NO325245B1 - Ftalayinon-piperidinderivater, legemidler inneholdende disse og deres anvendelse - Google Patents
Ftalayinon-piperidinderivater, legemidler inneholdende disse og deres anvendelse Download PDFInfo
- Publication number
- NO325245B1 NO325245B1 NO20033618A NO20033618A NO325245B1 NO 325245 B1 NO325245 B1 NO 325245B1 NO 20033618 A NO20033618 A NO 20033618A NO 20033618 A NO20033618 A NO 20033618A NO 325245 B1 NO325245 B1 NO 325245B1
- Authority
- NO
- Norway
- Prior art keywords
- salts
- tetrahydro
- piperidin
- compounds
- solvates
- Prior art date
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- 239000003814 drug Substances 0.000 title claims description 17
- 229940079593 drug Drugs 0.000 title claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 97
- -1 pyridin-4-yl-carbonyl Chemical group 0.000 claims description 58
- 150000003839 salts Chemical class 0.000 claims description 57
- 150000004677 hydrates Chemical class 0.000 claims description 28
- 239000012453 solvate Substances 0.000 claims description 28
- 238000011282 treatment Methods 0.000 claims description 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- 238000004519 manufacturing process Methods 0.000 claims description 11
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 10
- 201000010099 disease Diseases 0.000 claims description 8
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 8
- 208000010668 atopic eczema Diseases 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 5
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims description 3
- VBKPPDYGFUZOAJ-UHFFFAOYSA-N 5-oxopentanoic acid Chemical compound OC(=O)CCCC=O VBKPPDYGFUZOAJ-UHFFFAOYSA-N 0.000 claims description 3
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 3
- 208000006673 asthma Diseases 0.000 claims description 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 3
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims description 3
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 claims description 3
- 125000006514 pyridin-2-ylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims description 3
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims description 3
- NHVCANZLYPMKSR-LEWJYISDSA-N (4as,8ar)-2-(1-acetylpiperidin-4-yl)-4-(3,4-diethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1-one Chemical compound C1=C(OCC)C(OCC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(C(C)=O)CC1 NHVCANZLYPMKSR-LEWJYISDSA-N 0.000 claims description 2
- PMSDQTJDMYHMRP-VQTJNVASSA-N (4as,8ar)-4-(3,4-diethoxyphenyl)-2-(1-methylsulfonylpiperidin-4-yl)-4a,5,8,8a-tetrahydrophthalazin-1-one Chemical compound C1=C(OCC)C(OCC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(S(C)(=O)=O)CC1 PMSDQTJDMYHMRP-VQTJNVASSA-N 0.000 claims description 2
- IRQAORMVIRUVSL-IZZNHLLZSA-N (4as,8ar)-4-(3,4-diethoxyphenyl)-2-[1-(4-methylphenyl)sulfonylpiperidin-4-yl]-4a,5,8,8a-tetrahydrophthalazin-1-one Chemical compound C1=C(OCC)C(OCC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(S(=O)(=O)C=2C=CC(C)=CC=2)CC1 IRQAORMVIRUVSL-IZZNHLLZSA-N 0.000 claims description 2
- IDSNOSDXUZNXFS-RRPNLBNLSA-N (4as,8ar)-4-(3,4-dimethoxyphenyl)-2-[1-[5-(dimethylamino)naphthalen-1-yl]sulfonylpiperidin-4-yl]-4a,5,8,8a-tetrahydrophthalazin-1-one Chemical compound C1=C(OC)C(OC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(S(=O)(=O)C=2C3=CC=CC(=C3C=CC=2)N(C)C)CC1 IDSNOSDXUZNXFS-RRPNLBNLSA-N 0.000 claims description 2
- MFSYFDUUARWTFQ-CJRXIRLBSA-N 2-[4-[(4as,8ar)-4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,8,8a-tetrahydrophthalazin-2-yl]piperidin-1-yl]acetamide;hydrochloride Chemical compound Cl.C1=C(OC)C(OC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(CC(N)=O)CC1 MFSYFDUUARWTFQ-CJRXIRLBSA-N 0.000 claims description 2
- OBLQGGDVCNLUBG-VQTJNVASSA-N 4-[(4as,8ar)-4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,8,8a-tetrahydrophthalazin-2-yl]-n-tert-butylpiperidine-1-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(C(=O)NC(C)(C)C)CC1 OBLQGGDVCNLUBG-VQTJNVASSA-N 0.000 claims description 2
- HPAKPHNDMHWESA-FCHUYYIVSA-N 5-[4-[(4as,8ar)-4-(3,4-diethoxyphenyl)-1-oxo-4a,5,8,8a-tetrahydrophthalazin-2-yl]piperidin-1-yl]-5-oxopentanoic acid Chemical compound C1=C(OCC)C(OCC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(C(=O)CCCC(O)=O)CC1 HPAKPHNDMHWESA-FCHUYYIVSA-N 0.000 claims description 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 2
- 208000011231 Crohn disease Diseases 0.000 claims description 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 2
- 201000004681 Psoriasis Diseases 0.000 claims description 2
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- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 2
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- 239000012876 carrier material Substances 0.000 claims description 2
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
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- DZUJGZGLPQEEDQ-LEWJYISDSA-N (4as,8ar)-2-[1-[2-(4-amino-3,5-dichlorophenyl)-2-oxoethyl]piperidin-4-yl]-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1-one Chemical compound C1=C(OC)C(OC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(CC(=O)C=2C=C(Cl)C(N)=C(Cl)C=2)CC1 DZUJGZGLPQEEDQ-LEWJYISDSA-N 0.000 claims 1
- LSOGXQFCQOSGNV-BJKOFHAPSA-N (4as,8ar)-4-(3,4-diethoxyphenyl)-2-[1-(2-morpholin-4-ylacetyl)piperidin-4-yl]-4a,5,8,8a-tetrahydrophthalazin-1-one Chemical compound C1=C(OCC)C(OCC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(C(=O)CN2CCOCC2)CC1 LSOGXQFCQOSGNV-BJKOFHAPSA-N 0.000 claims 1
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- RLBQZJLGPGGCRU-BJKOFHAPSA-N (4as,8ar)-4-(3,4-diethoxyphenyl)-2-[1-(pyridine-4-carbonyl)piperidin-4-yl]-4a,5,8,8a-tetrahydrophthalazin-1-one Chemical compound C1=C(OCC)C(OCC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(C(=O)C=2C=CN=CC=2)CC1 RLBQZJLGPGGCRU-BJKOFHAPSA-N 0.000 claims 1
- YWHBSFAATHJDAA-VQTJNVASSA-N (4as,8ar)-4-(3,4-dimethoxyphenyl)-2-(1-pyrimidin-2-ylpiperidin-4-yl)-4a,5,8,8a-tetrahydrophthalazin-1-one Chemical compound C1=C(OC)C(OC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(C=2N=CC=CN=2)CC1 YWHBSFAATHJDAA-VQTJNVASSA-N 0.000 claims 1
- ZLSJEILNOWSWRS-VQTJNVASSA-N (4as,8ar)-4-(3,4-dimethoxyphenyl)-2-(1-thieno[2,3-d]pyrimidin-4-ylpiperidin-4-yl)-4a,5,8,8a-tetrahydrophthalazin-1-one Chemical compound C1=C(OC)C(OC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(C=2C=3C=CSC=3N=CN=2)CC1 ZLSJEILNOWSWRS-VQTJNVASSA-N 0.000 claims 1
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- AMRVEJYMDSINDP-XZOQPEGZSA-N (4as,8ar)-4-(3,4-dimethoxyphenyl)-2-[1-(4-nitrophenyl)piperidin-4-yl]-4a,5,8,8a-tetrahydrophthalazin-1-one Chemical compound C1=C(OC)C(OC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(C=2C=CC(=CC=2)[N+]([O-])=O)CC1 AMRVEJYMDSINDP-XZOQPEGZSA-N 0.000 claims 1
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- LWTZEJDQHWUMON-XZOQPEGZSA-N (4as,8ar)-4-(3,4-dimethoxyphenyl)-2-[1-(pyridin-4-ylmethyl)piperidin-4-yl]-4a,5,8,8a-tetrahydrophthalazin-1-one Chemical compound C1=C(OC)C(OC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(CC=2C=CN=CC=2)CC1 LWTZEJDQHWUMON-XZOQPEGZSA-N 0.000 claims 1
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01103496 | 2001-02-15 | ||
| PCT/EP2002/001547 WO2002064584A1 (en) | 2001-02-15 | 2002-02-14 | Phthalayinone-piperidino-derivatives as pde4 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20033618D0 NO20033618D0 (no) | 2003-08-14 |
| NO20033618L NO20033618L (no) | 2003-10-15 |
| NO325245B1 true NO325245B1 (no) | 2008-03-10 |
Family
ID=8176497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20033618A NO325245B1 (no) | 2001-02-15 | 2003-08-14 | Ftalayinon-piperidinderivater, legemidler inneholdende disse og deres anvendelse |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US6953853B2 (cs) |
| EP (1) | EP1362044A1 (cs) |
| JP (1) | JP4301812B2 (cs) |
| KR (1) | KR20030074817A (cs) |
| CN (1) | CN1524080A (cs) |
| AU (1) | AU2002234634B2 (cs) |
| BG (1) | BG108124A (cs) |
| BR (1) | BR0207278A (cs) |
| CA (1) | CA2438520C (cs) |
| CZ (1) | CZ20032491A3 (cs) |
| EA (1) | EA200300836A1 (cs) |
| EE (1) | EE05386B1 (cs) |
| HR (1) | HRP20030636B1 (cs) |
| HU (1) | HUP0303193A3 (cs) |
| IL (1) | IL156812A0 (cs) |
| MX (1) | MXPA03007310A (cs) |
| NO (1) | NO325245B1 (cs) |
| NZ (1) | NZ527424A (cs) |
| PL (1) | PL363391A1 (cs) |
| SK (1) | SK11382003A3 (cs) |
| WO (1) | WO2002064584A1 (cs) |
| ZA (1) | ZA200306815B (cs) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ527424A (en) | 2001-02-15 | 2005-02-25 | Altana Pharma Ag | Phthalayinone-piperidino-derivatives as PDE4 inhibitors |
| IL160271A0 (en) * | 2001-09-19 | 2004-07-25 | Altana Pharma Ag | Pharmaceutical compositions containing pde4-inhibitors and nsaid |
| JP2005538138A (ja) * | 2002-08-10 | 2005-12-15 | アルタナ ファルマ アクチエンゲゼルシャフト | Ｐｄｅ４インヒビターとしてのピリダジノン誘導体 |
| ES2286491T3 (es) * | 2002-08-10 | 2007-12-01 | Nycomed Gmbh | Piperidina-ftalazonas sustituidas con pirrolidinadiona, como agentes inhibidores de la pde4. |
| HRP20050197A2 (en) * | 2002-08-10 | 2006-06-30 | Altana Pharma Ag | Piperidine-n-oxide-derivatives |
| AU2003255376A1 (en) * | 2002-08-10 | 2004-03-11 | Altana Pharma Ag | Piperidine-derivatives as pde4 inhibitors |
| PL378247A1 (pl) * | 2003-01-14 | 2006-03-20 | Altana Pharma Ag | Inhibitory PDE4 w terapii nowotworów komórek limfoidalnych |
| WO2004098633A1 (en) * | 2003-05-12 | 2004-11-18 | Altana Pharma Ag | Composition comprising a pde-4 inhibitor and a tnf alpha antagonist |
| WO2004098605A1 (en) * | 2003-05-12 | 2004-11-18 | Altana Pharma Ag | Pharmaceutical composition comprising a pde4 inhibitor and il-1 trap |
| WO2004098606A1 (en) * | 2003-05-12 | 2004-11-18 | Altana Pharma Ag | Composition comprising a pde4 inhibitor and shuil-1r ii |
| WO2004098578A2 (en) * | 2003-05-12 | 2004-11-18 | Altana Pharma Ag | Composition comprising a pde4 inhibitor and a tnf-alfa antagonist selected from infliximab, adalimumab, cdp870 and cdp517 |
| EA012279B1 (ru) * | 2003-05-22 | 2009-08-28 | Никомед Гмбх | Композиция, включающая ингибитор pde4 и ингибитор pde5 |
| MXPA06002521A (es) * | 2003-09-05 | 2006-06-20 | Altana Pharma Ag | Uso de inhibidores de pde4 para el tratamiento de diabetes mellitus. |
| EP1716133B1 (en) * | 2004-02-04 | 2008-03-26 | Nycomed GmbH | 2-(piperidin-4-yl)-4,5-dihydro-2h-pyridazin-3-one derivatives as pde4 inhibitors |
| WO2005075457A1 (en) * | 2004-02-04 | 2005-08-18 | Altana Pharma Ag | Phthalazinone-derivatives as pde4 inhibitors |
| US20080227790A1 (en) * | 2004-02-04 | 2008-09-18 | Altana Pharma Ag | Pyridazinone Derivatives and their Use as Pde4 Inhibitors |
| JP5091106B2 (ja) | 2005-03-08 | 2012-12-05 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 真性糖尿病の治療のためのロフルミラスト |
| EP1956906A4 (en) | 2005-11-09 | 2009-12-30 | Combinatorx Inc | METHODS, COMPOSITIONS AND KITS FOR THE TREATMENT OF PATHOLOGIES |
| WO2007084560A2 (en) * | 2006-01-17 | 2007-07-26 | Signal Pharmaceuticals, Llc | INHIBITORS OF TNFα, PDE4 AND B-RAF, COMPOSITIONS THEREOF AND METHODS OF USE THEREWITH |
| JP5349302B2 (ja) * | 2006-07-05 | 2013-11-20 | タケダ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 炎症性肺疾患の治療のためのＨＭＧ−ＣｏＡレダクターゼインヒビターとホスホジエステラーゼ４インヒビターとの組合せ物 |
| TW200831493A (en) * | 2006-12-20 | 2008-08-01 | Glaxo Group Ltd | Compounds |
| DK2148876T3 (da) * | 2007-05-16 | 2012-01-16 | Nycomed Gmbh | Pyrazolonderivater som PDE4-inhibitorer |
| AR074318A1 (es) * | 2008-11-14 | 2011-01-05 | Nycomed Gmbh | Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias. |
| PE20140648A1 (es) * | 2011-06-17 | 2014-05-30 | Takeda Gmbh | Novedosos derivados de ftalazinona-pirrolopirimidinacarboxamida |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| EP3165224A1 (en) | 2015-11-09 | 2017-05-10 | Albert-Ludwigs-Universität Freiburg | Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders |
| JP6820717B2 (ja) | 2016-10-28 | 2021-01-27 | 株式会社日立ハイテク | プラズマ処理装置 |
| CN113121417A (zh) * | 2019-12-30 | 2021-07-16 | 苏州盛迪亚生物医药有限公司 | 一种新型哌啶衍生物及其药物用途 |
| WO2021192210A1 (ja) | 2020-03-27 | 2021-09-30 | 株式会社日立ハイテク | 半導体製造方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9205794A (es) * | 1991-10-09 | 1993-04-01 | Syntex Inc | Compuesto de benzo- y pirido- piridazinona y piridazinotiona |
| ATE234270T1 (de) | 1992-12-02 | 2003-03-15 | Pfizer | Cathecoldiether als selektive pde iv hemmungsmittel |
| DE19533975A1 (de) | 1995-09-14 | 1997-03-20 | Merck Patent Gmbh | Arylalkyl-diazinone |
| SI0971901T1 (en) | 1997-01-15 | 2003-10-31 | Altana Pharma Ag | Phthalazinones |
| AU1760399A (en) | 1997-12-15 | 1999-07-05 | Byk Gulden Lomberg Chemische Fabrik Gmbh | New phthalazinones |
| EE04312B1 (et) * | 1997-12-15 | 2004-06-15 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Dihüdrobensofuraanid, nende kasutamine ravimite valmistamiseks ning neid sisaldavad ravimid |
| EP0934933A1 (en) | 1998-02-06 | 1999-08-11 | Byk Gulden Lomberg Chemische Fabrik GmbH | Phthalazinones |
| ATE270278T1 (de) * | 1998-03-14 | 2004-07-15 | Altana Pharma Ag | Phthalazinone pde iii/iv hemmer |
| AU7654200A (en) | 1999-09-14 | 2001-04-17 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phthalazinone derivatives as pd3/4 inhibitors |
| CA2388121A1 (en) * | 1999-10-25 | 2001-05-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phthalazinone derivatives as pde 4 inhibitors |
| JP2003512466A (ja) | 1999-10-25 | 2003-04-02 | アルタナ ファルマ アクチエンゲゼルシャフト | Ｐｄｅ４インヒビターとしてのテトラヒドロチオピランフタラジノン誘導体 |
| KR20030031907A (ko) | 2000-06-05 | 2003-04-23 | 알타나 파마 아게 | β-2-아드레날린 수용체 작동물질로서 뿐만 아니라ＰＤＥ4-억제제로서 효과적인 화합물 |
| NZ527424A (en) * | 2001-02-15 | 2005-02-25 | Altana Pharma Ag | Phthalayinone-piperidino-derivatives as PDE4 inhibitors |
| US7186710B2 (en) | 2001-04-25 | 2007-03-06 | Altana Pharma Ag | Phthalazinones |
| EP1385838A1 (en) | 2001-04-25 | 2004-02-04 | ALTANA Pharma AG | Piperazino-derivatives and their use as pde4 inhibitor |
| JP2005538138A (ja) | 2002-08-10 | 2005-12-15 | アルタナ ファルマ アクチエンゲゼルシャフト | Ｐｄｅ４インヒビターとしてのピリダジノン誘導体 |
| ES2286491T3 (es) | 2002-08-10 | 2007-12-01 | Nycomed Gmbh | Piperidina-ftalazonas sustituidas con pirrolidinadiona, como agentes inhibidores de la pde4. |
| HRP20050197A2 (en) | 2002-08-10 | 2006-06-30 | Altana Pharma Ag | Piperidine-n-oxide-derivatives |
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2002
- 2002-02-14 NZ NZ527424A patent/NZ527424A/en not_active IP Right Cessation
- 2002-02-14 EE EEP200300311A patent/EE05386B1/xx not_active IP Right Cessation
- 2002-02-14 CZ CZ20032491A patent/CZ20032491A3/cs unknown
- 2002-02-14 MX MXPA03007310A patent/MXPA03007310A/es active IP Right Grant
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- 2002-02-14 SK SK1138-2003A patent/SK11382003A3/sk unknown
- 2002-02-14 CN CNA02805038XA patent/CN1524080A/zh active Pending
- 2002-02-14 HU HU0303193A patent/HUP0303193A3/hu unknown
- 2002-02-14 CA CA2438520A patent/CA2438520C/en not_active Expired - Fee Related
- 2002-02-14 EP EP02701277A patent/EP1362044A1/en not_active Withdrawn
- 2002-02-14 EA EA200300836A patent/EA200300836A1/ru unknown
- 2002-02-14 AU AU2002234634A patent/AU2002234634B2/en not_active Ceased
- 2002-02-14 JP JP2002564515A patent/JP4301812B2/ja not_active Expired - Fee Related
- 2002-02-14 IL IL15681202A patent/IL156812A0/xx unknown
- 2002-02-14 US US10/467,832 patent/US6953853B2/en not_active Expired - Fee Related
- 2002-02-14 KR KR10-2003-7010552A patent/KR20030074817A/ko not_active Withdrawn
- 2002-02-14 PL PL02363391A patent/PL363391A1/xx unknown
- 2002-02-14 WO PCT/EP2002/001547 patent/WO2002064584A1/en not_active Ceased
- 2002-02-14 BR BR0207278-5A patent/BR0207278A/pt not_active IP Right Cessation
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2003
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- 2003-09-01 ZA ZA200306815A patent/ZA200306815B/en unknown
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Also Published As
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|---|---|
| EE05386B1 (et) | 2011-02-15 |
| US7531540B2 (en) | 2009-05-12 |
| HRP20030636B1 (en) | 2012-05-31 |
| AU2002234634B2 (en) | 2007-07-26 |
| NO20033618L (no) | 2003-10-15 |
| CN1524080A (zh) | 2004-08-25 |
| PL363391A1 (en) | 2004-11-15 |
| MXPA03007310A (es) | 2003-12-04 |
| US20040067946A1 (en) | 2004-04-08 |
| US20050234062A1 (en) | 2005-10-20 |
| EA200300836A1 (ru) | 2004-02-26 |
| US20070129373A1 (en) | 2007-06-07 |
| HRP20030636A2 (en) | 2005-06-30 |
| CA2438520A1 (en) | 2002-08-22 |
| HUP0303193A2 (hu) | 2003-12-29 |
| NZ527424A (en) | 2005-02-25 |
| HUP0303193A3 (en) | 2007-08-28 |
| WO2002064584A1 (en) | 2002-08-22 |
| NO20033618D0 (no) | 2003-08-14 |
| BG108124A (bg) | 2004-08-31 |
| IL156812A0 (en) | 2004-02-08 |
| US7179810B2 (en) | 2007-02-20 |
| CZ20032491A3 (cs) | 2004-01-14 |
| US6953853B2 (en) | 2005-10-11 |
| JP4301812B2 (ja) | 2009-07-22 |
| EE200300311A (et) | 2003-10-15 |
| CA2438520C (en) | 2011-10-04 |
| BR0207278A (pt) | 2004-02-10 |
| JP2004518727A (ja) | 2004-06-24 |
| KR20030074817A (ko) | 2003-09-19 |
| SK11382003A3 (sk) | 2004-01-08 |
| ZA200306815B (en) | 2004-06-17 |
| EP1362044A1 (en) | 2003-11-19 |
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Owner name: TAKEDA GMBH, DE |
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