NO851160L - Fremgangsmaate for fremstilling av cyklosporiner - Google Patents
Fremgangsmaate for fremstilling av cyklosporinerInfo
- Publication number
- NO851160L NO851160L NO851160A NO851160A NO851160L NO 851160 L NO851160 L NO 851160L NO 851160 A NO851160 A NO 851160A NO 851160 A NO851160 A NO 851160A NO 851160 L NO851160 L NO 851160L
- Authority
- NO
- Norway
- Prior art keywords
- nva
- cyclosporine
- val
- mebmt
- ser
- Prior art date
Links
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- 238000000034 method Methods 0.000 title claims description 35
- 238000002360 preparation method Methods 0.000 title claims description 9
- 108010036941 Cyclosporins Proteins 0.000 title description 52
- 229960001265 ciclosporin Drugs 0.000 claims description 136
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims description 72
- 108010036949 Cyclosporine Proteins 0.000 claims description 70
- 229930105110 Cyclosporin A Natural products 0.000 claims description 29
- 125000000539 amino acid group Chemical group 0.000 claims description 17
- 238000004519 manufacturing process Methods 0.000 claims description 11
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- 239000001257 hydrogen Substances 0.000 claims description 9
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/19—Antibiotic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848407618A GB8407618D0 (en) | 1984-03-23 | 1984-03-23 | Organic compounds |
| GB848411922A GB8411922D0 (en) | 1984-05-10 | 1984-05-10 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO851160L true NO851160L (no) | 1985-09-24 |
Family
ID=26287502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO851160A NO851160L (no) | 1984-03-23 | 1985-03-22 | Fremgangsmaate for fremstilling av cyklosporiner |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4639434A (es) |
| JP (1) | JPH08838B2 (es) |
| AT (1) | AT388737B (es) |
| BE (1) | BE901980A (es) |
| CA (1) | CA1247546A (es) |
| CH (1) | CH667274A5 (es) |
| CS (1) | CS249542B2 (es) |
| DE (1) | DE3509809A1 (es) |
| DK (1) | DK128285A (es) |
| ES (1) | ES8702926A1 (es) |
| FI (1) | FI851120L (es) |
| FR (1) | FR2561651B1 (es) |
| GB (1) | GB2155936B (es) |
| GR (1) | GR850716B (es) |
| HU (1) | HU200786B (es) |
| IL (1) | IL74681A (es) |
| IT (1) | IT1199962B (es) |
| LU (1) | LU85819A1 (es) |
| NL (1) | NL8500828A (es) |
| NO (1) | NO851160L (es) |
| NZ (1) | NZ211526A (es) |
| PH (2) | PH21868A (es) |
| PT (1) | PT80149B (es) |
| SE (1) | SE461334B (es) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0314861A1 (en) | 1984-10-04 | 1989-05-10 | Sandoz Ag | Labeled derivatives of cyclosporins |
| US4798823A (en) * | 1987-06-03 | 1989-01-17 | Merck & Co., Inc. | New cyclosporin analogs with modified "C-9 amino acids" |
| DE3884470T2 (de) * | 1987-06-17 | 1994-03-10 | Sandoz Ag | Cyclosporine und deren Benutzung als Arzneimittel. |
| DE3888357T2 (de) * | 1987-06-22 | 1994-09-15 | Merck & Co Inc | Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen. |
| US5227467A (en) * | 1987-08-03 | 1993-07-13 | Merck & Co., Inc. | Immunosuppressive fluorinated cyclosporin analogs |
| KR920003601B1 (ko) * | 1987-09-03 | 1992-05-04 | 유니버시티 어브 죠지아 리서취 화운데이션 인코포레이티드 | 점안 싸이클로스포린(cyclosporin)의 조성물 |
| US4839342A (en) * | 1987-09-03 | 1989-06-13 | University Of Georgia Research Foundation, Inc. | Method of increasing tear production by topical administration of cyclosporin |
| US5089390A (en) * | 1987-09-04 | 1992-02-18 | Syntex (U.S.A.) Inc. | 2-methyl-4-hexene- and 2-methyl-4-heptene-1,2-diol derivatives |
| US4914188A (en) * | 1987-11-16 | 1990-04-03 | Merck & Co., Inc. | Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin |
| US5236899A (en) * | 1987-11-16 | 1993-08-17 | Merck & Co., Inc. | 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance |
| CH679119A5 (es) * | 1988-05-13 | 1991-12-31 | Sandoz Ag | |
| US5540931A (en) * | 1989-03-03 | 1996-07-30 | Charles W. Hewitt | Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants |
| US4996193A (en) * | 1989-03-03 | 1991-02-26 | The Regents Of The University Of California | Combined topical and systemic method of administration of cyclosporine |
| GB8916901D0 (en) | 1989-07-24 | 1989-09-06 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US5122511A (en) * | 1990-02-27 | 1992-06-16 | Merck & Co., Inc. | Immunosuppressive cyclosporin analogs with modified amino acids at position-8 |
| US5202310A (en) * | 1990-06-06 | 1993-04-13 | Levy Gary A | Cyclosporine metabolites |
| EP0484281B2 (en) | 1990-11-02 | 2000-11-22 | Novartis AG | Cyclosporins |
| DE69133095T2 (de) * | 1990-11-20 | 2003-03-27 | Dade Behring Marburg Gmbh | Cyclosporin-Immunoassay |
| US5747330A (en) * | 1996-06-05 | 1998-05-05 | Poli Industria Chimica | Antibiotic producing microbe |
| US20030220234A1 (en) * | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
| ATE314388T1 (de) | 1997-10-08 | 2006-01-15 | Isotechnika Inc | Deuterierte und undeuterierte cyclosporin-analoga und ihre verwendung als immunmodulierende agentien |
| US5990274A (en) | 1997-11-25 | 1999-11-23 | Dade Behring Inc. | Cyclosporine derivatives and uses thereof |
| US7449544B2 (en) * | 1999-11-30 | 2008-11-11 | Cyclacel Limited | p21 peptides |
| JP2005506990A (ja) * | 2001-10-19 | 2005-03-10 | アイソテクニカ インコーポレーテッド | 新規のシクロスポリン類似体のマイクロエマルションプレコンセントレート |
| ES2326040T3 (es) * | 2001-10-19 | 2009-09-29 | Isotechnika Inc. | Sintesis de analogos de ciclosporina. |
| WO2004082629A2 (en) * | 2003-03-17 | 2004-09-30 | Albany Molecular Research, Inc. | Novel cyclosporins |
| US7378391B2 (en) * | 2004-09-29 | 2008-05-27 | Amr Technology, Inc. | Cyclosporin alkyne analogues and their pharmaceutical uses |
| WO2006039164A2 (en) * | 2004-09-29 | 2006-04-13 | Amr Technology, Inc. | Novel cyclosporin analogues and their pharmaceutical uses |
| WO2006041631A2 (en) * | 2004-10-06 | 2006-04-20 | Amr Technology, Inc. | Novel cyclosporin alkynes and their utility as pharmaceutical agents |
| US7696165B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
| US7696166B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
| WO2008069917A2 (en) | 2006-11-20 | 2008-06-12 | Scynexis, Inc. | Novel cyclic peptides |
| RU2630690C9 (ru) | 2010-12-15 | 2017-12-28 | КонтраВир Фармасьютикалз, Инк. | МОЛЕКУЛЫ АНАЛОГОВ ЦИКЛОСПОРИНА, МОДИФИЦИРОВАННЫЕ ПО 1 и 3 АМИНОКИСЛОТЕ |
| AU2012229236B2 (en) | 2011-03-11 | 2017-05-18 | Beth Israel Deaconess Medical Center, Inc. | Anti-CD40 antibodies and uses thereof |
| CN104877013B (zh) * | 2015-06-03 | 2018-04-20 | 兰州大学 | 环孢菌素t及其制备方法和应用 |
| AU2016315873B2 (en) | 2015-09-04 | 2022-08-18 | Primatope Therapeutics Inc. | Humanized anti-CD40 antibodies and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57140753A (en) * | 1981-01-09 | 1982-08-31 | Sandoz Ag | Novel cyclosporine |
| DE3260468D1 (en) * | 1981-01-09 | 1984-09-06 | Sandoz Ag | Novel cyclosporins |
-
1985
- 1985-03-18 CH CH1194/85A patent/CH667274A5/de not_active IP Right Cessation
- 1985-03-19 FR FR858504172A patent/FR2561651B1/fr not_active Expired - Lifetime
- 1985-03-19 DE DE19853509809 patent/DE3509809A1/de not_active Ceased
- 1985-03-19 US US06/713,429 patent/US4639434A/en not_active Expired - Fee Related
- 1985-03-20 FI FI851120A patent/FI851120L/fi not_active Application Discontinuation
- 1985-03-20 GB GB08507270A patent/GB2155936B/en not_active Expired
- 1985-03-20 PH PH32013A patent/PH21868A/en unknown
- 1985-03-20 PH PH32014A patent/PH23357A/en unknown
- 1985-03-21 CA CA000477127A patent/CA1247546A/en not_active Expired
- 1985-03-21 ES ES541465A patent/ES8702926A1/es not_active Expired
- 1985-03-21 LU LU85819A patent/LU85819A1/fr unknown
- 1985-03-21 IL IL74681A patent/IL74681A/xx unknown
- 1985-03-21 NL NL8500828A patent/NL8500828A/nl not_active Application Discontinuation
- 1985-03-21 PT PT80149A patent/PT80149B/pt not_active IP Right Cessation
- 1985-03-21 DK DK128285A patent/DK128285A/da not_active Application Discontinuation
- 1985-03-21 GR GR850716A patent/GR850716B/el unknown
- 1985-03-21 HU HU851045A patent/HU200786B/hu not_active IP Right Cessation
- 1985-03-21 BE BE1/011217A patent/BE901980A/fr not_active IP Right Cessation
- 1985-03-21 SE SE8501392A patent/SE461334B/sv not_active IP Right Cessation
- 1985-03-21 NZ NZ211526A patent/NZ211526A/xx unknown
- 1985-03-22 JP JP60059339A patent/JPH08838B2/ja not_active Expired - Lifetime
- 1985-03-22 IT IT47852/85A patent/IT1199962B/it active
- 1985-03-22 AT AT0086385A patent/AT388737B/de not_active IP Right Cessation
- 1985-03-22 NO NO851160A patent/NO851160L/no unknown
- 1985-03-23 CS CS852132A patent/CS249542B2/cs unknown
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