NO323906B1 - Alfa-V-integrinreseptorantagonister, farmasoytisk preparat omfattende disse, og anvendelse derav for fremstilling av et medikament - Google Patents
Alfa-V-integrinreseptorantagonister, farmasoytisk preparat omfattende disse, og anvendelse derav for fremstilling av et medikament Download PDFInfo
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- NO323906B1 NO323906B1 NO20015858A NO20015858A NO323906B1 NO 323906 B1 NO323906 B1 NO 323906B1 NO 20015858 A NO20015858 A NO 20015858A NO 20015858 A NO20015858 A NO 20015858A NO 323906 B1 NO323906 B1 NO 323906B1
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- alkylamino
- alkyl
- hydrogen
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
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EP (1) | EP1187592B1 (de) |
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KR (1) | KR20020021380A (de) |
CN (1) | CN1589145A (de) |
AT (1) | ATE368462T1 (de) |
AU (1) | AU749351B2 (de) |
BG (1) | BG106232A (de) |
BR (1) | BR0011108A (de) |
CA (1) | CA2373937A1 (de) |
CY (1) | CY1107746T1 (de) |
CZ (1) | CZ20014308A3 (de) |
DE (1) | DE60035779T2 (de) |
DK (1) | DK1187592T3 (de) |
DZ (1) | DZ3263A1 (de) |
EA (1) | EA200101272A1 (de) |
EE (1) | EE200100642A (de) |
ES (1) | ES2288861T3 (de) |
HR (1) | HRP20010895A2 (de) |
HU (1) | HUP0302468A2 (de) |
IL (1) | IL146378A0 (de) |
IS (1) | IS6157A (de) |
NO (1) | NO323906B1 (de) |
PL (1) | PL353364A1 (de) |
PT (1) | PT1187592E (de) |
SK (1) | SK17442001A3 (de) |
TR (1) | TR200103431T2 (de) |
WO (1) | WO2000072801A2 (de) |
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AU2001277935B2 (en) * | 2000-07-26 | 2005-08-04 | Merck & Co., Inc. | Alpha v integrin receptor antagonists |
WO2002022616A2 (en) * | 2000-09-14 | 2002-03-21 | Merck & Co., Inc. | Alpha v integrin receptor antagonists |
US20050101593A1 (en) * | 2000-10-04 | 2005-05-12 | Meissner Robert S. | Phosphoric acid salt of an integrin receptor antagonist |
EP1349548A4 (de) * | 2001-01-03 | 2004-06-02 | Merck & Co Inc | Verfahren und zusammensetzungen zur behandlung von parodontose |
US20040136949A1 (en) | 2001-04-24 | 2004-07-15 | Matthias Grell | Combination therapy using anti-angiogenic agents and tnf alpha |
JP2005533001A (ja) * | 2002-03-04 | 2005-11-04 | メディミューン,インコーポレーテッド | インテグリンαvβ3アンタゴニストを他の物質と併用投与する癌の予防または治療方法 |
EP1487489A4 (de) * | 2002-03-04 | 2008-10-01 | Medimmune Inc | VERFAHREN ZUR PRÄVENTION ODER BEHANDLUNG VON ERKRANKUNGEN DURCH VERABREICHUNG EINES INTEGRIN avb3 ANTAGONISTEN IN KOMBINATION MIT EINEM HMG-CoA REDUKTASE-HEMMER ODER EINEM BISPHOSPHONAT |
US20040224986A1 (en) | 2002-08-16 | 2004-11-11 | Bart De Corte | Piperidinyl targeting compounds that selectively bind integrins |
WO2004058760A1 (en) | 2002-12-20 | 2004-07-15 | Pharmacia Corporation | Thiazole compounds as integrin receptor antagonists derivatives |
US7288655B2 (en) * | 2003-03-07 | 2007-10-30 | Merck & Co., Inc. | α v integrin receptor antagonists |
US8604185B2 (en) | 2004-07-20 | 2013-12-10 | Genentech, Inc. | Inhibitors of angiopoietin-like 4 protein, combinations, and their use |
EP2338518A1 (de) | 2006-01-18 | 2011-06-29 | Merck Patent GmbH | Spezifische Krebsbehandlung mit Integrin-Liganden |
MX2009007597A (es) | 2007-01-18 | 2009-07-22 | Merck Patent Gmbh | Terapia especifica y medicamento que utilizan ligandos de integrina para tratar el cancer. |
CL2008000467A1 (es) * | 2007-02-14 | 2008-08-22 | Janssen Pharmaceutica Nv | Compuestos derivados de 2-aminopirimidina, moduladores del receptor histamina h4; su procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un trastorno inflamatorio seleccionado de alegia, asma |
US9345739B2 (en) | 2007-11-08 | 2016-05-24 | The General Hospital Corporation | Methods and compositions for the treatment of proteinuric diseases |
BRPI1011206A2 (pt) | 2009-05-25 | 2016-03-15 | Merck Patent Gmbh | administração contínua de ligantes de integrina para tratar câncer |
US8901144B2 (en) | 2013-02-07 | 2014-12-02 | Scifluor Life Sciences, Llc | Fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives |
RS56711B1 (sr) * | 2013-02-07 | 2018-03-30 | Scifluor Life Sciences Inc | Fluorirani antagonisti integrina |
GB201305668D0 (en) | 2013-03-28 | 2013-05-15 | Glaxosmithkline Ip Dev Ltd | Avs6 Integrin Antagonists |
PT3929196T (pt) | 2013-09-24 | 2023-09-11 | Fujifilm Corp | Composição farmacêutica de um novo composto contendo azoto ou seu sal, ou seu complexo de metal |
GB201417018D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
GB201417094D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
GB201417011D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
GB201417002D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compound |
EP3925959A1 (de) * | 2015-02-19 | 2021-12-22 | OcuTerra Therapeutics, Inc. | Fluorierte derivate von 3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propansäure und verwendungen davon |
GB201604680D0 (en) | 2016-03-21 | 2016-05-04 | Glaxosmithkline Ip Dev Ltd | Chemical Compounds |
US10118929B2 (en) | 2016-04-27 | 2018-11-06 | Scifluor Life Sciences, Inc. | Nonanoic and decanoic acid derivatives and uses thereof |
JP2019524702A (ja) * | 2016-07-05 | 2019-09-05 | ザ ロックフェラー ユニバーシティー | テトラヒドロナフチルリジンペンタンアミドインテグリンアンタゴニスト |
EP3509590A4 (de) | 2016-09-07 | 2020-12-02 | Pliant Therapeutics, Inc. | N-acyl-aminosäure-verbindungen und verfahren zur verwendung |
KR102510858B1 (ko) * | 2016-11-08 | 2023-03-15 | 브리스톨-마이어스 스큅 컴퍼니 | 알파 v 인테그린 억제제로서의 아졸 아미드 및 아민 |
WO2018089355A1 (en) * | 2016-11-08 | 2018-05-17 | Bristol-Myers Squibb Company | Cyclobutane- and azetidine-containing mono and spirocyclic compounds as alpha v integrin inhibitors |
WO2018160522A1 (en) | 2017-02-28 | 2018-09-07 | Lazuli, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
CA3054604A1 (en) | 2017-02-28 | 2018-09-07 | Morphic Therapeutic, Inc. | Inhibitors of .alpha.v.beta.6 integrin |
TW202035400A (zh) | 2018-08-29 | 2020-10-01 | 美商莫菲克醫療股份有限公司 | 抑制αvβ6整合素 |
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US3843798A (en) | 1973-03-12 | 1974-10-22 | Stanley Drug Products Inc | Methods and compositions for inducing resistance to bacterial infections |
US5025025A (en) | 1989-06-28 | 1991-06-18 | Ciba-Geigy Corporation | (Arylsulfonamido- and pyridyl-)-substituted carboxylic acids and derivatives thereof and use for suppressing thromboxane activity |
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CA2190870A1 (en) | 1994-05-27 | 1995-12-07 | George D. Hartman | Compounds for inhibiting osteoclast-mediated bone resorption |
EP0880511A4 (de) | 1996-01-16 | 1999-06-16 | Merck & Co Inc | Integrin-rezeptor-antagonisten |
PT796855E (pt) | 1996-03-20 | 2002-07-31 | Hoechst Ag | Inibicao da reabsorcao nos ossos e antagonistas de vitronectina |
JP2000508319A (ja) | 1996-04-10 | 2000-07-04 | メルク エンド カンパニー インコーポレーテッド | αvβ3拮抗薬 |
US5668159A (en) | 1996-05-08 | 1997-09-16 | The Dupont Merck Pharmaceutical Company | 1,3,4-thiadiazoles and 1,3,4-oxadiazoles as IIb/IIIa antagonists |
AU724191B2 (en) | 1996-08-29 | 2000-09-14 | Merck & Co., Inc. | Integrin antagonists |
EP0946165B1 (de) * | 1996-10-30 | 2003-04-09 | Merck & Co., Inc. | Integrin antagonist |
EP0946164A4 (de) | 1996-10-30 | 2000-08-23 | Merck & Co Inc | Integrin antagonisten |
CA2277273C (en) | 1997-01-17 | 2008-03-25 | Merck & Co., Inc. | Integrin antagonists |
US6017926A (en) | 1997-12-17 | 2000-01-25 | Merck & Co., Inc. | Integrin receptor antagonists |
ATE299023T1 (de) | 1997-12-17 | 2005-07-15 | Merck & Co Inc | Integrinrezeptor antagonisten |
IL136495A0 (en) * | 1997-12-17 | 2001-06-14 | Merck & Co Inc | Integrin receptor antagonists |
EP1047425A4 (de) | 1997-12-17 | 2009-04-22 | Merck & Co Inc | Integrinrezeptor antagonisten |
US6048861A (en) * | 1997-12-17 | 2000-04-11 | Merck & Co., Inc. | Integrin receptor antagonists |
ATE298338T1 (de) | 1997-12-17 | 2005-07-15 | Merck & Co Inc | Integrin-rezeptor-antagonisten |
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2000
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- 2000-05-30 CA CA002373937A patent/CA2373937A1/en not_active Abandoned
- 2000-05-30 BR BR0011108-2A patent/BR0011108A/pt not_active IP Right Cessation
- 2000-05-30 CZ CZ20014308A patent/CZ20014308A3/cs unknown
- 2000-05-30 HU HU0302468A patent/HUP0302468A2/hu unknown
- 2000-05-30 AU AU57246/00A patent/AU749351B2/en not_active Ceased
- 2000-05-30 DE DE60035779T patent/DE60035779T2/de not_active Expired - Fee Related
- 2000-05-30 TR TR2001/03431T patent/TR200103431T2/xx unknown
- 2000-05-30 AT AT00942652T patent/ATE368462T1/de not_active IP Right Cessation
- 2000-05-30 IL IL14637800A patent/IL146378A0/xx unknown
- 2000-05-30 PT PT00942652T patent/PT1187592E/pt unknown
- 2000-05-30 EP EP00942652A patent/EP1187592B1/de not_active Expired - Lifetime
- 2000-05-30 PL PL00353364A patent/PL353364A1/xx not_active Application Discontinuation
- 2000-05-30 DK DK00942652T patent/DK1187592T3/da active
- 2000-05-30 SK SK1744-2001A patent/SK17442001A3/sk unknown
- 2000-05-30 EE EEP200100642A patent/EE200100642A/xx unknown
- 2000-05-30 KR KR1020017015498A patent/KR20020021380A/ko not_active Application Discontinuation
- 2000-05-30 JP JP2000620913A patent/JP3808707B2/ja not_active Expired - Fee Related
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- 2000-05-30 WO PCT/US2000/014901 patent/WO2000072801A2/en active IP Right Grant
- 2000-05-31 US US09/583,522 patent/US6410526B1/en not_active Expired - Fee Related
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2001
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- 2001-11-30 NO NO20015858A patent/NO323906B1/no not_active IP Right Cessation
- 2001-12-18 BG BG106232A patent/BG106232A/xx unknown
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2006
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2007
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