NO330183B1 - Cyanoguanidinprodroger - Google Patents
Cyanoguanidinprodroger Download PDFInfo
- Publication number
- NO330183B1 NO330183B1 NO20045374A NO20045374A NO330183B1 NO 330183 B1 NO330183 B1 NO 330183B1 NO 20045374 A NO20045374 A NO 20045374A NO 20045374 A NO20045374 A NO 20045374A NO 330183 B1 NO330183 B1 NO 330183B1
- Authority
- NO
- Norway
- Prior art keywords
- tert
- piperidyl
- butoxycarbonyl
- hexyl
- cyano
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims description 99
- 239000000203 mixture Substances 0.000 claims description 37
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- 125000000217 alkyl group Chemical group 0.000 claims description 8
- UUAGVPDTFQKJSV-UHFFFAOYSA-N tert-butyl 4-[2-(chloromethoxycarbonyloxy)ethyl]piperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(CCOC(=O)OCCl)CC1 UUAGVPDTFQKJSV-UHFFFAOYSA-N 0.000 claims description 8
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38083602P | 2002-05-17 | 2002-05-17 | |
| PCT/DK2003/000318 WO2003097601A1 (fr) | 2002-05-17 | 2003-05-15 | Promedicaments de cyanoguanidine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20045374L NO20045374L (no) | 2004-12-08 |
| NO330183B1 true NO330183B1 (no) | 2011-02-28 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20045374A NO330183B1 (no) | 2002-05-17 | 2004-12-08 | Cyanoguanidinprodroger |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20070249676A1 (fr) |
| EP (1) | EP1507760B1 (fr) |
| JP (1) | JP4625694B2 (fr) |
| KR (1) | KR101010871B1 (fr) |
| CN (1) | CN100503570C (fr) |
| AT (1) | ATE368649T1 (fr) |
| AU (1) | AU2003229534B2 (fr) |
| BR (1) | BR0309996A (fr) |
| CA (1) | CA2485351C (fr) |
| DE (1) | DE60315288T2 (fr) |
| ES (1) | ES2290454T3 (fr) |
| HK (1) | HK1076812A1 (fr) |
| IL (1) | IL165086A (fr) |
| IS (1) | IS7562A (fr) |
| MX (1) | MXPA04011322A (fr) |
| NO (1) | NO330183B1 (fr) |
| PL (1) | PL228742B1 (fr) |
| RU (1) | RU2326867C2 (fr) |
| WO (1) | WO2003097601A1 (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7253193B2 (en) | 2002-05-17 | 2007-08-07 | Leo Pharma A/S | Cyanoguanidine prodrugs |
| CA2594508C (fr) | 2004-12-22 | 2013-10-01 | Leo Pharma A/S | Composes de 1-cyanoguanidine |
| EP1917244A2 (fr) | 2005-08-24 | 2008-05-07 | Abbott GmbH & Co. KG | Composes guanidine a substitution hetaryl et utilisation en tant que partenaires de liaison pour des recepteurs de 5-ht5 |
| EP2197443A4 (fr) * | 2007-09-26 | 2014-01-01 | Gemin X Pharmaceuticals Canada Inc | Compositions et procédés pour influer sur les teneurs en nad+ en utilisant un inhibiteur de nicotinamide phosphoribosyle transférase |
| RU2011111728A (ru) | 2008-08-29 | 2012-10-10 | Топотаргет А/С (Dk) | Новые производные мочевины и тиомочевины |
| CA2751495C (fr) | 2009-02-06 | 2013-08-20 | Tianjin Hemay Bio-Tech Co., Ltd. | Compositions pharmaceutiques contenant des pyridyl-cyanoguanidines, leurs methodes de preparation et utilisations |
| EP2453883A1 (fr) | 2009-07-17 | 2012-05-23 | Topo Target A/S | Procédé de prédiction de l utilité de l administration d acide nicotinique ou d un précurseur ou d un pro-médicament de l acide nicotinique pour réduire la gravité des effets secondaires d un traitement anticancéreux à base d inhibiteurs de nicotinamide phosphoribosyltransférase |
| US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
| WO2011121055A1 (fr) | 2010-03-31 | 2011-10-06 | Topotarget A/S | Dérivés de pyridinyle comprenant un groupement cyanoguanidine ou acide squarique |
| WO2012137225A1 (fr) * | 2011-04-08 | 2012-10-11 | Sphaera Pharma Pvt. Ltd | Réactifs de méthylformyle substitué et procédé d'utilisation de ceux-ci pour modifier des propriétés physicochimiques et/ou pharmacocinétiques de composés |
| AU2013284487A1 (en) * | 2012-06-27 | 2015-02-19 | Sunflower Research Llc | Compounds and therapeutic uses thereof |
| CN116640238B (zh) * | 2023-05-30 | 2024-05-03 | 华侨大学 | 一种胍基吡啶壳聚糖鎓盐及其制备方法和应用 |
Family Cites Families (6)
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| US5919816A (en) * | 1994-11-14 | 1999-07-06 | Bionumerik Pharmaceuticals, Inc. | Formulations and methods of reducing toxicity of antineoplastic agents |
| GB9711125D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| WO2000061559A1 (fr) * | 1999-04-09 | 2000-10-19 | Shionogi Bioresearch Corp. | Composes de cyanoguanidine n-substitues |
| AU1494702A (en) * | 2000-11-21 | 2002-06-03 | Leo Pharma As | Cyanoguanidine prodrugs |
| US20030045515A1 (en) * | 2001-05-24 | 2003-03-06 | Lise Binderup | Combination medicament for treatment of neoplastic diseases |
| PL372761A1 (en) * | 2002-05-17 | 2005-08-08 | Leo Pharma A/S | Cyanoguanidine prodrugs |
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2003
- 2003-05-15 ES ES03722311T patent/ES2290454T3/es not_active Expired - Lifetime
- 2003-05-15 DE DE60315288T patent/DE60315288T2/de not_active Expired - Lifetime
- 2003-05-15 CN CNB038140772A patent/CN100503570C/zh not_active Expired - Fee Related
- 2003-05-15 MX MXPA04011322A patent/MXPA04011322A/es active IP Right Grant
- 2003-05-15 RU RU2004136991/04A patent/RU2326867C2/ru active
- 2003-05-15 EP EP03722311A patent/EP1507760B1/fr not_active Expired - Lifetime
- 2003-05-15 JP JP2004505334A patent/JP4625694B2/ja not_active Expired - Fee Related
- 2003-05-15 KR KR1020047018603A patent/KR101010871B1/ko active IP Right Grant
- 2003-05-15 BR BR0309996-2A patent/BR0309996A/pt not_active Application Discontinuation
- 2003-05-15 AU AU2003229534A patent/AU2003229534B2/en not_active Ceased
- 2003-05-15 CA CA2485351A patent/CA2485351C/fr not_active Expired - Lifetime
- 2003-05-15 PL PL372769A patent/PL228742B1/pl unknown
- 2003-05-15 AT AT03722311T patent/ATE368649T1/de not_active IP Right Cessation
- 2003-05-15 WO PCT/DK2003/000318 patent/WO2003097601A1/fr active IP Right Grant
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2004
- 2004-11-08 IL IL165086A patent/IL165086A/en active IP Right Grant
- 2004-11-29 IS IS7562A patent/IS7562A/is unknown
- 2004-12-08 NO NO20045374A patent/NO330183B1/no not_active IP Right Cessation
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2005
- 2005-10-10 HK HK05108938.3A patent/HK1076812A1/xx not_active IP Right Cessation
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2007
- 2007-06-28 US US11/823,571 patent/US20070249676A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20070249676A1 (en) | 2007-10-25 |
| CN100503570C (zh) | 2009-06-24 |
| JP4625694B2 (ja) | 2011-02-02 |
| RU2326867C2 (ru) | 2008-06-20 |
| HK1076812A1 (en) | 2006-01-27 |
| JP2005538949A (ja) | 2005-12-22 |
| DE60315288D1 (de) | 2007-09-13 |
| ES2290454T3 (es) | 2008-02-16 |
| KR20050016412A (ko) | 2005-02-21 |
| BR0309996A (pt) | 2005-02-22 |
| CN1662501A (zh) | 2005-08-31 |
| CA2485351A1 (fr) | 2003-11-27 |
| IL165086A (en) | 2011-11-30 |
| IL165086A0 (en) | 2005-12-18 |
| IS7562A (is) | 2004-11-29 |
| NO20045374L (no) | 2004-12-08 |
| PL372769A1 (en) | 2005-08-08 |
| AU2003229534B2 (en) | 2009-08-27 |
| DE60315288T2 (de) | 2008-04-10 |
| KR101010871B1 (ko) | 2011-01-26 |
| AU2003229534A1 (en) | 2003-12-02 |
| EP1507760A1 (fr) | 2005-02-23 |
| PL228742B1 (pl) | 2018-05-30 |
| ATE368649T1 (de) | 2007-08-15 |
| EP1507760B1 (fr) | 2007-08-01 |
| CA2485351C (fr) | 2011-12-06 |
| WO2003097601A1 (fr) | 2003-11-27 |
| RU2004136991A (ru) | 2005-06-10 |
| MXPA04011322A (es) | 2005-02-17 |
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