NO830042L - 4-difenylmetyl-1-((oxoalkyl)imino)metyl-piperidiner og derivater derav. - Google Patents
4-difenylmetyl-1-((oxoalkyl)imino)metyl-piperidiner og derivater derav.Info
- Publication number
- NO830042L NO830042L NO830042A NO830042A NO830042L NO 830042 L NO830042 L NO 830042L NO 830042 A NO830042 A NO 830042A NO 830042 A NO830042 A NO 830042A NO 830042 L NO830042 L NO 830042L
- Authority
- NO
- Norway
- Prior art keywords
- methyl
- acid
- imino
- diphenylmethyl
- piperidine
- Prior art date
Links
- -1 IMINO Chemical class 0.000 title description 3
- 101000740162 Homo sapiens Sodium- and chloride-dependent transporter XTRP3 Proteins 0.000 title 1
- 102100037189 Sodium- and chloride-dependent transporter XTRP3 Human genes 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 6
- 150000001875 compounds Chemical class 0.000 claims description 35
- 239000002253 acid Substances 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 18
- 238000002360 preparation method Methods 0.000 claims description 18
- 150000003839 salts Chemical class 0.000 claims description 18
- 239000012458 free base Substances 0.000 claims description 7
- LNSWILOGIZECFQ-UHFFFAOYSA-N 8-[(4-benzhydrylpiperidin-1-yl)methylideneamino]octan-2-one Chemical compound C1CN(C=NCCCCCCC(=O)C)CCC1C(C=1C=CC=CC=1)C1=CC=CC=C1 LNSWILOGIZECFQ-UHFFFAOYSA-N 0.000 claims description 3
- 125000001841 imino group Chemical group [H]N=* 0.000 claims description 3
- 125000005188 oxoalkyl group Chemical group 0.000 claims description 3
- REGDQFLMEUPLNG-UHFFFAOYSA-N 1-(4-benzhydrylpiperidin-1-yl)-n-[6-(2-methyl-1,3-dioxolan-2-yl)hexyl]methanimine Chemical compound C1CC(C(C=2C=CC=CC=2)C=2C=CC=CC=2)CCN1C=NCCCCCCC1(C)OCCO1 REGDQFLMEUPLNG-UHFFFAOYSA-N 0.000 claims description 2
- OOHPMNYAILKCMV-UHFFFAOYSA-N 1-[(4-benzhydrylpiperidin-1-yl)methylideneamino]propan-2-one Chemical compound C1CN(C=NCC(=O)C)CCC1C(C=1C=CC=CC=1)C1=CC=CC=C1 OOHPMNYAILKCMV-UHFFFAOYSA-N 0.000 claims 1
- KIGQNWOOYHMSJP-UHFFFAOYSA-N 10-[(4-benzhydrylpiperidin-1-yl)methylideneamino]decan-2-one Chemical compound C1CN(C=NCCCCCCCCC(=O)C)CCC1C(C=1C=CC=CC=1)C1=CC=CC=C1 KIGQNWOOYHMSJP-UHFFFAOYSA-N 0.000 claims 1
- NMUCGASDIVPPNF-UHFFFAOYSA-N 8-[(4-benzhydrylpiperidin-1-yl)methylideneamino]octan-2-ol Chemical compound C1CN(C=NCCCCCCC(O)C)CCC1C(C=1C=CC=CC=1)C1=CC=CC=C1 NMUCGASDIVPPNF-UHFFFAOYSA-N 0.000 claims 1
- YXVLSWZNPIIZNR-UHFFFAOYSA-N n-[8-[(4-benzhydrylpiperidin-1-yl)methylideneamino]octan-2-ylidene]hydroxylamine Chemical compound C1CN(C=NCCCCCCC(C)=NO)CCC1C(C=1C=CC=CC=1)C1=CC=CC=C1 YXVLSWZNPIIZNR-UHFFFAOYSA-N 0.000 claims 1
- 230000027119 gastric acid secretion Effects 0.000 abstract description 6
- 230000005764 inhibitory process Effects 0.000 abstract description 5
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 33
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 25
- 239000000243 solution Substances 0.000 description 18
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- 238000004519 manufacturing process Methods 0.000 description 13
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- 238000002844 melting Methods 0.000 description 6
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- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
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- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
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- 239000002775 capsule Substances 0.000 description 3
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- 230000002401 inhibitory effect Effects 0.000 description 3
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- KVBGVZZKJNLNJU-UHFFFAOYSA-N naphthalene-2-sulfonic acid Chemical compound C1=CC=CC2=CC(S(=O)(=O)O)=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-N 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
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- 239000007858 starting material Substances 0.000 description 3
- CKHACJQHTLEVBI-UHFFFAOYSA-N 2-(7-oxooctyl)isoindole-1,3-dione Chemical compound C1=CC=C2C(=O)N(CCCCCCC(=O)C)C(=O)C2=C1 CKHACJQHTLEVBI-UHFFFAOYSA-N 0.000 description 2
- IHQJXDLHKZENCY-UHFFFAOYSA-N 4-benzhydrylpiperidine-1-carbaldehyde Chemical compound C1CN(C=O)CCC1C(C=1C=CC=CC=1)C1=CC=CC=C1 IHQJXDLHKZENCY-UHFFFAOYSA-N 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
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- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- 150000001241 acetals Chemical class 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
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- 239000002552 dosage form Substances 0.000 description 2
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- WQWJAPIRSZZBRI-UHFFFAOYSA-N ethyl 2-acetyl-7-(1,3-dioxoisoindol-2-yl)heptanoate Chemical compound C1=CC=C2C(=O)N(CCCCCC(C(=O)OCC)C(C)=O)C(=O)C2=C1 WQWJAPIRSZZBRI-UHFFFAOYSA-N 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 150000002576 ketones Chemical group 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 description 2
- HPYKRLQBMUPOFA-UHFFFAOYSA-N piperidin-1-ylmethanimine Chemical class N=CN1CCCCC1 HPYKRLQBMUPOFA-UHFFFAOYSA-N 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
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- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 description 1
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 description 1
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- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 description 1
- KHVGUXUSDXHEMC-UHFFFAOYSA-N 1-(4-benzhydrylpiperidin-1-yl)-n-[(2-methyl-1,3-dioxolan-2-yl)methyl]methanimine Chemical compound C1CC(C(C=2C=CC=CC=2)C=2C=CC=CC=2)CCN1C=NCC1(C)OCCO1 KHVGUXUSDXHEMC-UHFFFAOYSA-N 0.000 description 1
- KHFFLMUXVPHZNB-UHFFFAOYSA-N 1-(4-benzhydrylpiperidin-1-yl)-n-[8-(2-methyl-1,3-dioxolan-2-yl)octyl]methanimine Chemical compound C1CC(C(C=2C=CC=CC=2)C=2C=CC=CC=2)CCN1C=NCCCCCCCCC1(C)OCCO1 KHFFLMUXVPHZNB-UHFFFAOYSA-N 0.000 description 1
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- KKEIAWKQIBIEQN-UHFFFAOYSA-N naphthalene-2-sulfonic acid;piperidine Chemical compound C1CCNCC1.C1=CC=CC2=CC(S(=O)(=O)O)=CC=C21 KKEIAWKQIBIEQN-UHFFFAOYSA-N 0.000 description 1
- ZODDGFAZWTZOSI-UHFFFAOYSA-N nitric acid;sulfuric acid Chemical compound O[N+]([O-])=O.OS(O)(=O)=O ZODDGFAZWTZOSI-UHFFFAOYSA-N 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 230000001175 peptic effect Effects 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000013223 sprague-dawley female rat Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000002731 stomach secretion inhibitor Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- C07D209/49—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide and having in the molecule an acyl radical containing a saturated three-membered ring, e.g. chrysanthemumic acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/345,128 US4370335A (en) | 1982-02-02 | 1982-02-02 | Antisecretory 4-diphenylmethyl-1-[(oxoalkyl)imino]methyl-piperidines and their derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
NO830042L true NO830042L (no) | 1983-08-03 |
Family
ID=23353650
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO830042A NO830042L (no) | 1982-02-02 | 1983-01-07 | 4-difenylmetyl-1-((oxoalkyl)imino)metyl-piperidiner og derivater derav. |
Country Status (14)
Country | Link |
---|---|
US (1) | US4370335A (de) |
EP (1) | EP0087853B1 (de) |
JP (1) | JPS58146564A (de) |
KR (1) | KR840003251A (de) |
AT (1) | ATE19512T1 (de) |
AU (1) | AU552804B2 (de) |
DE (1) | DE3363208D1 (de) |
DK (1) | DK7983A (de) |
ES (1) | ES518881A0 (de) |
FI (1) | FI830105L (de) |
IL (1) | IL67674A0 (de) |
NO (1) | NO830042L (de) |
PH (1) | PH17775A (de) |
ZA (1) | ZA83109B (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4528293A (en) * | 1983-10-11 | 1985-07-09 | Mcneilab, Inc. | Heteroaromatic derivatives of iminomethyl piperidines and use to inhibit gastric acid secretion |
US4594351A (en) * | 1983-10-11 | 1986-06-10 | Mcneilab, Inc. | Furan or thiophene derivatives of iminomethyl piperidines and use to inhibit gastric secretion |
JP5463055B2 (ja) * | 2009-02-27 | 2014-04-09 | 公益財団法人相模中央化学研究所 | フタルイミド誘導体及びそれらの製造方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE794596A (fr) * | 1972-01-28 | 1973-05-16 | Richardson Merrell Inc | Piperidinoalcanone-oximes substituees et leur procede de preparation |
US3946022A (en) * | 1974-03-04 | 1976-03-23 | Richardson-Merrell Inc. | Piperidine derivatives |
FR2314179A1 (fr) * | 1975-06-12 | 1977-01-07 | Ile De France | Nouvelles enamines et leur procede de preparation |
US4251655A (en) * | 1978-03-29 | 1981-02-17 | Mcneilab, Inc. | Substituted N-iminomethylpiperidines |
-
1982
- 1982-02-02 US US06/345,128 patent/US4370335A/en not_active Expired - Lifetime
-
1983
- 1983-01-07 ZA ZA83109A patent/ZA83109B/xx unknown
- 1983-01-07 PH PH28361A patent/PH17775A/en unknown
- 1983-01-07 NO NO830042A patent/NO830042L/no unknown
- 1983-01-10 DK DK7983A patent/DK7983A/da not_active Application Discontinuation
- 1983-01-11 ES ES518881A patent/ES518881A0/es active Granted
- 1983-01-12 IL IL67674A patent/IL67674A0/xx unknown
- 1983-01-12 FI FI830105A patent/FI830105L/fi not_active Application Discontinuation
- 1983-01-13 EP EP83300168A patent/EP0087853B1/de not_active Expired
- 1983-01-13 AT AT83300168T patent/ATE19512T1/de not_active IP Right Cessation
- 1983-01-13 DE DE8383300168T patent/DE3363208D1/de not_active Expired
- 1983-01-21 KR KR1019830000234A patent/KR840003251A/ko not_active Application Discontinuation
- 1983-01-28 AU AU10862/83A patent/AU552804B2/en not_active Ceased
- 1983-01-31 JP JP58013031A patent/JPS58146564A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU1086283A (en) | 1983-08-11 |
KR840003251A (ko) | 1984-08-20 |
EP0087853A3 (en) | 1983-10-05 |
ZA83109B (en) | 1984-08-29 |
EP0087853A2 (de) | 1983-09-07 |
DK7983D0 (da) | 1983-01-10 |
FI830105L (fi) | 1983-08-03 |
AU552804B2 (en) | 1986-06-19 |
EP0087853B1 (de) | 1986-04-30 |
ES8402820A1 (es) | 1984-03-01 |
US4370335A (en) | 1983-01-25 |
FI830105A0 (fi) | 1983-01-12 |
ES518881A0 (es) | 1984-03-01 |
ATE19512T1 (de) | 1986-05-15 |
DE3363208D1 (en) | 1986-06-05 |
IL67674A0 (en) | 1983-05-15 |
PH17775A (en) | 1984-12-11 |
JPS58146564A (ja) | 1983-09-01 |
DK7983A (da) | 1983-08-03 |
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