NO943811L - T-celle-epitoper av hovedallergenene fra Ambriosa artemisiifolia - Google Patents
T-celle-epitoper av hovedallergenene fra Ambriosa artemisiifoliaInfo
- Publication number
- NO943811L NO943811L NO943811A NO943811A NO943811L NO 943811 L NO943811 L NO 943811L NO 943811 A NO943811 A NO 943811A NO 943811 A NO943811 A NO 943811A NO 943811 L NO943811 L NO 943811L
- Authority
- NO
- Norway
- Prior art keywords
- amb
- peptides
- allergens
- cell epitopes
- artemisiifolia
- Prior art date
Links
- 239000013566 allergen Substances 0.000 title abstract 6
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 239000009342 ragweed pollen Substances 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 244000036975 Ambrosia artemisiifolia Species 0.000 abstract 1
- 235000003133 Ambrosia artemisiifolia Nutrition 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108091005601 modified peptides Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Pulmonology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Den foreliggende oppfinnelse tilveiebringer isolerte peptider av hovedproteinallergenene fra Ambrosia artemisiifolia, eller kort beisk-ambrosiapollen. Peptider innenfor rammen av denne oppfinnelse omfatter minst én T-celleepitop, eller fortrinnsvis minst to T-celleepitoper av et proteinallergen valgt fra allergenene Amb a 1.1, Amb a 1.2, Amb a 1.3, Amb a 1.4 og Amb a II. Det er beskrevet modifiserte peptider som har lignende eller forbedrede terapeutiske egenskaper som det tilsvarende, naturlig fore-kommende allergen eller del derav, men som har reduserte bivirkninger. Oppfinnelsen tilveiebringer også nukleinsyrer med sekvenser som koder for peptider ifølge oppfinnelsen. Det tilveiebringes også fremgangsmåter for behandling eller for diagnose av følsomhet for beisk-ambrosiapollenallergener hos et individ og terpautiske preparater omfattende ett eller flere peptider ifølge oppfinnelsen.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86667992A | 1992-04-09 | 1992-04-09 | |
| PCT/US1993/003156 WO1993021321A2 (en) | 1992-04-09 | 1993-04-06 | T CELL EPITOPES OF THE MAJOR ALLERGENS FROM $i(AMBROSIA ARTEMISIIFOLIA) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO943811D0 NO943811D0 (no) | 1994-10-07 |
| NO943811L true NO943811L (no) | 1994-12-06 |
Family
ID=25348157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO943811A NO943811L (no) | 1992-04-09 | 1994-10-07 | T-celle-epitoper av hovedallergenene fra Ambriosa artemisiifolia |
Country Status (12)
| Country | Link |
|---|---|
| EP (2) | EP0636180A1 (no) |
| JP (1) | JPH07507924A (no) |
| KR (1) | KR950700991A (no) |
| AU (1) | AU685392B2 (no) |
| CA (1) | CA2117779A1 (no) |
| FI (1) | FI944697A (no) |
| IL (1) | IL105352A0 (no) |
| MX (1) | MX9302024A (no) |
| NO (1) | NO943811L (no) |
| NZ (1) | NZ252013A (no) |
| WO (1) | WO1993021321A2 (no) |
| ZA (1) | ZA932530B (no) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6759234B1 (en) | 1994-09-02 | 2004-07-06 | Immulogic Pharmaceutical Corporation | Compositions and methods for administering to humans, peptides capable of down regulating an antigen specific immune response |
| AU748104B2 (en) * | 1994-09-02 | 2002-05-30 | Merck Patent Gmbh | Peptide compositions capable of down regulating an antigen specific immune response |
| NZ273815A (en) * | 1994-09-02 | 1999-05-28 | Immulogic Pharma Corp | Peptide compositions for treating protein allergies or autoimmune diseases containing at least two isolated and purified peptides |
| AU4146796A (en) * | 1994-10-27 | 1996-05-23 | Immulogic Pharmaceutical Corporation | T cell epitopes of the major allergens from ambrosia artemisiifolia |
| ATE296444T1 (de) | 1996-03-21 | 2005-06-15 | Circassia Ltd | Kryptische peptide und verfahren zu ihrer identifizierung |
| WO2001077353A2 (en) * | 2000-04-05 | 2001-10-18 | Syngenta Participations Ag | Expression of pollen allergens in plastids |
| EP1958645A1 (en) * | 2007-02-13 | 2008-08-20 | Biomay AG | Peptides derived from the major allergen of ragweed (Ambrosia artemisiifolia) and uses thereof |
| GB0710529D0 (en) | 2007-06-01 | 2007-07-11 | Circassia Ltd | Vaccine |
| ES2378870T5 (es) | 2008-08-15 | 2016-02-03 | Circassia Limited | Vacuna que comprende péptidos Amb a 1 para uso en el tratamiento de alergia a ambrosía |
| WO2010018384A1 (en) | 2008-08-15 | 2010-02-18 | Circassia Limited | T-cell antigen peptide from allergen for stimulation of il-10 production |
| GB0821806D0 (en) | 2008-11-28 | 2009-01-07 | Circassia Ltd | Compositions with reduced dimer formation |
| DK2723373T3 (en) * | 2011-06-27 | 2017-09-18 | Anergis S A | OVERLAPPING ADJUSTING PEPTIDES FOR TREATMENT |
| WO2017179025A1 (en) * | 2016-04-15 | 2017-10-19 | Alk-Abelló A/S | Epitope polypeptides of ragweed pollen allergens |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2049921C (en) * | 1989-03-17 | 2004-06-15 | Bruce Rogers | Allergenic proteins from ragweed and uses therefor |
-
1993
- 1993-04-06 EP EP93911584A patent/EP0636180A1/en not_active Withdrawn
- 1993-04-06 WO PCT/US1993/003156 patent/WO1993021321A2/en not_active Application Discontinuation
- 1993-04-06 CA CA002117779A patent/CA2117779A1/en not_active Abandoned
- 1993-04-06 NZ NZ252013A patent/NZ252013A/en unknown
- 1993-04-06 AU AU40462/93A patent/AU685392B2/en not_active Expired - Fee Related
- 1993-04-06 EP EP96202492A patent/EP0770681A3/en not_active Withdrawn
- 1993-04-06 JP JP5518403A patent/JPH07507924A/ja active Pending
- 1993-04-07 MX MX9302024A patent/MX9302024A/es unknown
- 1993-04-08 ZA ZA932530A patent/ZA932530B/xx unknown
- 1993-04-09 IL IL105352A patent/IL105352A0/xx unknown
-
1994
- 1994-10-07 FI FI944697A patent/FI944697A/fi not_active Application Discontinuation
- 1994-10-07 NO NO943811A patent/NO943811L/no unknown
- 1994-10-08 KR KR1019940703588A patent/KR950700991A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0770681A2 (en) | 1997-05-02 |
| JPH07507924A (ja) | 1995-09-07 |
| KR950700991A (ko) | 1995-02-20 |
| NZ252013A (en) | 1996-08-27 |
| FI944697A0 (fi) | 1994-10-07 |
| WO1993021321A2 (en) | 1993-10-28 |
| MX9302024A (es) | 1994-07-29 |
| EP0770681A3 (en) | 1997-06-04 |
| AU685392B2 (en) | 1998-01-22 |
| CA2117779A1 (en) | 1993-10-28 |
| WO1993021321A3 (en) | 1994-02-03 |
| EP0636180A1 (en) | 1995-02-01 |
| FI944697A (fi) | 1994-12-07 |
| AU4046293A (en) | 1993-11-18 |
| IL105352A0 (en) | 1993-08-18 |
| NO943811D0 (no) | 1994-10-07 |
| ZA932530B (en) | 1993-10-28 |
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