NO973625D0 - Karbapenem-3-karboksylsyreesterderivater - Google Patents

Karbapenem-3-karboksylsyreesterderivater

Info

Publication number
NO973625D0
NO973625D0 NO973625A NO973625A NO973625D0 NO 973625 D0 NO973625 D0 NO 973625D0 NO 973625 A NO973625 A NO 973625A NO 973625 A NO973625 A NO 973625A NO 973625 D0 NO973625 D0 NO 973625D0
Authority
NO
Norway
Prior art keywords
pct
alkyl group
carbapenem
substituted
carboxylic acid
Prior art date
Application number
NO973625A
Other languages
English (en)
Norwegian (no)
Other versions
NO973625L (no
Inventor
Takao Abe
Toshio Kumagai
Original Assignee
Lederle Japan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lederle Japan Ltd filed Critical Lederle Japan Ltd
Publication of NO973625D0 publication Critical patent/NO973625D0/no
Publication of NO973625L publication Critical patent/NO973625L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO973625A 1995-12-08 1997-08-06 Karbapenem-3-karboksylsyreesterderivater NO973625L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP34507695 1995-12-08
PCT/JP1996/003540 WO1997021712A1 (en) 1995-12-08 1996-12-04 Carbapenem-3-carboxylic acid ester derivatives

Publications (2)

Publication Number Publication Date
NO973625D0 true NO973625D0 (no) 1997-08-06
NO973625L NO973625L (no) 1997-08-06

Family

ID=18374125

Family Applications (1)

Application Number Title Priority Date Filing Date
NO973625A NO973625L (no) 1995-12-08 1997-08-06 Karbapenem-3-karboksylsyreesterderivater

Country Status (14)

Country Link
US (1) US5886172A (de)
EP (1) EP0808315B1 (de)
JP (1) JP4667542B2 (de)
KR (1) KR19980702089A (de)
AT (1) ATE200289T1 (de)
AU (1) AU705408B2 (de)
CA (1) CA2211075A1 (de)
DE (1) DE69612374T2 (de)
ES (1) ES2156303T3 (de)
HU (1) HUP9801156A3 (de)
IL (1) IL121240A (de)
NO (1) NO973625L (de)
TW (1) TW420681B (de)
WO (1) WO1997021712A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100345468B1 (ko) * 2000-07-10 2002-07-26 한국과학기술연구원 신규 1-베타메틸카바페넴 유도체 및 그의 제조방법
KR100446432B1 (ko) * 2001-08-13 2004-08-30 한국화학연구원 2-벤조티아졸 카바페넴 유도체 및 그의 제조방법
KR100451670B1 (ko) * 2001-09-14 2004-10-08 한국화학연구원 내성균에 대해 항생작용을 갖는 카바페넴 유도체 및 이의제조방법
JPWO2004035539A1 (ja) * 2002-10-18 2006-02-16 明治製菓株式会社 カルバペネム類の製造方法およびその製造に用いられる中間体
KR100599876B1 (ko) * 2004-08-31 2006-07-13 한국화학연구원 2-아릴메틸아제티딘 카바페넴 유도체 및 그의 제조방법
WO2009066917A2 (en) * 2007-11-23 2009-05-28 Kukje Pharm. Ind. Co., Ltd. 2-arylmethylazetidine-carbapenem-3-carboxylic acid ester derivative or its salt, process for the preparation thereof and pharmaceutical composition comprising the same
US8394922B2 (en) 2009-08-03 2013-03-12 Medarex, Inc. Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
CN102532139A (zh) * 2010-12-07 2012-07-04 重庆医药工业研究院有限责任公司 一种替比培南的制备方法
CN102558181B (zh) * 2010-12-15 2015-04-22 石药集团中奇制药技术（石家庄）有限公司 一种碳青霉烯抗生素的制备方法
CN102731507B (zh) * 2011-04-13 2015-04-01 石药集团中奇制药技术（石家庄）有限公司 泰比培南晶型、其制备方法及其在制备药物中的应用
CN102757430B (zh) * 2011-04-29 2016-04-13 上海医药工业研究院 一种替比培南的制备方法
CN102775409B (zh) * 2011-05-10 2016-08-03 上海医药工业研究院 一种替比培南匹伏酯的中间体的制备方法
CN102584812B (zh) * 2011-11-18 2014-03-12 深圳万乐药业有限公司 一种泰比培南酯杂质的制备方法
CN102503940B (zh) * 2011-11-22 2013-12-25 深圳万乐药业有限公司 制备泰比培南酯开环杂质的方法
SG11201506243XA (en) 2013-02-14 2015-09-29 Bristol Myers Squibb Co Tubulysin compounds, methods of making and use
US10077287B2 (en) 2014-11-10 2018-09-18 Bristol-Myers Squibb Company Tubulysin analogs and methods of making and use
US10889587B2 (en) 2017-02-06 2021-01-12 Spero Therapeutics, Inc. Tebipenem pivoxil crystalline forms, compositions including the same, methods of manufacture, and methods of use
EP4243783A1 (de) 2020-11-11 2023-09-20 Spero Therapeutics, Inc. Hochdosierte tebipenem-pivoxil-tablettenformulierung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60202886A (ja) * 1984-03-27 1985-10-14 Sankyo Co Ltd １―置換カルバペネム―３―カルボン酸誘導体
DK175029B1 (da) * 1988-04-01 2004-05-03 Sankyo Co 2-(heterocyclylthio)carbapenemderivater, farmaceutiske midler indeholdende dem, fremgangsmåde til fremstilling deraf samt deres anvendelse som antibiotika
JPH06157532A (ja) * 1992-11-17 1994-06-03 Sankyo Co Ltd 結晶性カルバペネム化合物
AU682510B2 (en) * 1993-07-01 1997-10-09 Pfizer Japan Inc. 2-(1-(1,3-thiazolin-2-yl)azetidin-3-yl)thio-carbapenem derivatives
JP3317604B2 (ja) * 1994-12-28 2002-08-26 日本ワイスレダリー株式会社 結晶形態のカルバペネム化合物

Also Published As

Publication number Publication date
ES2156303T3 (es) 2001-06-16
IL121240A0 (en) 1998-01-04
JP4667542B2 (ja) 2011-04-13
HUP9801156A2 (hu) 1998-09-28
EP0808315A1 (de) 1997-11-26
KR19980702089A (ko) 1998-07-15
IL121240A (en) 2001-08-08
JPH11504039A (ja) 1999-04-06
US5886172A (en) 1999-03-23
DE69612374D1 (de) 2001-05-10
AU1039997A (en) 1997-07-03
EP0808315B1 (de) 2001-04-04
ATE200289T1 (de) 2001-04-15
NO973625L (no) 1997-08-06
HUP9801156A3 (en) 1999-03-01
WO1997021712A1 (en) 1997-06-19
TW420681B (en) 2001-02-01
AU705408B2 (en) 1999-05-20
DE69612374T2 (de) 2001-07-12
CA2211075A1 (en) 1997-06-19

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application