NO930768D0 - Substituerte aminofosfonatderivater, fremgangsmaate for deres fremstilling og farmasoeytiske preparater derav - Google Patents

Substituerte aminofosfonatderivater, fremgangsmaate for deres fremstilling og farmasoeytiske preparater derav

Info

Publication number
NO930768D0
NO930768D0 NO930768A NO930768A NO930768D0 NO 930768 D0 NO930768 D0 NO 930768D0 NO 930768 A NO930768 A NO 930768A NO 930768 A NO930768 A NO 930768A NO 930768 D0 NO930768 D0 NO 930768D0
Authority
NO
Norway
Prior art keywords
substituted
procedures
preparation
pharmaceutical preparations
aminophosphonate derivatives
Prior art date
Application number
NO930768A
Other languages
English (en)
Other versions
NO303783B1 (no
NO930768L (no
Inventor
Hieu Trung Phan
Lan Mong Nguyen
Eric Niesor
Yves Guyon-Gellin
Craig Leigh Bentzen
Original Assignee
Symphar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symphar Sa filed Critical Symphar Sa
Publication of NO930768D0 publication Critical patent/NO930768D0/no
Publication of NO930768L publication Critical patent/NO930768L/no
Publication of NO303783B1 publication Critical patent/NO303783B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/661Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3882Arylalkanephosphonic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056Esters of arylalkanephosphonic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5537Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom the heteroring containing the structure -C(=O)-N-C(=O)- (both carbon atoms belong to the heteroring)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572Five-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576Six-membered rings
    • C07F9/58Pyridine rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576Six-membered rings
    • C07F9/59Hydrogenated pyridine rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539Five-membered rings
    • C07F9/6541Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C07F9/65517Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO930768A 1992-03-05 1993-03-03 Substituerte aminofosfonatderivater og farmas°ytiske preparater derav NO303783B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH704/92A CH683996A5 (fr) 1992-03-05 1992-03-05 Dérivés aminophosphonates substitués, leur procédé de préparation et compositions pharmaceutiques les contenant.

Publications (3)

Publication Number Publication Date
NO930768D0 true NO930768D0 (no) 1993-03-03
NO930768L NO930768L (no) 1993-09-06
NO303783B1 NO303783B1 (no) 1998-08-31

Family

ID=4193232

Family Applications (1)

Application Number Title Priority Date Filing Date
NO930768A NO303783B1 (no) 1992-03-05 1993-03-03 Substituerte aminofosfonatderivater og farmas°ytiske preparater derav

Country Status (17)

Country Link
US (1) US5424303A (no)
EP (1) EP0559079B1 (no)
JP (1) JPH0649083A (no)
KR (1) KR930019685A (no)
AT (1) ATE156829T1 (no)
AU (1) AU662957B2 (no)
CA (1) CA2091031A1 (no)
CH (1) CH683996A5 (no)
DE (1) DE69312984T2 (no)
DK (1) DK0559079T3 (no)
ES (1) ES2108772T3 (no)
FI (1) FI930974A (no)
GR (1) GR3025268T3 (no)
NO (1) NO303783B1 (no)
NZ (1) NZ247056A (no)
SG (1) SG43831A1 (no)
ZA (1) ZA931473B (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4433244A1 (de) * 1994-09-19 1996-03-28 Hoechst Ag Aminomethylphosphon- und Aminomethylphosphinsäure-Derivate und deren Verwendung zur Behandlung von degenerativen Gelenkserkrankungen
DE19502209A1 (de) * 1995-01-25 1996-08-01 Hoechst Ag Phosphonoessigsäure-Derivate und deren Verwendung zur Behandlung von degenerativen Gelenkserkrankungen
CH690264A5 (fr) * 1995-06-30 2000-06-30 Symphar Sa Dérivés aminophosphonates substitués, leur procédé de préparation et leur utilisation pour la préparation de compositions pharmaceutiques.
GB9626616D0 (en) * 1996-12-20 1997-02-05 Symphar Sa Novel compounds
GB9626536D0 (en) * 1996-12-20 1997-02-05 Symphar Sa Novel compounds
GB9626615D0 (en) * 1996-12-20 1997-02-05 Symphar Sa Novel compounds
JP3418322B2 (ja) 1997-08-28 2003-06-23 日本電信電話株式会社 使用状態表示機能付きicカードおよびicカードシステム
DE19748659A1 (de) * 1997-11-04 1999-05-06 Hoechst Ag Aminophosphoniumgruppen enthaltende vernetzte Copolymere für medizinische Verwendungen
AU761267C (en) 1998-09-09 2007-08-09 Metabasis Therapeutics, Inc. Novel heteroaromatic inhibitors of fructose 1,6-bisphosphatase
JP2003512426A (ja) 1999-10-27 2003-04-02 テバ ファーマシューティカル インダストリーズ リミティド 双極性気分障害における躁病の治療のための1−アミノインダンの使用。
US7563774B2 (en) 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
US20030114421A1 (en) * 2000-09-27 2003-06-19 Phan Hieu Trung Alpha-substituted beta-aminoethyl phosphonate derivatives
AU2001294792B2 (en) 2000-09-27 2006-12-14 Ilex Products, Inc. Alpha-substituted beta-aminoethyl phosphonates
GB0025849D0 (en) 2000-10-23 2000-12-06 Smithkline Beecham Plc Novel compounds
EP2520290B1 (en) * 2003-12-23 2014-12-10 Abraxis BioScience, LLC Propofol analogs, process for their preparation, and methods of use
JP4824968B2 (ja) * 2005-08-18 2011-11-30 株式会社クレハ ホスホン酸誘導体及びその酸付加塩、並びにそれを用いた農園芸用病害防除剤
JP2007318972A (ja) 2006-05-29 2007-12-06 Jtekt Corp モータ及び電動パワーステアリング装置
CN101003548B (zh) * 2006-12-12 2010-09-08 中国林业科学研究院林产化学工业研究所 松香基二萜改性α-氨基磷酸酯、制备方法及抗肿瘤应用
EP2854539A4 (en) * 2012-05-14 2016-03-09 Univ Kansas PHOSPHONATE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE
CN104987350B (zh) * 2015-01-29 2017-12-05 贵州大学 一类具有抗病毒活性的含苯并噻唑杂环的手性α‑氨基膦酸酯化合物及制备和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1200679B (de) * 1964-04-25 1965-09-09 Agfa Ag Lichtempfindliches Material mit eingelagerter Entwicklersubstanz
GB1298199A (en) * 1969-02-13 1972-11-29 Curwen & Newberry Ltd Improvements in or relating to boilers or fluid heaters
US4144224A (en) * 1976-11-26 1979-03-13 Ciba-Geigy Corporation Phosphonate stabilizers
CH675422A5 (no) * 1988-03-31 1990-09-28 Symphar Sa

Also Published As

Publication number Publication date
AU3394793A (en) 1993-09-09
DE69312984D1 (de) 1997-09-18
NO303783B1 (no) 1998-08-31
ZA931473B (en) 1993-09-23
NZ247056A (en) 1995-08-28
GR3025268T3 (en) 1998-02-27
FI930974A0 (fi) 1993-03-04
KR930019685A (ko) 1993-10-18
EP0559079A1 (en) 1993-09-08
DE69312984T2 (de) 1998-03-12
AU662957B2 (en) 1995-09-21
FI930974A (fi) 1993-09-06
US5424303A (en) 1995-06-13
CH683996A5 (fr) 1994-06-30
ES2108772T3 (es) 1998-01-01
NO930768L (no) 1993-09-06
EP0559079B1 (en) 1997-08-13
SG43831A1 (en) 1997-11-14
DK0559079T3 (da) 1998-03-30
ATE156829T1 (de) 1997-08-15
CA2091031A1 (en) 1993-09-06
JPH0649083A (ja) 1994-02-22

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