CS635685A2 - Zpusob stabilizace vodneho prostredku obsahujiciho amethokain - Google Patents
Zpusob stabilizace vodneho prostredku obsahujiciho amethokainInfo
- Publication number
- CS635685A2 CS635685A2 CS856356A CS635685A CS635685A2 CS 635685 A2 CS635685 A2 CS 635685A2 CS 856356 A CS856356 A CS 856356A CS 635685 A CS635685 A CS 635685A CS 635685 A2 CS635685 A2 CS 635685A2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- vodneho
- stabilizace
- prostredku
- obsahujiciho
- amethokain
- Prior art date
Links
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 abstract 2
- 229960002372 tetracaine Drugs 0.000 abstract 2
- 206010002091 Anaesthesia Diseases 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 229920002125 Sokalan® Polymers 0.000 abstract 1
- 230000037005 anaesthesia Effects 0.000 abstract 1
- 238000001949 anaesthesia Methods 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 229920000609 methyl cellulose Polymers 0.000 abstract 1
- 239000001923 methylcellulose Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pipeline Systems (AREA)
- Vehicle Body Suspensions (AREA)
- Indication And Recording Devices For Special Purposes And Tariff Metering Devices (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
A composition for topical percutaneous anaesthesia comprises an anaesthetic e.g. amethocaine, dispersed in an aqueous gel e.g. methylcellulose or sodium carbopol and water. Amethocaine stability is enhanced by the gel matrix.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB08422759A GB2163956B (en) | 1984-09-08 | 1984-09-08 | Percutaneous anaesthetic composition for topical application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS635685A2 true CS635685A2 (en) | 1988-06-15 |
| CS261887B2 CS261887B2 (en) | 1989-02-10 |
Family
ID=10566481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS856356A CS261887B2 (en) | 1984-09-08 | 1985-09-05 | Method of amethocaine containing aqueous agent stabilization |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP0175609B1 (en) |
| JP (1) | JPS6185316A (en) |
| KR (1) | KR860002267A (en) |
| AT (1) | ATE73352T1 (en) |
| AU (1) | AU581246B2 (en) |
| BE (1) | BE903186A (en) |
| CH (1) | CH666815A5 (en) |
| CS (1) | CS261887B2 (en) |
| DD (1) | DD236876A5 (en) |
| DE (2) | DE3531002A1 (en) |
| DK (1) | DK406785A (en) |
| FI (1) | FI853416A7 (en) |
| FR (1) | FR2569982B1 (en) |
| GB (1) | GB2163956B (en) |
| GR (1) | GR852142B (en) |
| HU (1) | HU193611B (en) |
| IL (1) | IL76092A0 (en) |
| IN (1) | IN165072B (en) |
| IS (1) | IS3035A7 (en) |
| IT (1) | IT1182854B (en) |
| LU (1) | LU86068A1 (en) |
| MA (1) | MA20519A1 (en) |
| NO (1) | NO853504L (en) |
| NZ (1) | NZ213325A (en) |
| OA (1) | OA08158A (en) |
| PH (1) | PH21731A (en) |
| PL (1) | PL255285A1 (en) |
| PT (1) | PT81079B (en) |
| ZA (1) | ZA856501B (en) |
| ZM (1) | ZM6185A1 (en) |
| ZW (1) | ZW14285A1 (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8712518D0 (en) * | 1987-05-28 | 1987-07-01 | Univ Belfast | Unit-dose film composition |
| GB8729855D0 (en) * | 1987-12-22 | 1988-02-03 | Drythanol Ltd | New dithranol compositions |
| GB9101986D0 (en) * | 1991-01-30 | 1991-03-13 | Smith & Nephew | Pharmaceutical compositions |
| SE9402453D0 (en) * | 1994-07-12 | 1994-07-12 | Astra Ab | New pharmaceutical preparation |
| US6284266B1 (en) | 1995-07-28 | 2001-09-04 | Zars, Inc. | Methods and apparatus for improved administration of fentanyl and sufentanil |
| US5658583A (en) * | 1995-07-28 | 1997-08-19 | Zhang; Jie | Apparatus and methods for improved noninvasive dermal administration of pharmaceuticals |
| US6245347B1 (en) | 1995-07-28 | 2001-06-12 | Zars, Inc. | Methods and apparatus for improved administration of pharmaceutically active compounds |
| US6955819B2 (en) | 1998-09-29 | 2005-10-18 | Zars, Inc. | Methods and apparatus for using controlled heat to regulate transdermal and controlled release delivery of fentanyl, other analgesics, and other medical substances |
| US6453648B1 (en) | 1999-07-06 | 2002-09-24 | Zars, Inc. | Method for manufacturing a heat generating apparatus |
| US6261595B1 (en) | 2000-02-29 | 2001-07-17 | Zars, Inc. | Transdermal drug patch with attached pocket for controlled heating device |
| KR20030083316A (en) * | 2002-04-20 | 2003-10-30 | 김성수 | Solid lidocaine pharmaceutical for local anesthesia of pharynx |
| EP2117521B1 (en) | 2006-11-03 | 2012-06-27 | Durect Corporation | Transdermal delivery systems comprising bupivacaine |
| WO2010129542A1 (en) | 2009-05-04 | 2010-11-11 | Jie Zhang | Methods of treating pains associated with neuroma, nerve entrapment, and other conditions |
| US9186334B2 (en) | 2009-05-04 | 2015-11-17 | Nuvo Research Inc. | Heat assisted lidocaine and tetracaine for transdermal analgesia |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB633062A (en) * | 1945-02-01 | 1949-12-12 | Benjamin Clayton | Improvements in or relating to ointment bases |
| GB948838A (en) * | 1961-12-04 | 1964-02-05 | Lucien Harnist | Hemorrhoidal compositions containing topical anesthetics |
| US3337406A (en) * | 1963-12-12 | 1967-08-22 | Mar Sal Inc | Treatment of arteriosclerotic diseases |
| SE387536B (en) * | 1973-03-13 | 1976-09-13 | Astra Laekemedel Ab | PROCEDURE FOR PREPARING A LOCAL AESTHETIC PREPARATION |
| DE2413143A1 (en) * | 1974-03-19 | 1975-10-09 | Inst Chimii Drevesiny Akademii | Local anaesthetic soln or ointment - contains high molecular deriv of para-amino-benzoic acid 2-diethyl-amino ethyl ester hydrochloride |
| JPS5467022A (en) * | 1977-11-07 | 1979-05-30 | Toko Yakuhin Kogyo Kk | Topical agent and production thereof |
| SE7713618L (en) * | 1977-12-01 | 1979-06-02 | Astra Laekemedel Ab | LOCAL ANESTHETIC MIXTURE |
| DE3234350A1 (en) * | 1982-09-16 | 1984-03-22 | Roland 3400 Göttingen Hemmann | Process for the preparation of a germicidal and surface-anaesthetic medicinal composition |
-
1984
- 1984-09-08 GB GB08422759A patent/GB2163956B/en not_active Expired
-
1985
- 1985-08-13 IS IS3035A patent/IS3035A7/en unknown
- 1985-08-14 IL IL76092A patent/IL76092A0/en unknown
- 1985-08-16 IN IN643/MAS/85A patent/IN165072B/en unknown
- 1985-08-26 PH PH32693A patent/PH21731A/en unknown
- 1985-08-27 ZA ZA856501A patent/ZA856501B/en unknown
- 1985-08-30 DE DE19853531002 patent/DE3531002A1/en not_active Withdrawn
- 1985-09-02 NZ NZ213325A patent/NZ213325A/en unknown
- 1985-09-03 PT PT81079A patent/PT81079B/en not_active IP Right Cessation
- 1985-09-03 AU AU47006/85A patent/AU581246B2/en not_active Ceased
- 1985-09-04 KR KR1019850006446A patent/KR860002267A/en not_active Withdrawn
- 1985-09-04 ZW ZW142/85A patent/ZW14285A1/en unknown
- 1985-09-04 GR GR852142A patent/GR852142B/el unknown
- 1985-09-04 LU LU86068A patent/LU86068A1/en unknown
- 1985-09-05 EP EP85401721A patent/EP0175609B1/en not_active Expired - Lifetime
- 1985-09-05 IT IT48529/85A patent/IT1182854B/en active
- 1985-09-05 CS CS856356A patent/CS261887B2/en unknown
- 1985-09-05 DD DD85280366A patent/DD236876A5/en unknown
- 1985-09-05 BE BE0/215548A patent/BE903186A/en not_active IP Right Cessation
- 1985-09-05 FR FR8513184A patent/FR2569982B1/en not_active Expired
- 1985-09-05 AT AT85401721T patent/ATE73352T1/en not_active IP Right Cessation
- 1985-09-05 DE DE8585401721T patent/DE3585580D1/en not_active Revoked
- 1985-09-05 ZM ZM61/85A patent/ZM6185A1/en unknown
- 1985-09-06 CH CH3849/85A patent/CH666815A5/en not_active IP Right Cessation
- 1985-09-06 OA OA58673A patent/OA08158A/en unknown
- 1985-09-06 PL PL25528585A patent/PL255285A1/en unknown
- 1985-09-06 MA MA20745A patent/MA20519A1/en unknown
- 1985-09-06 DK DK406785A patent/DK406785A/en unknown
- 1985-09-06 FI FI853416A patent/FI853416A7/en not_active Application Discontinuation
- 1985-09-06 HU HU853378A patent/HU193611B/en not_active IP Right Cessation
- 1985-09-06 JP JP60197484A patent/JPS6185316A/en active Pending
- 1985-09-06 NO NO853504A patent/NO853504L/en unknown
Also Published As
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