NO343234B1 - Fettsyresammensetning som inneholder DHA og EPA for behandling og/eller forebygging av amyloidose relaterte sykdommer - Google Patents
Fettsyresammensetning som inneholder DHA og EPA for behandling og/eller forebygging av amyloidose relaterte sykdommer Download PDFInfo
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- NO343234B1 NO343234B1 NO20074318A NO20074318A NO343234B1 NO 343234 B1 NO343234 B1 NO 343234B1 NO 20074318 A NO20074318 A NO 20074318A NO 20074318 A NO20074318 A NO 20074318A NO 343234 B1 NO343234 B1 NO 343234B1
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- fatty acid
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- dha
- epa
- amyloid
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- 230000007505 plaque formation Effects 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000021003 saturated fats Nutrition 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000010972 statistical evaluation Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 102000013498 tau Proteins Human genes 0.000 description 1
- 108010026424 tau Proteins Proteins 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
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- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64560405P | 2005-01-24 | 2005-01-24 | |
| SE0500174 | 2005-01-24 | ||
| PCT/IB2006/000106 WO2006077495A1 (en) | 2005-01-24 | 2006-01-24 | Use of a fatty acid composition containing dha for the production of a medical product or a food stuff for the treatment of amyloidos-rerelated diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20074318L NO20074318L (no) | 2007-10-24 |
| NO343234B1 true NO343234B1 (no) | 2018-12-17 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20074318A NO343234B1 (no) | 2005-01-24 | 2007-08-23 | Fettsyresammensetning som inneholder DHA og EPA for behandling og/eller forebygging av amyloidose relaterte sykdommer |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20090054523A1 (enExample) |
| EP (1) | EP1845999A4 (enExample) |
| JP (1) | JP5503846B2 (enExample) |
| KR (1) | KR101253696B1 (enExample) |
| CA (1) | CA2594781A1 (enExample) |
| NO (1) | NO343234B1 (enExample) |
| WO (1) | WO2006077495A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8324276B2 (en) | 2005-01-24 | 2012-12-04 | Pronova Biopharma Norge As | Fatty acid composition for treatment of alzheimer's disease and cognitive dysfunction |
| EP3263101A1 (en) | 2005-12-21 | 2018-01-03 | Brudy Technology, S.L. | Use of dha, epa or dha-derived epa for treating a pathology associated with cellular oxidative damage |
| ES2277557B1 (es) | 2005-12-21 | 2008-07-01 | Proyecto Empresarial Brudy, S.L. | Utilizacion de acido docosahexaenoico para el tratamiento del daño celular oxidativo. |
| KR100879816B1 (ko) | 2007-05-31 | 2009-01-22 | 학교법인 일송학원 | 꽁치류의 가수분해물을 포함하는 허혈성 뇌혈관질환 예방또는 개선용 조성물 |
| PT2374452T (pt) * | 2008-12-05 | 2019-10-31 | Ajinomoto Kk | Composição de nutrientes |
| CN108324706A (zh) * | 2009-02-02 | 2018-07-27 | 帝斯曼知识产权资产有限公司 | 改善认知功能和降低心率的方法 |
| US9532963B2 (en) * | 2009-03-09 | 2017-01-03 | Pronova Biopharma Norge As | Compositions comprising a fatty acid oil mixture and a free fatty acid, and methods and uses thereof |
| US20100239660A1 (en) * | 2009-03-19 | 2010-09-23 | Doughman Scott D | Product and use of omega-3s matching human tissue ratios for treatment of inflammatory and other conditions |
| US8124574B2 (en) | 2009-10-12 | 2012-02-28 | Conopco, Inc. | Mild, foaming liquid cleansers comprising low levels of fatty isethionate product and low total fatty acid and/or fatty acid soap content |
| US8105994B2 (en) | 2010-03-31 | 2012-01-31 | Conopco, Inc. | Personal wash cleanser comprising defined alkanoyl compounds, defined fatty acyl isethionate surfactant product and skin or hair benefit agent delivered in flocs upon dilution |
| CN107050457A (zh) | 2012-01-06 | 2017-08-18 | 翁特拉制药公司 | 游离酸形式的ω‑3多不饱和脂肪酸的富含dpa组合物 |
| EP2846779A4 (en) | 2012-05-07 | 2015-12-16 | Omthera Pharmaceuticals Inc | STATIN AND OMEGA-3 FATTY ACID COMPOSITIONS |
| KR20220010415A (ko) * | 2020-07-17 | 2022-01-25 | 대봉엘에스 주식회사 | 불포화 지방산을 특정 함량으로 포함하는 유지 조성물 및 이의 용도 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08143454A (ja) * | 1994-11-17 | 1996-06-04 | Kanagawa Kagaku Kenkyusho:Kk | 神経成長因子産生増強剤 |
| WO1996040106A2 (en) * | 1995-06-07 | 1996-12-19 | Martek Biosciences Corporation | Methods for controlling highly unsaturated fatty acid content in various tissues |
| WO2001084961A2 (en) * | 2000-05-08 | 2001-11-15 | N.V. Nutricia | Preparation for the prevention and/or treatment of vascular disorders |
| CN1380058A (zh) * | 2001-04-10 | 2002-11-20 | 上海体育运动技术学院 | 用于促进人体自身epa、dha合成的药物 |
| WO2003043570A2 (en) * | 2001-11-15 | 2003-05-30 | Galileo Laboratories, Inc. | Formulations and methods for treatment or amelioration of inflammatory conditions |
| EP1419780A1 (en) * | 1993-06-09 | 2004-05-19 | Martek Biosciences Corporation | Use of docosahexaenoic acid for the manufacture of a medicament for the treatment of senile dementia and Alzheimer's disease |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07268385A (ja) * | 1994-03-31 | 1995-10-17 | Snow Brand Milk Prod Co Ltd | 魚臭が低減されたカツオおよび/またはマグロ油 |
| JPH09511533A (ja) * | 1994-09-19 | 1997-11-18 | ザ、プロクター、エンド、ギャンブル、カンパニー | 顆粒状漂白組成物 |
| US6191154B1 (en) * | 1998-11-27 | 2001-02-20 | Case Western Reserve University | Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases |
| GB9901809D0 (en) * | 1999-01-27 | 1999-03-17 | Scarista Limited | Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes |
| US6395778B1 (en) * | 2000-01-11 | 2002-05-28 | Omegatech, Inc. | Process for making an enriched mixture of polyunsaturated fatty acid esters |
| GB0016045D0 (en) * | 2000-06-29 | 2000-08-23 | Laxdale Limited | Therapeutic combinations of fatty acids |
| US20030077342A1 (en) * | 2001-10-09 | 2003-04-24 | Maf Group, Llc | Anti-inflammatory complex containing eicosapentaenoic acid |
| US8324276B2 (en) * | 2005-01-24 | 2012-12-04 | Pronova Biopharma Norge As | Fatty acid composition for treatment of alzheimer's disease and cognitive dysfunction |
-
2006
- 2006-01-24 WO PCT/IB2006/000106 patent/WO2006077495A1/en not_active Ceased
- 2006-01-24 CA CA002594781A patent/CA2594781A1/en not_active Abandoned
- 2006-01-24 JP JP2007551765A patent/JP5503846B2/ja not_active Expired - Fee Related
- 2006-01-24 US US11/795,800 patent/US20090054523A1/en not_active Abandoned
- 2006-01-24 EP EP06710253A patent/EP1845999A4/en not_active Withdrawn
-
2007
- 2007-08-22 KR KR20077019198A patent/KR101253696B1/ko not_active Expired - Fee Related
- 2007-08-23 NO NO20074318A patent/NO343234B1/no not_active IP Right Cessation
-
2012
- 2012-06-21 US US13/529,592 patent/US20120277317A1/en not_active Abandoned
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1419780A1 (en) * | 1993-06-09 | 2004-05-19 | Martek Biosciences Corporation | Use of docosahexaenoic acid for the manufacture of a medicament for the treatment of senile dementia and Alzheimer's disease |
| JPH08143454A (ja) * | 1994-11-17 | 1996-06-04 | Kanagawa Kagaku Kenkyusho:Kk | 神経成長因子産生増強剤 |
| WO1996040106A2 (en) * | 1995-06-07 | 1996-12-19 | Martek Biosciences Corporation | Methods for controlling highly unsaturated fatty acid content in various tissues |
| WO2001084961A2 (en) * | 2000-05-08 | 2001-11-15 | N.V. Nutricia | Preparation for the prevention and/or treatment of vascular disorders |
| CN1380058A (zh) * | 2001-04-10 | 2002-11-20 | 上海体育运动技术学院 | 用于促进人体自身epa、dha合成的药物 |
| WO2003043570A2 (en) * | 2001-11-15 | 2003-05-30 | Galileo Laboratories, Inc. | Formulations and methods for treatment or amelioration of inflammatory conditions |
Non-Patent Citations (2)
| Title |
|---|
| HORROCKS L A ET AL, "Health benefits of docosahexaenoic acid (DHA)", DATABASE MEDLINE, US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US, Database accession no. NLM10479465, Dated: 01.01.0001 * |
| YAZAWA KAZUNAGA, "Importance of "health foods", EPA and DHA, for preventive medicine", DATABASE MEDLINE, US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US, Database accession no. NLM15137325, Dated: 01.01.0001 * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR101253696B1 (ko) | 2013-04-12 |
| EP1845999A1 (en) | 2007-10-24 |
| NO20074318L (no) | 2007-10-24 |
| WO2006077495A1 (en) | 2006-07-27 |
| KR20070104917A (ko) | 2007-10-29 |
| CA2594781A1 (en) | 2006-07-27 |
| EP1845999A4 (en) | 2010-09-22 |
| JP2008528475A (ja) | 2008-07-31 |
| US20090054523A1 (en) | 2009-02-26 |
| JP5503846B2 (ja) | 2014-05-28 |
| US20120277317A1 (en) | 2012-11-01 |
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| Date | Code | Title | Description |
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| MM1K | Lapsed by not paying the annual fees |