NO871861L - Fremgangsmaate for fremstilling av nye dopamin beta-hydroxylase inhibitorer. - Google Patents
Fremgangsmaate for fremstilling av nye dopamin beta-hydroxylase inhibitorer.Info
- Publication number
- NO871861L NO871861L NO871861A NO871861A NO871861L NO 871861 L NO871861 L NO 871861L NO 871861 A NO871861 A NO 871861A NO 871861 A NO871861 A NO 871861A NO 871861 L NO871861 L NO 871861L
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- hydrogen
- lower alkyl
- procedure
- hydroxylase inhibitors
- Prior art date
Links
- 108010015720 Dopamine beta-Hydroxylase Proteins 0.000 title 1
- 102100033156 Dopamine beta-hydroxylase Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- -1 amidino, aminoethylthio Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 150000004716 alpha keto acids Chemical group 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000003037 imidazol-2-yl group Chemical group [H]N1C([*])=NC([H])=C1[H] 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fire-Extinguishing Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Processing Of Solid Wastes (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86026386A | 1986-05-06 | 1986-05-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO871861D0 NO871861D0 (no) | 1987-05-05 |
| NO871861L true NO871861L (no) | 1987-11-09 |
Family
ID=25332828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO871861A NO871861L (no) | 1986-05-06 | 1987-05-05 | Fremgangsmaate for fremstilling av nye dopamin beta-hydroxylase inhibitorer. |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0244803B1 (da) |
| JP (1) | JP2581556B2 (da) |
| KR (1) | KR950013028B1 (da) |
| CN (1) | CN87103323A (da) |
| AT (2) | ATE113283T1 (da) |
| AU (1) | AU596410B2 (da) |
| CA (1) | CA1334199C (da) |
| DE (1) | DE3750685T2 (da) |
| DK (1) | DK229187A (da) |
| ES (1) | ES2065881T3 (da) |
| FI (1) | FI871981A7 (da) |
| HU (1) | HU198479B (da) |
| IL (1) | IL82401A0 (da) |
| NO (1) | NO871861L (da) |
| NZ (1) | NZ220184A (da) |
| PT (1) | PT84823B (da) |
| ZA (1) | ZA873176B (da) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4634711A (en) * | 1985-08-02 | 1987-01-06 | Smithkline Beckman Corporation | Pyridylalkyl imidazole-2-thiols |
| US4686231A (en) * | 1985-12-12 | 1987-08-11 | Smithkline Beckman Corporation | Inhibition of 5-lipoxygenase products |
| FI91754C (fi) * | 1986-12-02 | 1994-08-10 | Tanabe Seiyaku Co | Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi |
| EP0277384A3 (en) * | 1986-12-24 | 1990-05-23 | Janssen Pharmaceutica N.V. | 1h-imidazole-5-carboxylic acid derivatives |
| EP0285356A3 (en) * | 1987-03-30 | 1989-05-31 | Smithkline Beecham Corporation | Dopamine-beta-hydroxylase inhibitors |
| US4839375A (en) * | 1987-07-28 | 1989-06-13 | Merrell Dow Pharmaceuticals Inc. | (Aryl or heteroaromatic methyl)-2,2'-bi-1H-imidazoles and their use as anti-hypertensive agents |
| HU202516B (en) * | 1987-10-02 | 1991-03-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing (2-thenyl)-thiourea derivatives and yield increasing agents comprising such compounds |
| CA2002246A1 (en) * | 1988-12-01 | 1990-06-01 | Lawrence I. Kruse | Dopamine-.beta.-hydroxylase inhibitors |
| CA2002247A1 (en) * | 1988-12-01 | 1990-06-01 | Lawrence I. Kruse | Dopamine-.beta.-hydroxylase inhibitors |
| EP0449445A3 (en) * | 1990-03-27 | 1993-08-25 | Pfizer Inc. | Preparation of beta-ketoesters useful in preparing quinolone antibiotics |
| US5635521A (en) * | 1991-09-23 | 1997-06-03 | Sandoz Ltd. | Imidazolylmethyl-pyridines |
| DE19627310A1 (de) * | 1996-06-27 | 1998-01-02 | Schering Ag | Imidazolderivate als Stickstoffmonoxid-Synthase-Inhibitoren |
| GB2393958A (en) * | 2002-10-11 | 2004-04-14 | Portela & Ca Sa | Peripherally-selective imidazole inhibitors of dopamine-beta-hydroxylase |
| US7538107B2 (en) | 2006-08-15 | 2009-05-26 | Wyeth | Oxazinan-2-one derivatives useful as PR modulators |
| US7649007B2 (en) | 2006-08-15 | 2010-01-19 | Wyeth Llc | Oxazolidine derivatives as PR modulators |
| US7618989B2 (en) | 2006-08-15 | 2009-11-17 | Wyeth | Tricyclic oxazolidone derivatives useful as PR modulators |
| US7652018B2 (en) | 2006-08-15 | 2010-01-26 | Wyeth Llc | Imidazolidin-2-one derivatives useful as PR modulators |
| WO2009097416A1 (en) * | 2008-01-29 | 2009-08-06 | Vanda Pharmaceuticals, Inc. | Imidazolylalkyl- pyridines as dbh inhibitors |
| CN103214421B (zh) * | 2012-12-11 | 2016-03-02 | 上海博康精细化工有限公司 | 2-巯基-1-甲基咪唑的工业化生产方法 |
| AU2022213938A1 (en) | 2021-01-26 | 2023-09-07 | Asieris Pharmaceuticals (Shanghai) Co., Ltd. | Pathway modulator, pharmaceutical composition having same, use thereof, and therapeutic method using same |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE312877C (da) * | ||||
| FR1509975A (fr) * | 1965-10-21 | 1968-01-19 | Geigy Ag J R | Dérivés de l'imidazole et leur préparation |
| FR2073427A1 (en) * | 1969-11-28 | 1971-10-01 | Sogeras | 4-methyl-5-ethyl-n-heterocyclic thiazoles - with antianoxic activity |
| DE2862340D1 (en) * | 1978-02-01 | 1983-11-24 | Wellcome Found | Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof |
| GB2028317B (en) * | 1978-08-15 | 1982-11-10 | Pfizer Ltd | 2-(imidazol-1-ylmethyl)-pyridine and -quinoline thromboxane synthetase inhibitors |
| GR73560B (da) * | 1979-02-24 | 1984-03-15 | Pfizer | |
| DE3128277A1 (de) * | 1981-07-17 | 1983-02-03 | A. Nattermann & Cie GmbH, 5000 Köln | (omega)-(5-(1-imidazolylmethyl)-thien-2-y1)-alkancarbonsaeuren und deren derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| DE3228266A1 (de) * | 1982-07-29 | 1984-02-02 | A. Nattermann & Cie GmbH, 5000 Köln | Imidazolylalkylthiophene, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| DE3300795A1 (de) * | 1983-01-12 | 1984-07-12 | Bayer Ag, 5090 Leverkusen | Substituierte 4-imidazolyl-pyrazole, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel |
| PT78388B (en) * | 1983-04-12 | 1986-09-15 | Smithkline Beckman Corp | Dopamine-beta-hydroxylase inhibitors |
| US4532331A (en) * | 1983-04-12 | 1985-07-30 | Smithkline Beckman Corporation | 1-Benzyl-2-aminomethyl imidazole derivatives |
| US4634711A (en) * | 1985-08-02 | 1987-01-06 | Smithkline Beckman Corporation | Pyridylalkyl imidazole-2-thiols |
-
1987
- 1987-05-01 IL IL82401A patent/IL82401A0/xx not_active IP Right Cessation
- 1987-05-01 JP JP62106478A patent/JP2581556B2/ja not_active Expired - Fee Related
- 1987-05-04 ES ES87106440T patent/ES2065881T3/es not_active Expired - Lifetime
- 1987-05-04 EP EP87106440A patent/EP0244803B1/en not_active Expired - Lifetime
- 1987-05-04 NZ NZ220184A patent/NZ220184A/en unknown
- 1987-05-04 ZA ZA873176A patent/ZA873176B/xx unknown
- 1987-05-04 AT AT87106440T patent/ATE113283T1/de not_active IP Right Cessation
- 1987-05-04 PT PT84823A patent/PT84823B/pt not_active IP Right Cessation
- 1987-05-04 AU AU72463/87A patent/AU596410B2/en not_active Ceased
- 1987-05-04 DE DE3750685T patent/DE3750685T2/de not_active Expired - Fee Related
- 1987-05-05 CN CN198787103323A patent/CN87103323A/zh active Pending
- 1987-05-05 CA CA000536384A patent/CA1334199C/en not_active Expired - Fee Related
- 1987-05-05 HU HU872013A patent/HU198479B/hu not_active IP Right Cessation
- 1987-05-05 NO NO871861A patent/NO871861L/no unknown
- 1987-05-05 FI FI871981A patent/FI871981A7/fi not_active Application Discontinuation
- 1987-05-05 DK DK229187A patent/DK229187A/da not_active Application Discontinuation
- 1987-05-06 KR KR1019870004414A patent/KR950013028B1/ko not_active Expired - Fee Related
- 1987-10-12 AT AT0269087A patent/AT387967B/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FI871981A0 (fi) | 1987-05-05 |
| EP0244803B1 (en) | 1994-10-26 |
| KR950013028B1 (ko) | 1995-10-24 |
| CA1334199C (en) | 1995-01-31 |
| PT84823B (pt) | 1989-12-29 |
| IL82401A0 (en) | 1987-11-30 |
| FI871981A7 (fi) | 1987-11-07 |
| HU198479B (en) | 1989-10-30 |
| ATE113283T1 (de) | 1994-11-15 |
| CN87103323A (zh) | 1988-02-03 |
| DK229187D0 (da) | 1987-05-05 |
| AU596410B2 (en) | 1990-05-03 |
| JPH01100160A (ja) | 1989-04-18 |
| DK229187A (da) | 1987-11-07 |
| DE3750685D1 (de) | 1994-12-01 |
| KR870011104A (ko) | 1987-12-21 |
| AU7246387A (en) | 1987-11-12 |
| EP0244803A3 (en) | 1991-01-16 |
| NO871861D0 (no) | 1987-05-05 |
| PT84823A (en) | 1987-06-01 |
| ES2065881T3 (es) | 1995-03-01 |
| JP2581556B2 (ja) | 1997-02-12 |
| AT387967B (de) | 1989-04-10 |
| ZA873176B (en) | 1987-10-28 |
| HUT44029A (en) | 1988-01-28 |
| NZ220184A (en) | 1990-04-26 |
| EP0244803A2 (en) | 1987-11-11 |
| DE3750685T2 (de) | 1995-03-02 |
| ATA269087A (de) | 1988-09-15 |
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