NO932859L - 5-heteroyl-indolderivater - Google Patents
5-heteroyl-indolderivaterInfo
- Publication number
- NO932859L NO932859L NO93932859A NO932859A NO932859L NO 932859 L NO932859 L NO 932859L NO 93932859 A NO93932859 A NO 93932859A NO 932859 A NO932859 A NO 932859A NO 932859 L NO932859 L NO 932859L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- heteroyl
- indole derivatives
- hydrogen
- benzyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Luminescent Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65471291A | 1991-02-12 | 1991-02-12 | |
| PCT/US1992/000556 WO1992013856A1 (en) | 1991-02-12 | 1992-02-03 | 5-heteroyl indole derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO932859D0 NO932859D0 (no) | 1993-08-11 |
| NO932859L true NO932859L (no) | 1993-08-11 |
Family
ID=24625959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO93932859A NO932859L (no) | 1991-02-12 | 1993-08-11 | 5-heteroyl-indolderivater |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0571471B1 (pt) |
| JP (1) | JPH07121942B2 (pt) |
| KR (1) | KR930703305A (pt) |
| AT (1) | ATE135005T1 (pt) |
| AU (1) | AU655456B2 (pt) |
| CA (1) | CA2101521A1 (pt) |
| CZ (1) | CZ165693A3 (pt) |
| DE (1) | DE69208868T2 (pt) |
| DK (1) | DK0571471T3 (pt) |
| ES (1) | ES2084347T3 (pt) |
| FI (1) | FI933551A0 (pt) |
| GR (1) | GR3019778T3 (pt) |
| HU (1) | HUT65766A (pt) |
| IE (1) | IE920442A1 (pt) |
| IL (1) | IL100888A0 (pt) |
| MX (1) | MX9200569A (pt) |
| MY (1) | MY131298A (pt) |
| NO (1) | NO932859L (pt) |
| NZ (1) | NZ241584A (pt) |
| PT (1) | PT100114A (pt) |
| TW (1) | TW263508B (pt) |
| WO (1) | WO1992013856A1 (pt) |
| YU (1) | YU13792A (pt) |
| ZA (1) | ZA92969B (pt) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW288010B (pt) * | 1992-03-05 | 1996-10-11 | Pfizer | |
| CZ281763B6 (cs) * | 1992-04-07 | 1997-01-15 | Pfizer Inc. | Indolové deriváty představující 5-HT1 agonisty, způsob jejich přípravy, farmaceutické prostředky obsahující tyto látky, jejich použití a meziprodukty postupu přípravy |
| GB9211277D0 (en) | 1992-05-28 | 1992-07-15 | Glaxo Group Inc | Pharmaceutical compositions |
| GB9226537D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| GB9226532D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| ES2070087B1 (es) * | 1993-08-13 | 1996-02-16 | Pfizer | Derivados de indol |
| US5468768A (en) * | 1994-01-06 | 1995-11-21 | Bristol-Myers Squibb Company | Antimigraine derivatives of indolylcycloalkanylamines |
| US6423731B2 (en) | 1994-01-06 | 2002-07-23 | Zeneca Limited | Indole derivatives as prodrugs of 5-HT1-like receptor agonists |
| AU694226B2 (en) * | 1994-05-19 | 1998-07-16 | Merck Sharp & Dohme Limited | Piperazine, piperidine and tetrahydropyridine derivatives ofindol-3-ylalkyl as 5-HT1D-alpha agonists |
| AU2621995A (en) * | 1994-06-01 | 1995-12-21 | Zeneca Limited | Indole derivatives as prodrugs of 5-ht1-like receptor agonists |
| US5521196A (en) * | 1994-10-05 | 1996-05-28 | Eli Lilly And Company | 5-HT1F agonists for the treatment of migraine |
| US5521197A (en) * | 1994-12-01 | 1996-05-28 | Eli Lilly And Company | 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists |
| GB9501865D0 (en) * | 1995-01-31 | 1995-03-22 | Merck Sharp & Dohme | Therapeutic agents |
| NZ305166A (en) * | 1995-03-20 | 1998-12-23 | Lilly Co Eli | 5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles; preparation and medicaments |
| JPH11513666A (ja) * | 1995-10-10 | 1999-11-24 | イーライ・リリー・アンド・カンパニー | Ｎ−［２−置換−３−（２−アミノエチル）−１ｈ−インドール−５−イル］−アミド：新規５−ｈｔ▲下１ｆ▼作動剤 |
| GB9523583D0 (en) * | 1995-11-17 | 1996-01-17 | Merck Sharp & Dohme | Therapeutic agents |
| FR2754709B1 (fr) | 1996-10-23 | 1999-03-05 | Sanofi Sa | Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition |
| FR2763243A1 (fr) * | 1997-05-14 | 1998-11-20 | Pf Medicament | Utilisation d'amines indoliques comme medicaments antithrombotiques |
| ES2199553T3 (es) | 1998-03-09 | 2004-02-16 | H.Lundbeck A/S | Indoles sustituidos con 5-heteroarilo. |
| EP1089993B1 (en) * | 1998-06-30 | 2003-10-22 | Eli Lilly And Company | 5-ht1f agonists |
| CA2370147C (en) * | 1999-04-21 | 2009-07-28 | Allelix Biopharmaceuticals Inc. | Piperidine-indole compounds having 5-ht6 affinity |
| WO2001034146A1 (en) * | 1999-11-08 | 2001-05-17 | Smithkline Beecham Corporation | Novel anti-infectives |
| EP1326830A1 (en) | 2000-10-20 | 2003-07-16 | Biovitrum Ab | 2-, 3-, 4-, or 5-substituted-n1-(benzensulfonyl)indoles and their use in therapy |
| DE10121217A1 (de) * | 2001-04-30 | 2002-10-31 | Merck Patent Gmbh | 6H-Oxazolo[4,5-e]indol-Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden |
| WO2003099206A2 (en) | 2002-05-21 | 2003-12-04 | Bristol-Myers Squibb Company | Indole compounds useful as impdh inhibitors |
| BRPI0315959C1 (pt) * | 2002-11-28 | 2021-05-25 | Suven Life Sciences Ltd | composto, composição farmacêutica, uso do composto, método para o tratamento, método para reduzir a morbidez e a mortalidade associadas com o excesso de peso e processo para a preparação do composto |
| US7332508B2 (en) * | 2002-12-18 | 2008-02-19 | Novo Nordisk A/S | Substituted homopiperidine, piperidine or pyrrolidine derivatives |
| WO2005005439A1 (en) * | 2003-07-09 | 2005-01-20 | Suven Life Sciences Limited | Benzothiazino indoles |
| US20050245540A1 (en) * | 2003-12-09 | 2005-11-03 | Fujisawa Pharmaceutical Co., Ltd. | New methods |
| WO2005121132A1 (ja) * | 2004-06-11 | 2005-12-22 | Shionogi & Co., Ltd. | 抗ｈｃｖ作用を有する縮合ヘテロ環化合物 |
| PL1883451T3 (pl) | 2005-04-13 | 2011-05-31 | Neuraxon Inc | Podstawione związki indolowe mające aktywność hamowania NOS |
| SG172738A1 (en) * | 2005-07-29 | 2011-07-28 | 4Sc Ag | Novel heterocyclic nf-kb inhibitors |
| US7696229B2 (en) | 2006-02-17 | 2010-04-13 | Memory Pharmaceuticals Corporation | Compounds having 5-HT6 receptor affinity |
| ZA200809659B (en) | 2006-04-13 | 2010-03-31 | Neuraxon Inc | 1,5 and 3,6-substituted indole compounds having NOS inhibitory activity |
| JP2010500372A (ja) * | 2006-08-09 | 2010-01-07 | スミスクライン ビーチャム コーポレーション | オピオイド受容体に対するアンタゴニストまたはインバースアゴニストとしての新規化合物 |
| TW200848021A (en) | 2007-03-06 | 2008-12-16 | Wyeth Corp | Sulfonylated heterocycles useful for modulation of the progesterone receptor |
| CN101910157B (zh) | 2007-11-16 | 2014-05-07 | 纽尔亚商股份有限公司 | 吲哚化合物和治疗内脏痛的方法 |
| WO2012064744A2 (en) * | 2010-11-08 | 2012-05-18 | Lycera Corporation | Tetrahydroquinoline and related bicyclic compounds for inhibition of rorϒ activity and the treatment of disease |
| MX367341B (es) | 2012-05-08 | 2019-08-14 | Merck Sharp & Dohme | Tetrahidronaftiridina y compuestos biciclicos relacionados para la inhibicion de la actividad de rorgamma y el tratamiento de enfermedades. |
| WO2013169864A2 (en) | 2012-05-08 | 2013-11-14 | Lycera Corporation | TETRAHYDRO[1,8]NAPHTHYRIDINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORƴ AND THE TREATMENT OF DISEASE |
| WO2015095788A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | 2-ACYLAMIDOMETHYL AND SULFONYLAMIDOMETHYL BENZOXAZINE CARBAMATES FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE |
| US9783511B2 (en) | 2013-12-20 | 2017-10-10 | Lycera Corporation | Carbamate benzoxazine propionic acids and acid derivatives for modulation of RORgamma activity and the treatment of disease |
| US9809561B2 (en) | 2013-12-20 | 2017-11-07 | Merck Sharp & Dohme Corp. | Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease |
| AU2015222917A1 (en) | 2014-02-27 | 2016-09-15 | Lycera Corporation | Adoptive cellular therapy using an agonist of retinoic acid receptor-related orphan receptor gamma and related therapeutic methods |
| JP6728061B2 (ja) | 2014-05-05 | 2020-07-22 | リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ | ＲＯＲγアゴニストとして用いるテトラヒドロキノリンスルホンアミド及び関連化合物ならびに疾患の治療 |
| EP3209641A4 (en) | 2014-05-05 | 2018-06-06 | Lycera Corporation | Benzenesulfonamido and related compounds for use as agonists of ror and the treatement of disease |
| AU2016219183B2 (en) | 2015-02-11 | 2020-06-11 | Merck Sharp & Dohme Corp. | Substituted pyrazole compounds as RORgammaT inhibitors and uses thereof |
| EP3292119A4 (en) | 2015-05-05 | 2018-10-03 | Lycera Corporation | DIHYDRO-2H-BENZO[b][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATMENT OF DISEASE |
| AU2016276947A1 (en) | 2015-06-11 | 2017-12-14 | Lycera Corporation | Aryl dihydro-2h-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORy and the treatment of disease |
| WO2017075185A1 (en) | 2015-10-27 | 2017-05-04 | Merck Sharp & Dohme Corp. | Heteroaryl substituted benzoic acids as rorgammat inhibitors and uses thereof |
| US10344000B2 (en) | 2015-10-27 | 2019-07-09 | Merck Sharp & Dohme Corp. | Substituted bicyclic pyrazole compounds as RORgammaT inhibitors and uses thereof |
| JP2018535958A (ja) | 2015-10-27 | 2018-12-06 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | ＲＯＲγＴ阻害薬としての置換インダゾール化合物及びその使用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8332437D0 (en) * | 1983-12-06 | 1984-01-11 | Glaxo Group Ltd | Chemical compounds |
| EP0225726B1 (en) * | 1985-11-08 | 1991-04-17 | Glaxo Group Limited | Indole derivatives |
| GB8600398D0 (en) * | 1986-01-08 | 1986-02-12 | Glaxo Group Ltd | Chemical compounds |
| GB8719167D0 (en) * | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
| GB8724912D0 (en) * | 1987-10-23 | 1987-11-25 | Wellcome Found | Indole derivatives |
| SI9111010B (sl) * | 1990-06-07 | 2005-02-28 | Astrazeneca Ab | 3,5-disubstituirani indolni derivati kot "5-HT1-podobni" receptorski agonisti |
-
1992
- 1992-01-28 TW TW081100627A patent/TW263508B/zh active
- 1992-02-03 CZ CS931656A patent/CZ165693A3/cs unknown
- 1992-02-03 HU HU9302328A patent/HUT65766A/hu unknown
- 1992-02-03 DK DK92904837.9T patent/DK0571471T3/da active
- 1992-02-03 EP EP92904837A patent/EP0571471B1/en not_active Expired - Lifetime
- 1992-02-03 DE DE69208868T patent/DE69208868T2/de not_active Expired - Fee Related
- 1992-02-03 KR KR1019930702398A patent/KR930703305A/ko not_active Application Discontinuation
- 1992-02-03 WO PCT/US1992/000556 patent/WO1992013856A1/en not_active Application Discontinuation
- 1992-02-03 AT AT92904837T patent/ATE135005T1/de not_active IP Right Cessation
- 1992-02-03 AU AU12637/92A patent/AU655456B2/en not_active Ceased
- 1992-02-03 CA CA002101521A patent/CA2101521A1/en not_active Abandoned
- 1992-02-03 ES ES92904837T patent/ES2084347T3/es not_active Expired - Lifetime
- 1992-02-03 JP JP4505422A patent/JPH07121942B2/ja not_active Expired - Lifetime
- 1992-02-06 IL IL100888A patent/IL100888A0/xx unknown
- 1992-02-10 PT PT100114A patent/PT100114A/pt not_active Application Discontinuation
- 1992-02-10 MX MX9200569A patent/MX9200569A/es unknown
- 1992-02-11 YU YU13792A patent/YU13792A/sh unknown
- 1992-02-11 IE IE044292A patent/IE920442A1/en not_active Application Discontinuation
- 1992-02-11 MY MYPI92000204A patent/MY131298A/en unknown
- 1992-02-11 NZ NZ241584A patent/NZ241584A/en unknown
- 1992-02-11 ZA ZA92969A patent/ZA92969B/xx unknown
-
1993
- 1993-08-11 NO NO93932859A patent/NO932859L/no unknown
- 1993-08-11 FI FI933551A patent/FI933551A0/fi not_active Application Discontinuation
-
1996
- 1996-04-29 GR GR960401158T patent/GR3019778T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI933551A (fi) | 1993-08-11 |
| CA2101521A1 (en) | 1992-08-13 |
| AU1263792A (en) | 1992-09-07 |
| HUT65766A (en) | 1994-07-28 |
| NZ241584A (en) | 1994-12-22 |
| WO1992013856A1 (en) | 1992-08-20 |
| DE69208868T2 (de) | 1996-10-17 |
| JPH07121942B2 (ja) | 1995-12-25 |
| IE920442A1 (en) | 1992-08-12 |
| NO932859D0 (no) | 1993-08-11 |
| AU655456B2 (en) | 1994-12-22 |
| DK0571471T3 (da) | 1996-04-01 |
| EP0571471A1 (en) | 1993-12-01 |
| GR3019778T3 (en) | 1996-07-31 |
| ZA92969B (en) | 1993-08-11 |
| PT100114A (pt) | 1993-05-31 |
| MX9200569A (es) | 1992-08-01 |
| KR930703305A (ko) | 1993-11-29 |
| JPH06500122A (ja) | 1994-01-06 |
| TW263508B (pt) | 1995-11-21 |
| ES2084347T3 (es) | 1996-05-01 |
| CZ165693A3 (en) | 1994-05-18 |
| IL100888A0 (en) | 1992-11-15 |
| FI933551A0 (fi) | 1993-08-11 |
| EP0571471B1 (en) | 1996-03-06 |
| ATE135005T1 (de) | 1996-03-15 |
| YU13792A (sh) | 1994-11-15 |
| MY131298A (en) | 2007-08-30 |
| HU9302328D0 (en) | 1993-10-28 |
| DE69208868D1 (de) | 1996-04-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0571471T3 (da) | 5-Heteroylindolderivater | |
| ATE24001T1 (de) | Substituierte 1-hydroxyethyl-triazolyl-derivate. | |
| DE69728544D1 (de) | Totalsynthese von acylfulvenen mit antitumorwirkung | |
| SE8603099D0 (sv) | Distamycin derivatives and process for their preparation | |
| FI952101A (fi) | Merkaptopyrrolidin-2-tioni | |
| ES2046229T3 (es) | Composicion antiulcerosa. | |
| DE68920717D1 (de) | Reaktivfarbstoffe. | |
| ATE115980T1 (de) | Neue thyroninderivate. | |
| TW334428B (en) | Novel benzodiazepine derivatives | |
| ZA89308B (en) | Process for preparing hydroxyalkylating agents,the agents so obtained,and their use | |
| ATE118488T1 (de) | Benzothiadiazepin-derivate. | |
| DK316589A (da) | Substituerede azacyclohexylderivater af rifamyciner | |
| FI874311A0 (fi) | 7-/(meta-substituerade)fenylglysin/ -1-karba-1-detiakefalosporiner. |