NO324719B1 - Anvendelse av 8-nitro-2,3,4,5-tetrahydro-1H-3-benzazepiner for fremstilling av en farmasoytisk sammensetning for behandling av soveuregelmessigheter - Google Patents
Anvendelse av 8-nitro-2,3,4,5-tetrahydro-1H-3-benzazepiner for fremstilling av en farmasoytisk sammensetning for behandling av soveuregelmessigheter Download PDFInfo
- Publication number
- NO324719B1 NO324719B1 NO19994343A NO994343A NO324719B1 NO 324719 B1 NO324719 B1 NO 324719B1 NO 19994343 A NO19994343 A NO 19994343A NO 994343 A NO994343 A NO 994343A NO 324719 B1 NO324719 B1 NO 324719B1
- Authority
- NO
- Norway
- Prior art keywords
- sleep
- treatment
- tetrahydro
- compound
- acid
- Prior art date
Links
- 208000019116 sleep disease Diseases 0.000 title claims abstract description 21
- 238000011282 treatment Methods 0.000 title claims abstract description 13
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 9
- 238000002360 preparation method Methods 0.000 title claims description 3
- TXJXCXSFIVCGDS-UHFFFAOYSA-N 34583-83-0 Chemical class C1CNCCC2=CC([N+](=O)[O-])=CC=C21 TXJXCXSFIVCGDS-UHFFFAOYSA-N 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 39
- 150000003839 salts Chemical class 0.000 claims abstract description 17
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims description 5
- 206010022437 insomnia Diseases 0.000 claims description 5
- 230000002265 prevention Effects 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 4
- XZPSYCOYKJRHKE-UHFFFAOYSA-N 5-(2,3-dihydro-1-benzofuran-7-yl)-3-methyl-8-nitro-1,2,4,5-tetrahydro-3-benzazepin-7-ol Chemical compound C1N(C)CCC2=CC([N+]([O-])=O)=C(O)C=C2C1C1=CC=CC2=C1OCC2 XZPSYCOYKJRHKE-UHFFFAOYSA-N 0.000 claims description 3
- 208000020685 sleep-wake disease Diseases 0.000 claims description 2
- 208000022925 sleep disturbance Diseases 0.000 abstract description 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract description 5
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- 239000003937 drug carrier Substances 0.000 abstract description 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
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- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
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- 238000004519 manufacturing process Methods 0.000 abstract 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK26597 | 1997-03-12 | ||
| US4150997P | 1997-03-24 | 1997-03-24 | |
| PCT/DK1998/000088 WO1998040072A1 (en) | 1997-03-12 | 1998-03-11 | Use of 2,3,4,5-tetrahydro-1h-3-benzazepines for the manufacture of a pharmaceutical composition for the treatment of sleep disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO994343D0 NO994343D0 (no) | 1999-09-07 |
| NO994343L NO994343L (no) | 1999-11-11 |
| NO324719B1 true NO324719B1 (no) | 2007-12-03 |
Family
ID=26063641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19994343A NO324719B1 (no) | 1997-03-12 | 1999-09-07 | Anvendelse av 8-nitro-2,3,4,5-tetrahydro-1H-3-benzazepiner for fremstilling av en farmasoytisk sammensetning for behandling av soveuregelmessigheter |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6211173B1 (ja) |
| EP (1) | EP1011679B1 (ja) |
| JP (1) | JP2001515484A (ja) |
| AT (1) | ATE245986T1 (ja) |
| AU (1) | AU742873B2 (ja) |
| BR (1) | BR9808234A (ja) |
| CA (1) | CA2283083C (ja) |
| CZ (1) | CZ296464B6 (ja) |
| DE (1) | DE69816832T2 (ja) |
| DK (1) | DK1011679T3 (ja) |
| ES (1) | ES2203933T3 (ja) |
| IL (1) | IL131670A (ja) |
| NO (1) | NO324719B1 (ja) |
| PL (1) | PL189822B1 (ja) |
| PT (1) | PT1011679E (ja) |
| WO (1) | WO1998040072A1 (ja) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006526021A (ja) * | 2003-05-22 | 2006-11-16 | シェーリング コーポレイション | 肥満およびｃｎｓ障害を治療する選択的ｄ１／ｄ５レセプタアンタゴニストとしての５ｈ−ベンゾ［ｄ］ナフト［２，１−ｂ］アゼピン誘導体 |
| EP1691811B1 (en) * | 2003-12-11 | 2014-07-23 | Sunovion Pharmaceuticals Inc. | Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression |
| US20050215521A1 (en) * | 2003-12-22 | 2005-09-29 | Karim Lalji | Modafinil combination therapy for improving sleep quality |
| US20050164987A1 (en) * | 2003-12-24 | 2005-07-28 | Barberich Timothy J. | Melatonin combination therapy for improving sleep quality |
| DK1742624T3 (da) * | 2004-02-18 | 2010-03-08 | Sepracor Inc | Dopamin-agonist-kombinationsterapi med sedativer til forbedring af søvnkvalitet |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK325188D0 (da) | 1988-06-15 | 1988-06-15 | Novo Industri As | Hidtil ukendte benzazepinderivater |
| US5470850A (en) | 1992-02-24 | 1995-11-28 | Novo Nordisk A/S | 2,3,4,5-tetrahydro-1H-3-benzazepines |
| DK26793D0 (da) | 1993-03-10 | 1993-03-10 | Novo Nordisk As | Benzofuranyl- eller dihydrobenzofuranyl-substituerede tricycliske benzazepiner, der anvendelse og fremstilling |
-
1998
- 1998-03-11 US US09/380,840 patent/US6211173B1/en not_active Expired - Fee Related
- 1998-03-11 CA CA002283083A patent/CA2283083C/en not_active Expired - Fee Related
- 1998-03-11 PL PL98335545A patent/PL189822B1/pl not_active IP Right Cessation
- 1998-03-11 EP EP98907896A patent/EP1011679B1/en not_active Expired - Lifetime
- 1998-03-11 AT AT98907896T patent/ATE245986T1/de active
- 1998-03-11 ES ES98907896T patent/ES2203933T3/es not_active Expired - Lifetime
- 1998-03-11 WO PCT/DK1998/000088 patent/WO1998040072A1/en active IP Right Grant
- 1998-03-11 CZ CZ0317799A patent/CZ296464B6/cs not_active IP Right Cessation
- 1998-03-11 IL IL13167098A patent/IL131670A/xx not_active IP Right Cessation
- 1998-03-11 DE DE69816832T patent/DE69816832T2/de not_active Expired - Lifetime
- 1998-03-11 AU AU66100/98A patent/AU742873B2/en not_active Ceased
- 1998-03-11 JP JP53910298A patent/JP2001515484A/ja not_active Ceased
- 1998-03-11 DK DK98907896T patent/DK1011679T3/da active
- 1998-03-11 PT PT98907896T patent/PT1011679E/pt unknown
- 1998-03-11 BR BR9808234-5A patent/BR9808234A/pt not_active Application Discontinuation
-
1999
- 1999-09-07 NO NO19994343A patent/NO324719B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK1011679T3 (da) | 2003-11-24 |
| NO994343L (no) | 1999-11-11 |
| ATE245986T1 (de) | 2003-08-15 |
| JP2001515484A (ja) | 2001-09-18 |
| BR9808234A (pt) | 2000-05-16 |
| DE69816832D1 (de) | 2003-09-04 |
| PT1011679E (pt) | 2003-12-31 |
| AU742873B2 (en) | 2002-01-17 |
| DE69816832T2 (de) | 2004-05-27 |
| CZ296464B6 (cs) | 2006-03-15 |
| EP1011679A1 (en) | 2000-06-28 |
| EP1011679B1 (en) | 2003-07-30 |
| ES2203933T3 (es) | 2004-04-16 |
| WO1998040072A1 (en) | 1998-09-17 |
| IL131670A0 (en) | 2001-01-28 |
| PL335545A1 (en) | 2000-04-25 |
| AU6610098A (en) | 1998-09-29 |
| US6211173B1 (en) | 2001-04-03 |
| CA2283083A1 (en) | 1998-09-17 |
| IL131670A (en) | 2005-07-25 |
| NO994343D0 (no) | 1999-09-07 |
| PL189822B1 (pl) | 2005-09-30 |
| CZ317799A3 (cs) | 2000-03-15 |
| CA2283083C (en) | 2007-09-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |