NO851083L - Farmasoeytisk blanding inneholdende tetracyklin- eller doksycyklin-salter og fremgangsmaate til fremstilling av en slik blanding - Google Patents
Farmasoeytisk blanding inneholdende tetracyklin- eller doksycyklin-salter og fremgangsmaate til fremstilling av en slik blandingInfo
- Publication number
- NO851083L NO851083L NO851083A NO851083A NO851083L NO 851083 L NO851083 L NO 851083L NO 851083 A NO851083 A NO 851083A NO 851083 A NO851083 A NO 851083A NO 851083 L NO851083 L NO 851083L
- Authority
- NO
- Norway
- Prior art keywords
- doxycycline
- mixture
- salts
- pharmaceutical
- preparing
- Prior art date
Links
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical class C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 title claims description 15
- 239000004098 Tetracycline Substances 0.000 title claims description 10
- 229960002180 tetracycline Drugs 0.000 title claims description 10
- 229930101283 tetracycline Natural products 0.000 title claims description 10
- 235000019364 tetracycline Nutrition 0.000 title claims description 10
- 150000003522 tetracyclines Chemical class 0.000 title claims description 10
- 239000000203 mixture Substances 0.000 title claims description 9
- 238000000034 method Methods 0.000 title claims description 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 12
- 239000000126 substance Substances 0.000 claims description 9
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 6
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 description 11
- 229960003722 doxycycline Drugs 0.000 description 6
- 210000003238 esophagus Anatomy 0.000 description 6
- 208000025865 Ulcer Diseases 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 235000019983 sodium metaphosphate Nutrition 0.000 description 3
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 230000036269 ulceration Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 235000019890 Amylum Nutrition 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- PAZJSJFMUHDSTF-UHFFFAOYSA-N alprenolol Chemical compound CC(C)NCC(O)COC1=CC=CC=C1CC=C PAZJSJFMUHDSTF-UHFFFAOYSA-N 0.000 description 1
- 229960002213 alprenolol Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000008119 colloidal silica Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 159000000014 iron salts Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL8400911A NL8400911A (nl) | 1984-03-22 | 1984-03-22 | Werkwijze ter bereiding van een farmaceutische toedieningsvorm die tetracycline of doxycyclinezouten bevat. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO851083L true NO851083L (no) | 1985-09-23 |
Family
ID=19843689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO851083A NO851083L (no) | 1984-03-22 | 1985-03-19 | Farmasoeytisk blanding inneholdende tetracyklin- eller doksycyklin-salter og fremgangsmaate til fremstilling av en slik blanding |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0159735A1 (de) |
| JP (1) | JPS60226812A (de) |
| AU (1) | AU4028485A (de) |
| DK (1) | DK128485A (de) |
| FI (1) | FI851134L (de) |
| GR (1) | GR850682B (de) |
| IL (1) | IL74683A0 (de) |
| NL (1) | NL8400911A (de) |
| NO (1) | NO851083L (de) |
| PT (1) | PT80138B (de) |
| ZA (1) | ZA852127B (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6396126A (ja) * | 1986-10-13 | 1988-04-27 | Taisho Pharmaceut Co Ltd | 安定化組成物 |
| ES2061623T3 (es) * | 1987-03-02 | 1994-12-16 | Brocades Pharma Bv | Procedimiento para la obtencion de una composicion farmaceutica y un granulado farmaceutico. |
| US5211958A (en) * | 1987-11-30 | 1993-05-18 | Gist-Brocades, N.V. | Pharmaceutical composition and process for its preparation |
| ATE72118T1 (de) * | 1987-11-30 | 1992-02-15 | Gist Brocades Nv | Pharmazeutische zusammensetzung und verfahren zu ihrer herstellung. |
| ATE108996T1 (de) * | 1988-02-25 | 1994-08-15 | Brocades Pharma Bv | Verfahren zur herstellung eines pharmazeutischen granulats. |
| CA2061520C (en) * | 1991-03-27 | 2003-04-22 | Lawrence J. Daher | Delivery system for enhanced onset and increased potency |
| CN1686145B (zh) * | 2005-04-12 | 2011-03-16 | 珠海天翼医药技术开发有限公司 | 一种多西环素口腔粘附片 |
| JP6441890B2 (ja) | 2013-03-15 | 2018-12-19 | ブレインツリー・ラボラトリーズ，インコーポレイテッド | 硫酸塩の両用経口薬学的組成物錠剤およびその使用の方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA982478A (en) * | 1971-04-12 | 1976-01-27 | Jerome Berk | Orally administered drug composition for therapy in the treatment of narcotic drug addiction |
| US4063307A (en) * | 1976-06-28 | 1977-12-13 | Teletype Corporation | Direct current power converter with start-up and protection circuits |
| SE8103843L (sv) * | 1981-06-18 | 1982-12-19 | Astra Laekemedel Ab | Farmaceutisk mixtur |
-
1984
- 1984-03-22 NL NL8400911A patent/NL8400911A/nl not_active Application Discontinuation
-
1985
- 1985-03-15 EP EP85200391A patent/EP0159735A1/de not_active Withdrawn
- 1985-03-19 GR GR850682A patent/GR850682B/el unknown
- 1985-03-19 NO NO851083A patent/NO851083L/no unknown
- 1985-03-20 JP JP60056267A patent/JPS60226812A/ja active Pending
- 1985-03-21 FI FI851134A patent/FI851134L/fi not_active Application Discontinuation
- 1985-03-21 DK DK128485A patent/DK128485A/da unknown
- 1985-03-21 PT PT80138A patent/PT80138B/pt unknown
- 1985-03-21 IL IL74683A patent/IL74683A0/xx unknown
- 1985-03-21 ZA ZA852127A patent/ZA852127B/xx unknown
- 1985-03-22 AU AU40284/85A patent/AU4028485A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL74683A0 (en) | 1985-06-30 |
| DK128485A (da) | 1985-09-23 |
| FI851134L (fi) | 1985-09-23 |
| PT80138A (en) | 1985-04-01 |
| EP0159735A1 (de) | 1985-10-30 |
| FI851134A0 (fi) | 1985-03-21 |
| GR850682B (de) | 1985-07-05 |
| JPS60226812A (ja) | 1985-11-12 |
| ZA852127B (en) | 1985-11-27 |
| PT80138B (en) | 1986-11-14 |
| NL8400911A (nl) | 1985-10-16 |
| AU4028485A (en) | 1985-09-26 |
| DK128485D0 (da) | 1985-03-21 |
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