AU2002314671B2 - New use of cyclolignans and new cyclolignans - Google Patents

New use of cyclolignans and new cyclolignans Download PDF

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Publication number
AU2002314671B2
AU2002314671B2 AU2002314671A AU2002314671A AU2002314671B2 AU 2002314671 B2 AU2002314671 B2 AU 2002314671B2 AU 2002314671 A AU2002314671 A AU 2002314671A AU 2002314671 A AU2002314671 A AU 2002314671A AU 2002314671 B2 AU2002314671 B2 AU 2002314671B2
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AU
Australia
Prior art keywords
igf
podophyllotoxin
compound
cells
compounds
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Ceased
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AU2002314671A
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AU2002314671A1 (en
Inventor
Magnus Axelson
Olle Larsson
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Axelar AB
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Axelar AB
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Publication of AU2002314671A1 publication Critical patent/AU2002314671A1/en
Assigned to BIOVITRUM AB reassignment BIOVITRUM AB Request for Assignment Assignors: AXELAR AB
Assigned to AXELAR AB reassignment AXELAR AB Request for Assignment Assignors: BIOVITRUM AB
Application granted granted Critical
Publication of AU2002314671B2 publication Critical patent/AU2002314671B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/54—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2002314671A 2001-06-19 2002-06-19 New use of cyclolignans and new cyclolignans Ceased AU2002314671B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE0102168A SE0102168D0 (sv) 2001-06-19 2001-06-19 New use and new compounds
SE0102168-2 2001-06-19
US30043101P 2001-06-26 2001-06-26
US60/300,431 2001-06-26
PCT/SE2002/001223 WO2002102805A1 (en) 2001-06-19 2002-06-19 NEW USE Of CYCLOLIGNANS AND NEW CYCLOLIGNANS

Publications (2)

Publication Number Publication Date
AU2002314671A1 AU2002314671A1 (en) 2003-05-15
AU2002314671B2 true AU2002314671B2 (en) 2008-09-18

Family

ID=20284528

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2002314671A Ceased AU2002314671B2 (en) 2001-06-19 2002-06-19 New use of cyclolignans and new cyclolignans
AU2002311731A Ceased AU2002311731B8 (en) 2001-06-19 2002-06-19 New use of specific cyclolignans

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2002311731A Ceased AU2002311731B8 (en) 2001-06-19 2002-06-19 New use of specific cyclolignans

Country Status (15)

Country Link
US (7) US7348358B2 (https=)
EP (5) EP1498121B1 (https=)
JP (2) JP2004534078A (https=)
KR (1) KR100940055B1 (https=)
CN (3) CN100503611C (https=)
AT (1) ATE441411T1 (https=)
AU (2) AU2002314671B2 (https=)
CA (2) CA2451047C (https=)
DK (1) DK1498121T3 (https=)
ES (1) ES2333014T3 (https=)
NO (1) NO332642B1 (https=)
NZ (2) NZ530172A (https=)
PT (1) PT1498121E (https=)
SE (1) SE0102168D0 (https=)
WO (2) WO2002102805A1 (https=)

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Also Published As

Publication number Publication date
US7629381B2 (en) 2009-12-08
KR20040007743A (ko) 2004-01-24
SE0102168D0 (sv) 2001-06-19
NO20035648D0 (no) 2003-12-17
JP5071910B2 (ja) 2012-11-14
KR100940055B1 (ko) 2010-02-04
US20060154982A1 (en) 2006-07-13
US7709526B2 (en) 2010-05-04
WO2002102805A1 (en) 2002-12-27
EP2186513A1 (en) 2010-05-19
WO2002102804A1 (en) 2002-12-27
EP1938819A2 (en) 2008-07-02
EP1938818A3 (en) 2010-04-07
DK1498121T3 (da) 2009-12-14
JP2005500300A (ja) 2005-01-06
US20040186169A1 (en) 2004-09-23
AU2002311731B8 (en) 2009-10-29
NO332642B1 (no) 2012-11-26
EP1938818A2 (en) 2008-07-02
PT1498121E (pt) 2009-12-04
ES2333014T3 (es) 2010-02-16
US20090326248A1 (en) 2009-12-31
NZ530172A (en) 2004-12-24
CA2451047A1 (en) 2002-12-27
ATE441411T1 (de) 2009-09-15
US8389747B2 (en) 2013-03-05
JP2004534078A (ja) 2004-11-11
CA2451047C (en) 2012-10-09
NZ530290A (en) 2005-05-27
CN1659171A (zh) 2005-08-24
US20040167208A1 (en) 2004-08-26
US20100216728A1 (en) 2010-08-26
CN100503611C (zh) 2009-06-24
CA2455328C (en) 2011-09-20
EP1397369A1 (en) 2004-03-17
EP1498121B1 (en) 2009-09-02
EP1498121A1 (en) 2005-01-19
WO2002102804A8 (en) 2004-05-13
AU2002311731B2 (en) 2009-02-26
US20080119528A1 (en) 2008-05-22
US20080221207A1 (en) 2008-09-11
US7348358B2 (en) 2008-03-25
US7662851B2 (en) 2010-02-16
CN1543466A (zh) 2004-11-03
AU2002311731C1 (en) 2009-09-03
NO20035648L (no) 2004-02-18
CN101606929A (zh) 2009-12-23
CA2455328A1 (en) 2002-12-27
EP1938819A3 (en) 2010-04-07

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