NO924076L - Antihypertensive midler - Google Patents

Antihypertensive midler

Info

Publication number
NO924076L
NO924076L NO92924076A NO924076A NO924076L NO 924076 L NO924076 L NO 924076L NO 92924076 A NO92924076 A NO 92924076A NO 924076 A NO924076 A NO 924076A NO 924076 L NO924076 L NO 924076L
Authority
NO
Norway
Prior art keywords
lower alkyl
aryl
halogen
optionally substituted
antihypertensive agents
Prior art date
Application number
NO92924076A
Other languages
English (en)
Norwegian (no)
Other versions
NO924076D0 (no
Inventor
Jose Repolles Moliner
Francisco Pubill Coy
Lydia Cabeza Llorente
Carlos Malet Falco
Original Assignee
Lacer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lacer Sa filed Critical Lacer Sa
Publication of NO924076D0 publication Critical patent/NO924076D0/no
Publication of NO924076L publication Critical patent/NO924076L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
NO92924076A 1991-02-27 1992-10-21 Antihypertensive midler NO924076L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP91102950A EP0500989B1 (en) 1991-02-27 1991-02-27 N-(alpha-substituted-pyridinyl) carbonyl dipeptide antihypertensive agents
PCT/EP1992/000400 WO1992015608A1 (en) 1991-02-27 1992-02-26 N-(α-SUBSTITUTED-PYRIDINYL)CARBONYL DIPEPTIDE ANTIHYPERTENSIVE AGENTS

Publications (2)

Publication Number Publication Date
NO924076D0 NO924076D0 (no) 1992-10-21
NO924076L true NO924076L (no) 1992-12-21

Family

ID=8206465

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92924076A NO924076L (no) 1991-02-27 1992-10-21 Antihypertensive midler

Country Status (18)

Country Link
US (1) US5432159A (cs)
EP (1) EP0500989B1 (cs)
JP (1) JPH05507295A (cs)
AT (1) ATE174343T1 (cs)
AU (1) AU650954B2 (cs)
BR (1) BR9204779A (cs)
CA (1) CA2081471A1 (cs)
CZ (1) CZ280952B6 (cs)
DE (1) DE69130605T2 (cs)
ES (1) ES2037613B1 (cs)
FI (1) FI924850A0 (cs)
HU (1) HUT62313A (cs)
NO (1) NO924076L (cs)
PL (1) PL167915B1 (cs)
PT (1) PT100148B (cs)
RO (1) RO111369B1 (cs)
RU (1) RU2098424C1 (cs)
WO (1) WO1992015608A1 (cs)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995014033A1 (en) * 1993-11-19 1995-05-26 Aktiebolaget Astra Novel dipeptide derivatives
EA003528B1 (ru) * 1997-04-04 2003-06-26 Пфайзер Продактс Инк. Производные никотинамида, их применение, фармацевтическая композиция, способ лечения и способ ингибирования изоферментов фдэ4 d
HUP0100831A3 (en) * 1998-09-22 2001-12-28 Kaneka Corp Process for the preparation of n2-(1(s)-carboxy-3-phenylpropyl)-l-lysyl-l-proline
JP2004518691A (ja) 2001-01-31 2004-06-24 ファイザー・プロダクツ・インク Ｐｄｅ４アイソザイムの阻害剤として有効なチアゾリル−、オキサゾリル−、ピロリル−、イミダゾリル−酸アミド誘導体
EA200300652A1 (ru) 2001-01-31 2003-12-25 Пфайзер Продактс Инк. Эфирные производные, полезные в качестве ингибиторов изозимов pde4
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
IL156413A0 (en) 2001-01-31 2004-01-04 Pfizer Prod Inc Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes
WO2003033471A1 (fr) * 2001-10-17 2003-04-24 Tobishi Pharmaceutical Co.,Ltd Nouveau derive de pyridone et agent therapeutique pour les maladies du systeme circulatoire les contenant
US7153822B2 (en) * 2002-01-29 2006-12-26 Wyeth Compositions and methods for modulating connexin hemichannels
SI21507A (sl) * 2003-05-16 2004-12-31 LEK farmacevtska dru�ba d.d. Postopek za pripravo spojin z ace inhibitornim delovanjem
JP2008536850A (ja) * 2005-04-14 2008-09-11 メルク エンド カムパニー インコーポレーテッド Ｖｌａ−４アンタゴニスト

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU537592B2 (en) * 1979-04-02 1984-07-05 E.R. Squibb & Sons, Inc. Mercaptoacyldipeptides
NZ202232A (en) * 1981-11-06 1985-08-16 Smithkline Beckman Corp N-carboxyalkylproline-containing tripeptides and pharmaceutical compositions
DE3332633A1 (de) * 1983-09-09 1985-04-04 Luitpold-Werk Chemisch-pharmazeutische Fabrik GmbH & Co, 8000 München Substituierte carbonsaeurederivate, verfahren zu ihrer herstellung, und arzneimittel

Also Published As

Publication number Publication date
BR9204779A (pt) 1993-08-17
FI924850L (fi) 1992-10-26
EP0500989B1 (en) 1998-12-09
FI924850A7 (fi) 1992-10-26
PT100148B (pt) 1999-06-30
RU2098424C1 (ru) 1997-12-10
WO1992015608A1 (en) 1992-09-17
AU1278392A (en) 1992-10-06
HU9203324D0 (en) 1993-01-28
CA2081471A1 (en) 1992-08-28
PT100148A (pt) 1993-05-31
DE69130605D1 (de) 1999-01-21
JPH05507295A (ja) 1993-10-21
EP0500989A1 (en) 1992-09-02
CZ322092A3 (en) 1993-02-17
HUT62313A (en) 1993-04-28
RO111369B1 (ro) 1996-09-30
DE69130605T2 (de) 1999-05-20
US5432159A (en) 1995-07-11
ES2037613A1 (es) 1993-06-16
NO924076D0 (no) 1992-10-21
ES2037613B1 (es) 1994-03-16
AU650954B2 (en) 1994-07-07
PL167915B1 (pl) 1995-12-30
FI924850A0 (fi) 1992-10-26
CZ280952B6 (cs) 1996-05-15
ATE174343T1 (de) 1998-12-15
PL296625A1 (en) 1993-08-09

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