NO328271B1 - Anvendelse av nitrogeninneholdende heteroarylforbindelser for fremstilling av medikamenter til forebyggelse av amyloidose samt nitrogeninneholdende heteroarylforbindelser egnet for slik anvendelse - Google Patents
Anvendelse av nitrogeninneholdende heteroarylforbindelser for fremstilling av medikamenter til forebyggelse av amyloidose samt nitrogeninneholdende heteroarylforbindelser egnet for slik anvendelse Download PDFInfo
- Publication number
- NO328271B1 NO328271B1 NO20042709A NO20042709A NO328271B1 NO 328271 B1 NO328271 B1 NO 328271B1 NO 20042709 A NO20042709 A NO 20042709A NO 20042709 A NO20042709 A NO 20042709A NO 328271 B1 NO328271 B1 NO 328271B1
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- Prior art keywords
- group
- hydrogen atom
- alkyl group
- bis
- diamine
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- YAAWASYJIRZXSZ-UHFFFAOYSA-N pyrimidine-2,4-diamine Chemical compound NC1=CC=NC(N)=N1 YAAWASYJIRZXSZ-UHFFFAOYSA-N 0.000 description 1
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- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
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- 239000008096 xylene Substances 0.000 description 1
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Classifications
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- C07D237/22—Nitrogen and oxygen atoms
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
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- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
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- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
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- C07D241/20—Nitrogen atoms
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- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
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- C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
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- C07D251/54—Three nitrogen atoms
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- Chemical & Material Sciences (AREA)
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- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
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PCT/JP2002/012265 WO2003045923A1 (en) | 2001-11-28 | 2002-11-25 | Preventives or remedies for alzheimer’s disease or amyloid protein fibrosis inhibitors containing nitrogen-containing heteroaryl compounds |
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TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
EP2316459B1 (en) * | 2002-07-29 | 2013-11-06 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds for use in methods of treating or preventing autoimmune diseases |
ES2445208T3 (es) | 2002-07-29 | 2014-02-28 | Rigel Pharmaceuticals, Inc. | Compuestos de 2,4-pirimidindiamina para uso en métodos para tratar o prevenir enfermedades autoinmunitarias |
WO2005003103A2 (en) * | 2003-06-30 | 2005-01-13 | Astrazeneca Ab | 2, 4, 6-tri-substituted 6-membered heterocycles and their use in the treatment of neurodegenerative diseases |
PT1656372E (pt) | 2003-07-30 | 2013-06-27 | Rigel Pharmaceuticals Inc | Métodos para o tratamento ou prevenção de doenças autoimunes com compostos de 2,4-pirimidinadiamina |
WO2006068770A1 (en) | 2004-11-24 | 2006-06-29 | Rigel Pharmaceuticals, Inc. | Spiro-2, 4-pyrimidinediamine compounds and their uses |
CA2591948C (en) | 2005-01-19 | 2013-11-12 | Rigel Pharmaceuticals, Inc. | Prodrugs of 2,4-pyrimidinediamine compounds and their uses |
CN101184493A (zh) * | 2005-03-04 | 2008-05-21 | 阿尔斯根公司 | 用乙胺嘧啶及类似物治疗肌萎缩性侧索硬化 |
US20070135437A1 (en) * | 2005-03-04 | 2007-06-14 | Alsgen, Inc. | Modulation of neurodegenerative diseases |
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US7989465B2 (en) | 2007-10-19 | 2011-08-02 | Avila Therapeutics, Inc. | 4,6-disubstituted pyrimidines useful as kinase inhibitors |
US7982036B2 (en) | 2007-10-19 | 2011-07-19 | Avila Therapeutics, Inc. | 4,6-disubstitued pyrimidines useful as kinase inhibitors |
US8393968B2 (en) * | 2008-09-03 | 2013-03-12 | Igt | Gaming system, gaming device and method for providing a strategy game having a plurality of awards |
US8210935B2 (en) * | 2008-11-12 | 2012-07-03 | Igt | Gaming system, gaming device and method of providing collectors and tokens associated with collectors |
US8287364B2 (en) * | 2008-11-13 | 2012-10-16 | Igt | Gaming system, gaming device, and method for providing a game in which a player collects emblems by positioning accumulators in a field |
KR101095026B1 (ko) * | 2009-01-23 | 2011-12-20 | 한국과학기술연구원 | 비스(스티릴)피리미딘 및 비스(스티릴)벤젠 유도체, 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 베타아밀로이드 집적 관련 질환의 예방 또는 치료용 약학적 조성물 |
CN102706839B (zh) * | 2011-01-31 | 2015-08-12 | 香港科技大学 | 水溶性aie发光剂及其在检测和延迟淀粉样蛋白质的淀粉样纤维化中的用途 |
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US10538516B2 (en) | 2015-03-25 | 2020-01-21 | National Center For Geriatrics And Gerontology | Oxadiazole derivative and pharmaceutical containing same |
WO2017106367A1 (en) * | 2015-12-15 | 2017-06-22 | D.E. Shaw Research, Llc | Method of treating neurodegenerative disorders by rescuing alpha-synuclein toxicity |
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---|---|---|---|---|
US2393755A (en) * | 1942-08-05 | 1946-01-29 | Gen Electric | Method of preparing hydroxyarylamino triazines |
GB9325217D0 (en) | 1993-12-09 | 1994-02-09 | Zeneca Ltd | Pyrimidine derivatives |
FR2720638B1 (fr) * | 1994-06-03 | 1997-04-04 | Oreal | Compositions cosmétiques antisolaires à base d'un mélange synergétique de filtres et utilisations. |
GB9523675D0 (en) * | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
WO1998052551A1 (fr) * | 1997-05-22 | 1998-11-26 | Kyowa Hakko Kogyo Co., Ltd. | Composes bisaryle et remedes contre le cancer contenant ces composes |
US6335339B1 (en) * | 1998-01-13 | 2002-01-01 | Scriptgen Pharmaceuticals, Inc. | Triazine antiviral compounds |
ATE342892T1 (de) * | 1998-08-29 | 2006-11-15 | Astrazeneca Ab | Pyrimidine verbindungen |
ES2270612T3 (es) * | 1998-08-29 | 2007-04-01 | Astrazeneca Ab | Compuestos de pirimidina. |
WO2001025220A1 (en) | 1999-10-07 | 2001-04-12 | Amgen Inc. | Triazine kinase inhibitors |
WO2001055093A1 (fr) | 2000-01-25 | 2001-08-02 | Japan Tobacco Inc. | Composes a base de n-arylhydrazide et leur utilisation en tant que medicaments |
JP2002145840A (ja) * | 2000-01-25 | 2002-05-22 | Japan Tobacco Inc | N−アリールヒドラジド化合物及びその医薬用途 |
GB0428082D0 (en) * | 2004-12-22 | 2005-01-26 | Welcome Trust The Ltd | Therapeutic compounds |
-
2002
- 2002-11-25 DE DE60233266T patent/DE60233266D1/de not_active Expired - Lifetime
- 2002-11-25 BR BR0214539-1A patent/BR0214539A/pt not_active Application Discontinuation
- 2002-11-25 PL PL02370531A patent/PL370531A1/xx unknown
- 2002-11-25 AT AT02783612T patent/ATE438629T1/de not_active IP Right Cessation
- 2002-11-25 IL IL16221002A patent/IL162210A0/xx unknown
- 2002-11-25 EP EP02783612A patent/EP1473289B1/en not_active Expired - Lifetime
- 2002-11-25 WO PCT/JP2002/012265 patent/WO2003045923A1/ja active Application Filing
- 2002-11-25 CA CA2468948A patent/CA2468948C/en not_active Expired - Fee Related
- 2002-11-25 CN CNB028238044A patent/CN100354267C/zh not_active Expired - Fee Related
- 2002-11-25 KR KR1020047008193A patent/KR101031720B1/ko not_active IP Right Cessation
- 2002-11-25 NZ NZ533147A patent/NZ533147A/en not_active IP Right Cessation
- 2002-11-25 MX MXPA04005027A patent/MXPA04005027A/es active IP Right Grant
- 2002-11-25 HU HU0402657A patent/HUP0402657A3/hu unknown
- 2002-11-25 ES ES02783612T patent/ES2330090T3/es not_active Expired - Lifetime
- 2002-11-25 JP JP2003547375A patent/JP4490690B2/ja not_active Expired - Fee Related
- 2002-11-25 US US10/497,183 patent/US7589105B2/en not_active Expired - Fee Related
- 2002-11-25 DK DK02783612T patent/DK1473289T3/da active
- 2002-11-25 AU AU2002349480A patent/AU2002349480B2/en not_active Ceased
- 2002-11-26 TW TW091134250A patent/TW200300688A/zh unknown
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2004
- 2004-05-27 IL IL162210A patent/IL162210A/en not_active IP Right Cessation
- 2004-06-28 NO NO20042709A patent/NO328271B1/no not_active IP Right Cessation
-
2005
- 2005-04-25 HK HK05103532.4A patent/HK1070371A1/xx not_active IP Right Cessation
-
2008
- 2008-02-06 US US12/068,407 patent/US8003645B2/en not_active Expired - Fee Related
-
2009
- 2009-07-27 US US12/458,891 patent/US20090286809A1/en not_active Abandoned
- 2009-07-27 US US12/458,890 patent/US20090286794A1/en not_active Abandoned
-
2011
- 2011-05-10 US US13/067,111 patent/US20110275641A1/en not_active Abandoned
- 2011-05-10 US US13/067,110 patent/US20110275640A1/en not_active Abandoned
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