NO943345L - Isostere anti-herpes peptid-derivater - Google Patents
Isostere anti-herpes peptid-derivaterInfo
- Publication number
- NO943345L NO943345L NO943345A NO943345A NO943345L NO 943345 L NO943345 L NO 943345L NO 943345 A NO943345 A NO 943345A NO 943345 A NO943345 A NO 943345A NO 943345 L NO943345 L NO 943345L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- acid residue
- peptide derivatives
- isostere
- nhch
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84991892A | 1992-03-12 | 1992-03-12 | |
| PCT/CA1993/000095 WO1993018056A1 (en) | 1992-03-12 | 1993-03-12 | Isosteric antiherpes peptide derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO943345D0 NO943345D0 (no) | 1994-09-09 |
| NO943345L true NO943345L (no) | 1994-09-09 |
Family
ID=25306833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO943345A NO943345L (no) | 1992-03-12 | 1994-09-09 | Isostere anti-herpes peptid-derivater |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0560267B1 (de) |
| JP (1) | JPH0625131A (de) |
| KR (1) | KR950700322A (de) |
| AT (1) | ATE169931T1 (de) |
| BR (1) | BR9306074A (de) |
| CA (1) | CA2131186C (de) |
| CZ (1) | CZ220994A3 (de) |
| DE (1) | DE69320390T2 (de) |
| EE (1) | EE9400312A (de) |
| FI (1) | FI944187A7 (de) |
| HU (2) | HUT68675A (de) |
| IL (1) | IL105001A0 (de) |
| LT (1) | LT3270B (de) |
| LV (1) | LV10461B (de) |
| MX (1) | MX9301343A (de) |
| NO (1) | NO943345L (de) |
| NZ (1) | NZ251266A (de) |
| PH (1) | PH30453A (de) |
| RU (1) | RU94040865A (de) |
| SG (1) | SG42995A1 (de) |
| SK (1) | SK107794A3 (de) |
| TW (1) | TW278080B (de) |
| WO (1) | WO1993018056A1 (de) |
| ZA (1) | ZA931745B (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5846941A (en) * | 1992-03-12 | 1998-12-08 | Boehringer Ingelheim (Canada) Ltd. | Isosteric antiherpes peptide derivatives II |
| CA2095408A1 (en) * | 1993-05-03 | 1994-11-04 | James Gus Chafouleas | Method of combating acyclovir-resistant herpes simplex viral infections |
| CA2230750C (en) * | 1994-12-28 | 2002-05-21 | Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee | Antiherpes peptidomimetic compounds |
| CA2152541C (en) * | 1995-06-23 | 1998-12-15 | Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee | Herpes ribonucleotide reductase inhibitors |
| US5948935A (en) * | 1997-01-23 | 1999-09-07 | Boehringer Ingelheim (Canada) Ltd. | Process and intermediates for (s)-α-amino-1-carboxycyclopentaneacetic acid |
| DE69943314D1 (de) * | 1998-02-12 | 2011-05-12 | Kapil N Bhalla | Sphingolipid-derivate und verfahren zu deren verwendung |
| CA3112326A1 (en) | 2018-09-12 | 2020-03-19 | Novartis Ag | Antiviral pyridopyrazinedione compounds |
| KR20250127350A (ko) | 2019-09-26 | 2025-08-26 | 노파르티스 아게 | 항바이러스성 피라졸로피리디논 화합물 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US481432A (en) | 1892-08-23 | soler | ||
| US4795740A (en) | 1986-05-20 | 1989-01-03 | Cohen Eric A | Antiviral peptides and means for treating herpes infections |
| US4837304A (en) | 1987-05-22 | 1989-06-06 | Merck & Co., Inc. | Inhibitor of ribonucleotide reductase |
| US4845195A (en) | 1987-05-22 | 1989-07-04 | Merck & Co., Inc. | Inhibitor of ribonucleotide reductase |
| DE69017113T2 (de) | 1989-07-07 | 1995-08-03 | Bio Mega Boehringer Ingelheim | Pentapeptidderivate, wirksam gegen Herpes, die eine ersetzte Asparaginsäureseitenkette enthalten. |
| CA1340684C (en) | 1989-07-07 | 1999-07-27 | Pierre Louis Beaulieu | Antiherpes pentapeptides |
| CA1340682C (en) * | 1989-07-07 | 1999-07-27 | Pierre Lavallee | Antiviral peptides having a 2-oxoalkyl amino acid side chain |
| EP0411333B1 (de) * | 1989-07-07 | 1995-05-31 | Bio-Mega/Boehringer Ingelheim Research Inc. | Antiherpes-Tetrapeptid-Derivate mit einer substituierten Seitenkette aus Asparaginsäure |
| US5110799A (en) | 1989-07-28 | 1992-05-05 | Merck & Co., Inc. | Antiherpetic agents |
| CA2018801C (en) | 1990-06-12 | 2000-08-22 | Pierre Louis Beaulieu | Antiherpes peptide derivatives having a 1,4-dioxo c n-terminus |
| CA2033447C (en) * | 1990-12-31 | 1999-08-31 | Robert Deziel | Synergistic combination for treating herpes infections |
-
1993
- 1993-03-09 DE DE69320390T patent/DE69320390T2/de not_active Expired - Fee Related
- 1993-03-09 EP EP93103711A patent/EP0560267B1/de not_active Expired - Lifetime
- 1993-03-09 SG SG1996001914A patent/SG42995A1/en unknown
- 1993-03-09 AT AT93103711T patent/ATE169931T1/de not_active IP Right Cessation
- 1993-03-10 IL IL105001A patent/IL105001A0/xx unknown
- 1993-03-11 PH PH45860A patent/PH30453A/en unknown
- 1993-03-11 ZA ZA931745A patent/ZA931745B/xx unknown
- 1993-03-11 MX MX9301343A patent/MX9301343A/es not_active IP Right Cessation
- 1993-03-11 JP JP5051004A patent/JPH0625131A/ja active Pending
- 1993-03-12 CZ CZ942209A patent/CZ220994A3/cs unknown
- 1993-03-12 WO PCT/CA1993/000095 patent/WO1993018056A1/en not_active Ceased
- 1993-03-12 FI FI944187A patent/FI944187A7/fi not_active Application Discontinuation
- 1993-03-12 BR BR9306074A patent/BR9306074A/pt not_active Application Discontinuation
- 1993-03-12 LT LTIP408A patent/LT3270B/lt not_active IP Right Cessation
- 1993-03-12 LV LVP-93-186A patent/LV10461B/en unknown
- 1993-03-12 NZ NZ251266A patent/NZ251266A/en unknown
- 1993-03-12 RU RU94040865/04A patent/RU94040865A/ru unknown
- 1993-03-12 HU HU9402593A patent/HUT68675A/hu unknown
- 1993-03-12 SK SK1077-94A patent/SK107794A3/sk unknown
- 1993-03-12 CA CA002131186A patent/CA2131186C/en not_active Expired - Fee Related
- 1993-03-23 TW TW082102135A patent/TW278080B/zh active
-
1994
- 1994-09-09 NO NO943345A patent/NO943345L/no unknown
- 1994-09-10 KR KR1019940703166A patent/KR950700322A/ko not_active Withdrawn
- 1994-11-23 EE EE9400312A patent/EE9400312A/xx unknown
-
1995
- 1995-06-23 HU HU95P/P00431P patent/HU211926A9/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX9301343A (es) | 1994-01-31 |
| IL105001A0 (en) | 1993-07-08 |
| NZ251266A (en) | 1996-08-27 |
| LTIP408A (en) | 1994-09-25 |
| CA2131186C (en) | 2000-12-12 |
| ATE169931T1 (de) | 1998-09-15 |
| SK107794A3 (en) | 1995-03-08 |
| NO943345D0 (no) | 1994-09-09 |
| TW278080B (de) | 1996-06-11 |
| ZA931745B (en) | 1993-09-24 |
| BR9306074A (pt) | 1997-11-18 |
| HUT68675A (en) | 1995-07-28 |
| AU671825B2 (en) | 1996-09-12 |
| CA2131186A1 (en) | 1993-09-16 |
| HU211926A9 (en) | 1996-01-29 |
| EP0560267B1 (de) | 1998-08-19 |
| AU3880793A (en) | 1993-10-05 |
| EE9400312A (et) | 1996-04-15 |
| PH30453A (en) | 1997-05-28 |
| LV10461B (en) | 1996-02-20 |
| RU94040865A (ru) | 1996-08-10 |
| FI944187A0 (fi) | 1994-09-12 |
| JPH0625131A (ja) | 1994-02-01 |
| LT3270B (en) | 1995-05-25 |
| DE69320390T2 (de) | 1999-02-11 |
| CZ220994A3 (en) | 1995-09-13 |
| HU9402593D0 (en) | 1994-11-28 |
| FI944187L (fi) | 1994-09-12 |
| KR950700322A (ko) | 1995-01-16 |
| DE69320390D1 (de) | 1998-09-24 |
| FI944187A7 (fi) | 1994-09-12 |
| EP0560267A1 (de) | 1993-09-15 |
| SG42995A1 (en) | 1997-10-17 |
| LV10461A (lv) | 1995-02-20 |
| WO1993018056A1 (en) | 1993-09-16 |
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