NO326525B1 - Sammensetning for intestinal avlevering og anvendelse av slike for fremstilling av medikament for behandling av intestinale infeksjoner. - Google Patents
Sammensetning for intestinal avlevering og anvendelse av slike for fremstilling av medikament for behandling av intestinale infeksjoner. Download PDFInfo
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- NO326525B1 NO326525B1 NO20023464A NO20023464A NO326525B1 NO 326525 B1 NO326525 B1 NO 326525B1 NO 20023464 A NO20023464 A NO 20023464A NO 20023464 A NO20023464 A NO 20023464A NO 326525 B1 NO326525 B1 NO 326525B1
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US17831800P | 2000-01-27 | 2000-01-27 | |
PCT/CA2001/000073 WO2001054514A1 (en) | 2000-01-27 | 2001-01-25 | Composition for intestinal delivery |
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EP (1) | EP1250056B1 (zh) |
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NO (1) | NO326525B1 (zh) |
NZ (1) | NZ520238A (zh) |
WO (1) | WO2001054514A1 (zh) |
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DE10105306A1 (de) * | 2001-02-02 | 2002-08-22 | Nutrinova Gmbh | Futtermittel für die Nutztieraufzucht enthaltend Sorbinsäure und Enzyme |
DE10105347A1 (de) * | 2001-02-05 | 2002-08-22 | Nutrinova Gmbh | Sorbinsäurepräparat enthaltend Probiotika als Futtermittelzusatz in der Nutztieraufzucht |
DE10110431A1 (de) * | 2001-03-05 | 2002-09-19 | Nutrinova Gmbh | Bacteriocinhaltiges Sorbinsäurepräparat als Futtermittelzusatz in der Nutztieraufzucht |
ITFI20020043A1 (it) * | 2002-03-08 | 2003-09-08 | Fernando Cantini | Un prodotto lipidico a base di monogliceridi e digliceridi dell'acidooleico,trigliceridi randomizzati e glicerolo,per alimentazione animale |
AU2003218576A1 (en) * | 2002-04-08 | 2003-10-27 | Peros Systemes Technologies Inc. | Composition for modulating a physiological reaction or inducing an immune response |
GB2399752A (en) * | 2003-03-26 | 2004-09-29 | Micap Plc | Pharmaceutical composition comprising a fungal cell or cell fragment as adjuvant |
WO2005084704A1 (en) * | 2004-03-02 | 2005-09-15 | Peros Systems Technologies Inc. | Digestive bypass composition for arthropod and uses thereof |
US20050282756A1 (en) | 2004-06-18 | 2005-12-22 | Mehta Nozer M | Oral delivery of peptide pharmaceutical compositions |
WO2006053383A1 (en) | 2004-11-22 | 2006-05-26 | Anadis Ltd | Bioactive compositions |
DE102005010288A1 (de) | 2005-03-02 | 2006-09-07 | Riemser Arzneimittel Ag | Pharmazeutisches, oral applizierbares Präparat zur Behandlung von Fischen, Herstellungsverfahren für dieses und seine Verwendung |
US8426466B2 (en) | 2006-05-22 | 2013-04-23 | Nexus Pharma, Inc. | Compositions and methods for enhancing active agent absorption |
EP2150243A4 (en) * | 2007-05-21 | 2013-08-21 | Nexus Pharma Inc | COMPOSITIONS AND METHODS FOR REINFORCED ACTIVE SUBSTANCE ABSORPTION |
US20090111736A1 (en) * | 2007-10-29 | 2009-04-30 | Sri International | Orally-Absorbed Solid Dose Formulation for Vancomycin |
KR101045516B1 (ko) * | 2008-10-06 | 2011-06-30 | 부산대학교 산학협력단 | 식물 세포벽을 구성하는 다양한 다당류를 분해하는 효소를 생산하는 클렙시엘라 속 미생물 |
RU2449779C1 (ru) * | 2010-12-20 | 2012-05-10 | Государственное образовательное учреждение высшего профессионального образования "БАШКИРСКИЙ ГОСУДАРСТВЕННЫЙ МЕДИЦИНСКИЙ УНИВЕРСИТЕТ ФЕДЕРАЛЬНОГО АГЕНТСТВА ПО ЗДРАВООХРАНЕНИЮ И СОЦИАЛЬНОМУ РАЗВИТИЮ" | Драже с оксиметилурацилом и нетилмицином для лечения инфекционных заболеваний кишечника |
CN102727521B (zh) * | 2012-06-13 | 2013-07-24 | 辽宁王牌速效制药有限公司 | 庆大霉素碳酸铋胶囊内容物肠道释放微丸的制备方法 |
CN107568117B (zh) * | 2017-09-15 | 2020-10-13 | 广东海大畜牧兽医研究院有限公司 | 一种鱼类免疫试剂 |
WO2019199238A1 (en) * | 2018-04-09 | 2019-10-17 | Vet Products Research And Innovation Center Company Limited | Inorganic mineral entrapped in nanoparticle production method thereof |
CN112826836A (zh) * | 2021-01-08 | 2021-05-25 | 深圳未知君生物科技有限公司 | 一种粪菌口服制剂及其制备方法 |
CN113234641B (zh) * | 2021-06-21 | 2022-07-19 | 西北民族大学 | 一株耐低温、产蛋白酶的芽孢杆菌s77及其应用 |
KR102673333B1 (ko) * | 2023-02-14 | 2024-06-10 | 한우림 영농조합법인 | 다이어트 효능이 있는 청귤식초 조성물 및 이의 제조방법 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2125400A1 (en) * | 1991-12-18 | 1993-06-24 | Gordon L. Amidon | Soybean protein or hydrolyzates in pharmaceutical compositions to protect bioactive peptides from enzymatic inactivation |
AU1808897A (en) * | 1995-12-13 | 1997-07-03 | Dullatur Limited | A calcitonin preparation |
EP0923312A1 (en) * | 1996-04-29 | 1999-06-23 | K.U. Leuven Research & Development | Oral delivery form having a high absorption efficiency and method for making same |
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2001
- 2001-01-25 IL IL15081801A patent/IL150818A0/xx not_active IP Right Cessation
- 2001-01-25 NZ NZ520238A patent/NZ520238A/en unknown
- 2001-01-25 KR KR1020027009726A patent/KR20030009344A/ko not_active Application Discontinuation
- 2001-01-25 CA CA002396711A patent/CA2396711A1/en not_active Abandoned
- 2001-01-25 MX MXPA02007202A patent/MXPA02007202A/es active IP Right Grant
- 2001-01-25 EP EP01902185A patent/EP1250056B1/en not_active Expired - Lifetime
- 2001-01-25 WO PCT/CA2001/000073 patent/WO2001054514A1/en active IP Right Grant
- 2001-01-25 AT AT01902185T patent/ATE337712T1/de not_active IP Right Cessation
- 2001-01-25 DE DE60122672T patent/DE60122672T2/de not_active Expired - Fee Related
- 2001-01-25 CN CNB018056059A patent/CN100366295C/zh not_active Expired - Fee Related
- 2001-01-25 AU AU29904/01A patent/AU2990401A/en not_active Abandoned
- 2001-01-25 JP JP2001555503A patent/JP2003520862A/ja not_active Withdrawn
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2002
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EP1250056A1 (en) | 2002-10-23 |
IL150818A0 (en) | 2003-02-12 |
WO2001054514A1 (en) | 2001-08-02 |
NO20023464D0 (no) | 2002-07-19 |
CN1406112A (zh) | 2003-03-26 |
CA2396711A1 (en) | 2001-08-02 |
AU2990401A (en) | 2001-08-07 |
JP2003520862A (ja) | 2003-07-08 |
ATE337712T1 (de) | 2006-09-15 |
DE60122672D1 (de) | 2006-10-12 |
KR20030009344A (ko) | 2003-01-29 |
DE60122672T2 (de) | 2007-08-30 |
CN100366295C (zh) | 2008-02-06 |
NO20023464L (no) | 2002-09-24 |
EP1250056B1 (en) | 2006-08-30 |
MXPA02007202A (es) | 2003-09-22 |
NZ520238A (en) | 2004-04-30 |
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