NO933503L - Dicytostelium dipeptidylaminopeptidase - Google Patents

Dicytostelium dipeptidylaminopeptidase

Info

Publication number
NO933503L
NO933503L NO933503A NO933503A NO933503L NO 933503 L NO933503 L NO 933503L NO 933503 A NO933503 A NO 933503A NO 933503 A NO933503 A NO 933503A NO 933503 L NO933503 L NO 933503L
Authority
NO
Norway
Prior art keywords
ddap
enzyme
dap
peptides
methods
Prior art date
Application number
NO933503A
Other languages
English (en)
Other versions
NO933503D0 (no
Inventor
Paul Robert Atkinson
Matthew Dale Hilton
Peter Karl Lambooy
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO933503D0 publication Critical patent/NO933503D0/no
Publication of NO933503L publication Critical patent/NO933503L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/485—Exopeptidases (3.4.11-3.4.19)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/11—Aminopeptidases (3.4.11)
    • C12Y304/11005—Prolyl aminopeptidase (3.4.11.5)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/815—Enzyme separation or purification by sorption

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Escalators And Moving Walkways (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polyamides (AREA)
  • Purification Treatments By Anaerobic Or Anaerobic And Aerobic Bacteria Or Animals (AREA)
  • Noodles (AREA)
  • Peptides Or Proteins (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Fats And Perfumes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

En ny dipeptidylamlnopeptldase isolert fra den cellulære slimsoppen Dictyostellum dlscodeum. Det nye DÅP enzymet, dDAP utviser en aktivitet som lingner noe på både DAP-I og DAP-III, men er veldig forskjellig fra disse enzymene l fysiske og andre enzymatiske karakter- trekk. Fremgangsmåte for anvendelse av dDAP enzymet for å fjerne dlpeptider fra N-terminusen til rekombinant produserte forløperproteiner eller peptider er også beskrevet. Fremgangsmåter for isolering og rensning av dDAP enzymet fra kulturer av D. siscodeum er også beskrevet.
NO933503A 1992-10-01 1993-09-30 Dicytostelium dipeptidylaminopeptidase NO933503L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95553992A 1992-10-01 1992-10-01

Publications (2)

Publication Number Publication Date
NO933503D0 NO933503D0 (no) 1993-09-30
NO933503L true NO933503L (no) 1994-04-05

Family

ID=25496954

Family Applications (1)

Application Number Title Priority Date Filing Date
NO933503A NO933503L (no) 1992-10-01 1993-09-30 Dicytostelium dipeptidylaminopeptidase

Country Status (26)

Country Link
US (2) US5565349A (no)
EP (2) EP0595476B1 (no)
JP (1) JP3550409B2 (no)
KR (1) KR100291528B1 (no)
CN (1) CN1060212C (no)
AT (1) ATE211169T1 (no)
AU (1) AU669735B2 (no)
BR (1) BR9303949A (no)
CA (1) CA2107279A1 (no)
CZ (2) CZ286950B6 (no)
DE (1) DE69331371T2 (no)
DK (1) DK0595476T3 (no)
ES (1) ES2169036T3 (no)
FI (1) FI934305L (no)
HU (1) HU219771B (no)
IL (1) IL107123A (no)
MX (1) MX9306021A (no)
MY (1) MY113378A (no)
NO (1) NO933503L (no)
NZ (1) NZ248810A (no)
PL (1) PL176930B1 (no)
PT (1) PT595476E (no)
RU (1) RU2096455C1 (no)
TW (1) TW257792B (no)
UA (1) UA27718C2 (no)
ZA (1) ZA937243B (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5573923A (en) * 1993-12-22 1996-11-12 Eli Lilly And Company Method for removing N-terminal dipeptides from precursor polypeptides with immobilized dipeptidylaminopeptidase from dictyostelium discoideum
US5614379A (en) * 1995-04-26 1997-03-25 Eli Lilly And Company Process for preparing anti-obesity protein
WO2000017332A1 (en) * 1998-09-21 2000-03-30 Eli Lilly And Company Production of soluble recombinant trypsinogen analogs
US6743600B1 (en) 1999-04-30 2004-06-01 Monsanto Technologies Llc Method of removing N-terminal alanine residues from polypeptides with Aeromonas aminopeptidase
US6794159B1 (en) 1999-04-30 2004-09-21 Pharmacia Corporation Method of removing n-terminal alanine residues from polypeptides with aeromonas aminopeptidase
WO2003010189A1 (en) * 2001-07-26 2003-02-06 Ajinomoto Co., Inc. Process for producing dipeptide, peptide synthase to be used therein and process for producing peptide synthase
AU2003248117A1 (en) * 2002-07-26 2004-03-29 Ajinomoto Co., Inc. Novel enzyme forming peptide, microorganism producing the same and process for producing dipeptide using them
EP2295579B1 (en) * 2002-07-26 2014-01-22 Ajinomoto Co., Inc. Novel peptide-forming enzyme gene
US8129139B2 (en) 2009-07-13 2012-03-06 Allergan, Inc. Process for obtaining botulinum neurotoxin
WO2011103325A1 (en) * 2010-02-17 2011-08-25 Elona Biotechnologies Methods for preparing human growth hormone
US11427814B2 (en) 2019-03-26 2022-08-30 Encodia, Inc. Modified cleavases, uses thereof and related kits
MX2021011726A (es) * 2019-03-26 2021-10-22 Encodia Inc Escindasas modificadas, usos de las mismas y kits relacionados.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK55685A (da) * 1985-02-07 1986-08-08 Nordisk Gentofte Enzym eller enzymkompleks med proteolytisk aktivitet
DE3519218A1 (de) * 1985-05-29 1986-12-04 Boehringer Mannheim Gmbh, 6800 Mannheim H(pfeil abwaerts)2(pfeil abwaerts)o(pfeil abwaerts)2(pfeil abwaerts)-bildende sarcosinoxidase, ihre herstellung und verwendung
US4894439A (en) * 1986-05-22 1990-01-16 Cetus Corporation N-terminal derivatives of tumor necrosis factor purified by microporous PTFE membranes
US5177003A (en) * 1987-04-16 1993-01-05 Phillips Petroleum Company Flavored protein products derived from Candida utilis
US4929700A (en) * 1987-04-16 1990-05-29 Cetus Corporation Production of purified, biologically active, bacterially produced recombinant human CSF-1
US5075222A (en) * 1988-05-27 1991-12-24 Synergen, Inc. Interleukin-1 inhibitors
JPH023698A (ja) * 1988-06-20 1990-01-09 Denki Kagaku Kogyo Kk ヒトリンホトキシンに対するモノクローナル抗体及びそれら抗体を産生するハイブリドーマ、並びにそれら抗体を用いたヒトリンホトキシンの精製方法、測定方法及び測定試薬
US5208218A (en) * 1988-09-19 1993-05-04 Ludwig Institute For Cancer Research T cell growth factor glycoproteins
US5175251A (en) * 1989-05-04 1992-12-29 Sri International Antimetastatic peptides with laminin activity
US5179196A (en) * 1989-05-04 1993-01-12 Sri International Purification of proteins employing ctap-iii fusions
US5126249A (en) * 1989-05-09 1992-06-30 Eli Lilly And Company Enzymatic removal of a protein amino-terminal sequence
US5173409A (en) * 1989-12-08 1992-12-22 Ecogen Inc. Recovery of bt endotoxin protein from lysed cell mixtures

Also Published As

Publication number Publication date
MX9306021A (es) 1994-05-31
DE69331371D1 (de) 2002-01-31
HUT70299A (en) 1995-09-28
ES2169036T3 (es) 2002-07-01
AU4871993A (en) 1994-04-14
EP0595476A2 (en) 1994-05-04
PL300537A1 (en) 1994-04-05
FI934305A7 (fi) 1994-04-02
NO933503D0 (no) 1993-09-30
HU9302773D0 (en) 1994-01-28
DE69331371T2 (de) 2002-08-14
EP0595476A3 (en) 1994-07-06
BR9303949A (pt) 1994-04-05
EP1094118A1 (en) 2001-04-25
JPH06197759A (ja) 1994-07-19
CA2107279A1 (en) 1994-04-02
HU219771B (hu) 2001-07-30
FI934305L (fi) 1994-04-02
UA27718C2 (uk) 2000-10-16
IL107123A0 (en) 1993-12-28
TW257792B (no) 1995-09-21
IL107123A (en) 1998-07-15
US5565330A (en) 1996-10-15
PT595476E (pt) 2002-06-28
KR940009329A (ko) 1994-05-20
US5565349A (en) 1996-10-15
JP3550409B2 (ja) 2004-08-04
CN1060212C (zh) 2001-01-03
PL176930B1 (pl) 1999-08-31
CZ286950B6 (en) 2000-08-16
KR100291528B1 (ko) 2001-06-01
CN1085253A (zh) 1994-04-13
ZA937243B (en) 1995-03-29
EP0595476B1 (en) 2001-12-19
DK0595476T3 (da) 2002-02-11
CZ203393A3 (en) 1994-04-13
RU2096455C1 (ru) 1997-11-20
ATE211169T1 (de) 2002-01-15
NZ248810A (en) 1994-12-22
FI934305A0 (fi) 1993-09-30
AU669735B2 (en) 1996-06-20
MY113378A (en) 2002-02-28
CZ287066B6 (cs) 2000-08-16

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