NO331715B1 - Anvendelse av 4-(4-metylpiperazin-1-ylmetyl)-N-[4-metyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)fenyl]-benzamid eller et farmasoytisk akseptabelt salt derav for fremstilling av et medikament for terapi eller prevensjon av diabetes - Google Patents

Anvendelse av 4-(4-metylpiperazin-1-ylmetyl)-N-[4-metyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)fenyl]-benzamid eller et farmasoytisk akseptabelt salt derav for fremstilling av et medikament for terapi eller prevensjon av diabetes Download PDF

Info

Publication number
NO331715B1
NO331715B1 NO20056188A NO20056188A NO331715B1 NO 331715 B1 NO331715 B1 NO 331715B1 NO 20056188 A NO20056188 A NO 20056188A NO 20056188 A NO20056188 A NO 20056188A NO 331715 B1 NO331715 B1 NO 331715B1
Authority
NO
Norway
Prior art keywords
diabetes
abl
compound
cells
beta
Prior art date
Application number
NO20056188A
Other languages
English (en)
Norwegian (no)
Other versions
NO20056188L (no
Inventor
Robert Per Hagerkvist
Nils Richard Welsh
Original Assignee
Robert Per Hagerkvist
Nils Richard Welsh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0312086A external-priority patent/GB0312086D0/en
Priority claimed from GB0402682A external-priority patent/GB0402682D0/en
Application filed by Robert Per Hagerkvist, Nils Richard Welsh filed Critical Robert Per Hagerkvist
Publication of NO20056188L publication Critical patent/NO20056188L/no
Publication of NO331715B1 publication Critical patent/NO331715B1/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO20056188A 2003-05-27 2005-12-23 Anvendelse av 4-(4-metylpiperazin-1-ylmetyl)-N-[4-metyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)fenyl]-benzamid eller et farmasoytisk akseptabelt salt derav for fremstilling av et medikament for terapi eller prevensjon av diabetes NO331715B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0312086A GB0312086D0 (en) 2003-05-27 2003-05-27 Organic compounds
GB0402682A GB0402682D0 (en) 2004-02-06 2004-02-06 Organic compounds
PCT/EP2004/005679 WO2004105763A2 (en) 2003-05-27 2004-05-26 Use of tyrosine kinase inhibitor to treat diabetes

Publications (2)

Publication Number Publication Date
NO20056188L NO20056188L (no) 2005-12-23
NO331715B1 true NO331715B1 (no) 2012-03-05

Family

ID=33492240

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20056188A NO331715B1 (no) 2003-05-27 2005-12-23 Anvendelse av 4-(4-metylpiperazin-1-ylmetyl)-N-[4-metyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)fenyl]-benzamid eller et farmasoytisk akseptabelt salt derav for fremstilling av et medikament for terapi eller prevensjon av diabetes

Country Status (21)

Country Link
US (1) US7875616B2 (ja)
EP (1) EP1631291B1 (ja)
JP (1) JP4776537B2 (ja)
KR (1) KR101102229B1 (ja)
AT (1) ATE439133T1 (ja)
BR (1) BRPI0410704A (ja)
CA (1) CA2526594C (ja)
DE (1) DE602004022540D1 (ja)
DK (1) DK1631291T3 (ja)
ES (1) ES2331800T3 (ja)
HK (1) HK1087638A1 (ja)
IL (1) IL171927A (ja)
IS (1) IS2712B (ja)
MA (1) MA27812A1 (ja)
MX (1) MXPA05012739A (ja)
NO (1) NO331715B1 (ja)
NZ (1) NZ543709A (ja)
PL (1) PL1631291T3 (ja)
PT (1) PT1631291E (ja)
RU (1) RU2365373C2 (ja)
WO (1) WO2004105763A2 (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1653934B1 (en) * 2003-08-15 2008-05-14 AB Science Use of c-kit inhibitors for treating type ii diabetes
US20060094682A1 (en) * 2004-10-29 2006-05-04 Odyssey Thera, Inc. Kinase inhibitors for the treatment of diabetes and obesity
WO2008001885A1 (fr) * 2006-06-30 2008-01-03 Kyowa Hakko Kirin Co., Ltd. INHIBITEUR DE KINASE Abl
CA2848210A1 (en) * 2011-09-15 2013-03-21 Novartis Ag Use of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one in the treatment of cancer in moderate hepatic impaired patients

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW225528B (ja) * 1992-04-03 1994-06-21 Ciba Geigy Ag
EP0773313B1 (de) * 1995-10-11 2000-08-09 ARTEVA TECHNOLOGIES S.à.r.l. Schwerentflammbare Sicherheitsgurte enthaltend phosphor-modifizierte Polyesterfasern
CO4940418A1 (es) * 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
GB9716557D0 (en) * 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
DK1033364T3 (da) * 1999-03-01 2005-06-06 Pfizer Prod Inc Cyanholdige oxamidsyrer og -derivater som thyroideareceptorligander
HUP0301865A3 (en) 2000-02-15 2005-12-28 Teva Pharma A method for synthesizing leflunomide
US7087608B2 (en) * 2000-03-03 2006-08-08 Robert Charles Atkins Use of PDGF receptor tyrosine kinase inhibitors for the treatment of diabetic nephropathy
MY128450A (en) * 2000-05-24 2007-02-28 Upjohn Co 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
JP2004518669A (ja) 2000-12-20 2004-06-24 スージェン・インコーポレーテッド 4−アリール置換インドリノン
AU2002334355A1 (en) 2001-09-06 2003-03-18 Prochon Biotech Ltd. Protein tyrosine kinase inhibitors
AUPS243002A0 (en) 2002-05-20 2002-06-13 Baker Medical Research Institute Therapeutic target and uses thereof
DE10235227A1 (de) * 2002-08-01 2004-02-19 Johann Berger Verfahren zur Herstellung eines gewebten Gurtbandes
AU2003259713A1 (en) 2002-08-09 2004-02-25 Theravance, Inc. Oncokinase fusion polypeptides associated with hyperproliferative and related disorders, nucleic acids encoding the same and methods for detecting and identifying the same
WO2004043408A2 (en) 2002-11-13 2004-05-27 Genpath Pharmaceuticals, Incorporated Gpc15: methods and compositions for treating cancer
DE10255360A1 (de) * 2002-11-27 2004-06-17 Johann Berger Verfahren zur Herstellung eines gewebten Gurtbandes

Also Published As

Publication number Publication date
IL171927A (en) 2011-10-31
AU2004243491A1 (en) 2004-12-09
US7875616B2 (en) 2011-01-25
JP4776537B2 (ja) 2011-09-21
PT1631291E (pt) 2009-10-28
RU2365373C2 (ru) 2009-08-27
HK1087638A1 (en) 2006-10-20
MA27812A1 (fr) 2006-03-01
DK1631291T3 (da) 2009-11-02
DE602004022540D1 (de) 2009-09-24
NO20056188L (no) 2005-12-23
IS2712B (is) 2011-01-15
IS8139A (is) 2005-11-22
RU2005140516A (ru) 2007-07-10
KR20060021865A (ko) 2006-03-08
EP1631291B1 (en) 2009-08-12
IL171927A0 (en) 2006-04-10
NZ543709A (en) 2009-04-30
CA2526594A1 (en) 2004-12-09
US20070072932A1 (en) 2007-03-29
CA2526594C (en) 2011-11-08
EP1631291A2 (en) 2006-03-08
JP2006528225A (ja) 2006-12-14
KR101102229B1 (ko) 2012-01-05
ES2331800T3 (es) 2010-01-15
PL1631291T3 (pl) 2010-04-30
MXPA05012739A (es) 2006-05-17
WO2004105763A3 (en) 2005-06-02
BRPI0410704A (pt) 2006-06-13
ATE439133T1 (de) 2009-08-15
WO2004105763A2 (en) 2004-12-09

Similar Documents

Publication Publication Date Title
Liu et al. Nephroprotective effects of polydatin against ischemia/reperfusion injury: a role for the PI3K/Akt signal pathway
US8614192B2 (en) Method for treating ocular cancer
Zhang et al. Anti-diabetic effect of mulberry leaf polysaccharide by inhibiting pancreatic islet cell apoptosis and ameliorating insulin secretory capacity in diabetic rats
Price et al. Dependence of cisplatin-induced cell death in vitro and in vivo on cyclin-dependent kinase 2
Abdul-Ghani et al. Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart
Liu et al. Mediation of β-endorphin by myricetin to lower plasma glucose in streptozotocin-induced diabetic rats
Danilova et al. Emerging roles for mesencephalic astrocyte-derived neurotrophic factor (MANF) in pancreatic beta cells and diabetes
Xie et al. Effect of ozone on vascular endothelial growth factor (VEGF) and related inflammatory cytokines in rats with diabetic retinopathy
Küser-Abalı et al. SIK2 is involved in the negative modulation of insulin-dependent Müller cell survival and implicated in hyperglycemia-induced cell death
Yu et al. Downregulation of TNF‐α/TNF‐R1 Signals by AT‐Lipoxin A4 May Be a Significant Mechanism of Attenuation in SAP‐Associated Lung Injury
NO331715B1 (no) Anvendelse av 4-(4-metylpiperazin-1-ylmetyl)-N-[4-metyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)fenyl]-benzamid eller et farmasoytisk akseptabelt salt derav for fremstilling av et medikament for terapi eller prevensjon av diabetes
US8470785B2 (en) Method for treating ocular cancer
CA2462638A1 (en) Methods and compositions for modulating apoptosis
JP2002501499A (ja) 免疫調節剤の用途
WO2008047880A1 (fr) Agent thérapeutique pour la polyarthrite rhumatoïde
CN110812470A (zh) 用于代谢调节的方法和组合物
AU2004243491B2 (en) Use of tyrosine kinase inhibitor to treat diabetes
CN100372537C (zh) 酪氨酸激酶抑制剂在治疗糖尿病中的用途
US20060067919A1 (en) Colon cancer metastasis inhibitor
WO2023074794A1 (ja) Hdac調節剤による糖尿病ならびに合併症の治療方法または治療剤
US20200405773A1 (en) Promoting and protecting functional beta cell mass by syntaxin 4 enrichment
Jobe et al. Protection from BB rat diabetes by the platelet-activating factor inhibitor BN50730
Maharsy Enhancing Cardiomyocyte Survival in Drug Induced Cardiac Injury
Ingaramo et al. Diabetes and Its Hepatic Complication
Scatizzi Dual roles for cell cycle inhibitors and apoptotic agonists in macrophages during inflammatory disease

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees