NO332402B1 - Indol, azaindol og relaterte heterocykliske N-substituerte piperazinderivater, farmasøytiske preparater omfattende slike samt slike forbindelser og prepareter for behandling av sykdom - Google Patents

Indol, azaindol og relaterte heterocykliske N-substituerte piperazinderivater, farmasøytiske preparater omfattende slike samt slike forbindelser og prepareter for behandling av sykdom

Info

Publication number
NO332402B1
NO332402B1 NO20060082A NO20060082A NO332402B1 NO 332402 B1 NO332402 B1 NO 332402B1 NO 20060082 A NO20060082 A NO 20060082A NO 20060082 A NO20060082 A NO 20060082A NO 332402 B1 NO332402 B1 NO 332402B1
Authority
NO
Norway
Prior art keywords
compounds
treatment
pharmaceutical compositions
formula
azaindole
Prior art date
Application number
NO20060082A
Other languages
English (en)
Norwegian (no)
Other versions
NO20060082L (no
Inventor
John F Kadow
Nicholas A Meanwell
Kap-Sun Yeung
Michelle Farkas
Malcolm Taylor
David Johnston
Thomas Stephen Coulter
J J Kim Wright
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20060082L publication Critical patent/NO20060082L/no
Publication of NO332402B1 publication Critical patent/NO332402B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20060082A 2003-07-01 2006-01-05 Indol, azaindol og relaterte heterocykliske N-substituerte piperazinderivater, farmasøytiske preparater omfattende slike samt slike forbindelser og prepareter for behandling av sykdom NO332402B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US48422403P 2003-07-01 2003-07-01
US49328303P 2003-08-07 2003-08-07
US54197004P 2004-02-05 2004-02-05
PCT/US2004/019890 WO2005004801A2 (en) 2003-07-01 2004-06-22 Indole, azaindole and related heterocyclic n-substituted piperazine derivatives

Publications (2)

Publication Number Publication Date
NO20060082L NO20060082L (no) 2006-03-28
NO332402B1 true NO332402B1 (no) 2012-09-10

Family

ID=34069101

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060082A NO332402B1 (no) 2003-07-01 2006-01-05 Indol, azaindol og relaterte heterocykliske N-substituerte piperazinderivater, farmasøytiske preparater omfattende slike samt slike forbindelser og prepareter for behandling av sykdom

Country Status (7)

Country Link
US (3) US20050075364A1 (enExample)
EP (1) EP1638568B1 (enExample)
JP (1) JP4584923B2 (enExample)
AT (1) ATE517625T1 (enExample)
IS (1) IS2881B (enExample)
NO (1) NO332402B1 (enExample)
WO (1) WO2005004801A2 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050075364A1 (en) * 2003-07-01 2005-04-07 Kap-Sun Yeung Indole, azaindole and related heterocyclic N-substituted piperazine derivatives
MXPA06005686A (es) 2003-11-20 2006-08-17 Janssen Pharmaceutica Nv 2-quinolinonas y 2-quinoxalinonas 7-fenilaquilo sustituidas como inhibidores de la poli(adp-ribosa)polimerasa.
KR101118582B1 (ko) 2003-11-20 2012-02-27 얀센 파마슈티카 엔.브이. 폴리(ａｄｐ-리보스)폴리머라제 저해제로서의 6-알케닐 및6-페닐알킬 치환된 2-퀴놀리논 및 2-퀴녹살리논
US20050124623A1 (en) * 2003-11-26 2005-06-09 Bender John A. Diazaindole-dicarbonyl-piperazinyl antiviral agents
EA012837B1 (ru) 2004-06-30 2009-12-30 Янссен Фармацевтика Н.В. Производные хиназолинона в качестве ингибиторов parp
ES2415771T3 (es) 2004-06-30 2013-07-26 Janssen Pharmaceutica N.V. Derivados de quinazolina como inhibidores de PARP
CN1980674B (zh) * 2004-06-30 2011-05-25 詹森药业有限公司 作为parp抑制剂的2,3-二氮杂萘衍生物
US20060100209A1 (en) * 2004-11-09 2006-05-11 Chong-Hui Gu Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US20060100432A1 (en) * 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
DE102005027567A1 (de) 2005-06-14 2006-12-21 Basf Ag Verfahren zum Passivieren von metallischen Oberflächen mit Säuregruppen aufweisenden Polymeren
US7396830B2 (en) * 2005-10-04 2008-07-08 Bristol-Myers Squibb Company Piperazine amidines as antiviral agents
US7851476B2 (en) * 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US20070259879A1 (en) * 2006-03-06 2007-11-08 Trimeris, Inc. Piperazine and piperidine biaryl derivatives
US7807671B2 (en) * 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
CN101432278B (zh) * 2006-04-25 2012-11-28 布里斯托尔-迈尔斯斯奎布公司 作为抗病毒剂的二酮基哌嗪和哌啶衍生物
US7504399B2 (en) * 2006-06-08 2009-03-17 Bristol-Meyers Squibb Company Piperazine enamines as antiviral agents
ATE542799T1 (de) 2007-03-08 2012-02-15 Janssen Pharmaceutica Nv Chinolinonderivate als parp und tank-inhibitoren
EP2215075B1 (en) 2007-10-26 2013-12-11 Janssen Pharmaceutica, N.V. Quinolinone derivatives as parp inhibitors
EP2271626B1 (en) 2008-03-27 2014-11-26 Janssen Pharmaceutica, N.V. Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors
EP2260026B1 (en) 2008-03-27 2011-06-22 Janssen Pharmaceutica, N.V. Quinazolinone derivatives as tubulin polymerization inhibitors
CN102076686B (zh) * 2008-06-25 2013-03-06 百时美施贵宝公司 作为hiv附着抑制剂的二酮哌啶衍生物
WO2009158394A1 (en) * 2008-06-25 2009-12-30 Bristol-Myers Squibb Company Diketo azolopiperidines and azolopiperazines as anti-hiv agents
EP2895475B1 (en) * 2012-08-09 2016-11-09 VIIV Healthcare UK (No.5) Limited Tricyclic amidine derivatives as hiv attachment inhibitors
EP2978762A1 (en) * 2013-03-27 2016-02-03 Bristol-Myers Squibb Company Piperazine and homopiperazine derivatives as hiv attachment inhibitors
BG111544A (bg) 2013-07-29 2015-01-30 Николай Цветков Субституирани бензамидни производни като in vitro mao-b инхибитори
CN107400130A (zh) * 2017-08-22 2017-11-28 长沙深橙生物科技有限公司 一种咪唑并吡啶衍生物的制备方法
US10111873B1 (en) 2018-01-17 2018-10-30 King Saud University Dihydropyrimidinone derivatives
CN114478367B (zh) * 2021-12-28 2025-01-17 乐威医药（江苏）股份有限公司 一种2,5-二氧代吡啶衍生物的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3188313A (en) * 1959-09-25 1965-06-08 Sterling Drug Inc 1-[(1-, 2- and 3-indolyl)-lower]piperazine derivatives and intermediates and processes for the preparation thereof
US6476034B2 (en) * 2000-02-22 2002-11-05 Bristol-Myers Squibb Company Antiviral azaindole derivatives

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2093090T3 (es) * 1989-12-28 1996-12-16 Upjohn Co Compuestos sustituidos diaromaticos anti-sida.
US5023265A (en) * 1990-06-01 1991-06-11 Schering Corporation Substituted 1-H-pyrrolopyridine-3-carboxamides
DK0594702T3 (da) 1991-07-03 1997-07-21 Upjohn Co Substituerede indoler som midler mod AIDS
WO1993005020A1 (en) 1991-09-06 1993-03-18 Merck & Co., Inc. Indoles as inhibitors of hiv reverse transcriptase
US5124327A (en) * 1991-09-06 1992-06-23 Merck & Co., Inc. HIV reverse transcriptase
RU2124511C1 (ru) * 1993-05-14 1999-01-10 Фармасьютикал Ко., Лтд Производные пиперазина
IT1265057B1 (it) 1993-08-05 1996-10-28 Dompe Spa Tropil 7-azaindolil-3-carbossiamidi
US5424329A (en) * 1993-08-18 1995-06-13 Warner-Lambert Company Indole-2-carboxamides as inhibitors of cell adhesion
GB9420521D0 (en) 1994-10-12 1994-11-30 Smithkline Beecham Plc Novel compounds
TW406075B (en) * 1994-12-13 2000-09-21 Upjohn Co Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
DE19814838C2 (de) 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
US6469006B1 (en) * 1999-06-15 2002-10-22 Bristol-Myers Squibb Company Antiviral indoleoxoacetyl piperazine derivatives
US20020061892A1 (en) * 2000-02-22 2002-05-23 Tao Wang Antiviral azaindole derivatives
DE60113543T2 (de) * 2000-07-10 2006-07-13 Bristol-Myers Squibb Co. Zusammensetzung und antivirale wirkung von substituierten indol-oxo-aceto-piperidin-derivaten
US6573262B2 (en) * 2000-07-10 2003-06-03 Bristol-Myers Sqibb Company Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives
US20030207910A1 (en) 2001-02-02 2003-11-06 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
KR20030079979A (ko) * 2001-02-02 2003-10-10 브리스톨-마이어스스퀴브컴파니 치환된 아자인돌옥소아세틱 피페라진 유도체의 조성물 및항바이러스 활성
US6825201B2 (en) * 2001-04-25 2004-11-30 Bristol-Myers Squibb Company Indole, azaindole and related heterocyclic amidopiperazine derivatives
US7037913B2 (en) 2002-05-01 2006-05-02 Bristol-Myers Squibb Company Bicyclo 4.4.0 antiviral derivatives
US20040063744A1 (en) * 2002-05-28 2004-04-01 Tao Wang Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides
US6900206B2 (en) 2002-06-20 2005-05-31 Bristol-Myers Squibb Company Indole, azaindole and related heterocyclic sulfonylureido piperazine derivatives
US20040063746A1 (en) 2002-07-25 2004-04-01 Alicia Regueiro-Ren Indole, azaindole and related heterocyclic ureido and thioureido piperazine derivatives
US20050075364A1 (en) * 2003-07-01 2005-04-07 Kap-Sun Yeung Indole, azaindole and related heterocyclic N-substituted piperazine derivatives
US7745625B2 (en) * 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
US7807671B2 (en) * 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3188313A (en) * 1959-09-25 1965-06-08 Sterling Drug Inc 1-[(1-, 2- and 3-indolyl)-lower]piperazine derivatives and intermediates and processes for the preparation thereof
US6476034B2 (en) * 2000-02-22 2002-11-05 Bristol-Myers Squibb Company Antiviral azaindole derivatives

Also Published As

Publication number Publication date
IS2881B (is) 2014-05-15
US8039486B2 (en) 2011-10-18
IS8215A (is) 2005-12-30
US20080132516A1 (en) 2008-06-05
US20050261296A1 (en) 2005-11-24
NO20060082L (no) 2006-03-28
JP2007516205A (ja) 2007-06-21
EP1638568A2 (en) 2006-03-29
ATE517625T1 (de) 2011-08-15
JP4584923B2 (ja) 2010-11-24
WO2005004801A2 (en) 2005-01-20
US20050075364A1 (en) 2005-04-07
EP1638568B1 (en) 2011-07-27
WO2005004801A3 (en) 2005-04-21
EP1638568A4 (en) 2008-08-06

Similar Documents

Publication Publication Date Title
NO332402B1 (no) Indol, azaindol og relaterte heterocykliske N-substituerte piperazinderivater, farmasøytiske preparater omfattende slike samt slike forbindelser og prepareter for behandling av sykdom
NO2021008I1 (no) fedratinib eller et farmasøytisk akseptabelt salt derav
WO2002085301A3 (en) Indole, azaindole and related heterocyclic amidopiperazine derivatives
DE60140814D1 (de) N-phenyl-2-pyrimidine-amine derivatives
GEP20053600B (en) 3-(4-Amidopyrrol-2-Ylmethlidene)-2- Indolinone Derivatives as Protein Kinase Inhibitors
BR0311541A (pt) indol, azaindol e 4-aquenil piperidina amidas heterocìclicas relacionadas
TR200201505T2 (tr) Terapötik maddeler olarak pirazolopirimidinler
MXPA05012466A (es) Derivados de quinolina como inhibidores de fosfodiesterasa.
DK1299382T3 (da) Præparat og antiviral virkning af substituerede indoloxoeddikesyrepiperazinderivater
ATE450533T1 (de) Carboxamidderivate
IS2734B (is) Pýrasólafleiður og notkun þar á, ásamt lyfjasamsetningum
HUP0303494A2 (hu) Bakteriális giráz inhibitorokat tartalmazó gyógyszerkészítmények és alkalmazásaik
HUP0101146A2 (hu) Foszfolipáz enzim inhibitor hatású indolszármazékok, valamint a vegyületeket tartalmazó gyógyászati készítmények
TR200200234T2 (tr) Tirozin Protein kinaz SYK purin türevleri inhibitörleri
MY119181A (en) Aryl pyrimidine derivatives
NO20054312L (no) HIV-replikasjonsinhiberende pyrimidiner og triaziner
SE0104341D0 (sv) New use
NO20070837L (no) Pyrido-pyrido pyrimidinderivater, fremstilling derav samt terapeutisk anvendelse for behandling av cancer.
PT828728E (pt) Di-hidrobenzofuranos de fenilo
WO2004000210A3 (en) Indole, azaindole and related heterocyclic sulfonylureido piperazine derivatives
WO2003080608A3 (en) Quinoline and aza-indole derivatives and their use as 5-ht6 ligands
DE60001586D1 (de) Diphenyl-piperidin derivate
DE59610031D1 (de) Cyclohexyldihydrobenzofurane
ATE318266T1 (de) 3-substituierte chinolin-4- carbonsäureamidderivate als nk-3- und nk-2- rezeptorantagonisten
WO2004011425A3 (en) Indole, azaindole and related heterocyclic ureido and thioureido piperazine derivatives

Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: VIIV HEALTHCARE UK (NO. 5) LIMITED, GB

MM1K Lapsed by not paying the annual fees