NO920945L - Nye 8-substituerte puriner som selektive adenosinreseptormidler - Google Patents
Nye 8-substituerte puriner som selektive adenosinreseptormidlerInfo
- Publication number
- NO920945L NO920945L NO92920945A NO920945A NO920945L NO 920945 L NO920945 L NO 920945L NO 92920945 A NO92920945 A NO 92920945A NO 920945 A NO920945 A NO 920945A NO 920945 L NO920945 L NO 920945L
- Authority
- NO
- Norway
- Prior art keywords
- selective
- new
- substituted purines
- receptor agents
- adenosin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/667,943 US5208240A (en) | 1991-03-12 | 1991-03-12 | 8-substituted purines as selective adenosine receptor agents |
Publications (3)
Publication Number | Publication Date |
---|---|
NO920945D0 NO920945D0 (no) | 1992-03-11 |
NO920945L true NO920945L (no) | 1992-09-14 |
NO300977B1 NO300977B1 (no) | 1997-08-25 |
Family
ID=24680310
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO920945A NO300977B1 (no) | 1991-03-12 | 1992-03-11 | Nye 8-substituerte puriner som selektive adenosinreseptormidler |
Country Status (18)
Country | Link |
---|---|
US (1) | US5208240A (no) |
EP (1) | EP0503563B1 (no) |
JP (1) | JP3131275B2 (no) |
KR (1) | KR100220887B1 (no) |
AT (1) | ATE250059T1 (no) |
AU (1) | AU643599B2 (no) |
CA (1) | CA2062837C (no) |
DE (1) | DE69233202T2 (no) |
DK (1) | DK0503563T3 (no) |
ES (1) | ES2207631T3 (no) |
FI (1) | FI108721B (no) |
HU (1) | HU215923B (no) |
IE (1) | IE920787A1 (no) |
IL (1) | IL101186A (no) |
NO (1) | NO300977B1 (no) |
NZ (1) | NZ241890A (no) |
PT (1) | PT503563E (no) |
ZA (1) | ZA921715B (no) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5565566A (en) * | 1987-04-24 | 1996-10-15 | Discovery Therapeutics, Inc. | N6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists |
DE4129603A1 (de) * | 1991-09-06 | 1993-03-11 | Thomae Gmbh Dr K | Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
US5521315A (en) * | 1993-01-12 | 1996-05-28 | Cell Therapeutics, Inc. | Olefin substituted long chain compounds |
WO1994019349A1 (en) * | 1993-02-26 | 1994-09-01 | Merrell Dow Pharmaceuticals Inc. | Xanthine derivatives as adenosine a1 receptor antagonists |
AU676323B2 (en) * | 1993-05-06 | 1997-03-06 | Merrell Dow Pharmaceuticals Inc. | 8-substituted xanthines as selective adenosine receptor agents |
FR2727315A1 (fr) * | 1994-11-30 | 1996-05-31 | Cooperative Agricole Laitiere | Utilisation d'un decapeptide a activite de type benzodiazepine pour la preparation de medicaments et de complements alimentaires |
US5786360A (en) | 1996-11-19 | 1998-07-28 | Link Technology Incorporated | A1 adenosine receptor antagonists |
EP0863148A1 (en) * | 1997-03-03 | 1998-09-09 | K.U. Leuven Research & Development | Compounds derived from adenosine, use of such compound as a medicament, method for synthesizing such a compound and intermediates thereof |
WO1998057651A1 (en) | 1997-06-18 | 1998-12-23 | Discovery Therapeutics, Inc. | Compositions and methods for preventing restenosis following revascularization procedures |
US5998386A (en) * | 1997-09-19 | 1999-12-07 | Feldman; Arthur M. | Pharmaceutical compositions and method of using same for the treatment of failing myocardial tissue |
US6060481A (en) * | 1998-05-28 | 2000-05-09 | The Penn State Research Foundation | Method for improving insulin sensitivity using an adenosine receptor antagonist |
AR020590A1 (es) * | 1998-06-02 | 2002-05-22 | Cadus Pharmaceutical Corp | 7-diazapurina-n-6 sustituida, un metodo para su preparacion, composiciones farmaceuticas que la comprenden |
US6680322B2 (en) | 1999-12-02 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
EP1305023A4 (en) * | 2000-08-01 | 2005-02-23 | Univ Virginia | USE OF SELECTIVE AGONISTS, ANTAGONISTS AND ALLOSTERIC AMPLIFIERS OF THE ADENOSINE A1 RECEPTOR TO INFLUENCE THE ANGIOGENESIS |
US6680324B2 (en) | 2000-12-01 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
US20020115635A1 (en) * | 2001-02-21 | 2002-08-22 | Pnina Fishman | Modulation of GSK-3beta activity and its different uses |
UA80258C2 (en) * | 2001-09-06 | 2007-09-10 | Biogen Inc | Methods of treating pulmonary disease |
CA2468673C (en) * | 2001-11-30 | 2011-01-25 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine a1 and a3 receptors and uses thereof |
KR20040068317A (ko) | 2001-12-20 | 2004-07-30 | 오에스아이 파마슈티컬스, 인코포레이티드 | 피리미딘 a₂b 선택성 길항 화합물, 그의 합성 방법 및용도 |
CA2516250A1 (en) | 2003-02-19 | 2004-09-02 | Endacea, Inc. | A1 adenosine receptor antagonists |
US7247639B2 (en) | 2003-06-06 | 2007-07-24 | Endacea, Inc. | A1 adenosine receptor antagonists |
US20090068101A9 (en) * | 2003-06-09 | 2009-03-12 | Endacea, Inc. | A1 Adenosine Receptor Antagonists |
WO2006099204A1 (en) * | 2005-03-11 | 2006-09-21 | Aderis Pharmaceuticals, Inc. | Substituted 9-alkyladenines and the use thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4397779A (en) * | 1978-08-09 | 1983-08-09 | Baxter Travenol Laboratories, Inc. | Preparation of xanthine tracers |
US4297494A (en) * | 1978-08-09 | 1981-10-27 | Baxter Travenol Laboratories, Inc. | Xanthine tracers |
EP0011399A1 (en) * | 1978-11-11 | 1980-05-28 | FISONS plc | N-substituted theophyllines, processes for their preparation and pharmaceutical compositions containing them |
US4452788A (en) * | 1982-04-21 | 1984-06-05 | Warner-Lambert Company | Substituted 8-phenylxanthines |
US4696932A (en) * | 1984-10-26 | 1987-09-29 | The United States Of America As Represented By The Department Of Health And Human Services | Biologically-active xanthine derivatives |
DE3522230A1 (de) * | 1985-06-21 | 1987-01-02 | Thomae Gmbh Dr K | Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
HU197746B (en) * | 1985-09-05 | 1989-05-29 | Sandoz Ag | Process for producing xantin derivatives and pharmaceutical compositions containing them |
US4968672A (en) * | 1987-01-02 | 1990-11-06 | The United States Of America As Represented By The Department Of Health And Human Services | Adenosine receptor prodrugs |
US5047534A (en) * | 1990-03-26 | 1991-09-10 | Merrell Dow Pharmaceuticals Inc. | Selective adenosine receptor agents |
-
1991
- 1991-03-12 US US07/667,943 patent/US5208240A/en not_active Expired - Lifetime
-
1992
- 1992-03-06 ZA ZA921715A patent/ZA921715B/xx unknown
- 1992-03-06 AU AU12138/92A patent/AU643599B2/en not_active Ceased
- 1992-03-09 NZ NZ241890A patent/NZ241890A/en unknown
- 1992-03-09 IL IL10118692A patent/IL101186A/en not_active IP Right Cessation
- 1992-03-10 DK DK92104089T patent/DK0503563T3/da active
- 1992-03-10 ES ES92104089T patent/ES2207631T3/es not_active Expired - Lifetime
- 1992-03-10 EP EP92104089A patent/EP0503563B1/en not_active Expired - Lifetime
- 1992-03-10 PT PT92104089T patent/PT503563E/pt unknown
- 1992-03-10 DE DE69233202T patent/DE69233202T2/de not_active Expired - Lifetime
- 1992-03-10 AT AT92104089T patent/ATE250059T1/de not_active IP Right Cessation
- 1992-03-11 IE IE078792A patent/IE920787A1/en not_active Application Discontinuation
- 1992-03-11 KR KR1019920003974A patent/KR100220887B1/ko not_active IP Right Cessation
- 1992-03-11 FI FI921052A patent/FI108721B/fi not_active IP Right Cessation
- 1992-03-11 HU HU9200822A patent/HU215923B/hu not_active IP Right Cessation
- 1992-03-11 NO NO920945A patent/NO300977B1/no not_active IP Right Cessation
- 1992-03-12 JP JP04087503A patent/JP3131275B2/ja not_active Expired - Lifetime
- 1992-03-12 CA CA002062837A patent/CA2062837C/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
KR100220887B1 (ko) | 1999-09-15 |
HUT61022A (en) | 1992-11-30 |
HU215923B (hu) | 1999-03-29 |
IE920787A1 (en) | 1992-09-23 |
IL101186A (en) | 1995-08-31 |
NO920945D0 (no) | 1992-03-11 |
ZA921715B (en) | 1992-11-25 |
DE69233202T2 (de) | 2004-06-24 |
EP0503563B1 (en) | 2003-09-17 |
PT503563E (pt) | 2003-12-31 |
JPH05112568A (ja) | 1993-05-07 |
AU643599B2 (en) | 1993-11-18 |
HU9200822D0 (en) | 1992-05-28 |
US5208240A (en) | 1993-05-04 |
DE69233202D1 (de) | 2003-10-23 |
EP0503563A3 (en) | 1992-12-02 |
JP3131275B2 (ja) | 2001-01-31 |
ATE250059T1 (de) | 2003-10-15 |
NZ241890A (en) | 1994-04-27 |
EP0503563A2 (en) | 1992-09-16 |
DK0503563T3 (da) | 2003-12-22 |
CA2062837C (en) | 2002-08-27 |
KR920018053A (ko) | 1992-10-21 |
FI921052A (fi) | 1992-09-13 |
ES2207631T3 (es) | 2004-06-01 |
IL101186A0 (en) | 1992-11-15 |
FI921052A0 (fi) | 1992-03-11 |
CA2062837A1 (en) | 1992-09-13 |
AU1213892A (en) | 1992-09-17 |
FI108721B (fi) | 2002-03-15 |
NO300977B1 (no) | 1997-08-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM1K | Lapsed by not paying the annual fees |