NO843773L - Fremgangsmaate for fremstilling av en inneslutningsforbindelse av 2-nitroksymetyl-6-klorpyridin - Google Patents
Fremgangsmaate for fremstilling av en inneslutningsforbindelse av 2-nitroksymetyl-6-klorpyridinInfo
- Publication number
- NO843773L NO843773L NO843773A NO843773A NO843773L NO 843773 L NO843773 L NO 843773L NO 843773 A NO843773 A NO 843773A NO 843773 A NO843773 A NO 843773A NO 843773 L NO843773 L NO 843773L
- Authority
- NO
- Norway
- Prior art keywords
- nitroxymethyl
- chloropyridine
- cyclodextrin
- occlusion
- compound
- Prior art date
Links
- KLKMRHCMLLGCSZ-UHFFFAOYSA-N (6-chloropyridin-2-yl)methyl nitrate Chemical compound [O-][N+](=O)OCC1=CC=CC(Cl)=N1 KLKMRHCMLLGCSZ-UHFFFAOYSA-N 0.000 title claims description 22
- 150000001875 compounds Chemical class 0.000 title claims description 21
- 238000000034 method Methods 0.000 title claims description 9
- 229920000858 Cyclodextrin Polymers 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 238000000862 absorption spectrum Methods 0.000 claims description 4
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 230000009102 absorption Effects 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 230000000704 physical effect Effects 0.000 claims description 2
- 239000002904 solvent Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 3
- 239000001116 FEMA 4028 Substances 0.000 description 2
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 2
- 235000011175 beta-cyclodextrine Nutrition 0.000 description 2
- 229960004853 betadex Drugs 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medical Informatics (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Cardiology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58190345A JPS6081166A (ja) | 1983-10-11 | 1983-10-11 | ２−ニトロオキシメチル−６−クロロピリジンのβ−シクロデキストリン包接化合物およびその製造法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO843773L true NO843773L (no) | 1985-04-12 |
Family
ID=16256648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO843773A NO843773L (no) | 1983-10-11 | 1984-09-20 | Fremgangsmaate for fremstilling av en inneslutningsforbindelse av 2-nitroksymetyl-6-klorpyridin |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4575548A (xx) |
| EP (1) | EP0141300A3 (xx) |
| JP (1) | JPS6081166A (xx) |
| KR (1) | KR850003414A (xx) |
| CN (1) | CN85102133A (xx) |
| AU (1) | AU576521B2 (xx) |
| CA (1) | CA1248523A (xx) |
| DK (1) | DK461184A (xx) |
| ES (1) | ES536654A0 (xx) |
| FI (1) | FI843944L (xx) |
| GR (1) | GR80531B (xx) |
| HU (1) | HU194285B (xx) |
| IL (1) | IL73076A (xx) |
| NO (1) | NO843773L (xx) |
| OA (1) | OA07832A (xx) |
| PH (1) | PH20203A (xx) |
| PT (1) | PT79320B (xx) |
| ZA (1) | ZA847350B (xx) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6034156A (ja) * | 1983-08-08 | 1985-02-21 | Hayashibara Biochem Lab Inc | エイコサペンタエン酸包接化合物及びこれを含有した飲食物 |
| JPS60202115A (ja) * | 1984-03-27 | 1985-10-12 | Ichiro Shibauchi | エポキシ樹脂用硬化剤 |
| ZA885069B (en) * | 1987-07-24 | 1989-03-29 | Fujisawa Pharmaceutical Co | Sustained-release percutaneous preparations |
| US5017566A (en) * | 1987-12-30 | 1991-05-21 | University Of Florida | Redox systems for brain-targeted drug delivery |
| US5002935A (en) * | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| CA1321192C (en) * | 1988-04-20 | 1993-08-10 | Abdul Majid | Inclusion complexes of cyclodextrins by agglomeration |
| US5997856A (en) * | 1988-10-05 | 1999-12-07 | Chiron Corporation | Method and compositions for solubilization and stabilization of polypeptides, especially proteins |
| US20040014695A1 (en) * | 1992-06-19 | 2004-01-22 | Supergen, Inc. | Pharmaceutical formulation |
| US5602112A (en) | 1992-06-19 | 1997-02-11 | Supergen, Inc. | Pharmaceutical formulation |
| US5824668A (en) * | 1996-11-07 | 1998-10-20 | Supergen, Inc. | Formulation for administration of steroid compounds |
| EP1176792A1 (en) * | 2000-07-24 | 2002-01-30 | Alcatel | Method and apparatus for providing an all digital loop with power-optimised mode |
| US20070009532A1 (en) * | 2005-07-06 | 2007-01-11 | Branimir Sikic | Treatment of patients with cancer using a calicheamicin-antibody conjugate in combination with zosuquidar |
| US20070010485A1 (en) * | 2005-07-06 | 2007-01-11 | Jeff Schwegman | Chemotherapeutic formulations of zosuquidar trihydrochloride and modified cyclodextrins |
| US20070010487A1 (en) * | 2005-07-06 | 2007-01-11 | Jeff Schwegman | Chemotherapeutic formulations of zosuquidar trihydrochloride and modified cyclodextrins |
| US20070010486A1 (en) * | 2005-07-06 | 2007-01-11 | Jeff Schwegman | Chemotherapeutic formulations of zosuquidar trihydrochloride and modified cyclodextrins |
| US20070010465A1 (en) * | 2005-07-06 | 2007-01-11 | Branimir Sikic | Zosuquidar, daunorubicin, and cytarabine for the treatment of cancer |
| US11812951B2 (en) | 2008-06-17 | 2023-11-14 | Apollo Endosurgery Us, Inc. | Endoscopic needle assembly |
| US12108939B2 (en) | 2008-06-17 | 2024-10-08 | Boston Scientific Scimed, Inc. | Endoscopic tissue grasping systems and methods |
| CA2692211C (en) * | 2009-12-14 | 2011-09-13 | Cellresin Technologies, Llc | Maturation or ripening inhibitor release from polymer, fiber, film, sheet or packaging |
| PT2976946T (pt) | 2011-03-27 | 2017-06-26 | Cellresin Tech Llc | Composições de ciclodextrina, artigos e métodos |
| US10182567B2 (en) | 2011-03-27 | 2019-01-22 | Cellresin Technologies, Llc | Cyclodextrin compositions, articles, and methods |
| US9320288B2 (en) | 2012-11-30 | 2016-04-26 | Cellresin Technologies, Llc | Controlled release compositions and methods of using |
| US9421793B2 (en) | 2014-06-26 | 2016-08-23 | Cellresin Technologies, Llc | Electrostatic printing of cyclodextrin compositions |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2959580A (en) * | 1956-10-17 | 1960-11-08 | Univ Minnesota | Formation of inclusion compounds |
| CH445129A (fr) * | 1964-04-29 | 1967-10-15 | Nestle Sa | Procédé pour la préparation de composés d'inclusion à poids moléculaire élevé |
| JPS56123912A (en) * | 1980-03-05 | 1981-09-29 | Nitto Electric Ind Co Ltd | Drug-containing tape preparation |
| HU182217B (en) * | 1980-10-17 | 1983-12-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing inclusive complexes of cyclodextrines and strong inorganic oxyacids |
| JPS57142962A (en) * | 1981-02-28 | 1982-09-03 | Santen Pharmaceut Co Ltd | Cyclodextrin clathrate compound of sulfur-containing compound |
| JPS6054304B2 (ja) * | 1981-10-16 | 1985-11-29 | 株式会社バコム | ジソピラミド包接化合物 |
| US4425336A (en) * | 1982-05-24 | 1984-01-10 | Key Pharmaceuticals, Inc. | 3,4-Dihydroxy-N-[3-(4-dihydroxyphenyl)-1-methyl-n-propyl]-beta-phenethylamine cyclodextrin complexes |
| DK311683A (da) * | 1982-07-26 | 1984-01-27 | Fujisawa Pharmaceutical Co | Fremgangsmaade til fremstilling af pyridylalkylnitratforbindelser |
| JPS6025967A (ja) * | 1983-07-21 | 1985-02-08 | Eisai Co Ltd | トリパミド包接化合物 |
| DE3329517A1 (de) * | 1983-08-16 | 1985-02-28 | Hoechst Ag, 6230 Frankfurt | Einschlussverbindung von n,n-dimethyl-2-chlor-5-(3-methyl-2-(phenylimino)-4-thiazolin-4-yl)phenylsulfonamid, verfahren zu ihrer herstellung sowie pharmazeutische praeparate |
| DE3337802A1 (de) * | 1983-10-18 | 1985-04-25 | Merck Patent Gmbh, 6100 Darmstadt | Pharmazeutische zubereitung |
-
1983
- 1983-10-11 JP JP58190345A patent/JPS6081166A/ja active Granted
-
1984
- 1984-09-18 ZA ZA847350A patent/ZA847350B/xx unknown
- 1984-09-20 NO NO843773A patent/NO843773L/no unknown
- 1984-09-21 AU AU33399/84A patent/AU576521B2/en not_active Ceased
- 1984-09-26 DK DK461184A patent/DK461184A/da not_active Application Discontinuation
- 1984-09-26 IL IL73076A patent/IL73076A/xx unknown
- 1984-09-26 US US06/654,471 patent/US4575548A/en not_active Expired - Fee Related
- 1984-09-28 CA CA000464361A patent/CA1248523A/en not_active Expired
- 1984-10-03 GR GR80531A patent/GR80531B/el unknown
- 1984-10-04 PT PT79320A patent/PT79320B/pt unknown
- 1984-10-08 FI FI843944A patent/FI843944L/fi not_active Application Discontinuation
- 1984-10-09 EP EP84112056A patent/EP0141300A3/en not_active Withdrawn
- 1984-10-10 HU HU843806A patent/HU194285B/hu not_active IP Right Cessation
- 1984-10-10 ES ES536654A patent/ES536654A0/es active Granted
- 1984-10-11 PH PH31326A patent/PH20203A/en unknown
- 1984-10-11 KR KR1019840006284A patent/KR850003414A/ko not_active Application Discontinuation
- 1984-10-11 OA OA58409A patent/OA07832A/xx unknown
-
1985
- 1985-04-01 CN CN198585102133A patent/CN85102133A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL73076A (en) | 1988-05-31 |
| FI843944L (fi) | 1985-04-12 |
| PT79320B (en) | 1986-09-08 |
| EP0141300A2 (en) | 1985-05-15 |
| FI843944A0 (fi) | 1984-10-08 |
| ES8506758A1 (es) | 1985-08-01 |
| EP0141300A3 (en) | 1986-01-29 |
| KR850003414A (ko) | 1985-06-17 |
| DK461184A (da) | 1985-04-12 |
| ES536654A0 (es) | 1985-08-01 |
| PH20203A (en) | 1986-10-20 |
| ZA847350B (en) | 1985-10-30 |
| GR80531B (en) | 1985-01-09 |
| JPS6245226B2 (xx) | 1987-09-25 |
| JPS6081166A (ja) | 1985-05-09 |
| PT79320A (en) | 1984-11-01 |
| HU194285B (en) | 1988-01-28 |
| CN85102133A (zh) | 1987-01-17 |
| HUT36832A (en) | 1985-10-28 |
| CA1248523A (en) | 1989-01-10 |
| AU3339984A (en) | 1985-04-18 |
| AU576521B2 (en) | 1988-09-01 |
| OA07832A (fr) | 1986-11-20 |
| IL73076A0 (en) | 1984-12-31 |
| US4575548A (en) | 1986-03-11 |
| DK461184D0 (da) | 1984-09-26 |
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