UA27718C2 - Дипептиділамінопептидаза, що виділена з dictiostelium discoideum та спосіб ферментативного відщеплення n-кінцевих дипептидів met-tyr, met-arg або met-asp від поліпептидної послідовності - Google Patents

Дипептиділамінопептидаза, що виділена з dictiostelium discoideum та спосіб ферментативного відщеплення n-кінцевих дипептидів met-tyr, met-arg або met-asp від поліпептидної послідовності

Info

Publication number
UA27718C2
UA27718C2 UA93002125A UA93002125A UA27718C2 UA 27718 C2 UA27718 C2 UA 27718C2 UA 93002125 A UA93002125 A UA 93002125A UA 93002125 A UA93002125 A UA 93002125A UA 27718 C2 UA27718 C2 UA 27718C2
Authority
UA
Ukraine
Prior art keywords
met
discoideum
dipeptipids
dipeptidylaminopeptipidase
dictiostelium
Prior art date
Application number
UA93002125A
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Пол Роберт Аткінсон
Пол Роберт Аткисон
Метью Дейл Хілтон
Мэью Дейл Хитон
Пітер Карл Ламбой
Питер Карл Ламбой
Original Assignee
Елі Ліллі Енд Компані
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Елі Ліллі Енд Компані, Эли Лилли Энд Компани filed Critical Елі Ліллі Енд Компані
Publication of UA27718C2 publication Critical patent/UA27718C2/uk

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/06Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/485Exopeptidases (3.4.11-3.4.19)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/18Ion-exchange chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/20Partition-, reverse-phase or hydrophobic interaction chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/36Extraction; Separation; Purification by a combination of two or more processes of different types
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/61Growth hormone [GH], i.e. somatotropin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/11Aminopeptidases (3.4.11)
    • C12Y304/11005Prolyl aminopeptidase (3.4.11.5)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/814Enzyme separation or purification
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/814Enzyme separation or purification
    • Y10S435/815Enzyme separation or purification by sorption

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Escalators And Moving Walkways (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
  • Polyamides (AREA)
  • Peptides Or Proteins (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Purification Treatments By Anaerobic Or Anaerobic And Aerobic Bacteria Or Animals (AREA)
  • Noodles (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Fats And Perfumes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
UA93002125A 1992-10-01 1993-09-29 Дипептиділамінопептидаза, що виділена з dictiostelium discoideum та спосіб ферментативного відщеплення n-кінцевих дипептидів met-tyr, met-arg або met-asp від поліпептидної послідовності UA27718C2 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95553992A 1992-10-01 1992-10-01

Publications (1)

Publication Number Publication Date
UA27718C2 true UA27718C2 (uk) 2000-10-16

Family

ID=25496954

Family Applications (1)

Application Number Title Priority Date Filing Date
UA93002125A UA27718C2 (uk) 1992-10-01 1993-09-29 Дипептиділамінопептидаза, що виділена з dictiostelium discoideum та спосіб ферментативного відщеплення n-кінцевих дипептидів met-tyr, met-arg або met-asp від поліпептидної послідовності

Country Status (26)

Country Link
US (2) US5565349A (no)
EP (2) EP1094118A1 (no)
JP (1) JP3550409B2 (no)
KR (1) KR100291528B1 (no)
CN (1) CN1060212C (no)
AT (1) ATE211169T1 (no)
AU (1) AU669735B2 (no)
BR (1) BR9303949A (no)
CA (1) CA2107279A1 (no)
CZ (2) CZ286950B6 (no)
DE (1) DE69331371T2 (no)
DK (1) DK0595476T3 (no)
ES (1) ES2169036T3 (no)
FI (1) FI934305A (no)
HU (1) HU219771B (no)
IL (1) IL107123A (no)
MX (1) MX9306021A (no)
MY (1) MY113378A (no)
NO (1) NO933503L (no)
NZ (1) NZ248810A (no)
PL (1) PL176930B1 (no)
PT (1) PT595476E (no)
RU (1) RU2096455C1 (no)
TW (1) TW257792B (no)
UA (1) UA27718C2 (no)
ZA (1) ZA937243B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5573923A (en) * 1993-12-22 1996-11-12 Eli Lilly And Company Method for removing N-terminal dipeptides from precursor polypeptides with immobilized dipeptidylaminopeptidase from dictyostelium discoideum
US5614379A (en) * 1995-04-26 1997-03-25 Eli Lilly And Company Process for preparing anti-obesity protein
EP1141263A4 (en) * 1998-09-21 2002-08-28 Lilly Co Eli PRODUCTION OF SOLUBLE RECOMBINANT TRYPSIN ANALOGS
US6794159B1 (en) 1999-04-30 2004-09-21 Pharmacia Corporation Method of removing n-terminal alanine residues from polypeptides with aeromonas aminopeptidase
US6743600B1 (en) 1999-04-30 2004-06-01 Monsanto Technologies Llc Method of removing N-terminal alanine residues from polypeptides with Aeromonas aminopeptidase
US8129139B2 (en) 2009-07-13 2012-03-06 Allergan, Inc. Process for obtaining botulinum neurotoxin
EP2536749A1 (en) * 2010-02-17 2012-12-26 Elona Biotechnologies Methods for preparing human growth hormone
US11427814B2 (en) 2019-03-26 2022-08-30 Encodia, Inc. Modified cleavases, uses thereof and related kits
AU2020247918B2 (en) * 2019-03-26 2022-06-30 Encodia, Inc. Modified cleavases, uses thereof and related kits

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK55685A (da) * 1985-02-07 1986-08-08 Nordisk Gentofte Enzym eller enzymkompleks med proteolytisk aktivitet
DE3519218A1 (de) * 1985-05-29 1986-12-04 Boehringer Mannheim Gmbh, 6800 Mannheim H(pfeil abwaerts)2(pfeil abwaerts)o(pfeil abwaerts)2(pfeil abwaerts)-bildende sarcosinoxidase, ihre herstellung und verwendung
US4894439A (en) * 1986-05-22 1990-01-16 Cetus Corporation N-terminal derivatives of tumor necrosis factor purified by microporous PTFE membranes
US4929700A (en) * 1987-04-16 1990-05-29 Cetus Corporation Production of purified, biologically active, bacterially produced recombinant human CSF-1
US5177003A (en) * 1987-04-16 1993-01-05 Phillips Petroleum Company Flavored protein products derived from Candida utilis
US5075222A (en) * 1988-05-27 1991-12-24 Synergen, Inc. Interleukin-1 inhibitors
JPH023698A (ja) * 1988-06-20 1990-01-09 Denki Kagaku Kogyo Kk ヒトリンホトキシンに対するモノクローナル抗体及びそれら抗体を産生するハイブリドーマ、並びにそれら抗体を用いたヒトリンホトキシンの精製方法、測定方法及び測定試薬
US5208218A (en) * 1988-09-19 1993-05-04 Ludwig Institute For Cancer Research T cell growth factor glycoproteins
US5179196A (en) * 1989-05-04 1993-01-12 Sri International Purification of proteins employing ctap-iii fusions
US5175251A (en) * 1989-05-04 1992-12-29 Sri International Antimetastatic peptides with laminin activity
US5126249A (en) * 1989-05-09 1992-06-30 Eli Lilly And Company Enzymatic removal of a protein amino-terminal sequence
US5173409A (en) * 1989-12-08 1992-12-22 Ecogen Inc. Recovery of bt endotoxin protein from lysed cell mixtures

Also Published As

Publication number Publication date
DE69331371D1 (de) 2002-01-31
EP0595476A2 (en) 1994-05-04
CN1060212C (zh) 2001-01-03
IL107123A0 (en) 1993-12-28
HU219771B (hu) 2001-07-30
EP1094118A1 (en) 2001-04-25
RU2096455C1 (ru) 1997-11-20
DK0595476T3 (da) 2002-02-11
KR100291528B1 (ko) 2001-06-01
ATE211169T1 (de) 2002-01-15
CZ287066B6 (cs) 2000-08-16
HUT70299A (en) 1995-09-28
CZ286950B6 (en) 2000-08-16
TW257792B (no) 1995-09-21
US5565349A (en) 1996-10-15
PT595476E (pt) 2002-06-28
ZA937243B (en) 1995-03-29
MX9306021A (es) 1994-05-31
CA2107279A1 (en) 1994-04-02
EP0595476B1 (en) 2001-12-19
NO933503D0 (no) 1993-09-30
AU669735B2 (en) 1996-06-20
US5565330A (en) 1996-10-15
KR940009329A (ko) 1994-05-20
AU4871993A (en) 1994-04-14
MY113378A (en) 2002-02-28
IL107123A (en) 1998-07-15
CN1085253A (zh) 1994-04-13
DE69331371T2 (de) 2002-08-14
FI934305A (fi) 1994-04-02
PL300537A1 (en) 1994-04-05
JP3550409B2 (ja) 2004-08-04
HU9302773D0 (en) 1994-01-28
NZ248810A (en) 1994-12-22
NO933503L (no) 1994-04-05
FI934305A0 (fi) 1993-09-30
JPH06197759A (ja) 1994-07-19
ES2169036T3 (es) 2002-07-01
EP0595476A3 (en) 1994-07-06
CZ203393A3 (en) 1994-04-13
PL176930B1 (pl) 1999-08-31
BR9303949A (pt) 1994-04-05

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