NO885185L - Fremgangsmaate til fremstilling av alkanolaminderivater. - Google Patents
Fremgangsmaate til fremstilling av alkanolaminderivater.Info
- Publication number
- NO885185L NO885185L NO88885185A NO885185A NO885185L NO 885185 L NO885185 L NO 885185L NO 88885185 A NO88885185 A NO 88885185A NO 885185 A NO885185 A NO 885185A NO 885185 L NO885185 L NO 885185L
- Authority
- NO
- Norway
- Prior art keywords
- formula
- added
- compound
- reaction
- mixture
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 13
- 238000002360 preparation method Methods 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 11
- JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 claims description 7
- 230000007062 hydrolysis Effects 0.000 claims description 2
- 238000006460 hydrolysis reaction Methods 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 239000011541 reaction mixture Substances 0.000 description 7
- METKIMKYRPQLGS-GFCCVEGCSA-N (R)-atenolol Chemical compound CC(C)NC[C@@H](O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-GFCCVEGCSA-N 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- 229960002274 atenolol Drugs 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 239000003960 organic solvent Substances 0.000 description 5
- AYKYOOPFBCOXSL-UHFFFAOYSA-N (4-hydroxyphenyl)acetonitrile Chemical compound OC1=CC=C(CC#N)C=C1 AYKYOOPFBCOXSL-UHFFFAOYSA-N 0.000 description 4
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- -1 4-(2-hydroxy-3-isopropylamino-propanoxy)phenyl-acetamide Chemical compound 0.000 description 3
- 229960000583 acetic acid Drugs 0.000 description 3
- 239000012362 glacial acetic acid Substances 0.000 description 3
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 3
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000003125 aqueous solvent Substances 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 150000002825 nitriles Chemical class 0.000 description 2
- 150000002924 oxiranes Chemical class 0.000 description 2
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 1
- WDGZJFDDPCUVPF-UHFFFAOYSA-N 2-[4-(oxiran-2-ylmethoxy)phenyl]acetonitrile Chemical compound C1=CC(CC#N)=CC=C1OCC1OC1 WDGZJFDDPCUVPF-UHFFFAOYSA-N 0.000 description 1
- VGJIPAKCLDHBAL-UHFFFAOYSA-N 2-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetonitrile Chemical compound CC(C)NCC(O)COC1=CC=C(CC#N)C=C1 VGJIPAKCLDHBAL-UHFFFAOYSA-N 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- 208000034809 Product contamination Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- LUMVCLJFHCTMCV-UHFFFAOYSA-M potassium;hydroxide;hydrate Chemical compound O.[OH-].[K+] LUMVCLJFHCTMCV-UHFFFAOYSA-M 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/06—Preparation of carboxylic acid amides from nitriles by transformation of cyano groups into carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8727716A GB2212801A (en) | 1987-11-26 | 1987-11-26 | Preparation of an alkanolamine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO885185D0 NO885185D0 (no) | 1988-11-21 |
| NO885185L true NO885185L (no) | 1989-05-29 |
Family
ID=10627586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO88885185A NO885185L (no) | 1987-11-26 | 1988-11-21 | Fremgangsmaate til fremstilling av alkanolaminderivater. |
Country Status (5)
| Country | Link |
|---|---|
| DK (1) | DK649088A (da) |
| FI (1) | FI885455A (da) |
| GB (1) | GB2212801A (da) |
| NO (1) | NO885185L (da) |
| SE (1) | SE8804255L (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5502078A (en) * | 1991-05-28 | 1996-03-26 | Zeneca Limited | Chemical compounds |
| GB9111425D0 (en) * | 1991-05-28 | 1991-07-17 | Ici Plc | Chemical compounds |
| GB9111426D0 (en) * | 1991-05-28 | 1991-07-17 | Ici Plc | Chemical compounds |
-
1987
- 1987-11-26 GB GB8727716A patent/GB2212801A/en not_active Withdrawn
-
1988
- 1988-11-21 DK DK649088A patent/DK649088A/da not_active Application Discontinuation
- 1988-11-21 NO NO88885185A patent/NO885185L/no unknown
- 1988-11-24 FI FI885455A patent/FI885455A/fi not_active Application Discontinuation
- 1988-11-25 SE SE8804255A patent/SE8804255L/ not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GB8727716D0 (en) | 1987-12-31 |
| FI885455A (fi) | 1989-05-27 |
| NO885185D0 (no) | 1988-11-21 |
| SE8804255L (sv) | 1989-05-27 |
| DK649088A (da) | 1989-05-27 |
| DK649088D0 (da) | 1988-11-21 |
| FI885455A0 (fi) | 1988-11-24 |
| SE8804255D0 (sv) | 1988-11-25 |
| GB2212801A (en) | 1989-08-02 |
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