NO951418L - Peptidderivater, deres fremstilling og anvendelse som terapeutika - Google Patents

Peptidderivater, deres fremstilling og anvendelse som terapeutika

Info

Publication number
NO951418L
NO951418L NO951418A NO951418A NO951418L NO 951418 L NO951418 L NO 951418L NO 951418 A NO951418 A NO 951418A NO 951418 A NO951418 A NO 951418A NO 951418 L NO951418 L NO 951418L
Authority
NO
Norway
Prior art keywords
group
alkyl group
diol
branched
straight chain
Prior art date
Application number
NO951418A
Other languages
English (en)
Other versions
NO951418D0 (no
Inventor
Sergio Mallart
Gilbert Lassalle
Thomas Andrew Purcell
Jean Claude Muller
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of NO951418D0 publication Critical patent/NO951418D0/no
Publication of NO951418L publication Critical patent/NO951418L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Forbindelser med formel (I) (I) hvor R representerer enten et hydrogenatom eller -en rettkjedet eller forgrenet (C1-C4)alkylgruppe eller en rettkjedet eller forgrenet -CO(C1-C4)alkylgruppe eller en rettkjedet eller for- grenet -C02 (C1-C4)alkylgruppe, R! representerer enten en fenylgruppe eller en cykloheksyl- gruppe, R2 representerer enten en gruppe eller en gruppe hvor R5 er et hydrogenatom eller en (C1-C4)alkylgruppe, og R3 og R4 representerer hver enten et hydrogenatom eller de representerer sammen resten av en dihydroksylert forbindelse som f.eks. butan-2,3-diol, 2,3-dimetylbutan-2,3-diol eller (la, 3tt, 5a)-2/6,6-trimetylbicyklof3.1.1]heptan-2,3-diol [(+)- a-pinandiol] i form av rene optiske eller geometriske isomerer eller som blandinger derav, og deres addisjonssalter med farmasøytisk tålbare syrer og baser. Forbindelsen har terapeutisk anvendelse.
NO951418A 1994-04-12 1995-04-11 Peptidderivater, deres fremstilling og anvendelse som terapeutika NO951418L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9404288A FR2718451B1 (fr) 1994-04-12 1994-04-12 Dérivés de peptides boroniques, leur préparation et leur application en thérapeutique.

Publications (2)

Publication Number Publication Date
NO951418D0 NO951418D0 (no) 1995-04-11
NO951418L true NO951418L (no) 1995-10-13

Family

ID=9461981

Family Applications (1)

Application Number Title Priority Date Filing Date
NO951418A NO951418L (no) 1994-04-12 1995-04-11 Peptidderivater, deres fremstilling og anvendelse som terapeutika

Country Status (17)

Country Link
EP (1) EP0677531A1 (no)
JP (1) JPH07285990A (no)
KR (1) KR950032225A (no)
CN (1) CN1113493A (no)
AU (1) AU1638095A (no)
CA (1) CA2146833A1 (no)
CZ (1) CZ92295A3 (no)
FI (1) FI951726A (no)
FR (1) FR2718451B1 (no)
HU (1) HUT71617A (no)
IL (1) IL113332A0 (no)
NO (1) NO951418L (no)
NZ (1) NZ270913A (no)
PL (1) PL308074A1 (no)
RU (1) RU95105419A (no)
SK (1) SK47695A3 (no)
ZA (1) ZA952983B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
CA2143533A1 (en) * 1994-03-04 1995-09-05 Kenneth D. Kurz Antithrombotic agents
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
US5639739A (en) * 1995-03-24 1997-06-17 The Dupont Merck Pharmaceutical Company Imidazole containing aminoboronic acids
FR2739858B1 (fr) * 1995-10-11 1997-11-14 Synthelabo Derives de n-sulfonyl- et n-sulfamoylpeptidylprolinamide, leur preparation et leur application en therapeutique
US5811402A (en) * 1996-03-22 1998-09-22 Eli Lilly And Company Antithrombotic diamides
FR2758329B1 (fr) * 1997-01-16 1999-02-12 Synthelabo Derives d'imidazole-4-butane boronique, leur preparation et leur utilisation en therapeutique

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4499082A (en) * 1983-12-05 1985-02-12 E. I. Du Pont De Nemours And Company α-Aminoboronic acid peptides
US5187157A (en) * 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
EP0315574A3 (de) * 1987-11-05 1990-08-22 Hoechst Aktiengesellschaft Renin-Inhibitoren

Also Published As

Publication number Publication date
IL113332A0 (en) 1995-07-31
CZ92295A3 (en) 1995-11-15
AU1638095A (en) 1995-10-19
RU95105419A (ru) 1997-01-10
JPH07285990A (ja) 1995-10-31
CN1113493A (zh) 1995-12-20
FI951726A0 (fi) 1995-04-11
HUT71617A (en) 1996-01-29
CA2146833A1 (fr) 1995-10-13
SK47695A3 (en) 1995-12-06
NZ270913A (en) 1996-05-28
FR2718451A1 (fr) 1995-10-13
PL308074A1 (en) 1995-10-16
ZA952983B (en) 1996-01-11
KR950032225A (ko) 1995-12-20
NO951418D0 (no) 1995-04-11
EP0677531A1 (fr) 1995-10-18
FR2718451B1 (fr) 1996-05-10
HU9501041D0 (en) 1995-06-28
FI951726A (fi) 1995-10-13

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