NO963368L - Nye 2-substituerte indan-2-mercaptoacetylamid-disulfidderivater som inhibitorer av enkefalinase og ACE - Google Patents

Nye 2-substituerte indan-2-mercaptoacetylamid-disulfidderivater som inhibitorer av enkefalinase og ACE

Info

Publication number
NO963368L
NO963368L NO963368A NO963368A NO963368L NO 963368 L NO963368 L NO 963368L NO 963368 A NO963368 A NO 963368A NO 963368 A NO963368 A NO 963368A NO 963368 L NO963368 L NO 963368L
Authority
NO
Norway
Prior art keywords
alkyl
hydrogen
group
integer
enkephalinase
Prior art date
Application number
NO963368A
Other languages
English (en)
Other versions
NO963368D0 (no
Inventor
Gary Alan Flynn
Douglas Wade Beight
Alan M Warshawsky
Shujaath Mehdi
John Fitzhugh French
John Herr Kehne
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22721746&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO963368(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of NO963368D0 publication Critical patent/NO963368D0/no
Publication of NO963368L publication Critical patent/NO963368L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Nye 2-substituerte indan-2-mercaptoacetylamid-disulfidderivater som inhibitorer av enkefalinase og ACE Foreliggende oppfinnelse an- går visse nye, 2-substituerte indan-2- merkaptoacetylamiddisulfidderivater som er anvendbare som inhibitorer av enke- falinase og av ACE. Forbindelse av formelen (CH2)i C02R3 formel (I) hvori ' n , RI og er et helt tall fra O til 3; er hver gang tatt uavhengig valgt fra gruppen bestå- ende av hydrogen, hydroksy, -OR4, hvori R, er en C,- C4-alkyl- eller en Ar-Y-gruppe, hvori Ar er aryl °9 Y er C0-C4-alkyl; eller hvor R, og R, er bundet til til- støtende karbonatorner, kan R, og R2 tas sammen med angitte, tilstøtende karboner for å danne en benzen- ring eller raetylendioksy; er hydrogen, C,-C4-alkyl, -CHjO-CfOJCCCH,),; er -(CH2) -, O, S, NR,, eller NC(0)R, hvori p er et helt tall O eller l. R, er hydrogen, en C,-C4-alkyl- eller en Ar-Y-gruppe, og R. er -CF3, C,-Clo-alkyl, eller en Ar-Y-gruppe; er et alkylenradikal valgt fra gruppen H3 hvori q G er et helt tall fra l til 5, og z er O, s, NH; er et radikal valgt fra gruppen (CH2), RB (CH2), C02R3 hvori m er et helt tall fra l til 3; R, er hydrogen, C,-C,-alkyl, -CHjCH,S(0),,CH3, eller Ar-Y- hvorl k er et helt tall fra O til 2: Rt er hydrogen, hydroksy, araino, Cj-C»-alkyl, N-metyl- amlno, N,N-dimetylamlno, -C02R3, -OC(0)R, hvori R, er hydrogen, Cj-C.-alkyl eller fenyl; R10 er l eller 2 substltuenter uavhengig valgt fra grup- pen bestående av hydrogen, C,-C4-alkyl, C1-C,-alkoksy eller halogen; R,, er hydrogen, C,-C,-alkyl eller Ar-Y-gruppe; V, er O, S eller NH; V, er N eller CH; V, er en direkte binding eller -C(0)-; eller stereoisomerer eller farmasøytisk akseptable salter derav.
NO963368A 1994-02-14 1996-08-13 Nye 2-substituerte indan-2-mercaptoacetylamid-disulfidderivater som inhibitorer av enkefalinase og ACE NO963368L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19552694A 1994-02-14 1994-02-14
PCT/US1994/014338 WO1995021857A1 (en) 1994-02-14 1994-12-13 Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace

Publications (2)

Publication Number Publication Date
NO963368D0 NO963368D0 (no) 1996-08-13
NO963368L true NO963368L (no) 1996-10-14

Family

ID=22721746

Family Applications (1)

Application Number Title Priority Date Filing Date
NO963368A NO963368L (no) 1994-02-14 1996-08-13 Nye 2-substituerte indan-2-mercaptoacetylamid-disulfidderivater som inhibitorer av enkefalinase og ACE

Country Status (12)

Country Link
US (2) US5567814A (no)
EP (1) EP0746566A1 (no)
JP (1) JP3561753B2 (no)
CN (1) CN1142831A (no)
AU (1) AU689192B2 (no)
CA (1) CA2183314C (no)
FI (1) FI963167A (no)
HU (1) HUT76479A (no)
IL (1) IL112604A (no)
NO (1) NO963368L (no)
WO (1) WO1995021857A1 (no)
ZA (1) ZA951063B (no)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds

Family Cites Families (40)

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US3334091A (en) * 1965-03-25 1967-08-01 Sandoz Ag Sedatives
GB1525845A (en) * 1976-07-30 1978-09-20 Ucb Sa 1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones
IE50839B1 (en) * 1980-02-26 1986-07-23 Wyeth John & Brother Ltd Novel processes for preparing proline derivatives and analogous compounds
EP0042100A1 (de) * 1980-06-13 1981-12-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
US4320057A (en) * 1980-06-23 1982-03-16 American Home Products Corporation Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones
US4415496A (en) * 1981-03-23 1983-11-15 Merck & Co., Inc. Bicyclic lactams
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
NZ204130A (en) * 1982-05-12 1986-03-14 Hoffmann La Roche Bicyclic heterocyclic compounds and pharmaceutical compositions
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IL78634A0 (en) * 1985-04-30 1986-08-31 Lilly Co Eli 7-substituted bicyclic pyrazolidinones
ZA874107B (no) * 1986-06-13 1987-12-09
ZA874106B (en) * 1986-06-13 1987-12-08 Merrell Dow Pharmaceuticals Inc. Novel antihypertensive agent
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GB8629875D0 (en) * 1986-12-15 1987-01-28 Hoffmann La Roche Pyridazodiazepine derivatives
US4824832A (en) * 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
US4879309A (en) * 1988-09-27 1989-11-07 Schering Corporation Mercapto-acylamino acids as antihypertensives
GB8926512D0 (en) * 1989-11-23 1990-01-10 Pfizer Ltd Therapeutic agents
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US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5208230A (en) * 1990-12-21 1993-05-04 Merrell Dow Pharmaceuticals Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
EP0492369B1 (en) * 1990-12-21 1997-09-17 Merrell Pharmaceuticals Inc. Novel amino and nitro containing tricyclic compounds useful as inhibitors of ace
US5308841A (en) * 1990-12-21 1994-05-03 Merrell Dow Pharmaceuticals Inc. Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5252601A (en) * 1991-05-03 1993-10-12 Merrell Dow Pharmaceuticals Inc. 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors
FR2679564A1 (fr) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
WO1993005809A1 (en) * 1991-09-16 1993-04-01 Schering Corporation Pharmaceutical compositions comprising natriuretic peptides or neutral endopeptidase inhibitors for treating or preventing myointimal proliferation
AU657793B2 (en) * 1991-09-27 1995-03-23 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
DE69220744T2 (de) * 1991-09-27 1997-11-13 Merrell Pharma Inc 2-Substituierte Indan-2-Mercaptoacetylamid-Verbindungen mit Enkephalinase und ACE-Hemmwirkung
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EP0625987B1 (en) * 1992-02-14 1998-04-01 Merrell Pharmaceuticals Inc. Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
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Also Published As

Publication number Publication date
FI963167A0 (fi) 1996-08-13
JPH09508905A (ja) 1997-09-09
EP0746566A1 (en) 1996-12-11
US5567814A (en) 1996-10-22
NO963368D0 (no) 1996-08-13
US5629309A (en) 1997-05-13
WO1995021857A1 (en) 1995-08-17
AU1401195A (en) 1995-08-29
FI963167A (fi) 1996-08-13
ZA951063B (en) 1995-10-13
HUT76479A (en) 1997-09-29
CA2183314A1 (en) 1995-08-17
CN1142831A (zh) 1997-02-12
CA2183314C (en) 1999-08-31
JP3561753B2 (ja) 2004-09-02
IL112604A (en) 2003-07-06
IL112604A0 (en) 1995-05-26
AU689192B2 (en) 1998-03-26

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