NO932276L - D-homo-(16-en)-11beta-aryl-4-oestrener, fremgangsmaate for deres fremstilling, saa vel som deres anvendelse som legemiddel - Google Patents
D-homo-(16-en)-11beta-aryl-4-oestrener, fremgangsmaate for deres fremstilling, saa vel som deres anvendelse som legemiddelInfo
- Publication number
- NO932276L NO932276L NO93932276A NO932276A NO932276L NO 932276 L NO932276 L NO 932276L NO 93932276 A NO93932276 A NO 93932276A NO 932276 A NO932276 A NO 932276A NO 932276 L NO932276 L NO 932276L
- Authority
- NO
- Norway
- Prior art keywords
- hydrogen atom
- homo
- aryl
- preparation
- well
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000004770 highest occupied molecular orbital Methods 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical group ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 239000003470 adrenal cortex hormone Substances 0.000 abstract 1
- 230000002280 anti-androgenic effect Effects 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- RKHQGWMMUURILY-UHRZLXHJSA-N cortivazol Chemical compound C([C@H]1[C@@H]2C[C@H]([C@]([C@@]2(C)C[C@H](O)[C@@H]1[C@@]1(C)C2)(O)C(=O)COC(C)=O)C)=C(C)C1=CC1=C2C=NN1C1=CC=CC=C1 RKHQGWMMUURILY-UHRZLXHJSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000044 progesterone antagonist Substances 0.000 abstract 1
- 239000000583 progesterone congener Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Steroid Compounds (AREA)
Abstract
Ny type av D-homo-(16-en )- aryl-4-østrener med generell formel (I) så vel som deres farmakologisk aksep- table addisjonssalter med syrer er be- skrevet. I formel (I) står X for et oksygenatom, hydroksyiminogrupperingen > N-OH eller 2 hydrogenatomer; R1 står for et hydrogenatom eller en metylgrup- pe; R2 står for en hydroksygruppe, en Cj-C^-alkoksy- eller C;-C10-acyloksy- gruppe; R11 står for et fluor-, klor- eller bromatom, i hvilket tilfelle R12 og R13 sammen betegner en ytterligere binding, eller Rl; står for en rett- kjedet eller forgrenet C1-C,,-alkylrest eller et hydrogenatom, i hvilket til- felle R12 og R12 hver betegner et hydro- genatom eller betegner sammen en ytter- ligere binding; og R3 og R* har de vanlige betydninger for konkurrerende progesteronantagonister angitt i be- skrivelsen. Også beskrevet er en frem- gangsmåte for fremstilling av disse nye forbindelser, farmasøytiske preparater inneholdende disse forbindelser, deres anvendelse for fremstilling av medika- menter, og nye mellomprodukter som er nødvendig for utførelse av fremgangs- måten. Disse nye forbindelser har sterk affinitet til gestagenreseptoren og sterke antigestagene, antiglukokorti- koidale, antimineralkortikoidale og antiandrogene egenskaper.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4042005A DE4042005A1 (de) | 1990-12-22 | 1990-12-22 | D-homo-(16-en)-11(beta)-aryl-4-estrene |
| PCT/EP1991/002495 WO1992011279A1 (de) | 1990-12-22 | 1991-12-21 | D-HOMO-(16-EN)-11β-ARYL-4-ESTRENE, VERFAHREN ZU IHRER HERSTELLUNG SOWIE DEREN VERWENDUNG ALS ARZNEIMITTEL |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO932276D0 NO932276D0 (no) | 1993-06-21 |
| NO932276L true NO932276L (no) | 1993-08-20 |
Family
ID=25899848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO93932276A NO932276L (no) | 1990-12-22 | 1993-06-21 | D-homo-(16-en)-11beta-aryl-4-oestrener, fremgangsmaate for deres fremstilling, saa vel som deres anvendelse som legemiddel |
Country Status (1)
| Country | Link |
|---|---|
| NO (1) | NO932276L (no) |
-
1993
- 1993-06-21 NO NO93932276A patent/NO932276L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO932276D0 (no) | 1993-06-21 |
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