NO324946B1 - 3-(heteroarylacetamido)-2-okso-azetidin-1-sulfonsyre-derivater som antibakterielle midler, samt fremstilling og anvendelse derav og farmasoytisk preparat - Google Patents
3-(heteroarylacetamido)-2-okso-azetidin-1-sulfonsyre-derivater som antibakterielle midler, samt fremstilling og anvendelse derav og farmasoytisk preparat Download PDFInfo
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- NO324946B1 NO324946B1 NO20031162A NO20031162A NO324946B1 NO 324946 B1 NO324946 B1 NO 324946B1 NO 20031162 A NO20031162 A NO 20031162A NO 20031162 A NO20031162 A NO 20031162A NO 324946 B1 NO324946 B1 NO 324946B1
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- Prior art keywords
- compound
- formula
- hydrogen
- preparation
- sulfonic acid
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- 239000001257 hydrogen Substances 0.000 claims description 13
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- 230000000694 effects Effects 0.000 description 1
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- DERLTVRRWCJVCP-UHFFFAOYSA-N ethene;ethyl acetate Chemical compound C=C.CCOC(C)=O DERLTVRRWCJVCP-UHFFFAOYSA-N 0.000 description 1
- LTOHTVPCWUZTJY-UHFFFAOYSA-N ethoxyethane;ethyl acetate;hexane Chemical compound CCOCC.CCCCCC.CCOC(C)=O LTOHTVPCWUZTJY-UHFFFAOYSA-N 0.000 description 1
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- 235000011187 glycerol Nutrition 0.000 description 1
- 244000000058 gram-negative pathogen Species 0.000 description 1
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
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- 229910052742 iron Inorganic materials 0.000 description 1
- 239000007951 isotonicity adjuster Substances 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
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- 229940039717 lanolin Drugs 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
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- XTAZYLNFDRKIHJ-UHFFFAOYSA-N n,n-dioctyloctan-1-amine Chemical compound CCCCCCCCN(CCCCCCCC)CCCCCCCC XTAZYLNFDRKIHJ-UHFFFAOYSA-N 0.000 description 1
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- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
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- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- GGOZGYRTNQBSSA-UHFFFAOYSA-N pyridine-2,3-diol Chemical compound OC1=CC=CN=C1O GGOZGYRTNQBSSA-UHFFFAOYSA-N 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
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- 229910052703 rhodium Inorganic materials 0.000 description 1
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- 235000013874 shellac Nutrition 0.000 description 1
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- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
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- 235000011152 sodium sulphate Nutrition 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
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- 125000001424 substituent group Chemical group 0.000 description 1
- UDYFLDICVHJSOY-UHFFFAOYSA-N sulfur trioxide-pyridine complex Substances O=S(=O)=O.C1=CC=NC=C1 UDYFLDICVHJSOY-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
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- 208000024891 symptom Diseases 0.000 description 1
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- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- DZLFLBLQUQXARW-UHFFFAOYSA-N tetrabutylammonium Chemical class CCCC[N+](CCCC)(CCCC)CCCC DZLFLBLQUQXARW-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23261700P | 2000-09-14 | 2000-09-14 | |
| PCT/IB2001/002115 WO2002022613A1 (en) | 2000-09-14 | 2001-09-14 | 3-(heteroaryl acetamido)-2-oxo-azetidine-1-sulfonic acids derivatives as antibacterial agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20031162L NO20031162L (no) | 2003-03-13 |
| NO20031162D0 NO20031162D0 (no) | 2003-03-13 |
| NO324946B1 true NO324946B1 (no) | 2008-01-07 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20031162A NO324946B1 (no) | 2000-09-14 | 2003-03-13 | 3-(heteroarylacetamido)-2-okso-azetidin-1-sulfonsyre-derivater som antibakterielle midler, samt fremstilling og anvendelse derav og farmasoytisk preparat |
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| EP (1) | EP1322648B1 (zh) |
| JP (1) | JP2004509122A (zh) |
| KR (1) | KR100854810B1 (zh) |
| CN (1) | CN1189469C (zh) |
| AT (1) | ATE298750T1 (zh) |
| AU (2) | AU1261402A (zh) |
| BR (1) | BR0113861A (zh) |
| CA (1) | CA2422375C (zh) |
| CZ (1) | CZ304586B6 (zh) |
| DE (1) | DE60111757T2 (zh) |
| DK (1) | DK1322648T3 (zh) |
| ES (1) | ES2244666T3 (zh) |
| HK (1) | HK1054377A1 (zh) |
| HU (1) | HUP0301025A3 (zh) |
| IL (2) | IL154593A0 (zh) |
| NO (1) | NO324946B1 (zh) |
| NZ (1) | NZ524292A (zh) |
| PL (1) | PL218196B1 (zh) |
| PT (1) | PT1322648E (zh) |
| SK (1) | SK2462003A3 (zh) |
| WO (1) | WO2002022613A1 (zh) |
| ZA (1) | ZA200302085B (zh) |
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| US8901293B2 (en) * | 2005-12-07 | 2014-12-02 | Basilea Pharmaceutica Ag | Useful combinations of monobactam antibiotics with beta-lactamase inhibitors |
| AU2012233003B2 (en) * | 2005-12-07 | 2014-12-18 | Basilea Pharmaceutica Ag | Useful combinations of monobactam antibiotics with beta-lactamase inhibitors |
| KR101320718B1 (ko) * | 2007-03-23 | 2013-10-21 | 바실리어 파마슈티카 아게 | 세균 감염 치료용 조합 약제 |
| US20110046101A1 (en) * | 2008-03-17 | 2011-02-24 | Dmitrienko Gary I | Bate-lactamase inhibitors |
| RS60310B1 (sr) | 2010-08-10 | 2020-07-31 | Rempex Pharmaceuticals Inc | Ciklični derivati estra boronske kiseline, postupak za pripremu injihove terapeutske upotrebe |
| US9012491B2 (en) | 2011-08-31 | 2015-04-21 | Rempex Pharmaceuticals, Inc. | Heterocyclic boronic acid ester derivatives and therapeutic uses thereof |
| UY34585A (es) * | 2012-01-24 | 2013-09-02 | Aicuris Gmbh & Co Kg | Compuestos b-lactámicos sustituidos con amidina, su preparación y uso |
| US9156858B2 (en) | 2012-05-23 | 2015-10-13 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US10561675B2 (en) | 2012-06-06 | 2020-02-18 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
| CN102757405B (zh) * | 2012-07-25 | 2014-04-16 | 山东理工大学 | 含噻二唑的香兰素衍生物、其制备方法及其用途 |
| US9101638B2 (en) | 2013-01-04 | 2015-08-11 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US9241947B2 (en) | 2013-01-04 | 2016-01-26 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US9642869B2 (en) | 2013-01-04 | 2017-05-09 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| EP2941247A4 (en) | 2013-01-04 | 2017-02-08 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| EP3139930A4 (en) | 2014-05-05 | 2018-01-17 | Rempex Pharmaceuticals, Inc. | Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof |
| HUE046836T2 (hu) | 2014-05-05 | 2020-03-30 | Rempex Pharmaceuticals Inc | Boronát sók szintézise és alkalmazásuk |
| CN106459096B (zh) | 2014-05-19 | 2019-03-08 | 莱姆派克斯制药公司 | 硼酸衍生物及其治疗用途 |
| EA201692301A1 (ru) | 2014-07-01 | 2017-06-30 | Ремпекс Фармасьютикалз, Инк. | Производные бороновой кислоты и их терапевтическое применение |
| WO2016081297A1 (en) | 2014-11-18 | 2016-05-26 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
| CN107207537B (zh) | 2014-12-19 | 2019-05-31 | 莱姆派克斯制药公司 | 用于生产硼酸衍生物的设备和连续流方法 |
| US20180051041A1 (en) | 2015-03-17 | 2018-02-22 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| EP3478693B1 (en) | 2016-06-30 | 2021-07-21 | Qpex Biopharma, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| CN107641119B (zh) * | 2016-07-21 | 2019-11-08 | 中国科学院上海药物研究所 | 单环β-内酰胺-铁载体轭合物及其制备方法和用途 |
| WO2018065636A1 (en) | 2016-12-21 | 2018-04-12 | Aicuris Anti-Infective Cures Gmbh | COMBINATION THERAPY WITH AMIDINE SUBSTITUTED ß-LACTAM COMPOUNDS AND ß-LACTAMASE INHIBITORS FOR INFECTIONS WITH ANTIBIOTIC RESISTANT BACTERIAL STRAINS |
| IL273551B2 (en) | 2017-10-11 | 2024-02-01 | Qpex Biopharma Inc | Boronic acid derivatives and their synthesis |
| JP7280273B2 (ja) | 2018-01-29 | 2023-05-23 | メッドシャイン ディスカバリー インコーポレイテッド | 細菌感染を治療するための単環β－ラクタム化合物 |
| JP7179185B2 (ja) | 2018-12-18 | 2022-11-28 | メッドシャイン ディスカバリー インコーポレイテッド | 医薬の製造おける単環式β－ラクタム化合物の使用 |
| SI25892A (sl) * | 2019-09-05 | 2021-03-31 | Gorenje Gospodinjski Aparati, D.O.O. | Pralni stroj, ki se polni s sprednje strani, z električnim svetlobnim telesom |
| JP2022548067A (ja) * | 2019-09-11 | 2022-11-16 | テンノア・セラピューティクス・（スージョウ）・リミテッド | 細菌感染症を治療するためのペナム誘導体 |
| KR20220084398A (ko) | 2019-11-22 | 2022-06-21 | 쑤저우 얼예 파마슈티칼 컴퍼니 리미티드 | 설포닐우레아 고리 치환 모노시클릭 β-락탐계 항생제 |
| US20230022708A1 (en) | 2019-12-19 | 2023-01-26 | Medshine Discovery Inc. | Application of compound in drug preparation |
| CN113754651B (zh) * | 2020-06-02 | 2023-04-18 | 中国医学科学院医药生物技术研究所 | 一种β-内酰胺化合物、其用途及其制备方法 |
| CA3229556A1 (en) * | 2021-08-20 | 2023-02-23 | Marvin Miller | Conjugates of monocyclic beta-lactams and siderophore mimetics |
| CN115304594B (zh) | 2022-10-12 | 2023-02-14 | 苏州二叶制药有限公司 | 磺酰脲环取代的化合物的盐型及其晶型 |
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|---|---|---|---|---|
| US4632985A (en) * | 1985-06-03 | 1986-12-30 | E. R. Squibb & Sons, Inc. | 3-acylamino-2-oxo-1-azetidinesulfonic acids |
| GB8810396D0 (en) * | 1988-05-03 | 1988-06-08 | Glaxo Group Ltd | Chemical process |
| US5112968A (en) | 1989-07-28 | 1992-05-12 | E. R. Squibb & Sons, Inc. | Monobactam hydrazide derivatives |
| US5250691A (en) * | 1991-09-09 | 1993-10-05 | E. R. Squibb & Sons, Inc. | Heteroaryl derivatives of monocyclic beta-lactam antibiotics |
| US5888998A (en) * | 1997-04-24 | 1999-03-30 | Synphar Laboratories, Inc. | 2-oxo-1-azetidine sulfonic acid derivatives as potent β-lactamase inhibitors |
| US5994340A (en) | 1997-08-29 | 1999-11-30 | Synphar Laboratories, Inc. | Azetidinone derivatives as β-lactamase inhibitors |
-
2001
- 2001-09-14 AT AT01980829T patent/ATE298750T1/de active
- 2001-09-14 BR BR0113861-8A patent/BR0113861A/pt active Search and Examination
- 2001-09-14 HU HU0301025A patent/HUP0301025A3/hu unknown
- 2001-09-14 CA CA2422375A patent/CA2422375C/en not_active Expired - Fee Related
- 2001-09-14 US US10/363,222 patent/US6916803B2/en not_active Expired - Fee Related
- 2001-09-14 IL IL15459301A patent/IL154593A0/xx active IP Right Grant
- 2001-09-14 PL PL360537A patent/PL218196B1/pl unknown
- 2001-09-14 AU AU1261402A patent/AU1261402A/xx active Pending
- 2001-09-14 AU AU2002212614A patent/AU2002212614B2/en not_active Ceased
- 2001-09-14 JP JP2002526866A patent/JP2004509122A/ja active Pending
- 2001-09-14 DE DE60111757T patent/DE60111757T2/de not_active Expired - Lifetime
- 2001-09-14 ZA ZA200302085A patent/ZA200302085B/en unknown
- 2001-09-14 KR KR1020037003718A patent/KR100854810B1/ko not_active IP Right Cessation
- 2001-09-14 DK DK01980829T patent/DK1322648T3/da active
- 2001-09-14 EP EP01980829A patent/EP1322648B1/en not_active Expired - Lifetime
- 2001-09-14 WO PCT/IB2001/002115 patent/WO2002022613A1/en active IP Right Grant
- 2001-09-14 NZ NZ524292A patent/NZ524292A/en unknown
- 2001-09-14 SK SK246-2003A patent/SK2462003A3/sk unknown
- 2001-09-14 ES ES01980829T patent/ES2244666T3/es not_active Expired - Lifetime
- 2001-09-14 PT PT01980829T patent/PT1322648E/pt unknown
- 2001-09-14 CN CNB018157319A patent/CN1189469C/zh not_active Expired - Fee Related
- 2001-09-14 CZ CZ2003-606A patent/CZ304586B6/cs not_active IP Right Cessation
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2003
- 2003-02-24 IL IL154593A patent/IL154593A/en not_active IP Right Cessation
- 2003-03-13 NO NO20031162A patent/NO324946B1/no not_active IP Right Cessation
- 2003-09-03 HK HK03106287A patent/HK1054377A1/xx not_active IP Right Cessation
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