NO321186B1 - Monoklonale anti-alfa-V-integrin-antistoffer, antistoffragmenter av disse, hybridomcellelinje som produserer dem, aminosyresekvenser som utgjor dem, DNA-sekvenser som koder for aminosyresekvensene, farmasoytisk preparat som omfatter antistoffene og antistoffragmentene, fremgangsmate for fremstilling av antistoffene og antistoffragmentene og anvendelse av antistoffene og antistoffragmentene for fremstilling av legemidler og diagnostiske forbindelser. - Google Patents
Monoklonale anti-alfa-V-integrin-antistoffer, antistoffragmenter av disse, hybridomcellelinje som produserer dem, aminosyresekvenser som utgjor dem, DNA-sekvenser som koder for aminosyresekvensene, farmasoytisk preparat som omfatter antistoffene og antistoffragmentene, fremgangsmate for fremstilling av antistoffene og antistoffragmentene og anvendelse av antistoffene og antistoffragmentene for fremstilling av legemidler og diagnostiske forbindelser. Download PDFInfo
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- NO321186B1 NO321186B1 NO19955167A NO955167A NO321186B1 NO 321186 B1 NO321186 B1 NO 321186B1 NO 19955167 A NO19955167 A NO 19955167A NO 955167 A NO955167 A NO 955167A NO 321186 B1 NO321186 B1 NO 321186B1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94120165 | 1994-12-20 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO955167D0 NO955167D0 (no) | 1995-12-19 |
| NO955167L NO955167L (no) | 1996-06-21 |
| NO321186B1 true NO321186B1 (no) | 2006-04-03 |
Family
ID=8216547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19955167A NO321186B1 (no) | 1994-12-20 | 1995-12-19 | Monoklonale anti-alfa-V-integrin-antistoffer, antistoffragmenter av disse, hybridomcellelinje som produserer dem, aminosyresekvenser som utgjor dem, DNA-sekvenser som koder for aminosyresekvensene, farmasoytisk preparat som omfatter antistoffene og antistoffragmentene, fremgangsmate for fremstilling av antistoffene og antistoffragmentene og anvendelse av antistoffene og antistoffragmentene for fremstilling av legemidler og diagnostiske forbindelser. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5985278A (sv) |
| EP (1) | EP0719859B1 (sv) |
| JP (1) | JP3898245B2 (sv) |
| KR (1) | KR100450368B1 (sv) |
| CN (1) | CN1117763C (sv) |
| AR (1) | AR001778A1 (sv) |
| AT (1) | ATE244306T1 (sv) |
| AU (1) | AU710234B2 (sv) |
| BR (1) | BR9505980B1 (sv) |
| CA (1) | CA2165573C (sv) |
| CO (1) | CO4480042A1 (sv) |
| CZ (1) | CZ290477B6 (sv) |
| DE (1) | DE69531187T2 (sv) |
| DK (1) | DK0719859T3 (sv) |
| ES (1) | ES2202336T3 (sv) |
| FI (1) | FI118536B (sv) |
| HU (1) | HU221061B1 (sv) |
| NO (1) | NO321186B1 (sv) |
| PL (1) | PL182961B1 (sv) |
| PT (1) | PT719859E (sv) |
| RU (1) | RU2205223C2 (sv) |
| SI (1) | SI0719859T1 (sv) |
| SK (1) | SK284932B6 (sv) |
| TR (1) | TR199501614A2 (sv) |
| UA (1) | UA40621C2 (sv) |
| ZA (1) | ZA9510806B (sv) |
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| EP0846702B1 (en) * | 1996-12-09 | 2009-03-11 | MERCK PATENT GmbH | Soluble recombinant alphaV beta3 adhesion receptor |
| PT1504764E (pt) * | 1997-08-08 | 2009-01-14 | Univ California | Tratamento da fibrose hepática com anticorpos contra integrina alfa-v-beta 6 |
| ID27810A (id) * | 1998-01-23 | 2001-04-26 | Merck Patent Gmbh | Antibodi menoclonal anti v-integrin dan kegunaan untuk mencegah penambahan v 6-integrin untuk fibronectin |
| US6160099A (en) * | 1998-11-24 | 2000-12-12 | Jonak; Zdenka Ludmila | Anti-human αv β3 and αv β5 antibodies |
| US6521593B1 (en) * | 1999-02-01 | 2003-02-18 | Childrens Hospital Los Angeles | Methods for inhibiting brain tumor growth |
| US7323552B2 (en) * | 2000-07-31 | 2008-01-29 | The General Hospital Corporation | Variant integrin polypeptides and uses thereof |
| US7153944B2 (en) * | 2000-07-31 | 2006-12-26 | The General Hospital Corporation | High affinity integrin polypeptides and uses thereof |
| US7064180B2 (en) | 2000-07-31 | 2006-06-20 | The General Hospital Corporation | High affinity integrin polypeptides and uses thereof |
| US7288390B2 (en) | 2000-08-07 | 2007-10-30 | Centocor, Inc. | Anti-dual integrin antibodies, compositions, methods and uses |
| US7163681B2 (en) | 2000-08-07 | 2007-01-16 | Centocor, Inc. | Anti-integrin antibodies, compositions, methods and uses |
| CN1507354A (zh) * | 2001-03-02 | 2004-06-23 | ͨ��ҽ�ƹ�˾ | 通过给予整合蛋白αvβ3拮抗剂并与其它预防或治疗药剂配合来预防或者治疗炎性疾病或自身免疫疾病的方法 |
| US20040136949A1 (en) | 2001-04-24 | 2004-07-15 | Matthias Grell | Combination therapy using anti-angiogenic agents and tnf alpha |
| US7829087B2 (en) * | 2001-07-09 | 2010-11-09 | Elan Pharmaceuticals, Inc. | Methods of treating cognitive impairment |
| JP4351043B2 (ja) | 2001-07-09 | 2009-10-28 | エラン ファーマシューティカルズ，インコーポレイテッド | アミロイド毒性の阻害方法 |
| JP2005525368A (ja) * | 2002-03-04 | 2005-08-25 | メディミューン，インコーポレーテッド | インテグリンαｖβ３アンタゴニストをＨＭＧ−ＣｏＡ還元酵素阻害剤またはビスフォスフォネートと併用投与する障害の予防または治療方法 |
| WO2003075957A1 (en) * | 2002-03-04 | 2003-09-18 | Medimmune, Inc. | The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents |
| CN100509851C (zh) * | 2002-03-13 | 2009-07-08 | 拜奥根Idec马萨诸塞公司 | 抗αvβ6抗体 |
| NZ535425A (en) * | 2002-03-13 | 2008-05-30 | Biogen Idec Inc | Anti-alphavbeta6 antibodies |
| EP1492870A4 (en) * | 2002-04-12 | 2005-08-03 | Raven Biotechnologies Inc | ANTIBODIES BINDING TO INTEGRIN-ALPHA-V-BETA-6 AND METHOD OF USE THEREOF |
| EP1499352A4 (en) * | 2002-04-12 | 2006-10-11 | Medimmune Inc | ANTI-INTERLEUKIN-9 RECOMBINANT ANTIBODIES |
| CA2514653A1 (en) * | 2003-01-30 | 2004-08-12 | Medimmune, Inc. | Uses of integrin alphavbeta3 antagonists |
| AU2004229501B2 (en) | 2003-04-11 | 2011-08-18 | Medimmune, Llc | Recombinant IL-9 antibodies and uses thereof |
| US7351739B2 (en) * | 2004-04-30 | 2008-04-01 | Wellgen, Inc. | Bioactive compounds and methods of uses thereof |
| EP2422811A2 (en) | 2004-10-27 | 2012-02-29 | MedImmune, LLC | Modulation of antibody specificity by tailoring the affinity to cognate antigens |
| CN104072614B (zh) | 2005-07-08 | 2017-04-26 | 生物基因Ma公司 | 抗-αvβ6 抗体及其用途 |
| NZ571068A (en) * | 2006-03-21 | 2012-06-29 | Genentech Inc | An antibody that can bind human alpha5beta1 |
| AU2007272995B2 (en) | 2006-07-10 | 2013-02-07 | Biogen Idec Ma Inc. | Compositions and methods for inhibiting growth of smad4-deficient cancers |
| AU2007272970C1 (en) | 2006-07-11 | 2013-01-10 | Roy C. Levitt | Rhinosinusitis prevention and therapy with proinflammatory cytokine inhibitors |
| CA3177366A1 (en) | 2006-08-10 | 2008-02-21 | Roy C. Levitt | Localized therapy of lower airways inflammatory disorders with proinflammatory cytokine inhibitors |
| US20090175784A1 (en) * | 2007-05-11 | 2009-07-09 | Joshua Goldstein | Anti-Alpha V Immunoliposome Composition, Methods, and Uses |
| US20090196913A1 (en) * | 2007-05-11 | 2009-08-06 | Ken Shi Kun Huang | Anti-Alpha-V Immunoliposome Composition, Methods, and Uses |
| JP5341889B2 (ja) * | 2007-07-17 | 2013-11-13 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 操作された抗αＶインテグリンハイブリッド抗体 |
| RU2490277C2 (ru) | 2007-09-26 | 2013-08-20 | Дженентек, Инк. | Новые антитела |
| CN102265156B (zh) | 2008-12-23 | 2014-11-05 | 默克专利有限公司 | 用于具有抗血管发生活性的抑制剂的生物标志 |
| PE20120770A1 (es) | 2009-03-25 | 2012-07-10 | Genentech Inc | ANTICUERPOS ANTI alfa5ß1 CON ACTIVIDAD SOBRE GLIOBLASTOMAS |
| CA2780773A1 (en) | 2009-11-13 | 2011-05-19 | Merck Patent Gmbh | Anti integrin antibodies linked to nanoparticles loaded with chemotherapeutic agents |
| WO2011103490A2 (en) * | 2010-02-18 | 2011-08-25 | The Regents Of The University Of California | INTEGRIN αVβ8 NEUTRALIZING ANTIBODY |
| WO2012027745A1 (en) * | 2010-08-27 | 2012-03-01 | University Of Miami | Treatment of renal diseases |
| TR201810294T4 (tr) | 2011-02-11 | 2018-08-27 | Merck Patent Gmbh | Prostat kanseri tedavisi için anti-alfa-v integrin antikoru. |
| KR102023496B1 (ko) | 2011-04-21 | 2019-09-20 | 시애틀 지네틱스, 인크. | 신규 결합제-약물 콘주게이트 (adc) 및 그의 용도 |
| KR102010098B1 (ko) * | 2011-08-17 | 2019-08-13 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 인테그린 알파-v 베타-8에 결합하는 항체 |
| WO2014143739A2 (en) | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Anti-alpha v beta 6 antibodies and uses thereof |
| WO2014144466A1 (en) | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Anti-alpha v beta 6 antibodies and uses thereof |
| US10022453B2 (en) | 2013-12-23 | 2018-07-17 | Bayer Pharma Aktiengesellschaft | Antibody drug conjugates (ADCs) with kinesin spindel protein (KSP) |
| MX2017003015A (es) | 2014-09-17 | 2017-05-23 | Merck Patent Gmbh | Metodo para tratar canceres solidos y/o metastasis de los mismos, medicamentos para los mismos, y metodo para predecir el resultado clinico para tratar canceres solidos y/o metastasis de los mismos. |
| MX2017003406A (es) | 2014-09-17 | 2017-06-19 | Merck Patent Gmbh | Metodo para tratar enfermedades de metastasis osea, medicamentos para las mismas, y metodo para predecir el resultado clinico para tratar enfermedades de metastasis osea. |
| MX2017017172A (es) | 2015-06-22 | 2018-02-23 | Bayer Pharma AG | Conjugados de ligador-principio activo (adcs) y conjugados de ligador-profarmaco (apdcs) con grupos enzimaticamente escindibles. |
| RU2018102358A (ru) | 2015-06-23 | 2019-07-25 | Байер Фарма Акциенгезельшафт | Нацеленные конъюгаты ksp ингибиторов |
| WO2017060322A2 (en) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Ptefb-inhibitor-adc |
| US20190144547A1 (en) | 2015-11-23 | 2019-05-16 | Merck Patent Gmbh | Anti-alpha-v integrin antibody for the treatment of fibrosis and/or fibrotic disorders |
| RU2018136778A (ru) | 2016-03-24 | 2020-04-24 | Байер Фарма Акциенгезельшафт | Пролекарства цитотоксических лекарственных средств, содержащие ферментативно расщепляемые группы |
| EP3919518A1 (en) | 2016-06-15 | 2021-12-08 | Bayer Pharma Aktiengesellschaft | Specific antibody-drug-conjugates (adcs) with ksp inhibitors and anti-cd123-antibodies |
| US20190242908A1 (en) | 2016-09-08 | 2019-08-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing and treating nephrotic syndrome |
| CA3047491A1 (en) | 2016-12-21 | 2018-06-28 | Bayer Aktiengesellschaft | Prodrugs of cytotoxic active agents having enzymatically cleavable groups |
| CN110072556B (zh) | 2016-12-21 | 2023-05-02 | 拜耳制药股份公司 | 具有ksp抑制剂的特异性抗体药物缀合物(adc) |
| BR112019012883A2 (pt) | 2016-12-21 | 2019-11-26 | Bayer Ag | conjugados de ligante-fármaco (adcs) que têm grupos enzimaticamente cliváveis |
| KR101961715B1 (ko) | 2018-07-18 | 2019-03-25 | (주) 삼진정밀 | 고효율 수처리장치 |
| CA3116669A1 (en) | 2018-10-19 | 2020-04-23 | Merck Patent Gmbh | Abituzumab for the treatment of colorectal cancer |
| KR101999620B1 (ko) | 2019-03-26 | 2019-07-12 | 조용진 | 부상슬러지 및 침전슬러지의 동시처리장치 |
| KR20220005471A (ko) * | 2019-04-08 | 2022-01-13 | 바이오젠 엠에이 인코포레이티드 | 항-인테그린 항체 및 이의 용도 |
| CN117143241B (zh) * | 2023-10-26 | 2024-02-23 | 迈威(上海)生物科技股份有限公司 | 与人整合素蛋白itgav/itgb8特异性结合的单克隆抗体 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU680411B2 (en) * | 1992-04-03 | 1997-07-31 | Genentech Inc. | Antibodies to alphavbeta3 integrin |
| US5753230A (en) * | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
-
1995
- 1995-12-06 DK DK95119233T patent/DK0719859T3/da active
- 1995-12-06 PT PT95119233T patent/PT719859E/pt unknown
- 1995-12-06 DE DE69531187T patent/DE69531187T2/de not_active Expired - Lifetime
- 1995-12-06 AT AT95119233T patent/ATE244306T1/de active
- 1995-12-06 EP EP95119233A patent/EP0719859B1/en not_active Expired - Lifetime
- 1995-12-06 ES ES95119233T patent/ES2202336T3/es not_active Expired - Lifetime
- 1995-12-06 SI SI9530683T patent/SI0719859T1/xx unknown
- 1995-12-13 CZ CZ19953288A patent/CZ290477B6/cs not_active IP Right Cessation
- 1995-12-13 AU AU40421/95A patent/AU710234B2/en not_active Ceased
- 1995-12-18 JP JP32887795A patent/JP3898245B2/ja not_active Expired - Fee Related
- 1995-12-18 CA CA2165573A patent/CA2165573C/en not_active Expired - Fee Related
- 1995-12-19 NO NO19955167A patent/NO321186B1/no not_active IP Right Cessation
- 1995-12-19 UA UA95125376A patent/UA40621C2/uk unknown
- 1995-12-19 US US08/574,699 patent/US5985278A/en not_active Expired - Lifetime
- 1995-12-19 SK SK1592-95A patent/SK284932B6/sk not_active IP Right Cessation
- 1995-12-19 RU RU95121105/13A patent/RU2205223C2/ru not_active IP Right Cessation
- 1995-12-19 CN CN95120901A patent/CN1117763C/zh not_active Expired - Fee Related
- 1995-12-19 FI FI956112A patent/FI118536B/sv not_active IP Right Cessation
- 1995-12-19 PL PL95311926A patent/PL182961B1/pl unknown
- 1995-12-19 HU HU9503638A patent/HU221061B1/hu not_active IP Right Cessation
- 1995-12-19 ZA ZA9510806A patent/ZA9510806B/xx unknown
- 1995-12-20 AR AR33473095A patent/AR001778A1/es active IP Right Grant
- 1995-12-20 CO CO95060553A patent/CO4480042A1/es unknown
- 1995-12-20 KR KR1019950052440A patent/KR100450368B1/ko not_active IP Right Cessation
- 1995-12-20 BR BRPI9505980-6A patent/BR9505980B1/pt not_active IP Right Cessation
- 1995-12-20 TR TR95/01614A patent/TR199501614A2/xx unknown
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