GB2163956B - Percutaneous anaesthetic composition for topical application - Google Patents

Percutaneous anaesthetic composition for topical application

Info

Publication number
GB2163956B
GB2163956B GB08422759A GB8422759A GB2163956B GB 2163956 B GB2163956 B GB 2163956B GB 08422759 A GB08422759 A GB 08422759A GB 8422759 A GB8422759 A GB 8422759A GB 2163956 B GB2163956 B GB 2163956B
Authority
GB
United Kingdom
Prior art keywords
topical application
anaesthetic composition
percutaneous
composition
percutaneous anaesthetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08422759A
Other versions
GB8422759D0 (en
GB2163956A (en
Inventor
Aaron David Woolfson
Dermot Francis Mccafferty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Etudes Scientifiques Et Industrielles De L'ile-De France Ste
Original Assignee
Etudes Scientifiques Et Industrielles De L'ile-De France Ste
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10566481&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB2163956(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to GB08422759A priority Critical patent/GB2163956B/en
Application filed by Etudes Scientifiques Et Industrielles De L'ile-De France Ste filed Critical Etudes Scientifiques Et Industrielles De L'ile-De France Ste
Publication of GB8422759D0 publication Critical patent/GB8422759D0/en
Priority to IS3035A priority patent/IS3035A7/en
Priority to IL76092A priority patent/IL76092A0/en
Priority to IN643/MAS/85A priority patent/IN165072B/en
Priority to PH32693A priority patent/PH21731A/en
Priority to ZA856501A priority patent/ZA856501B/en
Priority to DE19853531002 priority patent/DE3531002A1/en
Priority to NZ213325A priority patent/NZ213325A/en
Priority to PT81079A priority patent/PT81079B/en
Priority to AU47006/85A priority patent/AU581246B2/en
Priority to KR1019850006446A priority patent/KR860002267A/en
Priority to ZW142/85A priority patent/ZW14285A1/en
Priority to LU86068A priority patent/LU86068A1/en
Priority to GR852142A priority patent/GR852142B/el
Priority to EP85401721A priority patent/EP0175609B1/en
Priority to DD85280366A priority patent/DD236876A5/en
Priority to CS856356A priority patent/CS261887B2/en
Priority to FR8513184A priority patent/FR2569982B1/en
Priority to AT85401721T priority patent/ATE73352T1/en
Priority to DE8585401721T priority patent/DE3585580D1/en
Priority to IT48529/85A priority patent/IT1182854B/en
Priority to ZM61/85A priority patent/ZM6185A1/en
Priority to BE0/215548A priority patent/BE903186A/en
Priority to MA20745A priority patent/MA20519A1/en
Priority to HU853378A priority patent/HU193611B/en
Priority to OA58673A priority patent/OA08158A/en
Priority to NO853504A priority patent/NO853504L/en
Priority to DK406785A priority patent/DK406785A/en
Priority to PL25528585A priority patent/PL255285A1/en
Priority to CH3849/85A priority patent/CH666815A5/en
Priority to JP60197484A priority patent/JPS6185316A/en
Priority to FI853416A priority patent/FI853416L/en
Publication of GB2163956A publication Critical patent/GB2163956A/en
Publication of GB2163956B publication Critical patent/GB2163956B/en
Application granted granted Critical
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Abstract

A composition for topical percutaneous anaesthesia comprises an anaesthetic e.g. amethocaine, dispersed in an aqueous gel e.g. methylcellulose or sodium carbopol and water. Amethocaine stability is enhanced by the gel matrix.
GB08422759A 1984-09-08 1984-09-08 Percutaneous anaesthetic composition for topical application Expired GB2163956B (en)

Priority Applications (32)

Application Number Priority Date Filing Date Title
GB08422759A GB2163956B (en) 1984-09-08 1984-09-08 Percutaneous anaesthetic composition for topical application
IS3035A IS3035A7 (en) 1984-09-08 1985-08-13 Chemical composition for topical anesthesia and method of preparation.
IL76092A IL76092A0 (en) 1984-09-08 1985-08-14 Percutaneous anaesthetic composition for topical application and its preparation
IN643/MAS/85A IN165072B (en) 1984-09-08 1985-08-16
PH32693A PH21731A (en) 1984-09-08 1985-08-26 Percutaneous anaesthetic composition for topical application and associated method
ZA856501A ZA856501B (en) 1984-09-08 1985-08-27 Percutaneous anaestic composition for topical application and associated method
DE19853531002 DE3531002A1 (en) 1984-09-08 1985-08-30 TOPICAL, PERCUTANEAN, ANESTHETIC COMPOSITION
NZ213325A NZ213325A (en) 1984-09-08 1985-09-02 Topical percutaneous anaesthetic containing gelling agent
PT81079A PT81079B (en) 1984-09-08 1985-09-03 A process for the preparation of a composition containing 2-dimethylaminopyridine (ametocain) -butylamine benzoate for percutaneous nesthesia for topical use.
AU47006/85A AU581246B2 (en) 1984-09-08 1985-09-03 Percutaneous anaesthetic composition for topical application and associated method
KR1019850006446A KR860002267A (en) 1984-09-08 1985-09-04 Method of producing topical transdermal anesthetic composition
ZW142/85A ZW14285A1 (en) 1984-09-08 1985-09-04 Percutaneous anaesthetic composition for topical application and associated method
LU86068A LU86068A1 (en) 1984-09-08 1985-09-04 PERCUTANEOUS ANESTHETIC COMPOSITION FOR TOPICAL USE AND METHOD OF APPLICATION
GR852142A GR852142B (en) 1984-09-08 1985-09-04
BE0/215548A BE903186A (en) 1984-09-08 1985-09-05 PERCUTANEOUS ANESTHETIC COMPOSITION FOR TOPICAL USE AND METHOD OF APPLICATION
DD85280366A DD236876A5 (en) 1984-09-08 1985-09-05 METHOD FOR PRODUCING A PERCUTANEOUS ANESTHETIC COMPOSITION
EP85401721A EP0175609B1 (en) 1984-09-08 1985-09-05 Transdermal anaesthetic composition for topical use and process for its application
CS856356A CS261887B2 (en) 1984-09-08 1985-09-05 Method of amethocaine containing aqueous agent stabilization
FR8513184A FR2569982B1 (en) 1984-09-08 1985-09-05 PERCUTANEOUS ANESTHETIC COMPOSITION FOR TOPICAL USE AND PREPARATION METHOD THEREOF
AT85401721T ATE73352T1 (en) 1984-09-08 1985-09-05 TRANSDERMAL ANESTHETICAL FOR TOPICAL USE AND METHODS OF ADMINISTRATION.
DE8585401721T DE3585580D1 (en) 1984-09-08 1985-09-05 TRANSDERMAL ANESTHETIC FOR LOCAL USE AND METHOD FOR USE THEREOF.
IT48529/85A IT1182854B (en) 1984-09-08 1985-09-05 PERCUTANEOUS ANESTHESIC COMPOSITION FOR TOPICAL USE AND APPLICATION PROCEDURE
ZM61/85A ZM6185A1 (en) 1984-09-08 1985-09-05 Percutaneous anaesthetic composition for tropical application and associated method
FI853416A FI853416L (en) 1984-09-08 1985-09-06 FOERFARANDE FOER FRAMSTAELLNING AV EN PERKUTANISK ANESTETISK KOMPOSITION FOER LOKAL APPLIKATION.
OA58673A OA08158A (en) 1984-09-08 1985-09-06 Percutaneous anesthetic composition for topical use and method of application.
HU853378A HU193611B (en) 1984-09-08 1985-09-06 Process for producing local anaesthetic compositions absorbing through the leather
MA20745A MA20519A1 (en) 1984-09-08 1985-09-06 PERCUTANEOUS ANESTHETIC COMPOSITION FOR TROPICAL USE AND METHOD OF APPLICATION
NO853504A NO853504L (en) 1984-09-08 1985-09-06 PROCEDURE FOR PREPARING A PERCUTANT ANAESTHETIC PREPARATION.
DK406785A DK406785A (en) 1984-09-08 1985-09-06 PERCUTANT EFFECTIVE LOCAL ANESTHETIC PREPARATION AND PROCEDURE FOR PREPARING THEREOF
PL25528585A PL255285A1 (en) 1984-09-08 1985-09-06 Method of obtaining an anaesthetic composition capable of acting through skin
CH3849/85A CH666815A5 (en) 1984-09-08 1985-09-06 PERCUTANEOUS ANESTHETIC COMPOSITION FOR TOPICAL USE.
JP60197484A JPS6185316A (en) 1984-09-08 1985-09-06 Percutaneous anesthetic composition for local application

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB08422759A GB2163956B (en) 1984-09-08 1984-09-08 Percutaneous anaesthetic composition for topical application

Publications (3)

Publication Number Publication Date
GB8422759D0 GB8422759D0 (en) 1984-10-10
GB2163956A GB2163956A (en) 1986-03-12
GB2163956B true GB2163956B (en) 1988-03-30

Family

ID=10566481

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08422759A Expired GB2163956B (en) 1984-09-08 1984-09-08 Percutaneous anaesthetic composition for topical application

Country Status (31)

Country Link
EP (1) EP0175609B1 (en)
JP (1) JPS6185316A (en)
KR (1) KR860002267A (en)
AT (1) ATE73352T1 (en)
AU (1) AU581246B2 (en)
BE (1) BE903186A (en)
CH (1) CH666815A5 (en)
CS (1) CS261887B2 (en)
DD (1) DD236876A5 (en)
DE (2) DE3531002A1 (en)
DK (1) DK406785A (en)
FI (1) FI853416L (en)
FR (1) FR2569982B1 (en)
GB (1) GB2163956B (en)
GR (1) GR852142B (en)
HU (1) HU193611B (en)
IL (1) IL76092A0 (en)
IN (1) IN165072B (en)
IS (1) IS3035A7 (en)
IT (1) IT1182854B (en)
LU (1) LU86068A1 (en)
MA (1) MA20519A1 (en)
NO (1) NO853504L (en)
NZ (1) NZ213325A (en)
OA (1) OA08158A (en)
PH (1) PH21731A (en)
PL (1) PL255285A1 (en)
PT (1) PT81079B (en)
ZA (1) ZA856501B (en)
ZM (1) ZM6185A1 (en)
ZW (1) ZW14285A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8956644B2 (en) 2006-11-03 2015-02-17 Durect Corporation Transdermal delivery systems
US9186273B2 (en) 2009-05-04 2015-11-17 Nuvo Research Inc. Methods of treating pains associated with neuroma, nerve entrapment, and other conditions
US9186334B2 (en) 2009-05-04 2015-11-17 Nuvo Research Inc. Heat assisted lidocaine and tetracaine for transdermal analgesia

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8712518D0 (en) * 1987-05-28 1987-07-01 Univ Belfast Unit-dose film composition
GB8729855D0 (en) * 1987-12-22 1988-02-03 Drythanol Ltd New dithranol compositions
GB9101986D0 (en) * 1991-01-30 1991-03-13 Smith & Nephew Pharmaceutical compositions
SE9402453D0 (en) * 1994-07-12 1994-07-12 Astra Ab New pharmaceutical preparation
US6245347B1 (en) 1995-07-28 2001-06-12 Zars, Inc. Methods and apparatus for improved administration of pharmaceutically active compounds
US6284266B1 (en) 1995-07-28 2001-09-04 Zars, Inc. Methods and apparatus for improved administration of fentanyl and sufentanil
US5658583A (en) 1995-07-28 1997-08-19 Zhang; Jie Apparatus and methods for improved noninvasive dermal administration of pharmaceuticals
US6955819B2 (en) 1998-09-29 2005-10-18 Zars, Inc. Methods and apparatus for using controlled heat to regulate transdermal and controlled release delivery of fentanyl, other analgesics, and other medical substances
US6453648B1 (en) 1999-07-06 2002-09-24 Zars, Inc. Method for manufacturing a heat generating apparatus
US6261595B1 (en) 2000-02-29 2001-07-17 Zars, Inc. Transdermal drug patch with attached pocket for controlled heating device
KR20030083316A (en) * 2002-04-20 2003-10-30 김성수 Solid lidocaine pharmaceutical for local anesthesia of pharynx

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB633062A (en) * 1945-02-01 1949-12-12 Benjamin Clayton Improvements in or relating to ointment bases
GB948838A (en) * 1961-12-04 1964-02-05 Lucien Harnist Hemorrhoidal compositions containing topical anesthetics
US3337406A (en) * 1963-12-12 1967-08-22 Mar Sal Inc Treatment of arteriosclerotic diseases
SE387536B (en) * 1973-03-13 1976-09-13 Astra Laekemedel Ab PROCEDURE FOR PREPARING A LOCAL AESTHETIC PREPARATION
DE2413143A1 (en) * 1974-03-19 1975-10-09 Inst Chimii Drevesiny Akademii Local anaesthetic soln or ointment - contains high molecular deriv of para-amino-benzoic acid 2-diethyl-amino ethyl ester hydrochloride
JPS5467022A (en) * 1977-11-07 1979-05-30 Toko Yakuhin Kogyo Kk Topical agent and production thereof
SE7713618L (en) * 1977-12-01 1979-06-02 Astra Laekemedel Ab LOCAL ANESTHETIC MIXTURE
DE3234350A1 (en) * 1982-09-16 1984-03-22 Roland 3400 Göttingen Hemmann Process for the preparation of a germicidal and surface-anaesthetic medicinal composition

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8956644B2 (en) 2006-11-03 2015-02-17 Durect Corporation Transdermal delivery systems
US9186273B2 (en) 2009-05-04 2015-11-17 Nuvo Research Inc. Methods of treating pains associated with neuroma, nerve entrapment, and other conditions
US9186334B2 (en) 2009-05-04 2015-11-17 Nuvo Research Inc. Heat assisted lidocaine and tetracaine for transdermal analgesia

Also Published As

Publication number Publication date
AU581246B2 (en) 1989-02-16
CS635685A2 (en) 1988-06-15
IT1182854B (en) 1987-10-05
LU86068A1 (en) 1986-03-11
IS3035A7 (en) 1986-03-09
DD236876A5 (en) 1986-06-25
ZW14285A1 (en) 1986-01-29
PT81079A (en) 1985-10-01
DK406785A (en) 1986-03-09
EP0175609A2 (en) 1986-03-26
ATE73352T1 (en) 1992-03-15
FI853416A0 (en) 1985-09-06
IN165072B (en) 1989-08-12
MA20519A1 (en) 1986-04-01
NO853504L (en) 1986-03-10
GB8422759D0 (en) 1984-10-10
FR2569982B1 (en) 1988-03-25
GB2163956A (en) 1986-03-12
CH666815A5 (en) 1988-08-31
ZA856501B (en) 1986-05-28
OA08158A (en) 1987-03-31
BE903186A (en) 1986-03-05
AU4700685A (en) 1986-03-13
JPS6185316A (en) 1986-04-30
CS261887B2 (en) 1989-02-10
FI853416L (en) 1986-03-09
DE3585580D1 (en) 1992-04-16
ZM6185A1 (en) 1986-01-23
DK406785D0 (en) 1985-09-06
IT8548529A0 (en) 1985-09-05
DE3531002A1 (en) 1986-03-20
KR860002267A (en) 1986-04-24
NZ213325A (en) 1989-06-28
FR2569982A1 (en) 1986-03-14
IL76092A0 (en) 1985-12-31
EP0175609A3 (en) 1987-01-28
PT81079B (en) 1987-10-20
GR852142B (en) 1985-12-24
PH21731A (en) 1988-02-10
HU193611B (en) 1987-11-30
EP0175609B1 (en) 1992-03-11
PL255285A1 (en) 1988-03-31
HUT39360A (en) 1986-09-29

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Legal Events

Date Code Title Description
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20020908