NO820982L - Fremgangsmaate for fremstilling av farmasoeytiske preparater inneholdende anti-inflammatoriske steroider - Google Patents
Fremgangsmaate for fremstilling av farmasoeytiske preparater inneholdende anti-inflammatoriske steroiderInfo
- Publication number
- NO820982L NO820982L NO820982A NO820982A NO820982L NO 820982 L NO820982 L NO 820982L NO 820982 A NO820982 A NO 820982A NO 820982 A NO820982 A NO 820982A NO 820982 L NO820982 L NO 820982L
- Authority
- NO
- Norway
- Prior art keywords
- stated
- steroid
- oil phase
- preparation
- liquid oil
- Prior art date
Links
- 150000003431 steroids Chemical class 0.000 title claims description 36
- 238000000034 method Methods 0.000 title claims description 16
- 238000002360 preparation method Methods 0.000 title claims description 12
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 3
- 230000003110 anti-inflammatory effect Effects 0.000 title description 9
- 239000003921 oil Substances 0.000 claims description 38
- 239000007788 liquid Substances 0.000 claims description 17
- CBGUOGMQLZIXBE-XGQKBEPLSA-N clobetasol propionate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CCl)(OC(=O)CC)[C@@]1(C)C[C@@H]2O CBGUOGMQLZIXBE-XGQKBEPLSA-N 0.000 claims description 8
- 229960004703 clobetasol propionate Drugs 0.000 claims description 8
- 150000002148 esters Chemical class 0.000 claims description 5
- 239000002674 ointment Substances 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- SNHRLVCMMWUAJD-SUYDQAKGSA-N betamethasone valerate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(OC(=O)CCCC)[C@@]1(C)C[C@@H]2O SNHRLVCMMWUAJD-SUYDQAKGSA-N 0.000 claims description 4
- 239000006071 cream Substances 0.000 claims description 4
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 4
- 229940057995 liquid paraffin Drugs 0.000 claims description 4
- 239000001993 wax Substances 0.000 claims description 4
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 3
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 claims description 2
- 235000021360 Myristic acid Nutrition 0.000 claims description 2
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims description 2
- 235000021314 Palmitic acid Nutrition 0.000 claims description 2
- 125000001931 aliphatic group Chemical group 0.000 claims description 2
- 239000000872 buffer Substances 0.000 claims description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 239000003995 emulsifying agent Substances 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims 2
- FBRAWBYQGRLCEK-AVVSTMBFSA-N Clobetasone butyrate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CCl)(OC(=O)CCC)[C@@]1(C)CC2=O FBRAWBYQGRLCEK-AVVSTMBFSA-N 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 claims 1
- CIWBQSYVNNPZIQ-XYWKZLDCSA-N betamethasone dipropionate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O CIWBQSYVNNPZIQ-XYWKZLDCSA-N 0.000 claims 1
- 229960005465 clobetasone butyrate Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 15
- 239000012071 phase Substances 0.000 description 13
- 238000009472 formulation Methods 0.000 description 11
- XTJFFFGAUHQWII-UHFFFAOYSA-N Dibutyl adipate Chemical compound CCCCOC(=O)CCCCC(=O)OCCCC XTJFFFGAUHQWII-UHFFFAOYSA-N 0.000 description 6
- 229940100539 dibutyl adipate Drugs 0.000 description 6
- 230000009885 systemic effect Effects 0.000 description 5
- 230000000699 topical effect Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 239000012188 paraffin wax Substances 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 239000012876 carrier material Substances 0.000 description 2
- 239000003246 corticosteroid Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- LZCLXQDLBQLTDK-UHFFFAOYSA-N ethyl 2-hydroxypropanoate Chemical compound CCOC(=O)C(C)O LZCLXQDLBQLTDK-UHFFFAOYSA-N 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 229960002117 triamcinolone acetonide Drugs 0.000 description 2
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 2
- IQXJCCZJOIKIAD-UHFFFAOYSA-N 1-(2-methoxyethoxy)hexadecane Chemical compound CCCCCCCCCCCCCCCCOCCOC IQXJCCZJOIKIAD-UHFFFAOYSA-N 0.000 description 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- UDHHXYYEUWKHMF-UHFFFAOYSA-N 6-butoxy-6-oxohexanoic acid Chemical class CCCCOC(=O)CCCCC(O)=O UDHHXYYEUWKHMF-UHFFFAOYSA-N 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229950009789 cetomacrogol 1000 Drugs 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000008387 emulsifying waxe Substances 0.000 description 1
- 229940116333 ethyl lactate Drugs 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 238000012886 linear function Methods 0.000 description 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8032111 | 1980-10-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO820982L true NO820982L (no) | 1983-09-26 |
Family
ID=10516496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO820982A NO820982L (no) | 1980-10-06 | 1982-03-24 | Fremgangsmaate for fremstilling av farmasoeytiske preparater inneholdende anti-inflammatoriske steroider |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4370322A (de) |
| JP (1) | JPS5793907A (de) |
| AU (1) | AU7602781A (de) |
| BE (1) | BE890633A (de) |
| CA (1) | CA1182048A (de) |
| CH (1) | CH649923A5 (de) |
| DE (1) | DE3139519A1 (de) |
| DK (1) | DK440081A (de) |
| ES (1) | ES506018A0 (de) |
| FI (1) | FI821167L (de) |
| FR (1) | FR2491333B1 (de) |
| IT (1) | IT1171569B (de) |
| NL (1) | NL8104512A (de) |
| NO (1) | NO820982L (de) |
| NZ (1) | NZ198553A (de) |
| PT (1) | PT73772B (de) |
| SE (1) | SE8105867L (de) |
| ZA (1) | ZA816872B (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR890000664B1 (ko) * | 1981-10-19 | 1989-03-22 | 바리 안소니 뉴우샘 | 미분된 베클로메타손 디프로피오네이트 일수화물의 제조방법 |
| US4482539A (en) * | 1983-05-13 | 1984-11-13 | Schering Corporation | Betamethasone dipropionate cream |
| US4489070A (en) * | 1983-05-13 | 1984-12-18 | Schering Corporation | Betamethasone dipropionate cream |
| US4515810A (en) * | 1983-10-06 | 1985-05-07 | American Cyanamid Company | Composition of matter |
| JPS615009A (ja) * | 1984-05-31 | 1986-01-10 | Mochida Pharmaceut Co Ltd | 制癌用磁性小胞体組成物 |
| JPS62138432A (ja) * | 1985-12-12 | 1987-06-22 | Shionogi & Co Ltd | 抗炎症ステロイドを含有する安定な錠剤 |
| US5326566A (en) * | 1991-05-17 | 1994-07-05 | Bristol-Myers Squibb Company | Use of dibutyl adipate and isopropyl myristate in topical and transdermal products |
| EP1411938B1 (de) * | 2001-07-02 | 2005-07-06 | Tas, Sinan | Verwendung von cyclopamine zur Herstellung eines Arzneimittels zur Behandlung von Psoriasis |
| KR20040034795A (ko) * | 2002-10-17 | 2004-04-29 | 박래옥 | 스테로이드 제제 및 태반 추출물을 함유한 염증성 피부병치료용 경피제 |
| FR2898499B1 (fr) * | 2006-03-15 | 2008-11-28 | Galderma Sa | Nouvelles compositions topiques sous forme d'emulsion h/e comprenant un glycol pro-penetrant |
| FR2898498B1 (fr) * | 2006-03-15 | 2008-11-28 | Galderma Sa | Nouvelles compositions topiques sous forme d'emulsion h/e comprenant un glycol pro-penetrant |
| US11957753B2 (en) | 2010-11-22 | 2024-04-16 | Bausch Health Ireland Limited | Pharmaceutical formulations containing corticosteroids for topical administration |
| US8809307B2 (en) * | 2010-11-22 | 2014-08-19 | Dow Pharmaceutical Sciences, Inc. | Pharmaceutical formulations containing corticosteroids for topical administration |
| BR112013027390A2 (pt) * | 2011-05-04 | 2017-01-17 | Chiesi Farma Spa | formulação farmacêutica |
| JP6997624B2 (ja) | 2015-06-18 | 2022-01-17 | ボシュ ヘルス ユーエス，エルエルシー． | 乾癬を治療するためのコルチコステロイドおよびレチノイドを含む局所用組成物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1792455A1 (de) * | 1968-09-05 | 1971-11-11 | Baerlocher Chem | Verwendung von Estern natuerlicher Fettsaeuregemische in kosmetischen und pharmazeutischen Zubereitungen sowie Reinigungsmitteln und Toilettenseifen |
| GB1438940A (en) * | 1972-07-19 | 1976-06-09 | Glaxo Lab Ltd | 17beta-haloalkoxycarbonyl-17alpha-oxysteroids |
| US3867528A (en) * | 1973-10-11 | 1975-02-18 | American Cyanamid Co | Steroidal topical cream base |
| US4070462A (en) * | 1976-10-26 | 1978-01-24 | Schering Corporation | Steroid ointment |
| IT1090703B (it) * | 1976-12-03 | 1985-06-26 | Scherer Ltd R P | Perfezionamento nelle composizioni utili quali veicolo per farmaci |
| US4083974A (en) * | 1977-03-07 | 1978-04-11 | The Upjohn Company | Topical steroidal anti-inflammatory preparations containing polyoxypropylene 15 stearyl ether |
| NL7800762A (nl) * | 1978-01-20 | 1979-07-24 | Acf Chemiefarma Nv | Vloeibare, voor injectie geschikte farmaceu- tische samenstellingen. |
| US4233295A (en) * | 1979-05-31 | 1980-11-11 | E. R. Squibb & Sons, Inc. | Corticosteroid formulations containing sebacate carrier |
-
1981
- 1981-10-02 PT PT73772A patent/PT73772B/pt unknown
- 1981-10-02 CH CH6355/81A patent/CH649923A5/de not_active IP Right Cessation
- 1981-10-05 DK DK440081A patent/DK440081A/da not_active Application Discontinuation
- 1981-10-05 IT IT49422/81A patent/IT1171569B/it active
- 1981-10-05 FR FR8118688A patent/FR2491333B1/fr not_active Expired
- 1981-10-05 AU AU76027/81A patent/AU7602781A/en not_active Abandoned
- 1981-10-05 BE BE0/206171A patent/BE890633A/fr not_active IP Right Cessation
- 1981-10-05 ES ES506018A patent/ES506018A0/es active Granted
- 1981-10-05 NL NL8104512A patent/NL8104512A/nl not_active Application Discontinuation
- 1981-10-05 ZA ZA816872A patent/ZA816872B/xx unknown
- 1981-10-05 CA CA000387255A patent/CA1182048A/en not_active Expired
- 1981-10-05 DE DE19813139519 patent/DE3139519A1/de not_active Withdrawn
- 1981-10-05 JP JP56158567A patent/JPS5793907A/ja active Pending
- 1981-10-05 SE SE8105867A patent/SE8105867L/xx not_active Application Discontinuation
- 1981-10-05 US US06/308,581 patent/US4370322A/en not_active Expired - Fee Related
- 1981-10-05 NZ NZ198553A patent/NZ198553A/xx unknown
-
1982
- 1982-03-24 NO NO820982A patent/NO820982L/no unknown
- 1982-04-02 FI FI821167A patent/FI821167L/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA1182048A (en) | 1985-02-05 |
| NL8104512A (nl) | 1982-05-03 |
| NZ198553A (en) | 1983-09-30 |
| ZA816872B (en) | 1982-09-29 |
| CH649923A5 (de) | 1985-06-28 |
| IT1171569B (it) | 1987-06-10 |
| PT73772A (en) | 1981-11-01 |
| FI821167A0 (fi) | 1982-04-02 |
| FR2491333B1 (fr) | 1985-09-27 |
| IT8149422A0 (it) | 1981-10-05 |
| US4370322A (en) | 1983-01-25 |
| SE8105867L (sv) | 1982-04-07 |
| DE3139519A1 (de) | 1982-06-16 |
| AU7602781A (en) | 1982-04-22 |
| DK440081A (da) | 1982-04-07 |
| BE890633A (fr) | 1982-04-05 |
| ES8306591A1 (es) | 1983-06-01 |
| ES506018A0 (es) | 1983-06-01 |
| FI821167L (fi) | 1983-10-03 |
| PT73772B (en) | 1983-10-14 |
| FR2491333A1 (fr) | 1982-04-09 |
| JPS5793907A (en) | 1982-06-11 |
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