ES2098786T3 - Nuevas benzopiranonas, procedimientos para su preparacion y utilizacion. - Google Patents

Nuevas benzopiranonas, procedimientos para su preparacion y utilizacion.

Info

Publication number
ES2098786T3
ES2098786T3 ES93921925T ES93921925T ES2098786T3 ES 2098786 T3 ES2098786 T3 ES 2098786T3 ES 93921925 T ES93921925 T ES 93921925T ES 93921925 T ES93921925 T ES 93921925T ES 2098786 T3 ES2098786 T3 ES 2098786T3
Authority
ES
Spain
Prior art keywords
group
atoms
alkyl
pct
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93921925T
Other languages
English (en)
Inventor
Michael Noldner
Shyam Sunder Chatterjee
Hermann Hauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Willmar Schwabe GmbH and Co KG
Original Assignee
Dr Willmar Schwabe GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Willmar Schwabe GmbH and Co KG filed Critical Dr Willmar Schwabe GmbH and Co KG
Application granted granted Critical
Publication of ES2098786T3 publication Critical patent/ES2098786T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE DESCRIBEN 2H - 1 - BENZOPIRANO - 2 - ONAS (DERIVADOS CUMARINA) DE LA FORMULA GENERAL I DONDE R1 SIGNIFICA UN RESTO HIDROXI, UN RESTO ALCOXI INFERIOR, UN RESTO CICLOALCOXI CON 4 HASTA 6 ATOMOS DE C O UN RESTO ALQUIL O RESTO ARILSULFONIL, R6 SO2O -, R2 Y R3 DE FORMA INDEPENDIENTE UNO DE OTRO SIGNIFICAN UN ATOMO DE HIDROGENO, RESTO HIDROXI, RESTO ALCOXI INFERIOR O RESTO CICLOALCOXI CON 4 HASTA 6 ATOMOS DE C, R4 ES UN ATOMO DE HIDROGENO, UN GRUPO ALQUIL INFERIOR CON 1 HASTA 4 ATOMOS DE C O UN RESTO FENIL, Y ES UN ATOMO DE NITROGENO, UN GRUPO CH O UN GRUPO COH, R5 ES UN RESTO FENIL, NAFTIL, PIRIDINIL O RESTO RIPIMIDINIL, QUE EVENTUALMENTE ES SUSTITUIDO DE FORMA RESPECTIVA CON 1 O 2 GRUPOS C1 - C15 - ALQUIL, RESPECTIVAMENTE CON 1 O 2 ATOMOS DE HALOGENO, CON HALOGENO Y AL MISMO TIEMPO C1- C5 ALQUIL, CON PERFLUOR ALQUIL CON 1 HASTA 3 ATOMOS DE C, C1 - C5 ALCOXI, HIDROXI, METILENDIOXI O NITRO, R6 ES UN RESTO ALQUIL INFERIOR, UN RESTO CICLOALQUIL CON 4 HASTA 6 ATOMOS DE C O UN RESTO FENIL, QUE EVENTUALMENTE ES SUSTITUIDO DE FORMA RESPECTIVA CON 1 O 2 GRUPOS C1 - C5 - ALQUIL, CON 1 O 2 ATOMOS DE HALOGENO O CON PERFLUOR ALQUIL CON 1 HASTA 3 ATOMOS DE C, Y N = 1 HASTA 4, ASI COMO SUS COMPUESTOS DE ADICION CON ACIDOS TOLERABLES FISIOLOGICAMENTE. SE DESCRIBEN ADEMAS PROCESOS PARA LA ELABORACION DE ESTOS COMPUESTOS ASI COMO NUEVOS PRODUCTOS INTERMEDIOS Y PROCESOS PARA SU ELABORACION. LOS NUEVOS DERIVADOS CUMARINA POSEEN ACTIVIDAD NEUROPROTECTIVA Y SICOFARMACOLOGICA. LOS MEDICAMENTOS QUE CONTIENEN ESTOS COMPUESTOS SON EVENTUALMENTE OBJETO DE LA INVENCION.
ES93921925T 1992-10-08 1993-10-06 Nuevas benzopiranonas, procedimientos para su preparacion y utilizacion. Expired - Lifetime ES2098786T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4233963A DE4233963A1 (de) 1992-10-08 1992-10-08 Neue Benzopyranone, Verfahren zu ihrer Herstellung und Verwendung

Publications (1)

Publication Number Publication Date
ES2098786T3 true ES2098786T3 (es) 1997-05-01

Family

ID=6470008

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93921925T Expired - Lifetime ES2098786T3 (es) 1992-10-08 1993-10-06 Nuevas benzopiranonas, procedimientos para su preparacion y utilizacion.

Country Status (9)

Country Link
US (1) US5550129A (es)
EP (1) EP0663911B1 (es)
JP (1) JP3575610B2 (es)
AT (1) ATE148697T1 (es)
AU (1) AU674167B2 (es)
CA (1) CA2146646C (es)
DE (2) DE4233963A1 (es)
ES (1) ES2098786T3 (es)
WO (1) WO1994008985A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2724656B1 (fr) * 1994-09-15 1996-12-13 Adir Nouveaux derives du benzopyranne, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5922719A (en) * 1997-08-11 1999-07-13 Warner-Lambert Company Coumarin dopamine D4 receptor antagonists
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
US6177566B1 (en) 1998-06-30 2001-01-23 Neurogen Corporation 6-(4-arylalkylpiperazin-1-yl) benzodioxane and 6-(4-arylalkylpiperazin-1-yl) chromane derivatives: dopamine receptor subtype specific ligands
WO2000000489A2 (en) * 1998-06-30 2000-01-06 Neurogen Corporation 6-(4-arylalkylpiperazin-1-yl)benzodioxane and 6-(4-arylalkylpiperazin-1-yl)chromane derivatives: dopamine receptor subtype specific ligands
AR059339A1 (es) * 2006-02-09 2008-03-26 Chugai Pharmaceutical Co Ltd Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene
WO2009014100A1 (ja) * 2007-07-20 2009-01-29 Chugai Seiyaku Kabushiki Kaisha ｐ２７蛋白質誘導剤
FR2949465B1 (fr) * 2009-09-01 2011-08-12 Pf Medicament Derives chromones, leur procede de preparation et leurs applications therapeutiques

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3538098A (en) * 1966-11-02 1970-11-03 Cassella Farbwerke Mainkur Ag Process for the production of coumarin derivatives
DE1670468A1 (de) * 1966-11-02 1971-03-18 Cassella Farbwerke Mainkur Ag Verfahren zur Herstellung von Derivaten des Cumarins
US3930003A (en) * 1970-07-17 1975-12-30 Troponwerke Dinklage & Co Coumarine derivatives and process for the preparation thereof
DE2108185A1 (en) * 1971-02-20 1972-09-07 Troponwerke Dinklage & Co, 5000 Köln-Mülheim N-(3-aminoalkyl-2-oxo-2h-1-benzopyran-7-yl) ureas - as coronary vasodilators
DE2448257A1 (de) * 1974-10-10 1976-04-22 Troponwerke Dinklage & Co Cumarinabkoemmlinge, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
CA2146646C (en) 2004-06-01
JPH08502269A (ja) 1996-03-12
EP0663911B1 (de) 1997-02-05
AU5111393A (en) 1994-05-09
WO1994008985A1 (de) 1994-04-28
DE4233963A1 (de) 1994-04-14
US5550129A (en) 1996-08-27
AU674167B2 (en) 1996-12-12
CA2146646A1 (en) 1994-04-28
EP0663911A1 (de) 1995-07-26
ATE148697T1 (de) 1997-02-15
JP3575610B2 (ja) 2004-10-13
DE59305415D1 (de) 1997-03-20

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