NO905306L - Spirocykliske forbindelser som inneholder nitrogen. - Google Patents
Spirocykliske forbindelser som inneholder nitrogen.Info
- Publication number
- NO905306L NO905306L NO90905306A NO905306A NO905306L NO 905306 L NO905306 L NO 905306L NO 90905306 A NO90905306 A NO 90905306A NO 905306 A NO905306 A NO 905306A NO 905306 L NO905306 L NO 905306L
- Authority
- NO
- Norway
- Prior art keywords
- compounds containing
- containing nitrogen
- spirocyclic compounds
- spirocyclic
- spirocycles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Fats And Perfumes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Dental Preparations (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44795089A | 1989-12-08 | 1989-12-08 | |
US61209190A | 1990-11-16 | 1990-11-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
NO905306D0 NO905306D0 (no) | 1990-12-07 |
NO905306L true NO905306L (no) | 1991-06-10 |
Family
ID=27035165
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO90905306A NO905306L (no) | 1989-12-08 | 1990-12-07 | Spirocykliske forbindelser som inneholder nitrogen. |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0431943B1 (fi) |
JP (1) | JPH0747576B2 (fi) |
KR (1) | KR910011859A (fi) |
CN (2) | CN1053613A (fi) |
AT (1) | ATE168377T1 (fi) |
AU (2) | AU6787390A (fi) |
CA (1) | CA2031633A1 (fi) |
DE (1) | DE69032480T2 (fi) |
ES (1) | ES2118715T3 (fi) |
FI (1) | FI906045A (fi) |
HU (1) | HU908122D0 (fi) |
IE (1) | IE904430A1 (fi) |
IL (1) | IL96507A0 (fi) |
NO (1) | NO905306L (fi) |
NZ (1) | NZ236315A (fi) |
PT (1) | PT96126A (fi) |
YU (1) | YU231790A (fi) |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
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EP0445974A3 (en) * | 1990-03-05 | 1992-04-29 | Merck Sharp & Dohme Ltd. | Spirocyclic antipsychotic agents |
IE911192A1 (en) * | 1990-04-12 | 1991-10-23 | Merck & Co Inc | Substituted aromatic sulfonamides as antiglaucoma agents |
NZ243065A (en) * | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
DK78692D0 (da) * | 1992-06-12 | 1992-06-12 | Lundbeck & Co As H | Dimere piperidin- og piperazinderivater |
US5578593A (en) * | 1992-12-11 | 1996-11-26 | Merck & Co., Inc. | Spiro piperidines and homologs promote release of growth hormone |
NZ258412A (en) * | 1992-12-11 | 1997-01-29 | Merck & Co Inc | Spiro-fused piperidine derivatives and pharmaceutical compositions |
EP0681571B1 (en) * | 1993-01-28 | 1998-07-29 | Merck & Co. Inc. | Spiro-substituted azacycles as tachykinin receptor antagonists |
CA2163995A1 (en) * | 1993-06-07 | 1994-12-22 | Malcolm Maccoss | Spiro-substituted azacycles as neurokinin antagonists |
US5484923A (en) * | 1993-06-10 | 1996-01-16 | Merck & Co., Inc. | Process of making spirocycles and analogs thereof |
US5439914A (en) * | 1994-02-18 | 1995-08-08 | Merck & Co., Inc. | Spirocycles |
US5464788A (en) * | 1994-03-24 | 1995-11-07 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
WO1995028389A1 (fr) * | 1994-04-15 | 1995-10-26 | Yamanouchi Pharmaceutical Co., Ltd. | Compose spiro et composition medicinale issue de ce compose |
US5434158A (en) * | 1994-04-26 | 1995-07-18 | Merck & Co., Inc. | Spiro-substituted azacycles as neurokinin-3 antagonists |
US5607936A (en) * | 1994-09-30 | 1997-03-04 | Merck & Co., Inc. | Substituted aryl piperazines as neurokinin antagonists |
US5679706A (en) * | 1994-09-30 | 1997-10-21 | Bristol-Myers Squibb Company | Combination of a potassium channel activator and an antiarrhythmic agent |
HUP9600928A3 (en) * | 1996-04-10 | 1999-03-29 | Richter Gedeon Vegyeszet | Use of spiro[2h-1-benzopyran-2,4'-piperidin]-4(3h)-one derivatives for the preparation of pharmaceutical compositions treating dementia, novel derivatives and process for their preparation |
US6156783A (en) * | 1996-04-30 | 2000-12-05 | Smithkline Beecham P.L.C. | Spiroazabicyclic compounds, processes for their preparation, and their pharmaceutical use |
US6110935A (en) * | 1997-02-13 | 2000-08-29 | The Regents Of The University Of California | Benzofurazan compounds for enhancing glutamatergic synaptic responses |
TW526195B (en) | 1997-06-10 | 2003-04-01 | Novartis Ag | Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use |
US6013652A (en) * | 1997-12-04 | 2000-01-11 | Merck & Co., Inc. | Spiro-substituted azacycles as neurokinin antagonists |
EP1235808A2 (en) * | 1999-06-07 | 2002-09-04 | Warner-Lambert Company | Tricyclic analgesics |
CN1361779A (zh) * | 1999-07-21 | 2002-07-31 | 阿斯特拉曾尼卡有限公司 | 新化合物 |
KR20020030802A (ko) | 1999-09-03 | 2002-04-25 | 야마모토 카즈모토 | 삼환식 아미노 알코올 유도체의 제조 방법 |
AU2003235912A1 (en) * | 2002-05-10 | 2003-11-11 | Taisho Pharmaceutical Co., Ltd. | Spiro-ring compound |
RS20050208A (en) | 2002-09-09 | 2007-08-03 | Janssen Pharmaceutica N.V., | Hydroxy alkyl substituted 1,3,8- triazaspiro/4,5/decan-4- one derivatives useful for the treatment of orl-1 receptor mediated disorders |
BRPI0409078A (pt) | 2003-04-04 | 2006-04-18 | Merck & Co Inc | composto, métodos para o tratamento ou prevenção de distúrbios, doenças ou condições responsivas à ativação do receptor de melanocortina-4, para o tratamento ou prevenção de obesidade, para o tratamento ou prevenção de um distúrbio relacionado com a obesidade, para o tratamento ou prevenção de diabete melito, para o tratamento ou prevenção da disfunção sexual masculina ou feminina e para o tratamento ou prevenção de disfunção erétil, composição farmacêutica, métodos para o tratamento de disfução erétil em um mamìfero, para o tratamento de diabete em um mamìfero e para o tratamento de obesidade em um mamìfero, e, uso de um composto |
JPWO2004092179A1 (ja) * | 2003-04-14 | 2006-07-06 | 日本曹達株式会社 | スピロ誘導体、製造法および抗酸化薬 |
US20060079566A1 (en) | 2003-10-03 | 2006-04-13 | Ching-Shih Chen | PDK-1/Akt signaling inhibitors |
EP1732893A2 (en) | 2004-03-29 | 2006-12-20 | Pfizer Japan, Inc. | Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as orl1-receptor antagonist |
SE0401539D0 (sv) * | 2004-06-15 | 2004-06-15 | Astrazeneca Ab | New compounds |
EP1634873A1 (en) | 2004-08-27 | 2006-03-15 | Laboratorios Del Dr. Esteve, S.A. | Sigma receptor inhibitors |
EP2325174A1 (en) | 2004-08-27 | 2011-05-25 | Laboratorios Del. Dr. Esteve, S.A. | Sigma receptor inhibitors |
SI1781618T1 (sl) | 2004-08-27 | 2013-01-31 | Laboratorios Del Dr. Esteve, S.A. | Inhibitorji sigma receptorja |
EP1781619B1 (en) | 2004-08-27 | 2011-08-17 | Laboratorios Del Dr. Esteve, S.A. | Sigma receptor inhibitors |
US7655670B2 (en) * | 2005-06-02 | 2010-02-02 | Janssen Pharmaceutica N.V. | 3-spirocyclic indolyl derivatives useful as ORL-1 receptor modulators |
US7935712B2 (en) * | 2005-07-19 | 2011-05-03 | Merck Sharp & Dohme Corp. | Spirochromanone derivatives as acetyl coenzyme A carboxylase (ACC) inhibitors |
TW200804393A (en) | 2005-11-14 | 2008-01-16 | Solvay Pharm Gmbh | Novel N-sulfamoyl-N'-benzopyranpiperidines for medical use |
WO2007063385A2 (en) * | 2005-12-01 | 2007-06-07 | Pfizer Products Inc. | Spirocyclic amine histamine-3 receptor antagonists |
EP1829875A1 (en) | 2006-03-01 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Pyrazole derivatives as sigma receptor inhibitors |
EP1829866A1 (en) | 2006-03-02 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Sigma receptor inhibitors |
EP1829867A1 (en) | 2006-03-03 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Imidazole compounds having pharmaceutical activity towards the sigma receptor |
AU2007326950B2 (en) * | 2006-11-29 | 2010-10-14 | Pfizer Products Inc. | Spiroketone acetyl-CoA carboxylase inhibitors |
US8138197B2 (en) | 2007-01-12 | 2012-03-20 | Msd K.K. | Spirochromanon derivatives |
PE20081559A1 (es) * | 2007-01-12 | 2008-11-20 | Merck & Co Inc | DERIVADOS DE ESPIROCROMANONA SUSTITUIDOS COMO INHIBIDORES DE ACETIL CoA CARBOXILASA |
MX2009011006A (es) | 2007-04-09 | 2009-11-02 | Janssen Pharmaceutica Nv | Derivados de 1,3,8-trisustituido-1,3,8-triaza-espiro[4.5]decano-4- ona como ligandos del receptor de orl-1 para el tratamiento de ansiedad y depresion. |
WO2008144266A1 (en) * | 2007-05-16 | 2008-11-27 | Merck & Co., Inc. | Spiroindalones |
US8039502B2 (en) | 2007-07-24 | 2011-10-18 | The Ohio State University Research Foundation | Anti-infective agents against intracellular pathogens |
CN102016590A (zh) * | 2008-02-28 | 2011-04-13 | 生命技术公司 | 荧光偏振hERG试验 |
EP2116539A1 (en) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
US10412788B2 (en) | 2008-06-13 | 2019-09-10 | Lg Chem, Ltd. | Heating element and manufacturing method thereof |
US20120108823A1 (en) | 2009-04-22 | 2012-05-03 | The Ohio State University Research Foundation | Anti-francisella agents |
UA107943C2 (en) | 2009-11-16 | 2015-03-10 | Lilly Co Eli | Compounds of spiropiperidines as antagonists of the orl-1 receptors |
EP2353598A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for use in the prevention and/or treatment of postoperative pain |
EP2353591A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
EP2595989B1 (en) | 2010-05-06 | 2016-07-13 | Vertex Pharmaceuticals Incorporated | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels |
EP2388005A1 (en) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy |
EP2395003A1 (en) | 2010-05-27 | 2011-12-14 | Laboratorios Del. Dr. Esteve, S.A. | Pyrazole compounds as sigma receptor inhibitors |
TWI543984B (zh) | 2010-07-09 | 2016-08-01 | 艾伯維公司 | 作為s1p調節劑的螺-哌啶衍生物 |
EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
EP2670752B1 (en) | 2011-02-02 | 2016-03-16 | Vertex Pharmaceuticals Incorporated | Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels |
WO2012112743A1 (en) | 2011-02-18 | 2012-08-23 | Vertex Pharmaceuticals Incorporated | Chroman - spirocyclic piperidine amides as modulators of ion channels |
US8828996B2 (en) | 2011-03-14 | 2014-09-09 | Vertex Pharmaceuticals Incorporated | Morpholine-spirocyclic piperidine amides as modulators of ion channels |
EP2524694A1 (en) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in diabetes type-2 associated pain |
AU2014211728B2 (en) * | 2013-02-04 | 2018-05-17 | Merck Patent Gmbh | Spiro-quinazolinone derivatives useful for the treatment of neurological diseases and conditions |
MA39147B1 (fr) | 2013-12-17 | 2019-12-31 | Esteve Labor Dr | Combinaisons d'inhibiteurs de la recapture de sérotonine-norépinéphrine (snri) et de ligands des récepteurs sigma |
WO2018108627A1 (de) | 2016-12-12 | 2018-06-21 | Bayer Cropscience Aktiengesellschaft | Verwendung substituierter indolinylmethylsulfonamide oder deren salze zur steigerung der stresstoleranz in pflanzen |
CN108752360B (zh) * | 2018-04-12 | 2019-10-29 | 牡丹江医学院 | 一种治疗小儿腹泻的化合物及其制备方法 |
US11458124B2 (en) | 2018-07-12 | 2022-10-04 | UCBBiopharma Srl | Spirocyclic indane analogues as IL-17 modulators |
AU2020373047A1 (en) | 2019-10-31 | 2022-05-19 | ESCAPE Bio, Inc. | Solid forms of an S1P-receptor modulator |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3301857A (en) | 1963-08-26 | 1967-01-31 | Hoffmann La Roche | Spiro |
US3649635A (en) * | 1969-10-24 | 1972-03-14 | Warner Lambert Co | Spiropyranopyridines |
US3686186A (en) * | 1970-10-05 | 1972-08-22 | William J Houlihan | Substituted isochroman or phthalan piperidenes |
JPS4867287A (fi) * | 1971-12-20 | 1973-09-13 | ||
JPS5224748B2 (fi) * | 1972-07-04 | 1977-07-02 | ||
JPS5343513B2 (fi) * | 1972-09-20 | 1978-11-20 | ||
IL45823A (en) * | 1973-10-20 | 1977-10-31 | Hoechst Ag | Substituted 1-phenyl-4-alkyl(dialkyl or cyclic) aminoalkyl-1,4-dihydro-2h-isoquinoline-3-one derivatives |
DE2353702C3 (de) | 1973-10-26 | 1979-03-29 | Guenter 7000 Stuttgart Haag | Einbruchsicherung für Flächen |
US3959475A (en) * | 1973-12-12 | 1976-05-25 | American Hoechst Corporation | Substituted 1,3-dihydrospiro(isobenzofuran)s |
US3962259A (en) * | 1973-12-12 | 1976-06-08 | American Hoechst Corporation | 1,3-Dihydrospiro[isobenzofuran]s and derivatives thereof |
JPS5089377A (fi) * | 1973-12-19 | 1975-07-17 | ||
JPS50111082A (fi) * | 1974-02-18 | 1975-09-01 | ||
DE2535338A1 (de) | 1975-08-07 | 1977-02-17 | Bayer Ag | Chromanone-(4) |
DE2611910A1 (de) | 1976-03-20 | 1977-09-22 | Bayer Ag | Chromanone-(4) |
JPS5368784A (en) * | 1976-11-30 | 1978-06-19 | Sumitomo Chem Co Ltd | Novel spiroamine derivatives and their preparation |
ES468860A1 (es) * | 1977-04-21 | 1979-09-16 | Hoechst Ag | Un procedimiento para preparar espiro (indolin-3,4'-piperi- dina)s. |
US4209625A (en) | 1977-04-21 | 1980-06-24 | American Hoechst Corporation | Spiro[indoline-3,4'-piperidine]s |
DE2745306A1 (de) | 1977-10-07 | 1979-04-19 | Bayer Ag | Insektizide mittel |
JPS54109983A (en) * | 1978-02-13 | 1979-08-29 | Sumitomo Chem Co Ltd | Novel spiroamine derivative and its preparation |
DE2814983A1 (de) | 1978-04-07 | 1979-10-18 | Bayer Ag | Neue chromanon-derivate |
US4166120A (en) * | 1978-04-14 | 1979-08-28 | American Hoechst Corporation | Analgesic and tranquilizing benzoylpropyl-spiro[dihydrobenzofuran]piperidines and pyrrolidines |
US4166119A (en) * | 1978-04-14 | 1979-08-28 | American Hoechst Corporation | Analgesic and tranquilizing spiro[dihydrobenzofuran]piperidines and pyrrolidines |
US4307235A (en) | 1978-08-23 | 1981-12-22 | American Hoechst Corporation | Spiro[indoline-3,4'-piperidine]s |
JPS55139333A (en) * | 1979-04-13 | 1980-10-31 | Dai Ichi Seiyaku Co Ltd | Spiro compound |
JPS55139381A (en) * | 1979-04-13 | 1980-10-31 | Dai Ichi Seiyaku Co Ltd | Spiroisochroman |
JPS55143980A (en) * | 1979-04-27 | 1980-11-10 | Dai Ichi Seiyaku Co Ltd | Anti-allergic preparation |
FR2498603A1 (fr) * | 1981-01-29 | 1982-07-30 | Delalande Sa | Nouveaux derives spiro-1 isobenzofuranniques et spiro-1 isobenzothiopheniques, leur procede de preparation et leur application en therapeutique |
US4349549A (en) * | 1981-05-18 | 1982-09-14 | Syntex (U.S.A.) Inc. | Anti-hypertensive 1-substituted spiro(piperidine-oxobenzoxazine)s |
JPS5815979A (ja) * | 1981-07-11 | 1983-01-29 | Kyowa Hakko Kogyo Co Ltd | 新規なピペリジン誘導体およびその製造法 |
US4353900A (en) * | 1981-10-19 | 1982-10-12 | Syntex (U.S.A.) Inc. | 9-(Arylalkyl or aroylalkyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones |
JPS5959685A (ja) * | 1982-09-28 | 1984-04-05 | Kyowa Hakko Kogyo Co Ltd | 新規なピペリジン誘導体 |
US4420485A (en) * | 1982-09-29 | 1983-12-13 | Hoechst-Roussel Pharmaceuticals Inc. | 1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines] |
US4558049A (en) * | 1982-11-24 | 1985-12-10 | Farmitalia Carlo Erba S.P.A. | Antipsycotic benzoxazines |
DE3308554A1 (de) * | 1983-03-10 | 1984-09-13 | Hoechst Ag, 6230 Frankfurt | 1-/1,3-dioxolan-2-ylmethyl)-azole, ihre salze, verfahren zu ihrer herstellung und ihre verwendung |
DK139684A (da) * | 1983-04-11 | 1984-10-12 | Janssen Pharmaceutica Nv | N-aryl-alpha-amino-carboxamider |
US4452802A (en) | 1983-08-25 | 1984-06-05 | Hoechst-Roussel Pharmaceuticals Incorporated | Antihypertensive spiro[benzofuran-azalkanes] |
JPS60158190A (ja) * | 1984-01-30 | 1985-08-19 | Eisai Co Ltd | ヒダントイン誘導体およびその製法ならびにそれを含有する医薬 |
-
1990
- 1990-11-29 IL IL96507A patent/IL96507A0/xx unknown
- 1990-12-03 NZ NZ236315A patent/NZ236315A/en unknown
- 1990-12-06 ES ES90313262T patent/ES2118715T3/es not_active Expired - Lifetime
- 1990-12-06 EP EP90313262A patent/EP0431943B1/en not_active Expired - Lifetime
- 1990-12-06 CA CA002031633A patent/CA2031633A1/en not_active Abandoned
- 1990-12-06 AT AT90313262T patent/ATE168377T1/de not_active IP Right Cessation
- 1990-12-06 DE DE69032480T patent/DE69032480T2/de not_active Expired - Fee Related
- 1990-12-07 KR KR1019900020064A patent/KR910011859A/ko not_active Application Discontinuation
- 1990-12-07 IE IE443090A patent/IE904430A1/en unknown
- 1990-12-07 NO NO90905306A patent/NO905306L/no unknown
- 1990-12-07 HU HU908122A patent/HU908122D0/hu unknown
- 1990-12-07 FI FI906045A patent/FI906045A/fi not_active Application Discontinuation
- 1990-12-07 YU YU231790A patent/YU231790A/sh unknown
- 1990-12-07 CN CN90110421A patent/CN1053613A/zh active Pending
- 1990-12-07 PT PT96126A patent/PT96126A/pt unknown
- 1990-12-07 JP JP2419271A patent/JPH0747576B2/ja not_active Expired - Lifetime
- 1990-12-07 AU AU67873/90A patent/AU6787390A/en not_active Abandoned
-
1994
- 1994-05-24 AU AU63297/94A patent/AU6329794A/en not_active Abandoned
-
1995
- 1995-01-06 CN CN95100709A patent/CN1110685A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
CN1110685A (zh) | 1995-10-25 |
PT96126A (pt) | 1991-09-30 |
NZ236315A (en) | 1994-09-27 |
EP0431943A2 (en) | 1991-06-12 |
EP0431943B1 (en) | 1998-07-15 |
ES2118715T3 (es) | 1998-10-01 |
AU6787390A (en) | 1991-06-13 |
KR910011859A (ko) | 1991-08-07 |
DE69032480D1 (de) | 1998-08-20 |
HU908122D0 (en) | 1991-06-28 |
NO905306D0 (no) | 1990-12-07 |
JPH0747576B2 (ja) | 1995-05-24 |
IE904430A1 (en) | 1991-06-19 |
FI906045A (fi) | 1991-06-09 |
YU231790A (sh) | 1993-05-28 |
IL96507A0 (en) | 1991-08-16 |
CA2031633A1 (en) | 1991-06-09 |
ATE168377T1 (de) | 1998-08-15 |
FI906045A0 (fi) | 1990-12-07 |
AU6329794A (en) | 1994-07-21 |
JPH04217960A (ja) | 1992-08-07 |
DE69032480T2 (de) | 1999-05-06 |
EP0431943A3 (en) | 1992-03-25 |
CN1053613A (zh) | 1991-08-07 |
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