NO951266D0 - Imidazol-holdige inhibitorer for farnesyl-protein-transferase - Google Patents
Imidazol-holdige inhibitorer for farnesyl-protein-transferaseInfo
- Publication number
- NO951266D0 NO951266D0 NO951266A NO951266A NO951266D0 NO 951266 D0 NO951266 D0 NO 951266D0 NO 951266 A NO951266 A NO 951266A NO 951266 A NO951266 A NO 951266A NO 951266 D0 NO951266 D0 NO 951266D0
- Authority
- NO
- Norway
- Prior art keywords
- imidazole
- protein transferase
- farnesyl protein
- containing inhibitors
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/04—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22115394A | 1994-03-31 | 1994-03-31 | |
US29291694A | 1994-08-19 | 1994-08-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
NO951266D0 true NO951266D0 (no) | 1995-03-31 |
NO951266L NO951266L (no) | 1995-10-02 |
Family
ID=26915545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO951266A NO951266L (no) | 1994-03-31 | 1995-03-31 | Imidazol-holdige inhibitorer for farnesyl-protein-transferase |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0675112A1 (no) |
JP (1) | JPH07304750A (no) |
KR (1) | KR950032174A (no) |
CN (1) | CN1112117A (no) |
AU (1) | AU1615895A (no) |
CA (1) | CA2146059A1 (no) |
CZ (1) | CZ82195A3 (no) |
FI (1) | FI951554A (no) |
HU (1) | HUT72440A (no) |
IL (1) | IL113196A0 (no) |
NO (1) | NO951266L (no) |
PL (1) | PL307950A1 (no) |
RU (1) | RU95104898A (no) |
Families Citing this family (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5439918A (en) | 1994-03-14 | 1995-08-08 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5661161A (en) * | 1994-09-29 | 1997-08-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5652257A (en) * | 1994-09-29 | 1997-07-29 | Merck & Co., Inc. | Heterocycle-containing inhibitors of farnesyl-protein transferase |
EP0837875A4 (en) * | 1995-03-29 | 1998-10-07 | Merck & Co Inc | FARNESYLE TRANSFERASE INHIBITORS |
EP0837857A4 (en) * | 1995-03-29 | 1998-08-05 | Merck & Co Inc | FARNESYL-PROTEIN TRANSFERASE INHIBITORS |
US5627202A (en) * | 1995-03-29 | 1997-05-06 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5624936A (en) * | 1995-03-29 | 1997-04-29 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
CA2226623A1 (en) * | 1995-07-13 | 1997-01-30 | University Of Cincinnati | Compounds useful in the treatment of neurofibromatosis |
US5703241A (en) * | 1995-10-16 | 1997-12-30 | Merck & Co., Inc. | Inhibitor of farnesyl-protein transferase |
DK0873123T3 (da) * | 1995-11-06 | 2003-08-04 | Univ Pittsburgh | Inhibitorer af protein-isoprenyltransferaser |
JP2000500502A (ja) * | 1995-11-22 | 2000-01-18 | メルク エンド カンパニー インコーポレーテッド | ファルネシル―タンパク質トランスフェラーゼ阻害剤 |
AU704087B2 (en) * | 1996-01-30 | 1999-04-15 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
CA2243507A1 (en) * | 1996-01-30 | 1997-08-07 | Christopher J. Dinsmore | Inhibitors of farnesyl-protein transferase |
US6028201A (en) * | 1996-01-30 | 2000-02-22 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
WO1997036891A1 (en) * | 1996-04-03 | 1997-10-09 | Merk & Co., Inc. | Inhibitors of farnesyl-protein transferase |
WO1997036877A1 (en) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5965578A (en) * | 1996-04-03 | 1999-10-12 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
JP2000508631A (ja) * | 1996-04-03 | 2000-07-11 | メルク エンド カンパニー インコーポレーテッド | ファルネシルタンパク質トランスフェラーゼの阻害剤 |
CA2249601A1 (en) * | 1996-04-03 | 1997-10-23 | Thorsten E. Fisher | Inhibitors of farnesyl-protein transferase |
EP2409985A3 (en) | 1996-10-18 | 2013-05-01 | Vertex Pharmaceuticals Incorporated | Inhibitors de serine proteases, especially of the NS3 protease of the hepatitis C virus |
US5972966A (en) * | 1996-12-05 | 1999-10-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US6015817A (en) * | 1996-12-05 | 2000-01-18 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5932590A (en) * | 1996-12-05 | 1999-08-03 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5977134A (en) * | 1996-12-05 | 1999-11-02 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
TW527355B (en) * | 1997-07-02 | 2003-04-11 | Bristol Myers Squibb Co | Inhibitors of farnesyl protein transferase |
CA2312366A1 (en) * | 1997-12-04 | 1999-06-10 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
CA2336448A1 (en) * | 1998-07-02 | 2000-01-13 | Christopher J. Dinsmore | Inhibitors of prenyl-protein transferase |
US6562823B1 (en) * | 1998-07-02 | 2003-05-13 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
AU2478500A (en) * | 1998-12-08 | 2000-06-26 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
DE19937394A1 (de) * | 1999-08-07 | 2001-02-08 | Merck Patent Gmbh | Fluorenderivate |
CA2408343A1 (en) | 2000-05-11 | 2002-11-07 | Banyu Pharmaceutical Co., Ltd. | N-acyltetrahydroisoquinoline derivatives |
SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
US7759323B2 (en) | 2001-05-22 | 2010-07-20 | Eisai R & D Management Co., Ltd. | Highly purified antiendotoxin compound |
EP1443936A4 (en) | 2001-11-13 | 2006-01-11 | Bristol Myers Squibb Co | PROCESS FOR THE PREPARATION OF 3,7-DISUBSTITUE-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE COMPOUNDS |
MY148123A (en) | 2003-09-05 | 2013-02-28 | Vertex Pharma | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
KR20060130027A (ko) * | 2003-10-10 | 2006-12-18 | 버텍스 파마슈티칼스 인코포레이티드 | 세린 프로테아제, 특히 hcv ns3-ns4a 프로테아제의억제제 |
ATE550019T1 (de) | 2005-05-17 | 2012-04-15 | Merck Sharp & Dohme | Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs |
US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
PE20070427A1 (es) | 2005-08-30 | 2007-04-21 | Novartis Ag | Compuestos derivados de benzimidazoles sustituidos como inhibidores de tirosina quinasas |
GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
CN102614490A (zh) | 2006-02-27 | 2012-08-01 | 弗特克斯药品有限公司 | 包含vx-950的共晶体和包含所述共晶体的药物组合物 |
WO2007109080A2 (en) | 2006-03-16 | 2007-09-27 | Vertex Pharmaceuticals Incorporated | Deuterated hepatitis c protease inhibitors |
TW200813039A (en) | 2006-04-19 | 2008-03-16 | Novartis Ag | 6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling |
FR2900573B1 (fr) * | 2006-05-05 | 2014-05-16 | Sederma Sa | Nouvelles compositions cosmetiques renfermant au moins un peptide contenant au moins un cycle aromatique bloque |
CA2664113C (en) | 2006-09-22 | 2013-05-28 | Merck & Co., Inc. | Use of platencin and platensimycin as fatty acid synthesis inhibitors to treat obesity, diabetes and cancer |
US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
PL2109608T3 (pl) | 2007-01-10 | 2011-08-31 | Msd Italia Srl | Indazole podstawione grupą amidową jako inhibitory polimerazy poli(ADP-rybozy)-(PARP) |
ATE542815T1 (de) | 2007-02-27 | 2012-02-15 | Vertex Pharma | Kokristalle und pharmazeutische zusammensetzungen damit |
CA2679426A1 (en) | 2007-02-27 | 2008-09-04 | Luc Farmer | Inhibitors of serine proteases |
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KR20100017866A (ko) | 2007-05-21 | 2010-02-16 | 노파르티스 아게 | Csf-1r 억제제, 조성물 및 사용 방법 |
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JP5443360B2 (ja) | 2007-08-30 | 2014-03-19 | バーテックス ファーマシューティカルズ インコーポレイテッド | 共結晶体およびそれを含む医薬組成物 |
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CN103080093A (zh) | 2010-03-16 | 2013-05-01 | 达纳-法伯癌症研究所公司 | 吲唑化合物及其应用 |
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SI2606134T1 (sl) | 2010-08-17 | 2019-08-30 | Sirna Therapeutics, Inc. | RNA-INTERFERENČNO POSREDOVANO ZAVIRANJE IZRAŽANJA GENA VIRUSA HEPATITISA B (HBV) Z UPORABO KRATKE INTERFERENČNE NUKLEINSKE KISLINE (siNA) |
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WO2012030685A2 (en) | 2010-09-01 | 2012-03-08 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
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DK2632472T3 (en) | 2010-10-29 | 2018-03-19 | Sirna Therapeutics Inc | RNA INTERFERENCE-MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERRING NUCLEIC ACIDS (SINA) |
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JP6106685B2 (ja) | 2011-11-17 | 2017-04-05 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | C−jun−n−末端キナーゼ(jnk)の阻害剤 |
EP3919620A1 (en) | 2012-05-02 | 2021-12-08 | Sirna Therapeutics, Inc. | Short interfering nucleic acid (sina) compositions |
JP6280554B2 (ja) | 2012-09-28 | 2018-02-14 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | Erk阻害剤である新規化合物 |
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US10000483B2 (en) | 2012-10-19 | 2018-06-19 | Dana-Farber Cancer Institute, Inc. | Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof |
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WO2014100065A1 (en) | 2012-12-20 | 2014-06-26 | Merck Sharp & Dohme Corp. | Substituted imidazopyridines as hdm2 inhibitors |
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Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2376860A1 (fr) | 1977-01-07 | 1978-08-04 | Parcor | Tetrahydro-4,5,6,7 thieno (2,3-c) et (3,2-c) pyridines, leur procede de preparation et leur application therapeutique |
DE3752373T2 (de) | 1986-10-13 | 2004-03-25 | Asahi Kasei Kogyo K.K. | Pyridin-derivate |
JPH02193971A (ja) | 1989-01-20 | 1990-07-31 | Yamanouchi Pharmaceut Co Ltd | トリ置換―2,3,4,5―テトラヒドロベンズアゼピン誘導体とその中間体 |
US5352705A (en) * | 1992-06-26 | 1994-10-04 | Merck & Co., Inc. | Inhibitors of farnesyl protein transferase |
JPH09504295A (ja) * | 1993-10-25 | 1997-04-28 | パーク・デイビス・アンド・カンパニー | タンパク質:ファルネシルトランスフェラーゼの置換されたテトラ‐およびペンタペプチド阻害剤 |
CA2170766A1 (en) * | 1993-11-05 | 1995-05-11 | Gary Louis Bolton | Substituted di- and tripeptide inhibitors of protein:farnesyl transferase |
-
1995
- 1995-03-30 RU RU95104898/04A patent/RU95104898A/ru unknown
- 1995-03-30 AU AU16158/95A patent/AU1615895A/en not_active Abandoned
- 1995-03-30 HU HU9500934A patent/HUT72440A/hu unknown
- 1995-03-30 IL IL11319695A patent/IL113196A0/xx unknown
- 1995-03-31 NO NO951266A patent/NO951266L/no unknown
- 1995-03-31 CA CA002146059A patent/CA2146059A1/en not_active Abandoned
- 1995-03-31 KR KR1019950007235A patent/KR950032174A/ko not_active Application Discontinuation
- 1995-03-31 PL PL95307950A patent/PL307950A1/xx unknown
- 1995-03-31 EP EP95302188A patent/EP0675112A1/en not_active Withdrawn
- 1995-03-31 JP JP7075486A patent/JPH07304750A/ja active Pending
- 1995-03-31 FI FI951554A patent/FI951554A/fi not_active Application Discontinuation
- 1995-03-31 CZ CZ95821A patent/CZ82195A3/cs unknown
- 1995-03-31 CN CN95103978A patent/CN1112117A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
CN1112117A (zh) | 1995-11-22 |
PL307950A1 (en) | 1995-10-02 |
FI951554A0 (fi) | 1995-03-31 |
CA2146059A1 (en) | 1995-10-01 |
CZ82195A3 (en) | 1996-09-11 |
FI951554A (fi) | 1995-10-01 |
EP0675112A1 (en) | 1995-10-04 |
AU1615895A (en) | 1995-10-12 |
KR950032174A (ko) | 1995-12-20 |
HU9500934D0 (en) | 1995-05-29 |
HUT72440A (en) | 1996-04-29 |
NO951266L (no) | 1995-10-02 |
JPH07304750A (ja) | 1995-11-21 |
RU95104898A (ru) | 1996-12-27 |
IL113196A0 (en) | 1995-06-29 |
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