NO853504L - Fremgangsmaate for fremstilling av et percutant, anaestetisk preparat. - Google Patents
Fremgangsmaate for fremstilling av et percutant, anaestetisk preparat.Info
- Publication number
- NO853504L NO853504L NO853504A NO853504A NO853504L NO 853504 L NO853504 L NO 853504L NO 853504 A NO853504 A NO 853504A NO 853504 A NO853504 A NO 853504A NO 853504 L NO853504 L NO 853504L
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- amethocaine
- calculated
- gel
- skin
- Prior art date
Links
- 230000003444 anaesthetic effect Effects 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 title claims description 44
- 238000000034 method Methods 0.000 title claims 10
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229960002372 tetracaine Drugs 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 230000000699 topical effect Effects 0.000 claims abstract description 8
- 206010002091 Anaesthesia Diseases 0.000 claims abstract description 7
- 230000037005 anaesthesia Effects 0.000 claims abstract description 7
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 6
- 229920000609 methyl cellulose Polymers 0.000 claims abstract description 5
- 239000001923 methylcellulose Substances 0.000 claims abstract description 5
- 238000001949 anaesthesia Methods 0.000 claims abstract description 3
- 150000001875 compounds Chemical class 0.000 claims description 7
- 239000003349 gelling agent Substances 0.000 claims description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 4
- 229960001631 carbomer Drugs 0.000 claims description 4
- 239000000155 melt Substances 0.000 claims description 3
- 230000035515 penetration Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000001737 promoting effect Effects 0.000 claims description 2
- 230000000087 stabilizing effect Effects 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 14
- 239000000499 gel Substances 0.000 description 8
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 239000012071 phase Substances 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 239000004264 Petrolatum Substances 0.000 description 2
- 230000002745 absorbent Effects 0.000 description 2
- 239000002250 absorbent Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 239000008311 hydrophilic ointment Substances 0.000 description 2
- 210000000929 nociceptor Anatomy 0.000 description 2
- 229940066842 petrolatum Drugs 0.000 description 2
- 235000019271 petrolatum Nutrition 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 238000011477 surgical intervention Methods 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 1
- 238000005904 alkaline hydrolysis reaction Methods 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002690 local anesthesia Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 108091008700 nociceptors Proteins 0.000 description 1
- 230000037368 penetrate the skin Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pipeline Systems (AREA)
- Vehicle Body Suspensions (AREA)
- Indication And Recording Devices For Special Purposes And Tariff Metering Devices (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB08422759A GB2163956B (en) | 1984-09-08 | 1984-09-08 | Percutaneous anaesthetic composition for topical application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO853504L true NO853504L (no) | 1986-03-10 |
Family
ID=10566481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO853504A NO853504L (no) | 1984-09-08 | 1985-09-06 | Fremgangsmaate for fremstilling av et percutant, anaestetisk preparat. |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP0175609B1 (de) |
| JP (1) | JPS6185316A (de) |
| KR (1) | KR860002267A (de) |
| AT (1) | ATE73352T1 (de) |
| AU (1) | AU581246B2 (de) |
| BE (1) | BE903186A (de) |
| CH (1) | CH666815A5 (de) |
| CS (1) | CS261887B2 (de) |
| DD (1) | DD236876A5 (de) |
| DE (2) | DE3531002A1 (de) |
| DK (1) | DK406785A (de) |
| FI (1) | FI853416L (de) |
| FR (1) | FR2569982B1 (de) |
| GB (1) | GB2163956B (de) |
| GR (1) | GR852142B (de) |
| HU (1) | HU193611B (de) |
| IL (1) | IL76092A0 (de) |
| IN (1) | IN165072B (de) |
| IS (1) | IS3035A7 (de) |
| IT (1) | IT1182854B (de) |
| LU (1) | LU86068A1 (de) |
| MA (1) | MA20519A1 (de) |
| NO (1) | NO853504L (de) |
| NZ (1) | NZ213325A (de) |
| OA (1) | OA08158A (de) |
| PH (1) | PH21731A (de) |
| PL (1) | PL255285A1 (de) |
| PT (1) | PT81079B (de) |
| ZA (1) | ZA856501B (de) |
| ZM (1) | ZM6185A1 (de) |
| ZW (1) | ZW14285A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8712518D0 (en) * | 1987-05-28 | 1987-07-01 | Univ Belfast | Unit-dose film composition |
| GB8729855D0 (en) * | 1987-12-22 | 1988-02-03 | Drythanol Ltd | New dithranol compositions |
| GB9101986D0 (en) * | 1991-01-30 | 1991-03-13 | Smith & Nephew | Pharmaceutical compositions |
| SE9402453D0 (sv) * | 1994-07-12 | 1994-07-12 | Astra Ab | New pharmaceutical preparation |
| US6245347B1 (en) | 1995-07-28 | 2001-06-12 | Zars, Inc. | Methods and apparatus for improved administration of pharmaceutically active compounds |
| US6284266B1 (en) | 1995-07-28 | 2001-09-04 | Zars, Inc. | Methods and apparatus for improved administration of fentanyl and sufentanil |
| US5658583A (en) * | 1995-07-28 | 1997-08-19 | Zhang; Jie | Apparatus and methods for improved noninvasive dermal administration of pharmaceuticals |
| US6955819B2 (en) | 1998-09-29 | 2005-10-18 | Zars, Inc. | Methods and apparatus for using controlled heat to regulate transdermal and controlled release delivery of fentanyl, other analgesics, and other medical substances |
| US6453648B1 (en) | 1999-07-06 | 2002-09-24 | Zars, Inc. | Method for manufacturing a heat generating apparatus |
| US6261595B1 (en) | 2000-02-29 | 2001-07-17 | Zars, Inc. | Transdermal drug patch with attached pocket for controlled heating device |
| KR20030083316A (ko) * | 2002-04-20 | 2003-10-30 | 김성수 | 인두의 국소마취를 위한 고형 리도케인 제제 |
| DK2117521T3 (da) | 2006-11-03 | 2012-09-03 | Durect Corp | Transdermale indgivelsessystemer omfattende bupivacain |
| JP5648174B2 (ja) | 2009-05-04 | 2015-01-07 | ヌボ リサーチ インコーポレイテッド | 神経腫、神経絞扼、および他の状態と関連する疼痛を処置する方法 |
| US9186334B2 (en) | 2009-05-04 | 2015-11-17 | Nuvo Research Inc. | Heat assisted lidocaine and tetracaine for transdermal analgesia |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB633062A (en) * | 1945-02-01 | 1949-12-12 | Benjamin Clayton | Improvements in or relating to ointment bases |
| GB948838A (en) * | 1961-12-04 | 1964-02-05 | Lucien Harnist | Hemorrhoidal compositions containing topical anesthetics |
| US3337406A (en) * | 1963-12-12 | 1967-08-22 | Mar Sal Inc | Treatment of arteriosclerotic diseases |
| SE387536B (sv) * | 1973-03-13 | 1976-09-13 | Astra Laekemedel Ab | Forfarande for framstellning av en lokalanestetisk beredning |
| DE2413143A1 (de) * | 1974-03-19 | 1975-10-09 | Inst Chimii Drevesiny Akademii | Arzneipraeparat mit lokalanaesthetischer wirkung |
| JPS5467022A (en) * | 1977-11-07 | 1979-05-30 | Toko Yakuhin Kogyo Kk | Topical agent and production thereof |
| SE7713618L (sv) * | 1977-12-01 | 1979-06-02 | Astra Laekemedel Ab | Lokalanestetisk blandning |
| DE3234350A1 (de) * | 1982-09-16 | 1984-03-22 | Roland 3400 Göttingen Hemmann | Verfahren zur herstellung eines keimtoetenden und oberflaechenanaesthesierenden heilmittels |
-
1984
- 1984-09-08 GB GB08422759A patent/GB2163956B/en not_active Expired
-
1985
- 1985-08-13 IS IS3035A patent/IS3035A7/is unknown
- 1985-08-14 IL IL76092A patent/IL76092A0/xx unknown
- 1985-08-16 IN IN643/MAS/85A patent/IN165072B/en unknown
- 1985-08-26 PH PH32693A patent/PH21731A/en unknown
- 1985-08-27 ZA ZA856501A patent/ZA856501B/xx unknown
- 1985-08-30 DE DE19853531002 patent/DE3531002A1/de not_active Withdrawn
- 1985-09-02 NZ NZ213325A patent/NZ213325A/xx unknown
- 1985-09-03 AU AU47006/85A patent/AU581246B2/en not_active Ceased
- 1985-09-03 PT PT81079A patent/PT81079B/pt not_active IP Right Cessation
- 1985-09-04 GR GR852142A patent/GR852142B/el unknown
- 1985-09-04 ZW ZW142/85A patent/ZW14285A1/xx unknown
- 1985-09-04 KR KR1019850006446A patent/KR860002267A/ko not_active Application Discontinuation
- 1985-09-04 LU LU86068A patent/LU86068A1/fr unknown
- 1985-09-05 CS CS856356A patent/CS261887B2/cs unknown
- 1985-09-05 EP EP85401721A patent/EP0175609B1/de not_active Expired - Lifetime
- 1985-09-05 DE DE8585401721T patent/DE3585580D1/de not_active Revoked
- 1985-09-05 IT IT48529/85A patent/IT1182854B/it active
- 1985-09-05 DD DD85280366A patent/DD236876A5/de unknown
- 1985-09-05 BE BE0/215548A patent/BE903186A/fr not_active IP Right Cessation
- 1985-09-05 ZM ZM61/85A patent/ZM6185A1/xx unknown
- 1985-09-05 AT AT85401721T patent/ATE73352T1/de not_active IP Right Cessation
- 1985-09-05 FR FR8513184A patent/FR2569982B1/fr not_active Expired
- 1985-09-06 MA MA20745A patent/MA20519A1/fr unknown
- 1985-09-06 CH CH3849/85A patent/CH666815A5/fr not_active IP Right Cessation
- 1985-09-06 NO NO853504A patent/NO853504L/no unknown
- 1985-09-06 PL PL25528585A patent/PL255285A1/xx unknown
- 1985-09-06 JP JP60197484A patent/JPS6185316A/ja active Pending
- 1985-09-06 OA OA58673A patent/OA08158A/xx unknown
- 1985-09-06 HU HU853378A patent/HU193611B/hu not_active IP Right Cessation
- 1985-09-06 FI FI853416A patent/FI853416L/fi not_active Application Discontinuation
- 1985-09-06 DK DK406785A patent/DK406785A/da unknown
Also Published As
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