NO932276L - D-HOMO (16-EN) -11BETA-ARYL-4-EASTERS, PROCEDURE FOR THEIR PREPARATION, AS WELL AS THEIR USE AS A MEDICINE - Google Patents
D-HOMO (16-EN) -11BETA-ARYL-4-EASTERS, PROCEDURE FOR THEIR PREPARATION, AS WELL AS THEIR USE AS A MEDICINEInfo
- Publication number
- NO932276L NO932276L NO93932276A NO932276A NO932276L NO 932276 L NO932276 L NO 932276L NO 93932276 A NO93932276 A NO 93932276A NO 932276 A NO932276 A NO 932276A NO 932276 L NO932276 L NO 932276L
- Authority
- NO
- Norway
- Prior art keywords
- hydrogen atom
- homo
- aryl
- preparation
- well
- Prior art date
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- Steroid Compounds (AREA)
Abstract
Ny type av D-homo-(16-en )- aryl-4-østrener med generell formel (I) så vel som deres farmakologisk aksep- table addisjonssalter med syrer er be- skrevet. I formel (I) står X for et oksygenatom, hydroksyiminogrupperingen > N-OH eller 2 hydrogenatomer; R1 står for et hydrogenatom eller en metylgrup- pe; R2 står for en hydroksygruppe, en Cj-C^-alkoksy- eller C;-C10-acyloksy- gruppe; R11 står for et fluor-, klor- eller bromatom, i hvilket tilfelle R12 og R13 sammen betegner en ytterligere binding, eller Rl; står for en rett- kjedet eller forgrenet C1-C,,-alkylrest eller et hydrogenatom, i hvilket til- felle R12 og R12 hver betegner et hydro- genatom eller betegner sammen en ytter- ligere binding; og R3 og R* har de vanlige betydninger for konkurrerende progesteronantagonister angitt i be- skrivelsen. Også beskrevet er en frem- gangsmåte for fremstilling av disse nye forbindelser, farmasøytiske preparater inneholdende disse forbindelser, deres anvendelse for fremstilling av medika- menter, og nye mellomprodukter som er nødvendig for utførelse av fremgangs- måten. Disse nye forbindelser har sterk affinitet til gestagenreseptoren og sterke antigestagene, antiglukokorti- koidale, antimineralkortikoidale og antiandrogene egenskaper.A new type of D-homo- (16-en) - aryl-4-osteiner of general formula (I) as well as their pharmacologically acceptable addition salts with acids has been described. In formula (I), X represents an oxygen atom, the hydroxyiminogroup> N-OH or 2 hydrogen atoms; R 1 represents a hydrogen atom or a methyl group; R 2 represents a hydroxy group, a C 1 -C 4 alkoxy or C 1 -C 10 acyloxy group; R11 represents a fluorine, chlorine or bromine atom, in which case R12 and R13 together represent an additional bond, or R1; represents a straight or branched C1-C12 alkyl residue or hydrogen atom, in which case R12 and R12 each represent a hydrogen atom or together represent a further bond; and R3 and R * have the usual meanings for competing progesterone antagonists set forth in the specification. Also disclosed is a process for the preparation of these novel compounds, pharmaceutical compositions containing these compounds, their use in the manufacture of medicaments, and novel intermediates necessary for carrying out the process. These novel compounds have strong affinity for the progestagen receptor and strong antigen stakes, antiglucocorticoid, antimineral corticoid and antiandrogenic properties.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4042005A DE4042005A1 (en) | 1990-12-22 | 1990-12-22 | D-HOMO- (16-EN) -11 (BETA) -ARYL-4-ESTRENE |
PCT/EP1991/002495 WO1992011279A1 (en) | 1990-12-22 | 1991-12-21 | D-HOMO-(16-EN)-11β-ARYL-4-ESTRENES, PROCESS FOR PRODUCING THEM AND THEIR USE AS MEDICAMENTS |
Publications (2)
Publication Number | Publication Date |
---|---|
NO932276D0 NO932276D0 (en) | 1993-06-21 |
NO932276L true NO932276L (en) | 1993-08-20 |
Family
ID=25899848
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO93932276A NO932276L (en) | 1990-12-22 | 1993-06-21 | D-HOMO (16-EN) -11BETA-ARYL-4-EASTERS, PROCEDURE FOR THEIR PREPARATION, AS WELL AS THEIR USE AS A MEDICINE |
Country Status (1)
Country | Link |
---|---|
NO (1) | NO932276L (en) |
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1993
- 1993-06-21 NO NO93932276A patent/NO932276L/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO932276D0 (en) | 1993-06-21 |
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