NO953573L - Benzopyraner som kaliumkanalåpnere - Google Patents

Benzopyraner som kaliumkanalåpnere

Info

Publication number
NO953573L
NO953573L NO953573A NO953573A NO953573L NO 953573 L NO953573 L NO 953573L NO 953573 A NO953573 A NO 953573A NO 953573 A NO953573 A NO 953573A NO 953573 L NO953573 L NO 953573L
Authority
NO
Norway
Prior art keywords
formula
dotted line
covalent bond
benzopyrans
potassium channel
Prior art date
Application number
NO953573A
Other languages
English (en)
Other versions
NO953573D0 (no
Inventor
Alexander Roderick Mackenzie
Sandra Marina Monaghan
Original Assignee
Pfizer Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939304917A external-priority patent/GB9304917D0/en
Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev
Publication of NO953573L publication Critical patent/NO953573L/no
Publication of NO953573D0 publication Critical patent/NO953573D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Glass Compositions (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Pyrane Compounds (AREA)
  • Dental Preparations (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

Foreliggende oppfinnelse vedrører forbindelser med formel (I) og de farmasøytisk akseptable salter derav, hvor den stiplede linje betyr en valgfri kovalent binding; X betyr O, NH, S eller en direkte binding; R3 betyr hydroksy når den stiplede linje ikke betyr en kovalent binding, og R3 er fraværende når den stiplede linje betyr en kovalent binding; R4 (a) når X betyr O, betyr en gruppe med formel (i), (b) når X betyr O, NH eller S, betyr valgfritt substituert hydroksyfenyl, (c) betyr en valgfritt substituert 4- til 7-leddet heterocyklisk ring, eller (d) når X betyr NH, betyr en gruppe med formel (ii). Forbindelsene er nyttige ved behandling av sykdommer forbundet med forandret tonisitet eller motilitet av glatte muskler.
NO953573A 1993-03-10 1995-09-11 Benzopyraner som kaliumkanalåpnere NO953573D0 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939304917A GB9304917D0 (en) 1993-03-10 1993-03-10 Benzopyrans
GB939308368A GB9308368D0 (en) 1993-03-10 1993-04-22 Benzopyrans
PCT/EP1994/000637 WO1994020491A1 (en) 1993-03-10 1994-03-04 Benzopyranes as potassium channel openers

Publications (2)

Publication Number Publication Date
NO953573L true NO953573L (no) 1995-09-11
NO953573D0 NO953573D0 (no) 1995-09-11

Family

ID=26302564

Family Applications (1)

Application Number Title Priority Date Filing Date
NO953573A NO953573D0 (no) 1993-03-10 1995-09-11 Benzopyraner som kaliumkanalåpnere

Country Status (23)

Country Link
US (1) US5677324A (no)
EP (1) EP0690855B1 (no)
JP (1) JP3137649B2 (no)
CN (1) CN1119014A (no)
AT (1) ATE146468T1 (no)
AU (1) AU674940B2 (no)
BR (1) BR9406818A (no)
CA (1) CA2155837C (no)
CZ (1) CZ230895A3 (no)
DE (1) DE69401201T2 (no)
DK (1) DK0690855T3 (no)
EG (1) EG20542A (no)
ES (1) ES2097041T3 (no)
FI (1) FI115055B (no)
GR (1) GR3022517T3 (no)
HU (1) HUT73784A (no)
IL (1) IL108841A0 (no)
MY (1) MY110494A (no)
NO (1) NO953573D0 (no)
NZ (1) NZ262897A (no)
PL (1) PL310553A1 (no)
SG (1) SG42910A1 (no)
WO (1) WO1994020491A1 (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4841700A (en) 1999-05-12 2000-11-21 Nitromed, Inc. Nitrosated and nitrosylated potassium channel activators, compositions and methods of use
AU2001286557A1 (en) * 2000-08-23 2002-03-04 Merck Frosst Canada And Co. Method of treating or preventing urinary incontinence using prostanoid ep1 receptor antagonists
RU2006129320A (ru) * 2004-02-12 2008-02-27 Уорнер-Ламберт Компани Ллс (Us) Способ стимулирования роста волос
CN104487427B (zh) * 2012-06-25 2017-03-15 萨尼奥纳有限责任公司 四唑衍生物和它们作为钾通道调节剂的用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1479518A (en) * 1973-12-27 1977-07-13 Erba Carlo Spa 5,6-benzo-ypsilon-pyrone derivatives
DE3811017A1 (de) * 1988-03-31 1989-10-19 Hoechst Ag Ungesaettigte n-benzopyranyllactame
EP0346724A1 (de) * 1988-06-16 1989-12-20 MERCK PATENT GmbH Chromanderivate

Also Published As

Publication number Publication date
CA2155837A1 (en) 1994-09-15
AU6282694A (en) 1994-09-26
US5677324A (en) 1997-10-14
NZ262897A (en) 1997-06-24
JPH08503225A (ja) 1996-04-09
WO1994020491A1 (en) 1994-09-15
SG42910A1 (en) 1997-10-17
EG20542A (en) 1999-07-31
DE69401201T2 (de) 1997-04-17
ATE146468T1 (de) 1997-01-15
FI115055B (fi) 2005-02-28
CZ230895A3 (en) 1995-12-13
HUT73784A (en) 1996-09-30
BR9406818A (pt) 1996-09-10
ES2097041T3 (es) 1997-03-16
PL310553A1 (en) 1995-12-27
MY110494A (en) 1998-06-30
CA2155837C (en) 1999-07-27
DE69401201D1 (de) 1997-01-30
HU9501918D0 (en) 1995-09-28
NO953573D0 (no) 1995-09-11
FI954218A (fi) 1995-09-08
GR3022517T3 (en) 1997-05-31
IL108841A0 (en) 1994-06-24
CN1119014A (zh) 1996-03-20
DK0690855T3 (da) 1997-06-02
EP0690855B1 (en) 1996-12-18
EP0690855A1 (en) 1996-01-10
JP3137649B2 (ja) 2001-02-26
AU674940B2 (en) 1997-01-16
FI954218A0 (fi) 1995-09-08

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