssen Pharmaceutica N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)-methyl-1H-imidazoles and 1H-1,2,4-triazoles
EP0069442B1 (en) * 1981-06-06 1985-02-20 Pfizer Limited Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them
DE3217963A1 (de) * 1982-05-13 1983-11-17 Basf Ag, 6700 Ludwigshafen Dibenzofuranoxyalkyl-imidazoliumsalze, verfahren zu ihrer herstellung und ihre verwendung als mikrozide
US4861879A (en) * 1983-02-28 1989-08-29 Janssen Pharmaceutica N.V. [[4-[4-Phenyl-1-piperazinyl)phenoxymethyl]-1-3-dioxolan-2-yl]-methyl]-1H-imidazoles and 1H-1,2,4-triazoles
DE3319845A1 (de) * 1983-06-01 1984-12-06 Basf Ag, 6700 Ludwigshafen Arylalkylimidazolium- und -triazoliumsalze, verfahren zu ihrer herstellung und ihre verwendung als mikrozide
US5128351A (en) * 1990-05-04 1992-07-07 American Cyanamid Company Bis-aryl amide and urea antagonists of platelet activating factor
CN1078210C (zh) * 1994-01-24 2002-01-23 詹森药业有限公司 水溶性吡咯系杀真菌剂
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions

Also Published As

Publication number Publication date
CZ282897A3 (cs) 1998-06-17
US5900486A (en) 1999-05-04
KR100252433B1 (ko) 2000-08-01
CN1182739A (zh) 1998-05-27
MA26440A1 (fr) 2004-12-20
IL121691A0 (en) 1998-02-22
JPH10114758A (ja) 1998-05-06
CA2214669A1 (en) 1998-03-09
JP2965532B2 (ja) 1999-10-18
AU3685097A (en) 1998-03-12
KR19980024429A (ko) 1998-07-06
NO974125D0 (no) 1997-09-08
HUP9701479A2 (hu) 1999-02-01
NZ328607A (en) 1999-08-30
US5962686A (en) 1999-10-05
HU9701479D0 (en) 1997-10-28
HUP9701479A3 (en) 2001-02-28

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application