NO955074L - 1-substituerte istain- og oksindolderivater som inhibitorer til acetylkolinesterase - Google Patents

1-substituerte istain- og oksindolderivater som inhibitorer til acetylkolinesterase

Info

Publication number
NO955074L
NO955074L NO955074A NO955074A NO955074L NO 955074 L NO955074 L NO 955074L NO 955074 A NO955074 A NO 955074A NO 955074 A NO955074 A NO 955074A NO 955074 L NO955074 L NO 955074L
Authority
NO
Norway
Prior art keywords
lower alkyl
hydrogen
compounds
substituted
istain
Prior art date
Application number
NO955074A
Other languages
English (en)
Norwegian (no)
Other versions
NO955074D0 (no
Inventor
Bernard Robin Boar
Dennis Mark O'shea
Ian David Tomlinson
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of NO955074D0 publication Critical patent/NO955074D0/no
Publication of NO955074L publication Critical patent/NO955074L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
NO955074A 1993-06-16 1995-12-14 1-substituerte istain- og oksindolderivater som inhibitorer til acetylkolinesterase NO955074L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE19939302080A SE9302080D0 (sv) 1993-06-16 1993-06-16 New compounds
PCT/SE1994/000448 WO1994029272A1 (fr) 1993-06-16 1994-05-13 Derives de l'isatine a substitution 1 et de l'oxindole utiles comme inhibiteurs de l'acetylcholinesterase

Publications (2)

Publication Number Publication Date
NO955074D0 NO955074D0 (no) 1995-12-14
NO955074L true NO955074L (no) 1996-02-07

Family

ID=20390305

Family Applications (1)

Application Number Title Priority Date Filing Date
NO955074A NO955074L (no) 1993-06-16 1995-12-14 1-substituerte istain- og oksindolderivater som inhibitorer til acetylkolinesterase

Country Status (9)

Country Link
EP (1) EP0703901A1 (fr)
JP (1) JPH08511515A (fr)
AU (1) AU7010894A (fr)
CA (1) CA2164119A1 (fr)
FI (1) FI956074A (fr)
IS (1) IS4167A (fr)
NO (1) NO955074L (fr)
SE (1) SE9302080D0 (fr)
WO (1) WO1994029272A1 (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9103752D0 (sv) * 1991-12-18 1991-12-18 Astra Ab New compounds
KR20010041625A (ko) 1998-03-06 2001-05-25 아스트라제네카 악티에볼라그 신규 용도
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
CN1163224C (zh) 1998-09-30 2004-08-25 武田药品工业株式会社 改善膀胱排泄能力的药物
US6329416B1 (en) 1999-05-04 2001-12-11 American Home Products Corporation Combination regimens using 3,3-substituted indoline derivatives
US6444668B1 (en) 1999-05-04 2002-09-03 Wyeth Combination regimens using progesterone receptor modulators
US6423699B1 (en) 1999-05-04 2002-07-23 American Home Products Corporation Combination therapies using benzimidazolones
US6399593B1 (en) 1999-05-04 2002-06-04 Wyeth Cyclic regimens using cyclic urea and cyclic amide derivatives
US6358947B1 (en) 1999-05-04 2002-03-19 American Home Products Corporation Tetracyclic progesterone receptor modulator compounds and methods
US6319912B1 (en) 1999-05-04 2001-11-20 American Home Products Corporation Cyclic regimens using 2,1-benzisothiazoline 2,2-dioxides
US6369056B1 (en) 1999-05-04 2002-04-09 American Home Products Corporation Cyclic urea and cyclic amide derivatives
US6355648B1 (en) * 1999-05-04 2002-03-12 American Home Products Corporation Thio-oxindole derivatives
US6498154B1 (en) 1999-05-04 2002-12-24 Wyeth Cyclic regimens using quinazolinone and benzoxazine derivatives
US6407101B1 (en) 1999-05-04 2002-06-18 American Home Products Corporation Cyanopyrroles
US6380235B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Benzimidazolones and analogues
US6358948B1 (en) 1999-05-04 2002-03-19 American Home Products Corporation Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
US6509334B1 (en) 1999-05-04 2003-01-21 American Home Products Corporation Cyclocarbamate derivatives as progesterone receptor modulators
US6306851B1 (en) 1999-05-04 2001-10-23 American Home Products Corporation Cyclocarbamate and cyclic amide derivatives
US6391907B1 (en) * 1999-05-04 2002-05-21 American Home Products Corporation Indoline derivatives
US6462032B1 (en) 1999-05-04 2002-10-08 Wyeth Cyclic regimens utilizing indoline derivatives
US6417214B1 (en) 1999-05-04 2002-07-09 Wyeth 3,3-substituted indoline derivatives
US6380178B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Cyclic regimens using cyclocarbamate and cyclic amide derivatives
US6339098B1 (en) 1999-05-04 2002-01-15 American Home Products Corporation 2,1-benzisothiazoline 2,2-dioxides
UA73119C2 (en) 2000-04-19 2005-06-15 American Home Products Corpoir Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
WO2002070478A1 (fr) 2001-03-06 2002-09-12 Astrazeneca Ab Dérivés indolone capable de dégrader des vaisseaux
TW200508197A (en) * 2003-03-31 2005-03-01 Ucb Sa Indolone-acetamide derivatives, processes for preparing them and their uses
JP4914346B2 (ja) * 2004-05-27 2012-04-11 ユセベ ファルマ ソシエテ アノニム ベンズオキサゾロン誘導体、その調製方法及びその使用
ES2353394T3 (es) 2004-07-22 2011-03-01 Ucb Pharma, S.A. Derivados de indolona, procedimientos para prepararlos y sus usos.
GT200500185A (es) 2004-08-09 2006-04-10 Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos
WO2010090680A1 (fr) * 2008-12-15 2010-08-12 Wyeth Llc Agonistes de cb2 de type oxindole substitué
WO2011100373A1 (fr) 2010-02-09 2011-08-18 The Johns Hopkins University Procédés et compositions pour améliorer la fonction cognitive
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
HUE036280T2 (hu) 2012-12-13 2018-06-28 H Lundbeck As Vortioxetint és donepezilt tartalmazó készítmények
CA2904767C (fr) 2013-03-15 2022-06-21 Agenebio, Inc. Procedes et compositions pour ameliorer la fonction cognitive
WO2014144663A1 (fr) 2013-03-15 2014-09-18 The Johns Hopkins University Procédés et compositions pour améliorer la fonction cognitive
CN104530065A (zh) * 2013-05-13 2015-04-22 江西科技师范大学 1-n酰基取代吲哚酮衍生物的应用
CN103242332B (zh) * 2013-05-13 2015-11-04 江西科技师范大学 1-n酰基取代吲哚酮衍生物
US10925834B2 (en) 2015-05-22 2021-02-23 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH491106A (de) * 1964-06-11 1970-05-31 Ciba Geigy Verfahren zur Herstellung von neuen Thiosemicarbazonen

Also Published As

Publication number Publication date
CA2164119A1 (fr) 1994-12-22
JPH08511515A (ja) 1996-12-03
NO955074D0 (no) 1995-12-14
FI956074A0 (fi) 1995-12-18
IS4167A (is) 1994-12-17
FI956074A (fi) 1995-12-18
EP0703901A1 (fr) 1996-04-03
SE9302080D0 (sv) 1993-06-16
AU7010894A (en) 1995-01-03
WO1994029272A1 (fr) 1994-12-22

Similar Documents

Publication Publication Date Title
NO955074L (no) 1-substituerte istain- og oksindolderivater som inhibitorer til acetylkolinesterase
NO942316L (no) Isatinderivater, fremgangsmåter for deres fremstilling og farmasöytisk preparat omfattende slike derivater
DK0794949T3 (da) Hidtil ukendte 3,5-dioxo-(2H,4H)-1,2,4-triazinderivater, fremstilling heraf og deres anvendelse som lægemidler
HUP9901820A2 (hu) 4-Amino-pirimidin-származékok, ezeket tartalmazó gyógyszerkészítmények, alkalmazásuk és eljárás előállításukra
MX9305379A (es) Nuevos derivados de aminoacidos, procedimiento para su preparacion y preparado farmaceutico que los contiene.
DE3873612D1 (de) Dithioacetal-verbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
HUP0203971A2 (hu) Imidazoimidazolok és -triazolok mint gyulladásellenes szerek és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
ES8303293A1 (es) "procedimiento de preparar derivados carboxamidicos".
HUP0200310A2 (hu) Triciklikus pirazolszármazékok alkalmazása gyógyszerkészítmények előállítására és az új vegyületek
NO986055D0 (no) Nye heterocykliske forbindelser, deres fremstilling, farmas÷ytiske preparat
MY101208A (en) Phenyl-piperazine anti-arrhythmia agents.
HUP0303164A2 (hu) Kinazolinok mint MMP-13 gátlók, eljárás az előállításukra, intermedierjeik és a vegyületeket tartalmazó gyógyszerkészítmények
EE03446B1 (et) 8-asabitsüklo[3.2.1]okt-2-eeni derivaadid, nende valmistamine ja kasutamine
ES2149777T3 (es) Derivados de triazol que tienen actividad antifungica.
NO961000L (no) Piperidinderivater, fremgangsmåte for fremstilling derav og medikament og preparat inneholdende slike
DE69202120D1 (de) Harnstoffderivate, ihre Herstellung und ihre Verwendung bei der Therapie.
NO882334L (no) Fremgangsmaate for fremstilling av terapeutisk aktive alkansulfonanilid-derivater.
NO952402L (no) Substituerte 6-azaandrostenoner
NO961797L (no) Anvendelse av benzopyranderivater for fremstilling av farmasöytiske sammensetninger beregnet for behandling av patologier forbundet med den Na+-uavhengige C1-HCO3-utbytter
HUP0003962A2 (hu) Kinuklidinil-származékok, eljárás előállításukra, e vegyületeket tartalmazó gyógyászati készítmények, e vegyületek alkalmazása, valamint intermedierjeik
ATE32720T1 (de) 1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino(2,1alpha)isochinoline als zwischenprodukte und als pharmazeutische verbindungen verwendbar und methode zu ihrer herstellung.
HUP0202647A2 (hu) Új arilalkanoilszármazékok, előállításuk és alkalmazásuk, valamint e vegyületeket tartalmazó gyógyászati készítmények
HUP0100751A2 (hu) Új aril-vagy heteroaril-kinolinilfoszfonsav-származékok, eljárás előállításukra és ilyen vegyületeket tartalmazó gyógyszerkészítmények
SE8000699L (sv) Nya kinazolinderivat jemte sett for deras framstellning och farmaceutiska beredningar innehallande dem
RU94031211A (ru) Производные изатина, способ их получения и фармацевтическая композиция на их основе