NO932276L - D-HOMO (16-EN) -11BETA-ARYL-4-EASTERS, PROCEDURE FOR THEIR PREPARATION, AS WELL AS THEIR USE AS A MEDICINE - Google Patents

D-HOMO (16-EN) -11BETA-ARYL-4-EASTERS, PROCEDURE FOR THEIR PREPARATION, AS WELL AS THEIR USE AS A MEDICINE

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Publication number
NO932276L
NO932276L NO93932276A NO932276A NO932276L NO 932276 L NO932276 L NO 932276L NO 93932276 A NO93932276 A NO 93932276A NO 932276 A NO932276 A NO 932276A NO 932276 L NO932276 L NO 932276L
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NO
Norway
Prior art keywords
hydrogen atom
homo
aryl
preparation
well
Prior art date
Application number
NO93932276A
Other languages
Norwegian (no)
Other versions
NO932276D0 (en
Inventor
Wolfgang Schwede
Eckhard Ottow
Arwed Cleve
Walter Elger
Krzysztof Chwalisz
Martin Schneider
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4042005A external-priority patent/DE4042005A1/en
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO932276D0 publication Critical patent/NO932276D0/en
Publication of NO932276L publication Critical patent/NO932276L/en

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Abstract

Ny type av D-homo-(16-en )- aryl-4-østrener med generell formel (I) så vel som deres farmakologisk aksep- table addisjonssalter med syrer er be- skrevet. I formel (I) står X for et oksygenatom, hydroksyiminogrupperingen > N-OH eller 2 hydrogenatomer; R1 står for et hydrogenatom eller en metylgrup- pe; R2 står for en hydroksygruppe, en Cj-C^-alkoksy- eller C;-C10-acyloksy- gruppe; R11 står for et fluor-, klor- eller bromatom, i hvilket tilfelle R12 og R13 sammen betegner en ytterligere binding, eller Rl; står for en rett- kjedet eller forgrenet C1-C,,-alkylrest eller et hydrogenatom, i hvilket til- felle R12 og R12 hver betegner et hydro- genatom eller betegner sammen en ytter- ligere binding; og R3 og R* har de vanlige betydninger for konkurrerende progesteronantagonister angitt i be- skrivelsen. Også beskrevet er en frem- gangsmåte for fremstilling av disse nye forbindelser, farmasøytiske preparater inneholdende disse forbindelser, deres anvendelse for fremstilling av medika- menter, og nye mellomprodukter som er nødvendig for utførelse av fremgangs- måten. Disse nye forbindelser har sterk affinitet til gestagenreseptoren og sterke antigestagene, antiglukokorti- koidale, antimineralkortikoidale og antiandrogene egenskaper.A new type of D-homo- (16-en) - aryl-4-osteiner of general formula (I) as well as their pharmacologically acceptable addition salts with acids has been described. In formula (I), X represents an oxygen atom, the hydroxyiminogroup> N-OH or 2 hydrogen atoms; R 1 represents a hydrogen atom or a methyl group; R 2 represents a hydroxy group, a C 1 -C 4 alkoxy or C 1 -C 10 acyloxy group; R11 represents a fluorine, chlorine or bromine atom, in which case R12 and R13 together represent an additional bond, or R1; represents a straight or branched C1-C12 alkyl residue or hydrogen atom, in which case R12 and R12 each represent a hydrogen atom or together represent a further bond; and R3 and R * have the usual meanings for competing progesterone antagonists set forth in the specification. Also disclosed is a process for the preparation of these novel compounds, pharmaceutical compositions containing these compounds, their use in the manufacture of medicaments, and novel intermediates necessary for carrying out the process. These novel compounds have strong affinity for the progestagen receptor and strong antigen stakes, antiglucocorticoid, antimineral corticoid and antiandrogenic properties.

NO93932276A 1990-12-22 1993-06-21 D-HOMO (16-EN) -11BETA-ARYL-4-EASTERS, PROCEDURE FOR THEIR PREPARATION, AS WELL AS THEIR USE AS A MEDICINE NO932276L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4042005A DE4042005A1 (en) 1990-12-22 1990-12-22 D-HOMO- (16-EN) -11 (BETA) -ARYL-4-ESTRENE
PCT/EP1991/002495 WO1992011279A1 (en) 1990-12-22 1991-12-21 D-HOMO-(16-EN)-11β-ARYL-4-ESTRENES, PROCESS FOR PRODUCING THEM AND THEIR USE AS MEDICAMENTS

Publications (2)

Publication Number Publication Date
NO932276D0 NO932276D0 (en) 1993-06-21
NO932276L true NO932276L (en) 1993-08-20

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ID=25899848

Family Applications (1)

Application Number Title Priority Date Filing Date
NO93932276A NO932276L (en) 1990-12-22 1993-06-21 D-HOMO (16-EN) -11BETA-ARYL-4-EASTERS, PROCEDURE FOR THEIR PREPARATION, AS WELL AS THEIR USE AS A MEDICINE

Country Status (1)

Country Link
NO (1) NO932276L (en)

Also Published As

Publication number Publication date
NO932276D0 (en) 1993-06-21

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