NO861555L - Merkede og merkbare reagenser for fluorometriske analyser. - Google Patents
Merkede og merkbare reagenser for fluorometriske analyser.Info
- Publication number
- NO861555L NO861555L NO861555A NO861555A NO861555L NO 861555 L NO861555 L NO 861555L NO 861555 A NO861555 A NO 861555A NO 861555 A NO861555 A NO 861555A NO 861555 L NO861555 L NO 861555L
- Authority
- NO
- Norway
- Prior art keywords
- condensation product
- substance
- antibody
- antigen
- metal ion
- Prior art date
Links
- 239000003153 chemical reaction reagent Substances 0.000 title claims description 28
- 238000004458 analytical method Methods 0.000 title claims description 19
- 239000000126 substance Substances 0.000 claims description 52
- 239000007859 condensation product Substances 0.000 claims description 45
- 229910021645 metal ion Inorganic materials 0.000 claims description 38
- 125000004122 cyclic group Chemical group 0.000 claims description 31
- 229920002521 macromolecule Polymers 0.000 claims description 31
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 27
- 239000000427 antigen Substances 0.000 claims description 26
- 102000036639 antigens Human genes 0.000 claims description 26
- 108091007433 antigens Proteins 0.000 claims description 26
- 229910052747 lanthanoid Inorganic materials 0.000 claims description 25
- 150000002602 lanthanoids Chemical class 0.000 claims description 24
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical group O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 14
- 230000000295 complement effect Effects 0.000 claims description 14
- 239000000047 product Substances 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 10
- 238000002372 labelling Methods 0.000 claims description 9
- 230000003389 potentiating effect Effects 0.000 claims description 7
- 108010039918 Polylysine Proteins 0.000 claims description 6
- 239000013522 chelant Substances 0.000 claims description 6
- 239000007795 chemical reaction product Substances 0.000 claims description 6
- 125000005594 diketone group Chemical group 0.000 claims description 6
- 229920000656 polylysine Polymers 0.000 claims description 6
- 239000000872 buffer Substances 0.000 claims description 5
- 229910052771 Terbium Inorganic materials 0.000 claims 2
- LNBHUCHAFZUEGJ-UHFFFAOYSA-N europium(3+) Chemical compound [Eu+3] LNBHUCHAFZUEGJ-UHFFFAOYSA-N 0.000 claims 2
- 238000000605 extraction Methods 0.000 claims 2
- GZCRRIHWUXGPOV-UHFFFAOYSA-N terbium atom Chemical compound [Tb] GZCRRIHWUXGPOV-UHFFFAOYSA-N 0.000 claims 2
- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 claims 1
- 229930189603 alysine Natural products 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 description 12
- 229910052751 metal Inorganic materials 0.000 description 12
- 239000002184 metal Substances 0.000 description 12
- 239000000243 solution Substances 0.000 description 9
- 238000003556 assay Methods 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- SHXHPUAKLCCLDV-UHFFFAOYSA-N 1,1,1-trifluoropentane-2,4-dione Chemical compound CC(=O)CC(=O)C(F)(F)F SHXHPUAKLCCLDV-UHFFFAOYSA-N 0.000 description 4
- 239000008351 acetate buffer Substances 0.000 description 4
- -1 alkyl aldehydes Chemical class 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 239000010949 copper Substances 0.000 description 4
- 238000003018 immunoassay Methods 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- QAEDZJGFFMLHHQ-UHFFFAOYSA-N trifluoroacetic anhydride Chemical compound FC(F)(F)C(=O)OC(=O)C(F)(F)F QAEDZJGFFMLHHQ-UHFFFAOYSA-N 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 238000011088 calibration curve Methods 0.000 description 3
- 239000003446 ligand Substances 0.000 description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 102000004338 Transferrin Human genes 0.000 description 2
- 108090000901 Transferrin Proteins 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 230000009920 chelation Effects 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 238000007421 fluorometric assay Methods 0.000 description 2
- 239000008098 formaldehyde solution Substances 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000003127 radioimmunoassay Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- ZMBHCYHQLYEYDV-UHFFFAOYSA-N trioctylphosphine oxide Chemical compound CCCCCCCCP(=O)(CCCCCCCC)CCCCCCCC ZMBHCYHQLYEYDV-UHFFFAOYSA-N 0.000 description 2
- QLCMAPLSHSKAKP-UHFFFAOYSA-N 1,1,1-trifluoro-3-(thiophene-2-carbonyl)pentane-2,4-dione Chemical compound FC(F)(F)C(=O)C(C(=O)C)C(=O)C1=CC=CS1 QLCMAPLSHSKAKP-UHFFFAOYSA-N 0.000 description 1
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Substances CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 1
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 description 1
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 1
- UYQMAGRFYJIJOQ-UHFFFAOYSA-N 4,4,4-trifluoro-1-naphthalen-1-ylbutane-1,3-dione Chemical compound C1=CC=C2C(C(=O)CC(=O)C(F)(F)F)=CC=CC2=C1 UYQMAGRFYJIJOQ-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical class OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 150000001540 azides Chemical class 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- 230000001588 bifunctional effect Effects 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- ZBKFYXZXZJPWNQ-UHFFFAOYSA-N isothiocyanate group Chemical group [N-]=C=S ZBKFYXZXZJPWNQ-UHFFFAOYSA-N 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000009206 nuclear medicine Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920000729 poly(L-lysine) polymer Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000004451 qualitative analysis Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- TXBBUSUXYMIVOS-UHFFFAOYSA-N thenoyltrifluoroacetone Chemical compound FC(F)(F)C(=O)CC(=O)C1=CC=CS1 TXBBUSUXYMIVOS-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000012581 transferrin Substances 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/808—Automated or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/802—Chromogenic or luminescent peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848421318A GB8421318D0 (en) | 1984-08-22 | 1984-08-22 | Potentiating antibodies/other macro-molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO861555L true NO861555L (no) | 1986-04-18 |
Family
ID=10565671
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO861555A NO861555L (no) | 1984-08-22 | 1986-04-18 | Merkede og merkbare reagenser for fluorometriske analyser. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4857475A (de) |
| EP (1) | EP0222766B1 (de) |
| JP (1) | JPH0625765B2 (de) |
| AU (1) | AU4724185A (de) |
| DE (1) | DE3583507D1 (de) |
| DK (1) | DK184586D0 (de) |
| FI (1) | FI87022C (de) |
| GB (1) | GB8421318D0 (de) |
| NO (1) | NO861555L (de) |
| WO (1) | WO1986001604A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4886744A (en) * | 1985-04-25 | 1989-12-12 | Polaroid Corporation | Fluorescent conjugates and biological diagnostic assay system |
| GB8602304D0 (en) * | 1986-01-30 | 1986-03-05 | Dakubu S | Dihydropyridine condensation products |
| GB8622855D0 (en) * | 1986-09-23 | 1986-10-29 | Ekins R P | Determining biological substance |
| JPS6447952A (en) * | 1987-05-06 | 1989-02-22 | Saibaafuruua Inc | Immunoassay, reagent used therefor and making thereof |
| GB8803000D0 (en) * | 1988-02-10 | 1988-03-09 | Ekins Roger Philip | Determination of ambient concentrations of several analytes |
| SE8703682L (sv) * | 1987-09-24 | 1989-03-25 | Wallac Oy | Homogen bestaemningsmetod som utnyttjar affinitetsreaktioner |
| US5308754A (en) * | 1988-03-21 | 1994-05-03 | Kankare Jouko J | Electrogenerated luminescence in solution |
| SE8801702D0 (sv) * | 1988-05-05 | 1988-05-05 | Pharmacia Ab | Sett vid bestemning av enzymatisk aktivitet |
| US5240867A (en) * | 1989-02-09 | 1993-08-31 | Fujitsu Limited | Semiconductor integrated circuit having interconnection with improved design flexibility, and method of production |
| FI88654C (fi) * | 1991-03-15 | 1993-06-10 | Datacity Center Oy | Fluorescenshoejningsmetod |
| US5312922A (en) * | 1992-04-06 | 1994-05-17 | Nordion International Inc. | Europium and terbium chelators for time-resolved fluorometric assays |
| GB0210535D0 (en) * | 2002-05-08 | 2002-06-19 | Novartis Ag | Organic compounds |
| US7906343B2 (en) * | 2005-01-24 | 2011-03-15 | Sri International | Surface-enhanced lanthanide chelates |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3956341A (en) * | 1974-02-21 | 1976-05-11 | Smithkline Corporation | 1,3,5-Tricarbo-1,4-dihydropyridines |
| SE428332B (sv) * | 1979-03-08 | 1983-06-20 | Wallac Oy | Forfarande for fluorescensspektroskopisk bestemning av biologiskt aktivt emne, sasom hapten, antikropp eller antigen |
| US4352751A (en) * | 1979-09-10 | 1982-10-05 | Analytical Radiation Corporation | Species-linked diamine triacetic acids and their chelates |
-
1984
- 1984-08-22 GB GB848421318A patent/GB8421318D0/en active Pending
-
1985
- 1985-08-22 EP EP85904129A patent/EP0222766B1/de not_active Expired
- 1985-08-22 DE DE8585904129T patent/DE3583507D1/de not_active Expired - Fee Related
- 1985-08-22 AU AU47241/85A patent/AU4724185A/en not_active Abandoned
- 1985-08-22 US US06/862,215 patent/US4857475A/en not_active Expired - Lifetime
- 1985-08-22 WO PCT/GB1985/000377 patent/WO1986001604A1/en active IP Right Grant
- 1985-08-22 JP JP60503723A patent/JPH0625765B2/ja not_active Expired - Lifetime
-
1986
- 1986-04-18 NO NO861555A patent/NO861555L/no unknown
- 1986-04-22 DK DK184586A patent/DK184586D0/da not_active Application Discontinuation
-
1987
- 1987-02-20 FI FI870716A patent/FI87022C/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FI87022B (fi) | 1992-07-31 |
| DE3583507D1 (de) | 1991-08-22 |
| EP0222766B1 (de) | 1991-07-17 |
| FI870716A (fi) | 1987-02-20 |
| GB8421318D0 (en) | 1984-09-26 |
| JPH0625765B2 (ja) | 1994-04-06 |
| FI870716A0 (fi) | 1987-02-20 |
| JPS62501442A (ja) | 1987-06-11 |
| EP0222766A1 (de) | 1987-05-27 |
| WO1986001604A1 (en) | 1986-03-13 |
| DK184586A (da) | 1986-04-22 |
| US4857475A (en) | 1989-08-15 |
| DK184586D0 (da) | 1986-04-22 |
| AU4724185A (en) | 1986-03-24 |
| FI87022C (fi) | 1992-11-10 |
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