NO331495B1 - Nye forbindelser med selektiv inhiberende effekt ved GSK3 - Google Patents
Nye forbindelser med selektiv inhiberende effekt ved GSK3 Download PDFInfo
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- NO331495B1 NO331495B1 NO20053460A NO20053460A NO331495B1 NO 331495 B1 NO331495 B1 NO 331495B1 NO 20053460 A NO20053460 A NO 20053460A NO 20053460 A NO20053460 A NO 20053460A NO 331495 B1 NO331495 B1 NO 331495B1
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Gynecology & Obstetrics (AREA)
- AIDS & HIV (AREA)
- Orthopedic Medicine & Surgery (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0203754A SE0203754D0 (sv) | 2002-12-17 | 2002-12-17 | New compounds |
| PCT/SE2003/001955 WO2004055005A1 (fr) | 2002-12-17 | 2003-12-15 | Nouveaux composes possedant un effet d'inhibition selective de la gsk3 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20053460L NO20053460L (no) | 2005-08-12 |
| NO331495B1 true NO331495B1 (no) | 2012-01-16 |
Family
ID=20289907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20053460A NO331495B1 (no) | 2002-12-17 | 2005-07-15 | Nye forbindelser med selektiv inhiberende effekt ved GSK3 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7585853B2 (fr) |
| EP (2) | EP1575938B1 (fr) |
| JP (1) | JP4674088B2 (fr) |
| KR (1) | KR101110457B1 (fr) |
| CN (1) | CN100351250C (fr) |
| AT (1) | ATE454382T1 (fr) |
| AU (1) | AU2003287135B2 (fr) |
| BR (1) | BR0317294A (fr) |
| CA (1) | CA2508042C (fr) |
| DE (1) | DE60330910D1 (fr) |
| ES (1) | ES2337682T3 (fr) |
| HK (1) | HK1080856A1 (fr) |
| IL (1) | IL169016A (fr) |
| MX (1) | MXPA05006243A (fr) |
| NO (1) | NO331495B1 (fr) |
| NZ (1) | NZ540449A (fr) |
| SE (1) | SE0203754D0 (fr) |
| WO (1) | WO2004055005A1 (fr) |
| ZA (1) | ZA200504617B (fr) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7704995B2 (en) | 2002-05-03 | 2010-04-27 | Exelixis, Inc. | Protein kinase modulators and methods of use |
| SE0203753D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
| SE0203752D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
| DK1784396T3 (da) * | 2004-08-26 | 2011-02-14 | Pfizer | Pyrazol-substituerede aminoheteroaryl-forbindelser som proteinkinase-inhibitorer |
| AU2005276135B2 (en) * | 2004-08-26 | 2011-04-28 | Pfizer Inc. | Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors |
| US20100190980A1 (en) * | 2007-06-21 | 2010-07-29 | Taisho Pharmaceutical Co., Ltd | Pyrazinamide compound |
| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
| EP2138485A1 (fr) * | 2008-06-26 | 2009-12-30 | sanofi-aventis | Dérivés substitués de N-oxyde pyrazine |
| EP2370424A1 (fr) | 2008-11-10 | 2011-10-05 | Vertex Pharmaceuticals Incorporated | Composés utiles comme inhibiteurs de l atr kinase |
| DK3354650T3 (da) | 2008-12-19 | 2022-05-30 | Vertex Pharma | Forbindelser der er nyttige som inhibitorer af ATR-kinase |
| WO2011059388A1 (fr) * | 2009-11-13 | 2011-05-19 | Astrazeneca Ab | Pyrazine à substitution oxazolo[4,5-c]pyridine |
| KR20120120307A (ko) * | 2010-01-19 | 2012-11-01 | 아스트라제네카 아베 | 피라진 유도체 |
| JP2013526538A (ja) | 2010-05-12 | 2013-06-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｒキナーゼ阻害剤として有用な化合物 |
| JP2013529200A (ja) | 2010-05-12 | 2013-07-18 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｒキナーゼ阻害剤として有用な化合物 |
| AU2011253021A1 (en) | 2010-05-12 | 2012-11-29 | Vertex Pharmaceuticals Incorporated | 2 -aminopyridine derivatives useful as inhibitors of ATR kinase |
| EP2569289A1 (fr) | 2010-05-12 | 2013-03-20 | Vertex Pharmaceuticals Incorporated | Pyrazines utiles en tant qu'inhibiteurs de la kinase atr |
| WO2011143425A2 (fr) | 2010-05-12 | 2011-11-17 | Vertex Pharmaceuticals Incorporated | Composés utilisables en tant qu'inhibiteurs de la kinase atr |
| AU2011253025A1 (en) | 2010-05-12 | 2012-11-29 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| MX2013000103A (es) | 2010-06-23 | 2013-06-13 | Vertex Pharma | Derivados de pirrolo-pirazina utiles como inhibidores de cinasa art. |
| KR20140027974A (ko) | 2011-04-05 | 2014-03-07 | 버텍스 파마슈티칼스 인코포레이티드 | Ｔｒａ 키나제의 억제제로서 유용한 아미노피라진 화합물 |
| CN103748086B (zh) | 2011-05-23 | 2016-05-25 | 默克专利有限公司 | 吡啶和吡嗪衍生物 |
| EA026654B1 (ru) | 2011-05-23 | 2017-05-31 | Мерк Патент Гмбх | Производные тиазола |
| EP2723745A1 (fr) | 2011-06-22 | 2014-04-30 | Vertex Pharmaceuticals Inc. | Composés utiles comme inhibiteurs de la kinase atr |
| JP2014517079A (ja) | 2011-06-22 | 2014-07-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｒキナーゼ阻害剤として有用な化合物 |
| JP2014522818A (ja) | 2011-06-22 | 2014-09-08 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｒキナーゼ阻害剤として有用な化合物 |
| DE102011112978A1 (de) | 2011-09-09 | 2013-03-14 | Merck Patent Gmbh | Benzonitrilderivate |
| SG11201401093WA (en) | 2011-09-30 | 2014-04-28 | Vertex Pharma | Processes for making compounds useful as inhibitors of atr kinase |
| US8846686B2 (en) | 2011-09-30 | 2014-09-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| EP2751088B1 (fr) | 2011-09-30 | 2016-04-13 | Vertex Pharmaceuticals Incorporated | Composés utiles en tant qu'inhibiteurs de kinase atr |
| WO2013049720A1 (fr) | 2011-09-30 | 2013-04-04 | Vertex Pharmaceuticals Incorporated | Composés utiles en tant qu'inhibiteurs de kinase atr |
| JP6162126B2 (ja) | 2011-09-30 | 2017-08-23 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ａｔｒ阻害剤による膵臓癌及び非小細胞肺癌の治療 |
| US8841337B2 (en) | 2011-11-09 | 2014-09-23 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| EP2776420A1 (fr) | 2011-11-09 | 2014-09-17 | Vertex Pharmaceuticals Incorporated | Composés de pyrazine utiles comme inhibiteurs de kinase atr |
| JP2015502925A (ja) | 2011-11-09 | 2015-01-29 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ａｔｒキナーゼの阻害剤として有用なピラジン化合物 |
| US8846918B2 (en) | 2011-11-09 | 2014-09-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| US8846917B2 (en) | 2011-11-09 | 2014-09-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| DE102011119127A1 (de) | 2011-11-22 | 2013-05-23 | Merck Patent Gmbh | 3-Cyanaryl-1H-pyrrolo[2.3-b]pyridin-Derivate |
| US9045493B2 (en) | 2012-02-09 | 2015-06-02 | Merck Patent Gmbh | Furo[3,2-b]- and thieno[3,2-b]pyridin derivatives |
| HUE035253T2 (en) | 2012-04-05 | 2018-05-02 | Vertex Pharma | Compounds and combination therapies useful as inhibitors of ATR kinase |
| EP2904406B1 (fr) | 2012-10-04 | 2018-03-21 | Vertex Pharmaceuticals Incorporated | Procédée pour la détermination de dommage de adn augmenté par inhibition de atr |
| EP2909202A1 (fr) | 2012-10-16 | 2015-08-26 | Vertex Pharmaceuticals Incorporated | Composés utiles en tant qu'inhibiteurs de la kinase atr |
| HUE052808T2 (hu) | 2012-12-07 | 2021-05-28 | Vertex Pharma | Pirazolo[1,5-A]pirimidinek alkalmazása ATR kináz inhibítorként, rákos megbetegedések kezelésére |
| EP2970286A1 (fr) | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Inc. | Dérivés de pyrazolopyrimidine fusionnés utiles en tant qu'inhibiteurs de la kinase atr |
| RS59679B1 (sr) | 2013-12-06 | 2020-01-31 | Vertex Pharma | Jedinjenje 2-amino-6-fluoro-n-[5-fluoro-piridin-3-il]pirazolo[1,5-a]pirimidin-3-karboksamida korisno kao inhibitor atr kinaze, njegovo dobijanje, različiti čvrsti oblici i njegovi radioaktivno obeleženi derivati |
| US20170165230A1 (en) | 2014-04-09 | 2017-06-15 | Christopher Rudd | Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity |
| SI3152212T1 (sl) | 2014-06-05 | 2020-06-30 | Vertex Pharmaceuticals Inc. | Radioaktivno označeni derivati 2-amino-6-fluoro-N-(5-fluoro-piridin-3-IL)-pirazolo (1,5-A)pirimidin-3- karboksamidne spojine, koristni kot inhibitor kinaze ATR, priprava navedene spojine in njene različne trdne oblike |
| RS59054B1 (sr) | 2014-06-17 | 2019-08-30 | Vertex Pharma | Postupak za lečenje raka korišćenjem kombinacije chk1 i atr inhibitora |
| JO3589B1 (ar) | 2014-08-06 | 2020-07-05 | Novartis Ag | مثبطات كيناز البروتين c وطرق استخداماتها |
| MX2017006483A (es) * | 2014-11-18 | 2017-09-12 | Merck Sharp & Dohme | Compuestos aminopirazina con propiedades antagonistas a2a. |
| WO2017059357A1 (fr) | 2015-09-30 | 2017-04-06 | Vertex Pharmaceuticals Incorporated | Méthode de traitement du cancer utilisant une association d'agents endommageant l'adn et d'inhibiteurs de l'atr |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA26473A1 (fr) * | 1997-03-01 | 2004-12-20 | Glaxo Group Ltd | Composes pharmacologiquement actifs. |
| US6995161B2 (en) | 2000-02-16 | 2006-02-07 | Neurogen Corporation | Substituted arylpyrazines |
| JP2003525931A (ja) * | 2000-03-07 | 2003-09-02 | アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 置換された３−フェニル−５−アルコキシ−１，３，４−オキサジアゾール−２−オンおよびホルモン感受性リパーゼを阻害するためのその使用 |
| AR029489A1 (es) | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
| CN1329382C (zh) * | 2001-05-11 | 2007-08-01 | 比奥维特罗姆股份公司 | 治疗肥胖、ⅱ型糖尿病和cns－疾病的芳基磺酰胺化合物 |
| SE0102439D0 (sv) * | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
| SE0102438D0 (sv) * | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
| JP2003081937A (ja) * | 2001-09-07 | 2003-03-19 | Bayer Ag | ベンゼンスルホンアミド誘導体 |
| SE0203752D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
-
2002
- 2002-12-17 SE SE0203754A patent/SE0203754D0/xx unknown
-
2003
- 2003-12-15 WO PCT/SE2003/001955 patent/WO2004055005A1/fr active Application Filing
- 2003-12-15 KR KR1020057011137A patent/KR101110457B1/ko not_active IP Right Cessation
- 2003-12-15 CA CA2508042A patent/CA2508042C/fr not_active Expired - Fee Related
- 2003-12-15 AU AU2003287135A patent/AU2003287135B2/en not_active Ceased
- 2003-12-15 AT AT03781204T patent/ATE454382T1/de not_active IP Right Cessation
- 2003-12-15 CN CNB2003801066631A patent/CN100351250C/zh not_active Expired - Fee Related
- 2003-12-15 BR BR0317294-5A patent/BR0317294A/pt not_active IP Right Cessation
- 2003-12-15 US US10/539,543 patent/US7585853B2/en not_active Expired - Fee Related
- 2003-12-15 JP JP2004560223A patent/JP4674088B2/ja not_active Expired - Fee Related
- 2003-12-15 EP EP03781204A patent/EP1575938B1/fr not_active Expired - Lifetime
- 2003-12-15 NZ NZ540449A patent/NZ540449A/en not_active IP Right Cessation
- 2003-12-15 ES ES03781204T patent/ES2337682T3/es not_active Expired - Lifetime
- 2003-12-15 EP EP09180635A patent/EP2161265A3/fr not_active Withdrawn
- 2003-12-15 DE DE60330910T patent/DE60330910D1/de not_active Expired - Lifetime
- 2003-12-15 MX MXPA05006243A patent/MXPA05006243A/es active IP Right Grant
-
2005
- 2005-06-06 IL IL169016A patent/IL169016A/en not_active IP Right Cessation
- 2005-07-15 NO NO20053460A patent/NO331495B1/no not_active IP Right Cessation
-
2006
- 2006-01-16 ZA ZA200504617A patent/ZA200504617B/en unknown
- 2006-01-19 HK HK06100896.9A patent/HK1080856A1/xx not_active IP Right Cessation
-
2009
- 2009-08-21 US US12/545,213 patent/US20100075989A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2508042A1 (fr) | 2004-07-01 |
| CN100351250C (zh) | 2007-11-28 |
| KR20050084363A (ko) | 2005-08-26 |
| EP2161265A2 (fr) | 2010-03-10 |
| KR101110457B1 (ko) | 2012-02-17 |
| US7585853B2 (en) | 2009-09-08 |
| EP1575938B1 (fr) | 2010-01-06 |
| MXPA05006243A (es) | 2005-08-19 |
| WO2004055005A1 (fr) | 2004-07-01 |
| NZ540449A (en) | 2008-02-29 |
| EP1575938A1 (fr) | 2005-09-21 |
| WO2004055005A8 (fr) | 2005-06-30 |
| IL169016A (en) | 2013-08-29 |
| DE60330910D1 (de) | 2010-02-25 |
| ZA200504617B (en) | 2006-03-29 |
| AU2003287135A1 (en) | 2004-07-09 |
| JP4674088B2 (ja) | 2011-04-20 |
| ATE454382T1 (de) | 2010-01-15 |
| SE0203754D0 (sv) | 2002-12-17 |
| NO20053460L (no) | 2005-08-12 |
| US20060116362A1 (en) | 2006-06-01 |
| EP2161265A3 (fr) | 2010-06-02 |
| CA2508042C (fr) | 2012-01-10 |
| AU2003287135B2 (en) | 2007-01-25 |
| BR0317294A (pt) | 2005-11-08 |
| ES2337682T3 (es) | 2010-04-28 |
| US20100075989A1 (en) | 2010-03-25 |
| CN1729185A (zh) | 2006-02-01 |
| JP2006513180A (ja) | 2006-04-20 |
| HK1080856A1 (en) | 2006-05-04 |
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| MM1K | Lapsed by not paying the annual fees |