NO332642B1 - Anvendelse av picropodophyllin for fremstilling av et medikament for profylakse eller behandling av Ewings sarkom, glioblastoma, prostatacarcinoma, brystcarcinoma, magekreft, pankreatisk carcinoma, ovariecancer og endometrisk carcinoma - Google Patents

Anvendelse av picropodophyllin for fremstilling av et medikament for profylakse eller behandling av Ewings sarkom, glioblastoma, prostatacarcinoma, brystcarcinoma, magekreft, pankreatisk carcinoma, ovariecancer og endometrisk carcinoma

Info

Publication number
NO332642B1
NO332642B1 NO20035648A NO20035648A NO332642B1 NO 332642 B1 NO332642 B1 NO 332642B1 NO 20035648 A NO20035648 A NO 20035648A NO 20035648 A NO20035648 A NO 20035648A NO 332642 B1 NO332642 B1 NO 332642B1
Authority
NO
Norway
Prior art keywords
igf
carcinoma
cells
picropodophyllin
podophyllotoxin
Prior art date
Application number
NO20035648A
Other languages
English (en)
Norwegian (no)
Other versions
NO20035648D0 (no
NO20035648L (no
Inventor
Olle Larsson
Magnus Axelson
Original Assignee
Axelar Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axelar Ab filed Critical Axelar Ab
Publication of NO20035648D0 publication Critical patent/NO20035648D0/no
Publication of NO20035648L publication Critical patent/NO20035648L/no
Publication of NO332642B1 publication Critical patent/NO332642B1/no

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/54Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO20035648A 2001-06-19 2002-06-19 Anvendelse av picropodophyllin for fremstilling av et medikament for profylakse eller behandling av Ewings sarkom, glioblastoma, prostatacarcinoma, brystcarcinoma, magekreft, pankreatisk carcinoma, ovariecancer og endometrisk carcinoma NO332642B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0102168A SE0102168D0 (sv) 2001-06-19 2001-06-19 New use and new compounds
US30043101P 2001-06-26 2001-06-26
PCT/SE2002/001202 WO2002102804A1 (en) 2001-06-19 2002-06-19 New use of specific cyclolignans

Publications (3)

Publication Number Publication Date
NO20035648D0 NO20035648D0 (no) 2003-12-17
NO20035648L NO20035648L (no) 2004-02-18
NO332642B1 true NO332642B1 (no) 2012-11-26

Family

ID=20284528

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20035648A NO332642B1 (no) 2001-06-19 2002-06-19 Anvendelse av picropodophyllin for fremstilling av et medikament for profylakse eller behandling av Ewings sarkom, glioblastoma, prostatacarcinoma, brystcarcinoma, magekreft, pankreatisk carcinoma, ovariecancer og endometrisk carcinoma

Country Status (15)

Country Link
US (7) US7348358B2 (https=)
EP (5) EP1397369A1 (https=)
JP (2) JP2004534078A (https=)
KR (1) KR100940055B1 (https=)
CN (3) CN1659171A (https=)
AT (1) ATE441411T1 (https=)
AU (2) AU2002311731B8 (https=)
CA (2) CA2451047C (https=)
DK (1) DK1498121T3 (https=)
ES (1) ES2333014T3 (https=)
NO (1) NO332642B1 (https=)
NZ (2) NZ530172A (https=)
PT (1) PT1498121E (https=)
SE (1) SE0102168D0 (https=)
WO (2) WO2002102805A1 (https=)

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Also Published As

Publication number Publication date
CN1659171A (zh) 2005-08-24
AU2002311731B8 (en) 2009-10-29
JP2005500300A (ja) 2005-01-06
AU2002311731B2 (en) 2009-02-26
CA2455328C (en) 2011-09-20
US7629381B2 (en) 2009-12-08
NO20035648D0 (no) 2003-12-17
WO2002102804A8 (en) 2004-05-13
US20080221207A1 (en) 2008-09-11
CN100503611C (zh) 2009-06-24
DK1498121T3 (da) 2009-12-14
EP1938819A3 (en) 2010-04-07
CN1543466A (zh) 2004-11-03
JP5071910B2 (ja) 2012-11-14
EP1498121B1 (en) 2009-09-02
US7709526B2 (en) 2010-05-04
EP1938819A2 (en) 2008-07-02
AU2002311731C1 (en) 2009-09-03
EP1938818A2 (en) 2008-07-02
US8389747B2 (en) 2013-03-05
KR20040007743A (ko) 2004-01-24
US20040186169A1 (en) 2004-09-23
EP1498121A1 (en) 2005-01-19
ES2333014T3 (es) 2010-02-16
NZ530290A (en) 2005-05-27
CA2451047A1 (en) 2002-12-27
CA2455328A1 (en) 2002-12-27
EP1938818A3 (en) 2010-04-07
EP1397369A1 (en) 2004-03-17
US20100216728A1 (en) 2010-08-26
US20060154982A1 (en) 2006-07-13
WO2002102805A1 (en) 2002-12-27
PT1498121E (pt) 2009-12-04
JP2004534078A (ja) 2004-11-11
EP2186513A1 (en) 2010-05-19
US20080119528A1 (en) 2008-05-22
CA2451047C (en) 2012-10-09
SE0102168D0 (sv) 2001-06-19
US7348358B2 (en) 2008-03-25
WO2002102804A1 (en) 2002-12-27
KR100940055B1 (ko) 2010-02-04
ATE441411T1 (de) 2009-09-15
CN101606929A (zh) 2009-12-23
US20040167208A1 (en) 2004-08-26
US20090326248A1 (en) 2009-12-31
NZ530172A (en) 2004-12-24
NO20035648L (no) 2004-02-18
AU2002314671B2 (en) 2008-09-18
US7662851B2 (en) 2010-02-16

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